Abstract Number: 319 • 2012 ACR/ARHP Annual Meeting
Gamma Interferon-Induced Protein-10 (IP-10) As a Potential Biomarker for Disease Activity in Pediatric Localized Scleroderma
Background/Purpose: Pediatric localized scleroderma (LS) is an autoimmune disease affecting the skin and underlying tissue. Cutaneous findings assist in categorizing the patients into active or…Abstract Number: 320 • 2012 ACR/ARHP Annual Meeting
Evaluation of Anti-Citrullinated Type II Collagen and Anti-Citrullinated Vimentin Antibodies in Patients with Juvenile Idiopathic Arthritis
Background/Purpose: Several studies have identified anti-cyclic citrullinated peptide (CCP) antibodies as an important indicator for destructive disease in patients with juvenile idiopathic arthritis (JIA). This…Abstract Number: 321 • 2012 ACR/ARHP Annual Meeting
Glycosylation of Vitamin D Binding Protein Reduced in Juvenile Idiopathic Arthritis Patients At Risk of Disease Extension
Background/Purpose: Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic, childhood onset, autoimmune diseases with variable clinical outcomes.We investigated whether profiling of the…Abstract Number: 322 • 2012 ACR/ARHP Annual Meeting
Immune Response to Porphyromonas Gingivalis Citrullinated α-Enolase Cross-Reacts with Human α-Enolase in Polyarticular JIA Patients
Background/Purpose: Antibodies recognizing cyclic citrullinated peptides (CCP) are highly specific for rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (poly JIA), and may both predict…Abstract Number: 323 • 2012 ACR/ARHP Annual Meeting
Immunoprecipitation and Advanced Proteomics for the Discovery of Novel Antigenic Targets in Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic condition seen by pediatric rheumatologists. The pathogenesis of disease is poorly understood, but is believed to…Abstract Number: 324 • 2012 ACR/ARHP Annual Meeting
Measurement and Evaluation of Isotypes of Anti-Citrullinated Fibrinogen and Anti-Citrullinated Alpha-Enolase Antibodies in Juvenile Idiopathic Arthritis Patients
Background/Purpose: Anti-cyclic citrullinated peptide (CCP) antibodies in juvenile idiopathic arthritis (JIA) have been identified as an important indicator for destructive disease, as is the case…Abstract Number: 325 • 2012 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibody Isotyping and Identification of Citrullinated Proteins in the Synovial Fluid of Juvenile Idiopathic Arthritis Patients
Background/Purpose: Several citrullinated proteins have been detected in the serum and synovial fluid (SF) of rheumatoid arthritis (RA) patients. However, few studies have evaluated citrullination…Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting
Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts
Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…Abstract Number: 327 • 2012 ACR/ARHP Annual Meeting
Tolerogenic Dendritic Cells Ameliorates the Disease Severity of Murine Collagen-Induced Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovial inflammation, cartilage breakdown and bone destruction with the involvement of various types of…Abstract Number: 328 • 2012 ACR/ARHP Annual Meeting
IL-7; An Important Pro-Inflammatory Factor That Affects Myeloid Cell Function in RA and CIA
Background/Purpose: The aim of the study was to examine the role of IL-7 in the pathogenesis of rheumatoid arthritis (RA) as well as in collagen…Abstract Number: 329 • 2012 ACR/ARHP Annual Meeting
The SYK Inhibitor, Fostamatinib, Administered Alone or in Combination with Methotrexate in Rat Collagen-Induced Arthritis, Reduces Bone Erosions, Biomarkers of Cartilage/Bone Destruction, and Synovial Osteoclastogenic Cytokines
Background/Purpose: Spleen tyrosine kinase (SYK) is expressed in hematopoietic cells and is a major downstream regulator of signaling through Fcγ and immunoglobulin receptors as well…Abstract Number: 289 • 2012 ACR/ARHP Annual Meeting
Mycophenolate Mofetil and Abatacept Combination Therapy in Refractory Pediatric Systemic Lupus Erythematosus Nephritis
Background/Purpose: Nephritis (LN) in pediatric systemic lupus erythematosus (pSLE) requires treatment (tx) with corticosteroids (CS) and other agents such as mycophenolate mofetil (MMF) or cyclophosphamide…Abstract Number: 290 • 2012 ACR/ARHP Annual Meeting
Long-Term Outcomes in Neonatal Lupus
Background/Purpose: Several studies have evaluated mortality and short-term morbidity in neonatal lupus (NL), however there have been no substantive descriptions of the long term cardiac,…Abstract Number: 291 • 2012 ACR/ARHP Annual Meeting
Illness Features Associated with an Increased Risk of Mortality in Children with Juvenile Idiopathic Inflammatory Myopathies
Background/Purpose: Juvenile idiopathic inflammatory myopathies (JIIM) are potentially life-threatening systemic autoimmune diseases but little in known regarding factors associated with mortality. Methods: Patients enrolled in…Abstract Number: 292 • 2012 ACR/ARHP Annual Meeting
Clinical Utility of Anti-CADM-140/Melanoma Differentiation-Associated Gene 5 Autoantibody Titers in Patients with Juvenile Dermatomyositis and Rapidly Progressive Interstitial Lung Disease
Background/Purpose: The presence of anti-CADM-140/ (Melanoma Differentiation-Associated Gene 5: MDA5) autoantibody is specific for adult dermatomyositis (DM), especially in patients with little or no muscle…