Abstracts Archive - Page 2531 of 2607 - ACR Meeting Abstracts

Abstract Number: 1079 • 2012 ACR/ARHP Annual Meeting
Polyclonal CD4⁺Foxp3⁺treg Cells Induce TGFb-Dependent Tolerogenic Dendritic Cells That Suppress Murine Lupus-Like Syndrome
Qin Lan¹ and Song G. Zheng², ¹Medicine, University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine of USC, Los Angeles, CA
Background/Purpose: Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are…
Abstract Number: 1080 • 2012 ACR/ARHP Annual Meeting
Effect of Anti-NKG2A Antibody Treatment On NK Cell Receptor Expression in Rheumatoid Arthritis Patients
Joseph Wahle, John Bui and Kristen Bontadelli, Biopharmaceuticals Research Unit, Novo Nordisk, Seattle, WA
Background/Purpose: This study explored the effect of in vitroblockade of the NKG2A HLA-E interaction on peripheral NK cells from rheumatoid arthritis patients. To block this…
Abstract Number: 1081 • 2012 ACR/ARHP Annual Meeting
Toll-Like Receptor 7, 8 and 9 Activation of Primary Human Cells by Lupus Immune Complexes Is Dependent On Interleukin 1 Receptor Associated Kinase 4 Activity
Aaron Winkler¹, Weiyong Sun¹, Ken Dower², Elizabeth A. Murphy¹, Julia Shin¹, Michael Luong¹, Michael J. Primiano¹, Varenka A. Rodriguez², Tatyana Souza¹, Lih-Ling Lin³, J. Perry Hall¹, Katherine Lee⁴, Vikram R. Rao¹ and Margaret Fleming¹, ¹Inflammation & Remodeling, Pfizer, Cambridge, MA, ²Inflammation and Remodeling, Pfizer, Cambridge, MA, ³Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA, ⁴Worldwide Medicinal Chemistry, Pfizer, Cambridge, MA
Background/Purpose: Genetic, in vitro and in vivo evidence strongly implicate the activation of nucleic acid sensing toll like receptors (TLR) 7, 8, and 9 in…
Abstract Number: 1082 • 2012 ACR/ARHP Annual Meeting
Predictors of Persistence in People with Subacute Low Back Pain
Souraya Torbey¹, Ali Mansour¹, Kristina Herrmann¹, Marwan Baliki², Thomas J. Schnitzer³ and A. Vania Apkarian², ¹Northwestern University, Chicago, IL, ²Physiology, Northwestern University, Chicago, IL, ³PM&R and Int Med, Northwestern University, Chicago, IL
Background/Purpose: Acute pain is a vital adaptive and protective mechanism. Conversely, chronic pain is a persistent, maladaptive response that outlasts the normal healing period of…
Abstract Number: 1083 • 2012 ACR/ARHP Annual Meeting
Physicians’ Recommendations for Total Knee Arthroplasty in Younger Persons with Moderate Osteoarthritis
Liana Fraenkel¹, Lawrence Weis² and Lisa Suter³, ¹Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ²Medicine, Yale University, New Haven, CT, ³Medicine, Rheumatol, TAC S541, Yale University, New Haven, CT
Background/Purpose: Rates of total knee arthroplasty (TKA) are increasing among all age groups. The most rapidly growing population of patients undergoing TKA are those under…
Abstract Number: 1084 • 2012 ACR/ARHP Annual Meeting
In Vivo Kinematics of Three-Component Mobile-Bearing Total Ankle Replacement for Rheumatoid Arthritis
Keiji Iwamoto¹, Tetsuya Tomita², Takaharu Yamazaki³, Kenrin Shi⁴, Norimasa Shimizu¹, Masahiro Kurita¹, Kazuma Futai¹, Yasuo Kunugiza⁵, Hideki Yoshikawa⁶ and Kazuomi Sugamoto¹, ¹Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan, ²Dept of Orthopaedics, Osaka University Graduate School of Medicine, Osaka, Japan, ³The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan, ⁴Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan, ⁶Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: The standard treatment for end-stage arthritis of the ankle joint due to rheumatoid arthritis (RA) has been an ankle arthrodesis. Patients with RA who…
Abstract Number: 1085 • 2012 ACR/ARHP Annual Meeting
Differences in Baseline Characteristics Between TKR and THR Patients: Results From a National Research Consortium
Patricia D. Franklin¹, Benjamin Snyder², Jeroan Allison³, Wenjun Li¹, Milagros Rosal⁴, Leslie R. Harrold⁵, Bruce Barton³ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Orthopedics, University of Massachusetts Medical School, Worcester, MA, ³Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ⁴Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, ⁵Dept of Medicine, UMass Medical School, Worcester, MA
Background/Purpose: Both total knee replacement (TKR) and total hip replacement (THR) reliably relieve pain, restore function, and ensure mobility in patients with advanced joint arthritis;…
Abstract Number: 1086 • 2012 ACR/ARHP Annual Meeting
Has the Level of Disability At Time of TKR Changed Over the Past 10 Years?: Results From Two National Cohorts
Patricia D. Franklin¹, Wenjun Li¹, Benjamin Snyder², Courtland Lewis³, Philip Noble⁴ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Orthopedics, University of Massachusetts Medical School, Worcester, MA, ³CT Joint Replacement Institute, St. Francis Hospital, Hartford, CT, ⁴Baylor College of Medicine, Houston, TX
Background/Purpose: A growing numbers of younger adults report knee pain consistent with OA, although parallel analyses of knee x-rays show no increase in classic radiographic…
Abstract Number: 1087 • 2012 ACR/ARHP Annual Meeting
Do Younger TKR Patients Have Similar Disability At Time of Surgery As Older Adults?
Patricia D. Franklin¹, Wenjun Li¹, Leslie R. Harrold², Benjamin Snyder³, Courtland Lewis⁴, Philip Noble⁵ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Dept of Medicine, UMass Medical School, Worcester, MA, ³Orthopedics, University of Massachusetts Medical School, Worcester, MA, ⁴CT Joint Replacement Institute, St. Francis Hospital, Hartford, CT, ⁵Baylor College of Medicine, Houston, TX
Background/Purpose: The trend toward greater numbers of working-aged patients choosing TKR has raised concerns that younger patients may receive surgery prematurely. We compared the severity…
Abstract Number: 1088 • 2012 ACR/ARHP Annual Meeting
Factors Influencing Long-Term Recovery of Total Knee Arthroplasty
C. Allyson Jones¹, Gian S. Jhangri² and Maria E. Suarez-Almazor³, ¹Departments of Physical Therapy and School of Public Health, University of Alberta, Edmonton, AB, Canada, ²School of Public Health, University of Alberta, Edmonton, AB, Canada, ³The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Although a number of studies have examined short term outcomes after total knee arthroplasty (TKA), few have prospectively examined the long term trajectory of…
Abstract Number: 1089 • 2012 ACR/ARHP Annual Meeting
The Number of Ruptured Tendons As a Prognostic Factor for Reconstructing Extensor Tendon Rupture in Patients with Rheumatoid Arthritis
Yu Sakuma¹, Kensuke Ochi¹, Takuji Iwamoto¹, Shinji Yoshida², Asami Saitou¹, Katsunori Ikari¹ and Shigeki Momohara¹, ¹Department of orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Extensor tendon rupture seen in patients with rheumatoid arthritis (RA) is usually surgically treated in combination with extensor tendon reconstruction and wrist arthroplasty. However,…
Abstract Number: 1090 • 2012 ACR/ARHP Annual Meeting
A Comparison of Patient-Reported and Measured Range of Motion in a Cohort of Total Knee Replacement Patients
Jamie E. Collins¹, Benjamin N. Rome¹, Vladislav Lerner¹, Jeffrey N. Katz² and Elena Losina¹, ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Range of motion (ROM) is an important component of the assessment of total knee replacement (TKR) outcome. Traditionally, ROM is measured by a clinician…
Abstract Number: 1091 • 2012 ACR/ARHP Annual Meeting
Trends in Patient Physical Activity Before and After Primary Total Hip Arthroplasty
Anne Lübbeke¹, Dorith Zimmermann², Constantinos Roussos¹, Alexis Bonvin¹, Robin Peter¹ and Pierre Hoffmeyer¹, ¹Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, ²Geneva University Hospitals, Geneva, Switzerland
Background/Purpose: Total hip arthroplasties (THA) are performed to reduce pain and enhance patients’ function and physical activity (PA) level. PA is also recognized as the…
Abstract Number: 1092 • 2012 ACR/ARHP Annual Meeting
Effect of FULL Contact FOOT Orthosis On Plantar Fasciitis
Hilda A. Oliveira¹, Anamaria Jones², Emilia Moreira³, Fabio Jennings³ and Jamil Natour⁴, ¹Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Unifesp-EPM, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ⁴Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
EFFECT OF FULL CONTACT FOOT ORTHOSIS ON PLANTAR FASCIITIS Background/Purpose: Plantar fasciitis (PF) is an inflammation of the foot plantar fascia, characterized by stiffness in…
Abstract Number: 1093 • 2012 ACR/ARHP Annual Meeting
Obesity Is Not a Risk Factor for Poor Pain and Function Two Years After Total Knee Replacement
Lisa A. Mandl¹, Mark P. Figgie², Alejandro Gonzalez Della Valle³, Michael Alexiades³ and Susan M. Goodman¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Orthopedics, Hospital for Special Surgery, New York, NY, ³Orthopaedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Almost 90% of referring physicians think obesity increases the likelihood of poor outcomes after total knee replacement (TKR). However, current data are conflicting. The…

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