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  • Abstract Number: 2174 • 2012 ACR/ARHP Annual Meeting

    Natural History of Sjögren’s Syndrome Phenotypic Features in the Sjögren’s International Collaborative Clinical Alliance Registry

    Caroline Shiboski1, Alan N. Baer2, Mi Y. Lam1, Stephen Challacombe3, Hector Lanfranchi4, Morten Schiødt5, Hisanori Umehara6, Frederick B. Vivino7, Yan Zhao8, Yi Dong8, Bruce W. Kirkham9, Kenneth E. Sack10, Susumu Sugai11, Cristina F. Vollenweider12, Wen Zhang8, John S. Greenspan1, Troy Daniels13, Lindsey A. Criswell14 and Sjögren's International Collaborative Clinical Alliance15, 1Orofacial Sciences, University of California San Francisco, San Francisco, CA, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Kings College London, London, United Kingdom, 4University of Buenos Aires, Buenos Aires, Argentina, 5Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark, 6Internal Medicine, Division of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan, 7Medicine, Penn Presbyt Med Ctr, Philadelphia, PA, 8Rheumatology, PUMCH, Bejing, China, 9Rheum Dept/ Guys Hospital, Guys Hospital, London, United Kingdom, 10Dept of Medicine/Box0326, Univ of Calif-San Francisco, San Francisco, CA, 11Kanazawa Medical University, Ishikawa, Japan, 12Rheumatology, German Hospital, Buenos Aires, Argentina, 13Orofacial Sciences, Box 0422, University of California San Francisco, San Francisco, CA, 14Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, 15Orofacial Sciences, University of California San Francisco, University of California San Francisco, CA

    Background/Purpose: Sjögren’s syndrome (SS) is known to be a relatively stable or slowly progressing disease, however, few studies have actually followed patients over time while…
  • Abstract Number: 2175 • 2012 ACR/ARHP Annual Meeting

    Interstitial Lung Disease in Sjogren Syndrome: A Population-Based Study

    Carlotta Nannini1, Adlene Jebakumar2, Jay H. Ryu3, Cynthia S. Crowson4 and Eric L. Matteson2, 1Rheumatology Unit, Prato Hospital, Prato, Italy, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: The reported frequency of pulmonary involvement in primary Sjögren’s Syndrome (pSS) varies widely ranging from 8 to 75% depending on the detection method employed…
  • Abstract Number: 2176 • 2012 ACR/ARHP Annual Meeting

    Pulmonary Manifestations and Treatment of Primary Sjogren’s Syndrome-Associated Lung Involvement Patients: A Prospective Study

    Hui Gao1, Xuewu Zhang2, Jing He2, Min Feng2, Wei Zhao1, Yan Ding2 and Zhan-guo Li2, 1Emergency department & Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Peking University People's Hospital, Peking University People's Hospital, Beijing, China

    Background/Purpose: Pulmonary involvement is common in primary Sjögren’s syndrome (pSS). Clinicopathologic pulmonary manifestations associated with pSS have yet to be reviewed in a large series.…
  • Abstract Number: 2177 • 2012 ACR/ARHP Annual Meeting

    The Forced Oscillation Technique Is a Sensitive Method for Detection of Obstructive Airway Disease in Patients with Primary Sjögren’s Syndrome

    Anna M. Nilsson1, Elke Theander2, Roger Hesselstrand3, Per Wollmer4 and Thomas Mandl5, 1Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmo, Sweden, 2Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 3Rheumatology, Lund University, Lund, Sweden, 4Dept of Clinical Physiology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 5Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden

    Background/Purpose: To study signs of obstructive airway disease in patients with primary Sjögren’s syndrome (pSS) by the forced oscillation technique (FOT), a method that may…
  • Abstract Number: 2178 • 2012 ACR/ARHP Annual Meeting

    18-Fludeoxyglucose Positron Emission Tomography Is a Valuable Marker of Activity of Interstitial Lung Disease in Primary Sjogren’s Syndrome

    Camille Cohen1, Arsene Mekinian2, Michael Soussan3, Yurdagul Uzunhan4, Veronique Eder3, Robin Dhote5, Dominique Valeyre6 and Olivier Fain7, 1Jean Verdier Hospital, Bondy, France, 2Internal Medicine, Jean Verdier Hospital, Bondy, FL, France, 3Nuclear Medicine, Bobigny, France, 4Pneumology, Bobigny, France, 5Internal Medicine, Avicenne University Hospital, Bobigny, France, 6Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France, 7Internal Medicine, Jean Verdier Hospital, Bondy, France

    Background/Purpose: Purpose: To assess the value of 18-Fludeoxyglucose Positron Emission Tomography (PET) in patients with primary Sjogren's Syndrome (pSS).Methods: All patients with confirmed pSS (AECG)…
  • Abstract Number: 2179 • 2012 ACR/ARHP Annual Meeting

    High Resolution CT Findings and Concomitant Nontuberculosis Mycobacterial Infection (NTM) in Patients with the Diagnosis of Primary Sjogren’s Syndrome Evaluated At a Respiratory Referral Center

    Mehrnaz Maleki-Fischbach1 and Gloria M. Russell2, 1Medicine, National Jewish Health, Denver, CO, 2Pontificia Universidad Católica Madre y Maestra, Santiago, Dominican Republic

    Background/Purpose: Although lung disease can occur with primary Sjogren’s syndrome (pSS), far too little is known about the clinical phenotype or natural history of its lung…
  • Abstract Number: 2180 • 2012 ACR/ARHP Annual Meeting

    Coronary Flow Reserve and Asymmetric Dimethylarginine Levels: New Measurements for Identifying Subclinical Atherosclerosis in Patients with Primary Sjögren’s Syndrome

    F. Atzeni1, L. Boccassini1, M.C. Signorello2, MA Carrideo2, L. Gianturco2, V. De Gennaro Colonna3, L. Drago4, M. Turiel2 and P. Sarzi-Puttini1, 1Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, 2IRCCS Galeazzi Orthopedic Institute, University of Milan, Department of Health Technologies, Cardiology Unit,, Milan, Italy, 3Pharmacology Department, University of Milan, Milan, Italy, 4Laboratory Unit, IRCCS Galeazzi Orthopedic Institute, Department of Health Technologies, University of Milan, Milan, Italy

    Background/Purpose: Clinical and biochemical data suggest that autoimmune diseases are associated with endothelial dysfunction and increased atherosclerosis. We have previously shown that asymmetric dimethylarginine (ADMA)…
  • Abstract Number: 2181 • 2012 ACR/ARHP Annual Meeting

    Concomitant Atheosclerosis and Impaired Bone Health in Patients with Primary Sjogren’s Syndrome

    Clio P. Mavragani1, Fotini Gravani2, Andrianos Nezos1, Eleni Antypa3, Kiki Maselou4, Dimitrios Ioakeimidis5, Michael Koutsilieris1 and Haralampos M. Moutsopoulos6, 1Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, 2Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, 3Department of Radiology, General Hospital of Athens, Greece, 4Department of Immunolgy, General Hospital of Athens, Greece, 5Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Greece, Greece, 6Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece

    Background/Purpose: To determine the prevalence of subclinical atherosclerosis and impaired bone health in primary Sjogren’s syndrome (pSS) patients and to explore whether they associate with…
  • Abstract Number: 2141 • 2012 ACR/ARHP Annual Meeting

    Effects of Cigarette Smoking On EARLY Arthritis (CONAART)

    Maria Haye Salinas1, Ana C. Alvarez1, Rafael Chaparro del Moral2, Mariana Benegas2, Christian A. Waimann3, Rodolfo Perez Alamino4, Rodrigo Garcia Salinas5, Ana Lucía Barbaglia6, Veronica Bellomio7, Josefina Marcos8, Adrian Salas9, Cristian Quiroz10, Federico Ceccato11, Sergio Paira11, Dora Lia Vazquez12, Gabriela Salvatierra13, M. Crespo14, Edson Javier Velozo15, Oscar L. Rillo16, Enrique Soriano17, Antonio Catalan Pellet5, Alberto Berman Sr.18, Juan Carlos Marcos19, Gustavo Citera20 and Francisco Caeiro21, 1Rheumatology, Hospital Privado, Córdoba, Argentina, 2Rheumatology, Hospital Tornu, Buenos Aires, Argentina, 3Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Rheumatology, Louisiana State University, New Orleans, LA, 5Rheumatology, Hospital Rivadavia, Buenos Aires, Argentina, 6Rheumatology, Hospital Padilla, Tucuman, Argentina, 7Centro Medico Privado de Reumatologia, Tucuman, Argentina, 8Rheumatology Unit, HIGA San Martín La Plata, La Plata, Argentina, 9Hospital San Martin, La Plata, Argentina, 10Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 11Rheumatology, Hospital Jose Maria Cullen, Santa Fe, Argentina, 12Rheumatology, Centro Integral de Reumatologia, Santiago del Estero, Argentina, 13Rheumatology, Centro de enfermedades Reumaticas, Santiago Del Estero, Argentina, 14Rheumatology, Hospital Señor del Milagro, Salta, Argentina, 15Rheumatology, Sanatorio Adventista del Plata, Entre Rios, Argentina, 16Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, 17Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 18Internal Medicine, Hospital Padilla, Tucuman, Argentina, 19Rheumatology, Hospital San Martin, La Plata, Argentina, 20Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 21Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina

    Background/Purpose: According to recent reports the cigarette smoking persons have 2-4 times greater risk of developing rheumatoid arthritis (RA). The cigarette smoking is associated with…
  • Abstract Number: 2142 • 2012 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging-Proven Osteitis At Baseline Predicts the Early Rheumatoid Arthritis Patients Who Will Develop Rapid Radiographic Progression: MRI Is Beneficial to Find the Window of Opportunity in Early RA

    Mami Tamai1, Yoshikazu Nakashima2, Takahisa Suzuki3, Yoshiro Horai2, Akitomo Okada4, Junko Kita4, Shin-ya Kawashiri2, Naoki Iwamoto4, Kunihiro Ichinose5, Kazuhiko Arima4, Hideki Nakamura1, Tomoki Origuchi6, Masataka Uetani7, Kiyoshi Aoyagi8, Katsumi Eguchi9 and Atsushi Kawakami2, 1Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 4Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 6Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 7Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 8Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 9Sasebo City General Hospital, Sasebo, Nagasaki, Japan

    Background/Purpose: Window of opportunity exists in the earlier phase of rheumatoid arthritis (RA), thus, early recognition of the RA patients who will develop rapid radiographic…
  • Abstract Number: 2143 • 2012 ACR/ARHP Annual Meeting

    Analysis of Factors Associated with the Health Assessment Questionnaire Score Change in Five Years

    Shinji Yoshida1, Katsunori Ikari2, Kensuke Ochi3, Yoshiaki Toyama4, Atsuo Taniguchi5, Hisashi Yamanaka1 and Shigeki Momohara1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Shinjuku-ku, Japan, 3Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, 5Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: The Health Assessment Questionnaire (HAQ) score is thought to be a disease specific tool for the assessment of inflammatory joint disorders including rheumatoid arthritis…
  • Abstract Number: 2144 • 2012 ACR/ARHP Annual Meeting

    Early RA Patients Fulfilling the New 2010 ACR/EULAR Criteria, Display Better Clinical Responses to DMARD Therapy but Have Higher Radiographic Damage Progression Than Patients with Early RA Not Fulfilling the 2010 ACR/EULAR Criteria

    Ruediger Mueller1, Toni Kaegi1, Axel Finckh2 and Johannes von Kempis1, 1Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 2Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland

    Background/Purpose: New ACR/EULAR criteria for the classification of rheumatoid arthritis (RA) were recently proposed. The aim of this analysis was to examine the impact of…
  • Abstract Number: 2145 • 2012 ACR/ARHP Annual Meeting

    Age At Onset Determines Severity and  choice of Treatment in Early Rheumatoid Arthritis

    Lena Innala1, Bozena Möller2, Lotta Ljung3, Torgny Smedby4, Anna Södergren5, Staffan Magnusson6, Ewa H. Berglin5, Solbritt M. Rantapää-Dahlqvist7 and Solveig Wållberg-Jonsson5, 1Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, 2Department of Rheumatology, Sunderby Hospital, Luleå, Sweden, 3Clinical epidemiology unit, Karolinska Institutet, Stockholm, Sweden, 4Department of Rheumatology, Östersund hospital, Östersund, Sweden, 5Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, 6Department of Internal Medicine, Sundsvall Hospital, Sundsvall, Sweden, 7Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden

    Background/Purpose: Mortality is increased in rheumatoid arthritis (RA). Contributing factors are disease activity/severity and comorbidity. A relationship between age at onset and pharmacological treatment has…
  • Abstract Number: 2146 • 2012 ACR/ARHP Annual Meeting

    Impact of Severity Index for Rheumatoid Arthritis On Healthcare Costs and Utilizations in Patients with Rheumatoid Arthritis

    Onur Baser1, Li Wang2, Juan Du3, Hai Wang3 and Lin Xie4, 1President/Adjunct Professor of Internal Medicine, STATinMED Research/The University of Michigan, Ann Arbor, MI, 2Director, Analytic Research, STATinMED Research, Dallas, TX, 3STATinMED Research, Ann Arbor, MI, 4Director, Health Economics & Outcomes Research, STATinMED Research, Ann Arbor, MI

    Background/Purpose: Examine the impact of a claims-based severity index for rheumatoid arthritis (RA) on healthcare costs and utilizations of RA patients using large U.S. claims…
  • Abstract Number: 2147 • 2012 ACR/ARHP Annual Meeting

    Risks to Visit Emergency Room in Patients with Rheumatoid Arthritis: A Two-Year Retrospective Study

    Yoshiki Nagai, Naoto Yokogawa, Kota Shimada and Shoji Sugii, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan

    Background/Purpose: Patients with rheumatoid arthritis (RA) suffer from both physical disabilities and medical comorbidities and tend to use emergency room for many reasons. However, the…
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