Abstracts Archive - Page 2472 of 2605 - ACR Meeting Abstracts

Abstract Number: 1941 • 2012 ACR/ARHP Annual Meeting
Clinical Evaluation of Anti-Aminoacyl tRNA Synthetase Antibodies in Japanese Patients with Connective Tissue Diseases
Masakazu Matsushita, Toshio Kawamoto, Ken Yamaji, Naoto Tamura and Yoshinari Takasaki, Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Anti-Jo-1 antibody is an autoantibody specifically detected in sera of patients with polymyositis/dermatomyositis (PM/DM). The antigen corresponding to this autoantibody is histidyl-tRNA synthase, being…
Abstract Number: 1942 • 2012 ACR/ARHP Annual Meeting
Increased Levels of Eotaxin and MCP-1 in Juvenile Dermatomyositis Median 17 Years After Diagnosis; Associations with Disease Activity, Duration and Organ Damage
Helga Sanner¹, Thomas Schwartz², Berit Flatø¹, Maria Vistnes², Geir Christensen² and Ivar Sjaastad³, ¹Department of Rheumatology, Oslo University Hospital, Oslo, Norway, ²Institute for Experimental Medical Research, University of Oslo, Oslo, Norway, ³Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway
Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic vasculopathic disease of childhood affecting skeletal muscle, skin and other organs. Increased abundance of pro-inflammatory cytokines has been…
Abstract Number: 1943 • 2012 ACR/ARHP Annual Meeting
Autophagy Expressions Were Decreased in Circulating T Cells in Inflammatory Myopathies Patients
Fang Chen¹, Xiaoming Shu², Xin Lu³ and Guochun Wang¹, ¹Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China, ²China-Japan Friendship Hospital, Beijing, China, ³Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: The autophagy in circulating lymphocytes in IIM patients has not been clarified yet. Our research is aimed to study the autophagy in circulating T…
Abstract Number: 1944 • 2012 ACR/ARHP Annual Meeting
Expression of Human Leukocyte Antigen-G in Polymyositis or Dermatomyositis
Xiaolan Tian¹, Xiaoming Shu², Xin Lu¹, Qinglin Peng³ and Guochun Wang⁴, ¹Department of rheumatology, China-Japan Friendship Hospital, Beijing, China, ²Rheumatology, China-Japan Friendship Hospital, Beijing, China, ³Department of Rheumatology,, China-Japan Friendship Hospital, Beijing, China, ⁴Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: Human leukocyte antigen-G is a non-classical MHC--I molecule that may be involved in the pathogenesis of autoimmune diseases, but the significance of HLA-G in…
Abstract Number: 1945 • 2012 ACR/ARHP Annual Meeting
Anti-Transcription Intermediary Factor 1-Gamma (TIF1-Υ) Autoantibody Detection by ELISA and Immunoprecipitation in a Prospective Myositis Cohort: Predictive Value for Cancer Associated Myositis
Rohit Aggarwal¹, Noreen Fertig², Danielle Goudeau³, Chad Stephans⁴, Qi Zengbiao⁵, Diane Koontz⁵, Mary Lucas⁶, Marc C. Levesque³ and Chester V. Oddis⁷, ¹Rheumtology, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Myositis [particularly dermatomyositis (DM)] is associated with cancer and anti-transcription intermediary factor-1 gamma (TIF1γ) is a serologic risk factor for cancer associated myositis (CAM).…
Abstract Number: 1946 • 2012 ACR/ARHP Annual Meeting
Effect of Immunosuppressive Treatment On Gene Expression in Patients with Polymyositis and Dermatomyositis
Ingela M. Loell¹, Yi-Wen Chen², Marina Korotkova³, Kanneboyina Nagaraju² and Ingrid E. Lundberg⁴, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ²Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC, ³Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) muscle tissue is characterized by infiltrating T cells, macrophages and dendritic cells, as well as cytokines and chemokines. In…
Abstract Number: 1947 • 2012 ACR/ARHP Annual Meeting
Muscle Wasting in HTNFtg Mice, an Animal Model for Rheumatoid Arthritis, Due to Increased Cathepsin L and LC3B Expression
Martin Willburger¹, Birgit Niederreiter¹, Ewald Unger², Josef S. Smolen³, Kurt Redlich¹ and Silvia Hayer¹, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Center for Medical Physics and Biomedicla Engineering, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To investigate the impact of systemic inflammation on skeletal muscles in human tumor necrosis factor transgenic (hTNFtg) animals. Methods: We isolated triceps surae, quadriceps,…
Abstract Number: 1948 • 2012 ACR/ARHP Annual Meeting
Decreased C4A Gene Copy Numbers in Children with Juvenile Dermatomyositis: Association with Decreased C4 Protein and Lower Absolute Number of CD3 Negative CD16/56+ Natural Killer Cells
Lauren M. Pachman¹, Katherine E. Lintner², Yee Ling Wu², Lori J. Ferguson³, Gabrielle A. Morgan⁴, Chiang-Ching Huang⁵ and C. Yung Yu⁶, ¹Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ³Children's Hospital of Chicago Research Center, Cure JM Myositis Center, Chicago, IL, ⁴Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ⁵Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH
Background/Purpose: Juvenile Dermatomyositis (JDM), a systemic vasculopathy, is member of the family of autoimmune diseases. In 56% of untreated JDM, a decrease in the absolute…
Abstract Number: 1949 • 2012 ACR/ARHP Annual Meeting
Anti-Transcription Intermediary Factor 1-Gamma (TIF1-Υ) Autoantibody ELISA Development and Validation
Rohit Aggarwal¹, Chester V. Oddis², Noreen Fertig³, Danielle Goudeau⁴, Diane Koontz⁵, Chad Stephans⁶, Zengbiao Qi⁷ and Marc C. Levesque⁴, ¹Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Anti-transcription intermediary factor 1-gamma (TIF1-g) autoantibody is disease-specific for myositis and identifies a subset of dermatomyositis patients at risk of cancer. Currently non-quantitative immunoprecipitation…
Abstract Number: 1950 • 2012 ACR/ARHP Annual Meeting
Anti-Signal Recognition Particle Autoantibody ELISA Development and Validation: Utility in Patients with Necrotizing Myopathy
Rohit Aggarwal¹, Chester V. Oddis², Danielle Goudeau³, Chad Stephans⁴, Noreen Fertig⁵, Qi Zengbiao⁶, Diane Koontz⁶ and Marc C. Levesque³, ¹Rheumtology, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Anti-signal recognition particle (SRP) autoAb identifies a myositis subset with a necrotizing myopathy and poor prognosis. Currently, immunoprecipitation (IP) is used to identify anti-SRP.…
Abstract Number: 1951 • 2012 ACR/ARHP Annual Meeting
Elevated Level of Tumor Necrosis Factor-Like Weak Inducer of Apoptosis in Patients with Polymyositis or Dermatomyositis
Qinglin Peng, Xin Lu, Ning Zu, Lu Zhang and Guochun Wang, Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) family, has emerged as a cytokine that regulates multiple cellular…
Abstract Number: 1952 • 2012 ACR/ARHP Annual Meeting
The Effect of CXCL10 Blockade in C Protein-Induced Myositis
Jinhyun Kim¹, Jiyong Choi², Sung Hae Chang³, Ki Chul Shin⁴, Sung-Hye Park⁵, Hye Won Kim⁶, Hye Jin Oh⁴, Myeong Jae Yoon⁷, Bong Seung Ku⁸, Eun Young Lee⁶, Eun Bong Lee³, Hiroshi Kawachi⁹, Hitoshi Kohsaka¹⁰ and Yeong Wook Song¹¹, ¹Department of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁴Rheumatology, Seoul National University College of Medicine, Seoul, South Korea, ⁵Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁷Department of Internal Medicine, School of Medicine, Seoul National University, Seoul, South Korea, ⁸Rheumatology, Department of Internal Medicine, School of Medicine, Seoul National University Hospital, Seoul, Korea, Seoul, South Korea, ⁹Department of Cell Biology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea
Background/Purpose: CXCL10 (also called interferon-γ-inducible protein 10 [IP-10]) is a chemokine that plays a critical role in the infiltration of T cell in autoimmune disease…
Abstract Number: 1953 • 2012 ACR/ARHP Annual Meeting
Antibodies to NXP-2 and Transcriptional Intermediary Factor-Gamma Identify Patients with Cancer-Associated Dermatomyositis
David Fiorentino¹, Lisa Christopher-Stine², Lorinda Chung³, Bharathi Lingala⁴, Andrew L. Mammen⁵, Antony Rosen⁶ and Livia Casciola-Rosen⁶, ¹Dermatology, Stanford University School of Medicine, Redwood City, CA, ²Medicine and Neurology, Johns Hopkins University, Baltimore, MD, ³Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ⁴Dermatology, Stanford University, Redwood City, CA, ⁵NIAMS, NIH, Bethesda, MD, ⁶Division of Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is known to be associated with internal malignancy, and identifying patients at high risk is a high priority. Recently, several groups have…
Abstract Number: 1954 • 2012 ACR/ARHP Annual Meeting
Immune Responses to NXP-2 and TIF-g Are Associated with Distinct Clinical Phenotypes and Prognosis for Skin Disease in Dermatomyositis Patients
David Fiorentino¹, Lorinda Chung², Lisa Zaba¹, Bharathi Lingala³, Antony Rosen⁴ and Livia Casciola-Rosen⁴, ¹Dermatology, Stanford University School of Medicine, Redwood City, CA, ²Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Division of Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Myositis-specific antibodies have been proposed as tools for disease classification as they are correlated with certain clinical and genetic features. Recently, two new DM-specific…
Abstract Number: 1955 • 2012 ACR/ARHP Annual Meeting
Is the Pattern of Capillary Deposition of Complement Membrane Attack COPMLEX Useful in the Differential Diagnosis of Inflammatory?
Patrick Gordon¹, Nuria Villagra², Istvan Bodi², Andrew King², Stefan Buk², Tibor Hortobagyi² and Safa Al-Sarraj², ¹Department of Rheumatology, King's College London, London, United Kingdom, ²Department of Clinical Neuropathology, King's College Hospital, London, United Kingdom
Background/Purpose: Inflammatory myopathies are a heterogeneous group of diseases. We investigated if the location and pattern of deposition of complement membrane attack complex (MAC) can…

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