Abstracts Archive - Page 2484 of 2607 - ACR Meeting Abstracts

Abstract Number: 1817 • 2012 ACR/ARHP Annual Meeting
The Role of Repeating Tuberculin Skin Tests During Biologic Therapy
Joseph R. Lutt¹ and Kevin L. Winthrop², ¹Colorado Center for Arthritis & Osteoporosis, Boulder, CO, ²Dept of Infectious Disease, Oregon Health & Science University, Portland, OR
The Role of Repeating Tuberculin Skin Tests during Biologic TherapyBackground/Purpose: Prior to starting biologic therapy, it is recommended that all patients be screened for tuberculosis…
Abstract Number: 1818 • 2012 ACR/ARHP Annual Meeting
Latent Tuberculosis Detection and Tuberculosis Reactivation in Patients Receiving Anti-TNFá Drugs: A Nationwide Italian Survey
Fabrizio Cantini¹, Ennio Lubrano², Alessandro Mathieu³, Antonio Marchesoni⁴, Carlo Salvarani⁵, Raffaele Scarpa⁶ and Antonio Spadaro⁷, ¹U.O.C. Reumatologia, Prato Hospital, Prato, Italy, ²Cattedra di Reumatologia, Università del Molise, Campobasso, Italy, ³Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ⁴Rheumatology, Istituto Ortopedico Gaetano Pini, Milano, Italy, ⁵Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶c/o Medical University, Via Pansini 5, Naples, Italy, ⁷Cattedra di Reumatologia, Univeristà La Sapienza di Roma, Roma, Italy
Background/Purpose: Anti-TNFα drugs are associated with an increased risk of tuberculosis (TB) and several recommendation sets for latent tubercular infection (LTBI) detection and TB reactivation…
Abstract Number: 1778 • 2012 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A_2AR) Activation Stimulates Increased Expression of Collagen-1 and Collagen-3 by Different Signaling Pathways in Normal Human Dermal Fibroblasts
Miguel Perez Aso¹ and Bruce N. Cronstein², ¹NYU Univ Medical Center, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Pathological fibrosis in the skin and other organs is the hallmark of scleroderma and other fibrosing diseases. Adenosine, acting at A2AR, plays a critical…
Abstract Number: 1779 • 2012 ACR/ARHP Annual Meeting
The Loss of Syndecan-4 Aggravates Inflammatory Colitis in Mice
Athanasios Stratis¹, Dominik Bettenworth², Mareike Fröhling¹, Peter Paruzel¹, Adelheid Korb-Pap¹, Corinna Wehmeyer¹, Berno Dankbar¹, Frank Echtermeyer³, Andreas Lügering⁴ and Thomas Pap¹, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Muenster, Muenster, Germany, ²Department of Medicine B University Hospital Münster, University Hospital Muenster, Muenster, Germany, ³Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁴Department of Medicine B University of Münster, MVZ Portal 10, Münster, University Hospital Muenster, Muenster, Germany
Background/Purpose: Syndecan-4 (sdc4) is a transmembrane heparan sulfate proteoglycan. Several studies have implicated sdc4 in cell-matrix adhesion, cell migration, differentiation, proliferation and play an important…
Abstract Number: 1780 • 2012 ACR/ARHP Annual Meeting
Association Between Chondrocyte Hypertrophy and Angiogenesis of Cartilage in Osteoarthritis
Laurence Pesesse¹, Christelle Sanchez², Jean-Pierre Delcour³, Caroline Baudouin⁴, Philippe Msika⁴ and Yves Henrotin⁵, ¹Bone and Cartilage Research Unit, University of Liège, Liège, Belgium, ²Bone and Cartilage Research Unit, University of Liège, Liege, Belgium, ³Orthopedic surgery, Centre hospitalier du Bois de l'Abbaye, Seraing, Belgium, ⁴IRD Direction, Laboratoires Expanscience, Epernon, France, ⁵University of Liège, Bone and Cartilage Research Unit, Liège, Belgium
Background/Purpose: Chondrocyte hypertrophy is commonly observed in OA cartilage, associated with matrix mineralization and vascularization. In our previous work, we demonstrated that hypertrophic differentiation of…
Abstract Number: 1781 • 2012 ACR/ARHP Annual Meeting
Functional Analysis of the Primary Cilium in Rheumatoid Arthritis Synovial Fibroblasts
Kerstin Klein¹, Beat A. Michel¹, Alexander Vogetseder², Renate Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: The primary cilium is a microtubule-based, polarized, antenna structure that emanates from the cell surface of most mammalian cell types. It serves as a…
Abstract Number: 1782 • 2012 ACR/ARHP Annual Meeting
Dual Effects of Soluble FasL and Membrane Bound FasL On Fibroblast-Like Synoviocytes Cells (FLS) From Rheumatoid Arthritis (RA) Patients
Rachel Audo¹, Flavia Calmon-Hamaty¹, Bernard Combe², Michael Hahne¹ and Jacques Morel³, ¹IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ²Rheumatology, Hopital Lapeyronie, Montpellier, France, ³Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France
Background/Purpose: Membrane bound FasL (mFasL) is able to induce fibroblast-like synoviocytes (FLS) cell death. In experimental arthritis mouse models, injection of agonistic antibody (Ab) anti-Fas…
Abstract Number: 1783 • 2012 ACR/ARHP Annual Meeting
TNFα Influences RasGRP1 and RasGRP3 Expression Levels in PBMC, B and T Cells
Marie-Laure Potier¹, Martine Hiron¹, Clément Guillou¹, Céline Derambure², Olivier Boyer³, Xavier Le Loët⁴, Olivier Vittecoq⁵ and Thierry Lequerré⁶, ¹Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, ²Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, Rouen, France, ³Immunology, Inserm 905, Institute for Biomedical research, University of Rouen, Rouen, France, ⁴Rheumatology Department, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen Cedex, France, ⁵Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen Cedex, France, ⁶Rheumatology Department & Inserm 905, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen Cedex, France
Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis. B and T lymphocytes play a central role in the pathophysiology of RA. RasGRP is…
Abstract Number: 1784 • 2012 ACR/ARHP Annual Meeting
Dual Function of Interleukin-33 in Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis
Min W. So¹, Bon S. Koo¹, You J. Kim¹, You-G Kim¹, Wook J. Seo², Chang-K Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea
Background/Purpose: IL-33 is a new member of the IL-1 cytokine family. Recent studies in an animal model of murine collagen-induced arthritis and human rheumatoid arthritis…
Abstract Number: 1785 • 2012 ACR/ARHP Annual Meeting
MiR-30* Family Negatively Regulates B-Cell Activating Factor (BAFF) Synthesis in Rheumatoid Synoviocytes
Ghada Alsaleh¹, Antoine Francois², Lucas Philippe¹, Jean Sibilia¹, Jacques-Eric Gottenberg¹, Philippe Georgel³ and Dominique Wachsmann¹, ¹Université de Strasbourg, EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, ²Laboratory of Physiopathology of Arthritises, University of Strasbourg, Illkirch-Strasbourg, France, ³Université de Strasbourg, Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
Background/Purpose: In rheumatoid arthritis (RA) resident cells of the joint, fibroblast-like synoviocytes (RA FLS) acquire an aggressive phenotype in response to extrinsic factors such as…
Abstract Number: 1786 • 2012 ACR/ARHP Annual Meeting
Targeting CD1c-Expressing mDCs to Inhibit Increased Thymus and Activation Regulated Chemokine Levels in RA
M.R. Hillen¹, F.M. Moret¹, F.P.J.G. Lafeber², C.E. Hack³, T.R.D.J. Radstake⁴ and J.A.G. van Roon⁵, ¹Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymus and activation regulated chemokine (TARC) is a chemotactic factor that attracts cells expressing CCR4, including CD4 T cells with Th2, Th17 and Treg…
Abstract Number: 1787 • 2012 ACR/ARHP Annual Meeting
Evolution of the Cytokine and Chemokine Profile in Patients Receiving Oral Daily Vitamin D: Results From a Randomized Controlled Trial
Benjamin Terrier¹, Marlène Garrido² and Patrice Cacoub Sr.³, ¹Internal Medicine, Cochin University Hospital, Paris, France, ²I3 laboratory, Pitié-Salpétrière, Paris, France, ³Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Immunomodulatory effects of vitamin D were recently described in vitro, notably the expansion of regulatory T cells able to suppress inflammatory responses and the…
Abstract Number: 1788 • 2012 ACR/ARHP Annual Meeting
TSLP Induces TNFα Production by CD1c Myeloid Dendritic Cells and Myeloid DC-Activated T Cells From Rheumatoid Arthritis Patients
F.M. Moret¹, T.R.D.J. Radstake², J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon³, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Fibroblasts from rheumatoid arthritis…
Abstract Number: 1789 • 2012 ACR/ARHP Annual Meeting
Evidence for an Additive Effect of Tumor Necrosis Factor Alpha and Hypoxia to Promote Bone Destruction in Arthritis
Shankar Revu¹, Akilan Krishnamurthy², Vivekananda Sunkari³, Ileana R. Botusan³, Xiaowei Zheng³, Sergiu-Bogdan Catrina⁴ and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Hypoxia is a major feature of the inflamed rheumatoid arthritis synovial membrane and promotes osteoclasts formation in vitro. We aimed to investigate the molecular…
Abstract Number: 1790 • 2012 ACR/ARHP Annual Meeting
Notch Promotes Matrix Metalloproteinase 13 Expression by Inducing Interleukin-6 in Primary Murine Chondrocytes
Stefano Zanotti and Ernesto Canalis, Research, Saint Francis Hospital and Medical Center, Hartford, CT
Background/Purpose: Notch1 to Notch4 are transmembrane receptors that determine cell differentiation and function. Interactions of Notch with its ligands result in the cleavage of the…

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