Abstracts Archive - Page 2538 of 2607 - ACR Meeting Abstracts

Abstract Number: 983 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 As a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
Jing Cui¹ and International RA Consortium on Therapy (InteRACT)², ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy and Division of Genetics, Boston, MA
Background/Purpose: There are no biomarkers that predict response to anti-TNF therapy in rheumatoid arthritis (RA). Here, we conduct a genome-wide association study (GWAS) to identify…
Abstract Number: 984 • 2012 ACR/ARHP Annual Meeting
Association of Elevated C5a Levels, but Not the Presence of Anti-Cfh IgG Autoantibodies, with the Deletion of CFHR3 and CFHR1 in SLE
Jian Zhao¹, Seema Kamble¹, Yun Deng¹, Magdangal Erika¹, Daisuke Sakurai², Rongqun Li², Weiling Chen², Jennifer M. Grossman³, Bevra H. Hahn⁴ and Betty P. Tsao⁵, ¹Division of Rheumatology, Department of Medicine,, Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ²Division of Rheumatology, Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ³Div of Rheumatology, Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ⁴Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵Medicine/Rheumatology, Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Background/Purpose: We previously reported association of the deletion of complement regulator factor H related CFHR3 and CFHR1 genes (CFHR3-1Δ), rather than CFH exonic SNPs, with…
Abstract Number: 985 • 2012 ACR/ARHP Annual Meeting
Inverse Relation Between the tumor Necrosis Factor Promoter Methylation and Trascript Leveles in Leukocytes From Patients with Rheumatoid Arthritis
James R. Maxwell¹, Lyndsey H. Taylor², Richardo A. Pachecho², Neil Lawrence², Gordon W. Duff³, M. Dawn. Teare² and Anthony G. Wilson⁴, ¹University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, United Kingdom, ³Royal Hallamshire Hospital, Sheffield, United Kingdom, ⁴Infection and Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: The importance of the epigenetic signature in RA is unclear but levels of methylation of CpG motifs in the TNF promoter are known to…
Abstract Number: 986 • 2012 ACR/ARHP Annual Meeting
Genome Wide Association Studies of Knee Osteoarthritis in 2 Large North American Cohorts: A Meta-Analysis with 2667 Cases
Marc C. Hochberg¹, Laura Yerges-Armstrong², Changwan (Larry) Lu³, Michelle S. Yau⁴, Braxton D. Mitchell², Joanne M. Jordan⁵, Youfang Liu⁶, Jordan B. Renner⁷, T. McSherry⁸, D.M. Taverna⁸, David Duggan⁹, W.J. Mysiw¹⁰ and Rebecca D. Jackson¹⁰, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD, ⁴University of Maryland, Baltimore, MD, ⁵Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁶University of North Carolina, Chapel Hill, NC, ⁷University of North Carolina Department of Radiology, Chapel Hill, NC, ⁸TGen, Pheonix, AZ, ⁹Translational Genomics Research Institute, Phoenix, AZ, ¹⁰Ohio State University, Columbus, OH
Background/Purpose: A strong genetic contribution to knee osteoarthritis (OA) is widely recognized although few loci have been robustly associated with knee OA susceptibility. To identify…
Abstract Number: 987 • 2012 ACR/ARHP Annual Meeting
Autoimmune Susceptibility Genes Are Regulators of Gene Expression Response to ER Stress
William E. Bernal¹, Michael P. Morley² and Vivian G. Cheung³, ¹Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pediatrics & Genetics, Howard Hughes Medical Institute, Chevy Chase, MD; University of Pennsylvania, Philadelphia, PA
Background/Purpose: Endoplasmic recticulum (ER) stress is caused by excessive demands on the protein-processing capacity of the ER; inefficiencies in response to ER stress lead to…
Abstract Number: 988 • 2012 ACR/ARHP Annual Meeting
Zone-Specific Protein Profiles in Human Cartilage Unraveled by a Quantitative Proteomic Approach
Patricia Fernandez-Puente¹, Lucia Lourido², Valentina Calamia², Jesus Mateos³, Cristina Ruiz-Romero⁴, Martin K. Lotz⁵ and Francisco J. Blanco⁶, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ⁴Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Rheumatology Division, Proteomics Group/ProteoRed-ISCIII, INIBIC-C. Hospitalario, A Coruña, Spain
Background/Purpose: Articular cartilage consists of a single type of cells called chondrocytes, which comprise 2-5% of total tissue mass and an extracellular matrix (ECM) mainly…
Abstract Number: 989 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Analysis Reveals a Recessive Association of ERAP1 Variants with Behçet’s Disease and Epistasis Between ERAP1 and HLA-B*51
Elaine F. Remmers¹, Yohei Kirino², George Bertsias², Yoshiaki Ishigatsubo³, Yoonhee Kim⁴, Michael J. Ombrello⁵, Ilknur Tugal-Tutkun⁶, Emire Seyahi⁷, Yilmaz Ozyazgan⁸, F. Sevgi Sacli⁹, Burak Erer¹⁰, Zeliha Emrence¹¹, Atilla Cakar¹¹, Neslihan Abaci¹¹, Duran Ustek¹¹, Colleen Satorius¹, Mitsuhiro Takeno³, Ahmet Gül¹² and Daniel L. Kastner¹, ¹Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁴Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, ⁵Translational Genetics and Genomics Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁷Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁸Ophthalmology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁹Division of Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ¹⁰Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ¹¹Genetics, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, ¹²Department of Internal Medicine, Division of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Background/Purpose: We recently performed a genome-wide association study in 1215 patients with Behçet’s disease (BD) and 1278 controls from Turkey and found disease-associated variants within…
Abstract Number: 990 • 2012 ACR/ARHP Annual Meeting
Proteomic Shotgun Analysis of Mesenchymal Stem Cells Reveals an Alterated Regulation of Proteosomal Proteins in Osteoarthritis Patients
Jose Ramon Lamas, Rheumatology, Hospital Clinico San Carlos, Madrid, Spain
Background/Purpose: To describe proteins with a potential role in OA pathogenesis, in this study we have followed a proteomic approach based on a shotgun…
Abstract Number: 991 • 2012 ACR/ARHP Annual Meeting
MTHFR Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Associations with Intima Media Thickness Scores
Clio P. Mavragani¹, Maira Giannelou², Ioanna Papadaki³, Eleni Antypa⁴, Dimitrios Ioakeimidis⁵, Haralampos M. Moutsopoulos² and Michael Koutsilieris⁶, ¹Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ²Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ³Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ⁴Department of Radiology, General Hospital of Athens, Greece, ⁵Department of Rheumatology, General Hospital, Greece, ⁶Department of Physiology, Athens University Medical School, Athens, Greece
Background/Purpose: Previous studies identified polymorphisms in the gene coding for the Methylenetetrahydrofolatereductase (MTHFR) enzyme as genetic contributors for cardiovascular disease in the general population. The…
Abstract Number: 992 • 2012 ACR/ARHP Annual Meeting
Functional Genomics of the Human ITGAM Locus
Yebin Zhou¹, Dan C. Bullard¹, Alexander Szalai², Jianming Wu³ and Jeffrey C. Edberg⁴, ¹Genetics, University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology, University of alabama at birmingham, Birmingham, AL, ³Veterinary and Biomedical Science, Medicine, University of minnesota, St. Paul, MN, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: ITGAM encodes CD11b, the αM subunit of the Mac-1 -αMβ2 integrin. Mac-1 has many functions on leukocytes including its role as an adhesion molecule…
Abstract Number: 993 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide DNA Methylation Analysis Reveals Different Methylation Patterns in the OA Disease
Ignacio Rego-Pérez¹, Juan Fernandez-Tajes², Mercedes Fernandez-Moreno², Maria Tamayo Novas³, Alejandro Mosquera Rey³, Natividad Oreiro², Carlos Fernandez-Lopez², Jose Luis Fernandez Garcia³ and Francisco J. Blanco², ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña. Genetic Deparment., A Coruña, Spain
Background/Purpose: DNA methylation is a basic mechanism involved in epigenetic regulation that affects gene transcription by the addition of a methyl group to the cytosine…
Abstract Number: 994 • 2012 ACR/ARHP Annual Meeting
The Genome-Wide Expression of Human Osteoarthritic Cartilage Shows A Differential Pattern Between Two Subgroups of OA Patients
Ignacio Rego-Perez¹, Juan Fernandez-Tajes¹, Angel Soto-Hermida², Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera³, Natividad Oreiro¹, Carlos Fernandez-Lopez¹, Estefania Cortes Pereira¹, Sara Relaño-Fernandez¹ and Francisco J. Blanco¹, ¹INIBIC-Hospital Universitario A Coruña. Genomic Group. Rheumatology Division., A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Many genes, many of them still unknown, are involved in the etiology and development of OA. Today, different tools are available to try to…
Abstract Number: 954 • 2012 ACR/ARHP Annual Meeting
Diagnosis of Secondary Fibromyalgia in an Established Rheumatoid Arthritis Cohort
Yvonne C. Lee¹, Christine K. Iannaccone¹, Michelle A. Frits¹, M. Weinblatt² and Nancy A. Shadick³, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ³Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: The prevalence of fibromyalgia (FM) is 7-10 times higher among rheumatoid arthritis (RA) patients than the general population. However, the diagnosis of FM in…
Abstract Number: 955 • 2012 ACR/ARHP Annual Meeting
Post – Surgical Outcome Is Correlated with Pre – Surgical Symptoms of Fibromyalgia in Patients Undergoing Spinal Surgery
Jacob N. Ablin¹, Mark Berman², Eyal Behrbalk³, Dan Buskila⁴, Gilad Regev³ and Zvi Lidar³, ¹Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Internal Medicine F, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ³Department of Neurosurgery and Orthopedic, Department of Neurosurgery and Orthopedic, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁴Ben-Gurion University, Beer-Sheva, Israel
Background/Purpose: Chronic pain is a major symptom for which patients undergo spinal surgery. At the same time, chronic pain is considered an entity in and…
Abstract Number: 956 • 2012 ACR/ARHP Annual Meeting
Learning Disability in Fibromyalgia Patients: FMS Patients Report More Language and Spatial Difficulties
Robert S. Katz¹, Alexandra Small², Carlen Katz³ and Susan Shott¹, ¹Rush University Medical Center, Chicago, IL, ²University of Illinois Medical School, Chicago, IL, ³Rheumatology Associates, Chicago, IL
Background/Purpose: Fibromyalgia patients are reported to have central sensitization and abnormal central processing of sensory input. Fibromyalgia patients also have more neurocognitive complaints and abnormalities on…

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