Abstracts Archive - Page 2419 of 2425 - ACR Meeting Abstracts

Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Brett A. Tonkin¹, Evange Romas², Natalie A. Sims¹ and Nicole C. Walsh¹, ¹St Vincent's Institute of Medical Research, Melbourne, Australia, ²Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
Abstract Number: 36 • 2012 ACR/ARHP Annual Meeting
Role of FK506 Binding Protein 5 in Osteoclast Differentiation
Miho Kimura¹, Tatsuo Nagai², Reiko Matsushita², Atsushi Hashimoto³, Toshiyuki Miyashita⁴ and Shunsei Hirohata⁵, ¹Rheumatology and Infectious diseases, Kitasato University School of Medicine, Sagamihara, Japan, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ³Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan, ⁴Molecular Genetics, Kitasato University School of Medicine, Sagamihara, ⁵Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: RA is a chronic, systemic inflammatory disease characterized by the destruction of bone in the joints. Moreover, it is well appreciated that systemic osteoporosis…
Abstract Number: 37 • 2012 ACR/ARHP Annual Meeting
Development of a Mouse Model of Natural Osteoarthritis of Knee by Induction of obesity and Bipedal Walking
Hyun Ah Kim¹, Su Jin Park², Eun-Jeong Cheon³, Hyun A. Jung⁴ and Kyeong Min Son⁵, ¹Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea, ²Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ³Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Hallym university sacred heart hospital, Kyunggi, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Hallym university Chunchun sacred heart hospital, Chunchun, South Korea
Background/Purpose: Animal models of osteoarthritis(OA) are used extensively in research of its pathogenesis and in search of disease modifying anti-OA drugs. However, whether current animal models…
Abstract Number: 38 • 2012 ACR/ARHP Annual Meeting
Bone Marrow Lesions On Magnetic Resonance Imaging Are Not Associated with Regions of Hypermetabolism in an Animal Model of Osteoarthritis
Arash Panahifar¹, Jacob Jaremko², Robert GW Lambert², Walter P. Maksymowych³ and Michael R. Doschak¹, ¹Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The underlying histopathological basis for bone marrow lesions (BML) on magnetic resonance imaging (MRI) in osteoarthritis (OA) is unclear, but may be associated with…
Abstract Number: 39 • 2012 ACR/ARHP Annual Meeting
SDF-1 Induces Osteoclastogenesis in Rheumatoid Arthritis by Upregulating of RANKL Expression in Synovial Fibroblasts and CD4+ T Cells
Hae-Rim Kim¹, Kyoung-Woon Kim², Bo-Mi Kim¹, Mi La Cho³ and Sang-Heon Lee⁴, ¹Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, ²Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: Stromal cell-derived factor (SDF)-1 is involved in bone destructive process in rheumatoid arthritis (RA) and bony metastasis in malignancy, through inducing angiogenesis, producing matrix-degrading…
Abstract Number: 40 • 2012 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes
Jessica Bertrand¹, Richard Stange², Giovanna Nalesso³, Joanna Sherwood³, Lars Godmann⁴, Frank Echtermeyer⁵, Francesco Dell'Accio⁶ and Thomas Pap⁴, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Dept. of Anaesthesiology and Intensive Care Medicine, University hospital Hanover, Hanover, Germany, ⁶William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose: Blockade of syndecan-4 (Sdc4) signaling protects mice from cartilage degradation in experimentally induced osteoarthritis (OA). Cartilage damage results in changes of chondrocyte phenotype induced…
Abstract Number: 41 • 2012 ACR/ARHP Annual Meeting
Long-Distance Physical Connections Between Chondrocytes; Cell-to-Cell Communication within Articular Cartilage
Maria Dolores Mayan¹, Raquel Gago-Fuentes¹, Paula Carpintero-Fernandez², Patricia Fernandez-Puente², Purificacion Filgueira-Fernandez¹, Virgin Valiunas³, Peter Brink³, Gary Goldberg⁴ and Francisco J. Blanco Garcia⁵, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, ²Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ³Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, ⁴Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, ⁵Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain
Background/Purpose: It is believed that chondrocytes in cartilage do not connect each other, as they are isolated inside their lacunae separated from each other by…
Abstract Number: 42 • 2012 ACR/ARHP Annual Meeting
Role of Stromal Cell-Derived Factor-1 Alpha Through Smad and MAPK Pathway On Endochondral Ossification
Gunwoo Kim¹, Seungwoo Han², Younkwan Jung³, Eunju Lee³, Hyeri Park³, Shirine E. Usmani⁴, Veronica Ulici⁴ and Frank Beier⁴, ¹Rheumatology, Fatima research institude, Daegu Fatima Hospital, Daegu, South Korea, ²Rheumatology, Fatima research institute, Daegu Fatima Hospital, Daegu, South Korea, ³Laboratory for arthritis and bone biology, Fatima research institute, Daegu Fatima Hospital, Daegu, South Korea, ⁴Physiology and Pharmacology, Schulich School of Medicine and Dentistry, London, ON, Canada
Background/Purpose: The main cellular events of articular chondrocytes during osteoarthritis are a loss of the traits as permanent cartilage, and a transition to hypertrophic chondrocytes…
Abstract Number: 43 • 2012 ACR/ARHP Annual Meeting
Serum Amyloid A Level in Knee Osteoarthritis: Systemic and/or Local Production and Pro-Inflammatory Properties On Human Chondrocytes and Fibroblast-Like Synoviocytes
Dominique de Seny¹, Gaël Cobraiville², Sophie Neuville², Edith Charlier³, Biserka Relic¹, Florence Quesada Calvo³, Olivier Malaise³, Denis Malaise⁴, Laurence Lutteri⁵, Jean-Paul Chapelle⁵ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ³Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ⁴University of Liège, Liège, Belgium, ⁵Medical Chemistry - CHU Liège, Liège, Belgium
Background/Purpose: Knee osteoarthritis (OA) is a disease frequently seen in obese patients, but the relationship might be more linked to fat than to weight. A-SAA…
Abstract Number: 44 • 2012 ACR/ARHP Annual Meeting
Inhibition of WNT Signaling Pathway by Sclerostin Maintains Cartilage Homeostasis
Wafa Bouaziz¹, Thomas Funck-Brentano¹, Hilene Lin¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Cartilage homeostasis is regulated by several mechanisms that influence the anabolic and catabolic tissue balance. Among them, the local activation of Wnt signaling pathway…
Abstract Number: 45 • 2012 ACR/ARHP Annual Meeting
The Effects of Apremilast On Osteoclasts, Osteoblasts, and Osteocytes
Mary Adams and Peter Schafer, Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: Apremilast (APR), a small molecule specific inhibitor of phosphodiesterase 4, works intracellularly to modulate pro- and anti-inflammatory mediator production in both immune and non-immune…
Abstract Number: 6 • 2012 ACR/ARHP Annual Meeting
The Effect of Hydrogen Sulfide Donors On Inflammatory Mediators in Human Articular Osteoarthritic Chondrocytes
Elena F. Burguera¹, Angela Vela Anero², Rosa Meijide Failde² and Francisco J. Blanco¹, ¹Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Department of Medicine, University of A Coruña, A Coruña, Spain
Background/Purpose: Hydrogen sulfide (H2S) has recently been proposed as an endogenous mediator of inflammation in several pathology models. The aim of this work was to…
Abstract Number: 7 • 2012 ACR/ARHP Annual Meeting
Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in Their Chondrogenic Potential and Imbalance in Their Response to Oxidative Stress
Jesus Mateos¹, Alexandre De La Fuente², Ivan A. Lesende-Rodriguez², Maria Carmen Arufe² and Francisco J. Blanco¹, ¹Rheumatology Division, Proteomics Unit-ProteoRed/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Department of Medicine, Area of Anatomy and Human Embryology, University of A Coruña-INIBIC, A Coruña, Spain
Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) was associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…
Abstract Number: 8 • 2012 ACR/ARHP Annual Meeting
Supercharged Sox9 Protein Induces Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells
Yuan K. Chou¹, Shili Wu², Camilo Avendano², Tom Caldwell², Brian Maniaci², Kentaro Yomogida¹, Yong Zhu² and Cong-Qiu Chu³, ¹Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ²VivoScript, Inc, Costa Mesa, CA, ³Rheumatology, Oregon Health & Science Univ and Portland VA Medical Center, Portland, OR
Background/Purpose: Osteoarthritis (OA) is characterized by progressive breakdown of articular cartilage. Regeneration of cartilage has been an attractive approach to OA therapy. Sox9 is a…
Abstract Number: 9 • 2012 ACR/ARHP Annual Meeting
Function of the Chondrocyte PI-3 Kinase Akt Signaling Pathway Is Stimulus Dependent
Richard F. Loeser and Meredith Greene, Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Previous studies have shown that activation of the chondrocyte PI-3K-Akt signaling pathway by IGF-1 promotes chondrocyte survival and matrix synthesis. However, other studies have…

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