Abstract Number: 15 • 2012 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Stimulation Inhibits OC Formation by Suppressing NFkB Translocation to the Nucleus by A PKA-ERK1/2 Mediated Mechanism
Background/Purpose: Adenosine, a nucleoside released at sites of injury and hypoxia, mediates its effects via activation of G-protein-coupled receptors (A1, A2A, A2B, A3). Previously we…Abstract Number: 16 • 2012 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Diminishes Bone Destruction At Inflamed Sites, in Part, Via Downregulating Semaphorin4D-PlexinB1 Communication Between Osteoclasts and Osteoblasts
Background/Purpose: Communication between osteoclasts and osteoblasts is essential for bone homeostasis. Semaphorin4D (Sema4D), expressed on the surface of and secreted by osteoclasts, macrophages and T…Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…Abstract Number: 18 • 2012 ACR/ARHP Annual Meeting
Identification of 14-3-3å As a New Subchondral Bone Mediator Involved in Cartilage Degradation During Osteoarthritis
Background/Purpose: OA is a complex disease not limited to cartilage degeneration. Indeed, several experiments suggest that subchondral bone remodeling could initiate and/or contribute to cartilage…Abstract Number: 19 • 2012 ACR/ARHP Annual Meeting
Stress-Induced Cartilage Degradation Does Not Depend On NLRP3-Inflammasome in Osteoarthritis
Background/Purpose: The cartilage matrix breakdown in osteoarthritis (OA) is due to both abnormal mechanical stress and activation of catabolic processes involving metalloproteinases (MMPs). Currently, IL-1beta…Abstract Number: 20 • 2012 ACR/ARHP Annual Meeting
Osteoclastogenesis Is Inhibited by Immune Complexes Through Activating Fcγ Receptors
Background/Purpose: Rheumatoid arthritis is characterized by chronic inflammation and osteoclast-mediated bone loss. Co-stimulatory signalling via ITAM- and ITIM-coupled receptors is essential for osteoclast formation and…Abstract Number: 21 • 2012 ACR/ARHP Annual Meeting
IL-32 and IL-17 Interact and Aggravate Osteoclastogenesis in Rheumatoid Arthritis
Background/Purpose: Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We…Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…Abstract Number: 23 • 2012 ACR/ARHP Annual Meeting
Differential Effects of Bone Morphogenetic Protein 2 and 9 On Chondroprotective Transforming Growth Factor β Signaling
Background/Purpose: Osteoarthritis (OA) is a multifactorial disease characterized by loss of articular cartilage. TGFβ is considered as a protective factor against cartilage loss in young cartilage…Abstract Number: 24 • 2012 ACR/ARHP Annual Meeting
The Negative Effects of Glucocorticoids On Bone Are Primarily Mediated by Genes Involved in Osteoblast Differentiation and Bone Remodelling
Background/Purpose: Glucocorticoids are widely used as anti-inflammatory and immunosuppressive drug for the treatment of many inflammatory and auto-immune diseases. However, long-term and high-dose glucocorticoid treatment…Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting
Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists
Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…• 2012 ACR/ARHP Annual Meeting
Lee C. Howley Sr. Prize for Arthritis Research Introductory Talk I
Abstract Number: L10 • 2012 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis Patients with Stable Low Disease Activity On Methotrexate Plus Etanercept, Continuation of Etanercept 50 Mg Weekly or 25 Mg Weekly Are Both Clinically Superior to Discontinuation: Results From a Randomized, 3-Armed, Double-Blind Clinical Trial
Background/Purpose: The efficacy of etanercept (ETN) in combination with methotrexate (MTX) in the treatment of rheumatoid arthritis (RA) is well established, and long-term trials1 and…• 2012 ACR/ARHP Annual Meeting
Lee C. Howley Sr. Prize for Arthritis Research Introductory Talk II
Abstract Number: L9 • 2012 ACR/ARHP Annual Meeting
Inefficacy of Hydroxychoroquine in Primary Sjögren’s Syndrome: Results of the Joquer Randomized Placebo-Controlled Trial in Primary Sjögren’s Syndrome
Background/Purpose: Hydroxychloroquine (HQ, Plaquenil) is often prescribed in patients with primary Sjögren’s syndrome (pSS), notably for arthralgias, synovitis or purpura, but also only for dryness…