Abstracts Archive - Page 2472 of 2607 - ACR Meeting Abstracts

Abstract Number: 1998 • 2012 ACR/ARHP Annual Meeting
Relationship Between Changes in Bone Mineral Density and Incidence of Fracture with 6 Years of Denosumab Treatment
Michael A. Bolognese¹, Paul D. Miller², Jean-Yves Reginster³, Nathalie Franchimont⁴, Gerolamo Bianchi⁵, Roland Chapurlat⁶, Federico G. Hawkins⁷, David L. Kendler⁸, Beatriz Oliveri⁹, Jose R. Zanchetta¹⁰, Nadia Daizadeh⁴, Andrea Wang⁴, Rachel B. Wagman⁴ and Socrates Papapoulos¹¹, ¹Bethesda Health Research Center, Bethesda, MD, ²University of Colorado Health Sciences Center and Colorado Center for Bone Research, Lakewood, CO, ³Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium, ⁴Amgen Inc., Thousand Oaks, CA, ⁵LELICOMAR - Div Reumatologia, Azienda Sanitaria Genovese, Genoa, Italy, ⁶Hôpital Edouard Herriot, Lyon, France, ⁷Hospital Universitario, Madrid, Spain, ⁸University of British Columbia, Vancouver, BC, Canada, ⁹Laboratorio Enfermedades Metabólicas Oseas, Hospital de Clínicas, INIGEM UBA-CONICET, Buenos Aires, Argentina, ¹⁰Instituto de Investigaciones Metabólicas and University of Salvador, Buenos Aires, Argentina, ¹¹Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: During the first 3 years of denosumab treatment in FREEDOM, there were continued increases in bone mineral density (BMD) and a robust reduction in…
Abstract Number: 1999 • 2012 ACR/ARHP Annual Meeting
Immunogenicity and Safety of Two Doses of Influenza A H1N1⁄2009 Vaccine in Young Autoimmune Rheumatic Diseases Patients Under 9 Years Old
Guilherme Trudes¹, Nadia E. Aikawa², Lucia M. Campos³, Rosa M.R. Pereira⁴, Julio C. B. Moraes⁵, Ana Cristina Ribeiro⁶, Joao Miraglia⁷, Maria do Carmo S. Timenetsky⁸, Eloisa Bonfa⁴ and Clovis Artur Silva⁹, ¹Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Rheumatology, University of São Paulo, Sao Paulo, Brazil, ³Pediatric Rheumatology, University of São Paulo Medical School, São Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁵Rheumatology Divison, University of Sao Paulo, Sao Paulo, Brazil, ⁶Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁷Instituto Butantan, Fundação Butantan, São Paulo, Brazil, ⁸Instituto Adolfo Lutz - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁹Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: In 2010 the Advisory Committee on Immunization Practices from the CDC recommended that all children should receive the trivalent seasonal influenza vaccine containing the…
Abstract Number: 1959 • 2012 ACR/ARHP Annual Meeting
Low Fracture Incidence Is Maintained in Postmenopausal Women ≥75 Years with Osteoporosis with Long-Term Denosumab Treatment
Socrates Papapoulos¹, Michael McClung², Nathalie Franchimont³, Jonathan D. Adachi⁴, Henry G. Bone⁵, Claude-Laurent Benhamou⁶, Jordi Farrerons⁷, JC Gallagher⁸, Johan Halse⁹, Kurt Lippuner¹⁰, Salvatore Minisola¹¹, Ove Törring¹², Nadia Daizadeh³, Andrea Wang³, Rachel B. Wagman³ and Steven Boonen¹³, ¹Leiden University Medical Center, Leiden, Netherlands, ²Oregon Osteoporosis Center, Portland, OR, ³Amgen Inc., Thousand Oaks, CA, ⁴St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁵Michigan Bone and Mineral Clinic, Detroit, MI, ⁶Centre Hospitalier Régional d'Orléans, Orleans, France, ⁷Hospital de la Santa Creu I Sant Pau, Barcelona, Spain, ⁸Creighton University Medical Center, Omaha, NE, ⁹Osteoporoseklinikken, Oslo, Norway, ¹⁰Bern University Hospital, Bern, Switzerland, ¹¹Sapienza, Università di Roma, Rome, Italy, ¹²Karolinska Institutet Sodersjukhuset, Stockholm, Sweden, ¹³Leuven University, Leuven, Belgium
Background/Purpose: In the pivotal fracture trial, FREEDOM, denosumab increased bone mineral density (BMD) and reduced the incidence of new vertebral, nonvertebral, and hip fractures in…
Abstract Number: 1960 • 2012 ACR/ARHP Annual Meeting
Initiation of Tumor Necrosis Factor Alpha (TNFα) Antagonists and Risk of Fractures in Patients with Selected Rheumatic and Autoimmune Diseases
Vivian K. Kawai¹, Carlos Grijalva², Patrick Arbogast², Jeffrey R. Curtis³, Daniel H. Solomon⁴, Elizabeth S. Delzell⁵, Lang Chen⁶, Lisa Herrinton⁷, Liyan Liu⁷, Edward F. Mitchell Jr.², C. Michael Stein⁸ and Marie Griffin², ¹Vanderbilt University, Nashville, TN, ²Preventive Medicine, Vanderbilt University, Nashville, TN, ³Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁵Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Research, Kaiser Permanente, Oakland, CA, ⁸School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN
Initiation of Tumor Necrosis Factor Alpha (TNFα) antagonists and risk of fractures in patients with rheumatoid arthritis (RA)Background/Purpose: Inflammation mediates bone resorption, in part through…
Abstract Number: 1961 • 2012 ACR/ARHP Annual Meeting
In Postmenopausal Women with Osteoporosis, Denosumab Significantly Improved Trabecular Bone Score (TBS), an Index of Trabecular Microarchitecture
Michael McClung¹, Kurt Lippuner², Maria Luisa Brandi³, Jean-Marc Kaufman⁴, Jose R. Zanchetta⁵, Marc-Antoine Krieg⁶, Henry G. Bone⁷, Roland Chapurlat⁸, Didier Hans⁶, Andrea Wang⁹, Jang Yun⁹, Carol Zapalowski⁹ and Cesar Libanati⁹, ¹Oregon Osteoporosis Center, Portland, OR, ²University of Berne, Berne, Switzerland, ³University of Florence, Florence, Italy, ⁴University Hospital of Ghent, Ghent, Belgium, ⁵Instituto de Investigaciones Metabólicas and University of Salvador, Buenos Aires, Argentina, ⁶Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland, ⁷Michigan Bone and Mineral Clinic, Detroit, MI, ⁸Hôpital Edouard Herriot, Lyon, France, ⁹Amgen Inc., Thousand Oaks, CA
Background/Purpose: The trabecular bone score (TBS), a novel gray-level texture index determined from lumbar spine DXA scans, correlates with 3D parameters of trabecular bone microarchitecture…
Abstract Number: 1962 • 2012 ACR/ARHP Annual Meeting
The Specific Role of Glutaredoxin2 Isoform b (Glrx2b) in RANKL-Induced Osteoclastogenesis Through Activation of the p38-MAPK Signaling Pathway
Chang-Hoon Lee¹, Wan-Hee Yoo², Jin-Jung Choi³, Myong-Joo Hong⁴, Ji-Min Kim⁵ and Jeong-Tae Yeon⁶, ¹Department of Internal Medicine, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea, ²Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Internal Medicine, CHA University Hospital, Seongnam, South Korea, ⁴Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea, ⁶Department of anatomy, school of medicine, Wonkwang university, Iksan, Chonbuk, South Korea
Background/Purpose: Recently, reactive oxygen species (ROS) and antioxidant enzymes were shown to be closely associated with RANKL-mediated osteoclast differentiation. Although glutaredoxin2 (Glrx2) plays a role…
Abstract Number: 1963 • 2012 ACR/ARHP Annual Meeting
Fracture Sites, Frequencies and Causes in 9,720 Japanese Patients with Rheumatoid Arthritis: A Prospective Observational Cohort Study
Kensuke Ochi¹, Takefumi Furuya², Eisuke Inoue³, Katsunori Ikari⁴, Atsuo Taniguchi³, Shigeki Momohara⁴ and Hisashi Yamanaka², ¹Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Although rheumatoid arthritis (RA) is a risk factor for osteoporosis and fracture, limited data exist in the literature concerning fracture site and frequency in…
Abstract Number: 1964 • 2012 ACR/ARHP Annual Meeting
Rolofylline, an Adenosine A1R Antagonist, Acts As an Inverse Agonist to Inhibit Osteoclast Differentiation
Wenjie He¹ and Bruce N. Cronstein², ¹Dept of Med, Div of Rheum, NYU, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Previous work from our laboratory has uncovered a critical role of adenosine A1 receptor (A1R) in osteoclast formation both in vivo and in vitro.…
Abstract Number: 1965 • 2012 ACR/ARHP Annual Meeting
Adenosine Regulates Bone Metabolism Via A₁, A_2A and A_2B Receptors in Bone Marrow Cells From Normal and Patients with Multiple Myeloma
Wenjie He¹, Amitabha Mazumder² and Bruce N. Cronstein³, ¹Dept of Med, Div of Rheum, NYU, New York, NY, ²NYU Cancer Center, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Multiple myeloma is a haematologic malignancy that is characterized by osteolytic bone lesions, wherein coupled bone remodeling is disrupted with increased osteoclast activation and…
Abstract Number: 1966 • 2012 ACR/ARHP Annual Meeting
Cost-Effectiveness of Bazedoxifene Compared with Raloxifene in the Treatment of Postmenopausal Osteoporotic Women
Mickaël Hiligsmann¹, Wafa Ben Sedrine¹ and J.-Y. Reginster², ¹Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium, ²Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: Bazedoxifene is a novel selective estrogen receptor modulator (SERM) in development for the prevention and treatment of osteoporosis. In addition to the therapeutic value…
Abstract Number: 1967 • 2012 ACR/ARHP Annual Meeting
Hypophosphatemic Osteomalacia Induced by Tenofovir in Patients with Human Immunodeficiency Virus Infection
Beatriz Tejera¹, Lourdes Mateo-Soria², Susana Holgado³, Luisa Mariñoso⁴, Ricard Pérez⁵, Anna Bonjoch⁶, Melania Martínez-Morillo⁷, Dolors Grados³ and Alejandro Olivé³, ¹Rheumatology, University Hospital of Canary Islands, Santa Cruz de Tenerife, Spain, ²Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ³Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁴Pathology, Hospital del Mar, Barcelona, Spain, ⁵Radiology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁶HIV Unit, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁷Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Background/Purpose: treatment of human immunodeficiency virus (HIV) infection has dramatically changed survival prognosis of these patients.New drugs included in antiretroviral therapy are much more effective. …
Abstract Number: 1968 • 2012 ACR/ARHP Annual Meeting
The Specific Role of Vesicle-Associated Membrane Protein-Associated Protein B/C(VapB) As a Regulator of Osteoclastogenesis Via Modulation of Phospholipase Cã(PLCã2-Ca2+-NFAT Signaling
Chang-Hoon Lee¹, Wan-Hee Yoo², Jin-Jung Choi³, Myong-Joo Hong⁴, Ji-Min Kim⁵ and Sik-Won Choi⁶, ¹Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ²Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Internal Medicine, CHA University Hospital, Seongnam, South Korea, ⁴Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea, ⁶Department of Anatomy and Institute for Skeletal Disease, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea
Background/Purpose: Recently, Vesicle-Associated Membrane Protein-Associated Protein B/C(VapB) has been shown to regulate calcium homeostasis in myotrophic lateral sclerosis. Calcium signalingis also important in metabolic bone diseases,…
Abstract Number: 1969 • 2012 ACR/ARHP Annual Meeting
Correction of Vitamin D Insufficiency with the Fixed Daily Combination Strontium Ranelate 2 g/Vitamin D₃ 1000 IU Over 12 Months
René Rizzoli¹, Bess Dawson-Hughes², Jean-Marc Kaufman³, Patrice Fardellone⁴, Maria Luisa Brandi⁵, Bruno Vellas⁶, Julien Collette⁷ and Jean-Yves Reginster⁸, ¹Division of Bone Disease, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland, ²Jean Mayer United States Department of Agriculture, Human Nutrition Research, Center on Aging, Bone Metabolism Laboratory, Tufts University, Boston, MA, ³Department of Endocrinology, University Hospital of Ghent, Ghent, Belgium, ⁴Service de Rhumatologie, Hôpital Nord, C.H.U. d'Amiens, Amiens, France, ⁵Department of Internal Medicine, Endocrinology Unit, University of Florence, Firenze, Italy, ⁶CHU La Grave, Toulouse, France, ⁷University of Liege, Labo RIA, CHU Sart Tilman, Liege, Belgium, ⁸Department of Public Health, Epidemiology and Health Economics, University of Liege, Liege, Belgium
Background/Purpose: To assess the efficacy and safety over 1 year of a daily oral administration of the fixed combination of strontium ranelate (SrRan) 2 g/vitamin…
Abstract Number: 1970 • 2012 ACR/ARHP Annual Meeting
Utility of Spine Bone Mineral Density in Fracture Prediction within the Fracture Risk Assessment Tool (FRAX)
Tristan Blackburn¹, Diantha Howard² and Edward S. Leib³, ¹Rheumatology, Fletcher Allen Health Care, University of Vermont College of Medicine, Burlington, VT, ²Medicine, Vermont Center for Clinical and Translational Science, Burlington, VT, ³Medicine, Fletcher Allen Health Care, University of Vermont College of Medicine, Burlington, VT
Background/Purpose: Predicting which individuals are at risk to experience a fracture and modify that risk is important in preventative health. The WHO’s Fracture Risk Assesment…
Abstract Number: 1971 • 2012 ACR/ARHP Annual Meeting
Resolution of Effects On Bone Turnover Markers and Bone Mineral Density After Discontinuation of Long-Term Bisphosphonate Use
Kenneth G. Saag¹, Claude-Laurent Benhamou², Tobias De Villiers³, C. Conrad Johnston Jr.⁴, Bente Langdahl⁵, Andrew Denker⁶, Annpey Pong⁶, John P. McGinnis⁶, Elizabeth Rosenberg⁶ and Arthur Santora⁶, ¹Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ²Centre Hospitalier Régional d'Orléans, Orleans, France, ³Mediclinic Panorama and Department of Obstetrics & Gynecology, University of Stellenbosch, Cape Town, South Africa, ⁴Indiana University School of Medicine, Indianapolis, IN, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Merck Sharp & Dohme Corp., Whitehouse Station, NJ
Background/Purpose: While bisphosphonates (BP) have been well studied in long-term trials of up to 4 years' duration, relatively less is known about the immediate consequences…

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