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  • Abstract Number: 421 • 2013 ACR/ARHP Annual Meeting

    Enhanced Cardiovascular Risk Factor Screening In Rheumatoid Arthritis: Does This Have a Sustained Impact?

    Mark J Ponsford1, Jennifer K. Cooney2, Bethany Anthony3, Fflur A. Huws4, Lauren Evans1, Jeanette Thom5 and Yasmeen Ahmad1, 1Betsi Cadwaladr University Health Board, Peter Maddison Research Centre, Llandudno, United Kingdom, 2School of Sport, Health and Exercise Sciences, School of Sport, Health and Exercise Sciences, Bangor University, George Building, Bangor, Gwynedd, LL57 2PZ, UK., Bangor, United Kingdom, 3Health and Exercise Sciences, School of Sport, Health and Exercise Sciences, Bangor University, George Building, Bangor, Gwynedd, LL57 2PZ, UK., Bangor, United Kingdom, 4Health and Exercise Sciences, Bangor University, School of Sport, Health and Exercise Sciences, Bangor University, George Building, Bangor, Gwynedd, LL57 2PZ, UK., Bangor, United Kingdom, 5School of Sport, Health and Exercise Sciences, Bangor University, George Building, Bangor, Gwynedd, LL57 2PZ, UK., Bangor, United Kingdom

    Background/Purpose: Rheumatoid Arthritis (RA) patients face a burden of cardiovascular disease (CVD) twice that of the general population. RA patients have reduced physical fitness, a…
  • Abstract Number: 422 • 2013 ACR/ARHP Annual Meeting

    Disease Activity In Rheumatoid Arthritis Is Associated With Abnormal Left Ventricular Geometry

    Helga Midtbø1, Eva Gerdts1,2, Inge C. Olsen3, Tore K. Kvien4, Einar Davidsen1 and Anne Grete Semb3, 1Department of Heart Disease, Haukeland University Hospital, Bergen, Norway, 2Department of Cinical Science, University of Bergen, Bergen, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose :Disease activity is related to risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients1,2. Left ventricular (LV) geometry strongly predicts CV mortality and…
  • Abstract Number: 423 • 2013 ACR/ARHP Annual Meeting

    Serological Biomarkers For The Development Of Rheumatoid Arthritis Related Interstitial Lung Disease

    Elena Nikiphorou1, Esther Chan2, Vadivelu Saravanan2, Julie Dawson3, Navtej Sathi4, Felix Woodhead5, Mohamed Nisar6, Subhashini Arthanari6, Yasmeen Ahmad7, Adam Young8 and Clive Kelly2, 1Research Department of Epidemiology & Public Health, UCL and Rheumatology Department, St Albans City Hospital, ERAS, St Albans City Hospital & University College London (UCL), London, United Kingdom, 2Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom, 3Rheumatology, St Helens Hospital, St Helens, United Kingdom, 4Rheumatology, Wrightington Hospital, Wigan, United Kingdom, 5Respiratory, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom, 6Rheumatology, Burton Hospital, Burton-on-Trent, United Kingdom, 7Department of Rheumatology, Peter Maddison Research Centre, Bangor, United Kingdom, 8Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom

    Background/Purpose: Interstitial Lung Disease (ILD) is the commonest manifestation of lung disease in Rheumatoid Arthritis (RA) and the only complication reported to be increasing in…
  • Abstract Number: 424 • 2013 ACR/ARHP Annual Meeting

    2-Year Results From The Ample (Abatacept versus Adalimumab Comparison in Biologic-Naïve RA Patients with Background Methotrexate) Trial: Changes In Patient-Reported Outcomes In Response To Subcutaneous Abatacept Or Adalimumab In Rheumatoid Arthritis

    Roy Fleischmann1, ME Weinblatt2, M Schiff3, D Khanna4, MA Maldonado5, A Nadkarni6 and Daniel Furst7, 1University of Texas Southwestern Medical Center, Dallas, TX, 2Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, 3University of Colorado, Denver, CO, 4University of Michigan, Ann Arbor, MI, 5Bristol-Myers Squibb, Princeton, NJ, 6Bristol-Myers Squibb, Plainsboro, NJ, 7University of California at Los Angeles, Los Angeles, CA

    Background/Purpose: RA is a debilitating disease that can impact health-related quality of life (HRQoL) through impairment of activity, loss of independence and reduced work productivity.…
  • Abstract Number: 425 • 2013 ACR/ARHP Annual Meeting

    Efficacy, Pharmacokinetics, and Safety of Different Doses of Methotrexate in Combination With Adalimumab: Results From the Concerto Trial

    Gerd Burmester1, Alan J. Kivitz2, Hartmut Kupper3, Udayasankar Arulmani4, Stefan Florentinus5, Sandra Goss4, Suchitrita S. Rathmann4 and Roy Fleischmann6, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Altoona Center for Clinical Research, Duncansville, PA, 3AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 4AbbVie Inc., North Chicago, IL, 5AbbVie, Rungis, France, 6University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose:  Anti-TNF plus methotrexate (MTX) is more effective than either as monotherapy. Thus far, no controlled data are available on the benefit:risk of different doses…
  • Abstract Number: 426 • 2013 ACR/ARHP Annual Meeting

    Characteristics of Protocol-Specified Responders/Non-Responders Treated With Etanercept Plus Methotrexate in Period 1 of the Prize Study

    Paul Emery1, Annette Szumski2, Jack Bukowski3, Eustratios Bananis2 and Lisa Marshall4, 1Institute Rheumatic and Musculoskeletal Medicine University of Leeds, Leeds, United Kingdom, 2Specialty Care, Pfizer Inc., Collegeville, PA, 3Department of Specialty Care, Pfizer Inc, Collegeville, PA, 4Pfizer Inc., Collegeville, PA

    Background/Purpose: Although frequently effective, treatment with synthetic or biologic disease-modifying antirheumatic drugs (DMARDs) does not adequately control disease activity in all patients. Prompt identification of…
  • Abstract Number: 427 • 2013 ACR/ARHP Annual Meeting

    US Veterans With Rheumatoid Arthritis Who Switch Among Tumor Necrosis Factor Blocking Agents Have No Additional Clinical Benefit With The Change In Therapy and Incur Higher Costs

    Grant W. Cannon1, Scott L. DuVall2, Candace L. Hayden3, Liron Caplan4, Jeffrey R. Curtis5, Kaleb Michaud6, Ted R. Mikuls7, Andreas M. Reimold8, David H. Collier9, George Joseph9, David J. Harrison9 and Brian C. Sauer10, 1Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 2VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, 3Epidemiology, VA Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, UT, 4Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO, 5Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 9Amgen Inc., Thousand Oaks, CA, 10Epdemiology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT

    Background/Purpose:  While tumor necrosis factor (TNF) blockers can be effective in treating rheumatoid arthritis (RA), the benefit of switching among TNF blockers is not clear.…
  • Abstract Number: 428 • 2013 ACR/ARHP Annual Meeting

    Correlation Between Objective and Patient Self-Reported Clinical Improvement After Multiple Courses of Rituximab in Rheumatoid Arthritis Patients With Inadequate Response to Tumour Necrosis Factor Inhibitors: Data From Repeat Study

    Ioan Ancuta1, Catalin Codreanu2, Ruxandra Ionescu3, Magda Parvu4, Dan Nemes5, Rodica Chirieac6, Paulina Ciurea7, Maria Suta8, Andra Balanescu9, Eugenia Mociran10 and Elena Rezus11, 1“Dr. I. Cantacuzino” Hospital, Bucharest, Romania, 2Rheumatology, “Dr. I. Stoia” Center for Rheumatic Diseases, Bucharest, Romania, 3Internal Medicine, Clinic Hospital Sf. Maria, Bucharest, Romania, 4Internal Medicine, “N.Gh. Lupu” Clinical Hospital, Bucharest, Romania, 5Rehabilitation and Rheumatology, ”Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, 6C.M.I. Rodica Chirieac, Iasi, Romania, 7Emergency County Hospital, Craiova, Romania, 8Emergency County Hospital, Constanta, Romania, 9Internal Medicine and Rheumatology, University of Medicine and Pharmacy, Bucharest, Romania, 10Emergency County Hospital Dr Constantin Opis, Maramures, Romania, 11Rheumatology, Recovering Clinical Hospital, Iasi, Romania

    Background/Purpose: Rituximab (RTX) has been evaluated in many clinical trials and objective assessment of rheumatoid arthritis (RA) activity must comply with Treat to Target principles.…
  • Abstract Number: 429 • 2013 ACR/ARHP Annual Meeting

    Sustained Clinical Efficacy After Multiple Courses of Rituximab in Rheumatoid Arthritis Patients With Inadequate Response to Tumour Necrosis Factor Inhibitors: 2-Year Data From the Repeat (Repeated Courses in Routine Clinical Practice) Study

    Catalin Codreanu1, Ioan Ancuta2 and Ruxandra Ionescu3, 1Rheumatology, “Dr. I. Stoia” Center for Rheumatic Diseases, Bucharest, Romania, 2“Dr. I. Cantacuzino” Hospital, Bucharest, Romania, 3Internal Medicine, Clinic Hospital Sf. Maria, Bucharest, Romania

    Background/Purpose: In the last decade, biologic therapy changed dramatically treatment options for rheumatoid arthritis (RA). However, a significant number of patients failed to maintain the…
  • Abstract Number: 430 • 2013 ACR/ARHP Annual Meeting

    Comparing abatacept  to Adalimumab, Etanercept and Infliximab As First Or Second Line Agents in Patients With Rheumatoid arthritis: Experience From the rhumadata® Clinical Database and Registry

    Denis Choquette1, Diane Sauvageau2, Louis Bessette3, Boulos Haraoui4,5, Jean Pierre Pelletier1, Jean-Pierre Raynauld2, Edith Villeneuve2 and Louis Coupal1, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, 3Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, 4Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 5Rhumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada

    Background/Purpose: The order of use of biologic agents is still a question for debate. Phase III trial data in MTX-IR patients show comparable efficacy results…
  • Abstract Number: 431 • 2013 ACR/ARHP Annual Meeting

    Prediction Of Week 52 Treatment Response Based On A Week 12 Assessment In Rheumatoid Arthritis Patients Receiving Certolizumab Pegol: Comparison Of A Patient-Reported Instrument Versus Physician-Based Disease Activity Assessment

    Jeffrey R. Curtis1, Willem Koetse2, Jeymi Tambiah3, Lucian Ionescu4 and Yusuf Yazici5, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2UCB Pharma, Raleigh, NC, 3UCB Pharma, Smyrna, GA, 4UCB Pharma, Brussels, Belgium, 5New York University Hospital for Joint Diseases, New York, NY

    Background/Purpose: Guidelines support early intervention in rheumatoid arthritis (RA).1,2 The aim was to prospectively test whether outcome assessment at 12 weeks (wks) using a patient-reported…
  • Abstract Number: 432 • 2013 ACR/ARHP Annual Meeting

    Use Of Rituximab As Second Line Biologic Agent Compared With Adalimumab, Etanercept and Infliximab In Patients With Rheumatoid Arthritis. a Report From The Rhumadata® Clinical Database and Registry

    Louis Bessette1, Denis Choquette2, Diane Sauvageau3, Boulos Haraoui4, Jean Pierre Pelletier2, Jean-Pierre Raynauld3, Edith Villeneuve3 and Louis Coupal2, 1Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, 2Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 3Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, 4Rhumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada

    Background/Purpose: The order of use of biologic agents after failing a TNF inhibitor is still a question for debate. Phase III trial data in TNF-IR…
  • Abstract Number: 433 • 2013 ACR/ARHP Annual Meeting

    Retrospective Analysis Of Certolizumab Pegol Use During Pregnancy: Update Of Impact On Birth Outcomes

    Megan E. B. Clowse1, Douglas C. Wolf2, Frauke Förger3, John J. Cush4, Christian Stach5, Gordana Kosutic6, Susan Williams6, Chidi Maduka6 and Uma Mahadevan7, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Atlanta Gastroenterology Associates, Atlanta, GA, 3Department of Rheumatology and Clinical Immunology and Allergology, Inselspital, University of Bern, Bern, Switzerland, 4Baylor Research Institute and Baylor University Medical Center, Dallas, TX, 5UCB Pharma, Monheim, Germany, 6UCB Pharma, Raleigh, NC, 7UCSF Medical Center, San Francisco, CA

    Background/Purpose: Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF approved in 45 countries for the treatment of rheumatoid arthritis (RA) and/or Crohn's disease (CD). An…
  • Abstract Number: 434 • 2013 ACR/ARHP Annual Meeting

    Results Of 64 Weeks Of Treatment With An Anti-IL-17 Antibody, Ixekizumab, In Patients With Rheumatoid Arthritis In a Phase 2 Study

    Mark C. Genovese1, Hilde Carlier2, Janelle Erickson2, Daniel Braun2 and Subhashis Banerjee2, 1Division of Rheumatology, Stanford University, Palo Alto, CA, 2Eli Lilly & Company, Indianapolis, IN

    Background/Purpose: Ixekizumab, a monoclonal antibody that neutralizes IL-17A with high affinity and specificity, has been evaluated in patients (pts) with moderate to severe rheumatoid arthritis…
  • Abstract Number: 435 • 2013 ACR/ARHP Annual Meeting

    Final 5-Year Safety and Efficacy Results Of a Phase 3, Randomized, Placebo-Controlled Trial Of Golimumab In Methotrexate-naïve Patients With Rheumatoid Arthritis

    Paul Emery1, Roy Fleischmann2, Ingrid Strusberg3, Patrick Durez4, Peter Nash5, Eric Amante6, Melvin A. Churchill7, Won Park8, Bernardo Pons-Estel9, Chenglong Han10, Timothy A. Gathany10, Yiying Zhou11, Stephen Xu12 and Elizabeth C. Hsia12, 1Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and NIHR LMBRU, Leeds, United Kingdom, 2University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 3Instituto Reumatológico Strusberg, Cordoba, Argentina, 4Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, 5University of Queensland, Brisbane, Australia, 6University of Phillipines General Hospital, Manila, Philippines, 7Arthritis Center of Nebraska, Lincoln, NE, 8Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, 9Sanatorio Parque, Rosario, Argentina, 10Janssen Global Services, LLC., Malvern, PA, 11Biostatistics, Janssen Research & Development, LLC., Spring House, PA, 12Janssen Research & Development, LLC., Spring House, PA

    Background/Purpose: Final 5yr safety and efficacy results of subcutaneous golimumab (GLM)+/-MTX evaluated in a phase 3 trial (GO-BEFORE) of MTX-naïve pts with rheumatoid arthritis (RA)…
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