Abstract Number: 620 • 2012 ACR/ARHP Annual Meeting
Development of A Quantitative PCR Method to Determine Interferon Signature Metric Status in SLE Patients: Distribution and Clinical & Serological Associations in Two Lupus Clinical Trials
Background/Purpose: Elevated and coordinated expression of multiple Interferon-regulated genes (IRGs) in peripheral blood cells is present in most systemic lupus erythematosus (SLE) patients. Here we…Abstract Number: 621 • 2012 ACR/ARHP Annual Meeting
Prolonged Improvement of Systemic Lupus Erythematosus Following Systematic Administration of Rituximab and Cyclophosphamide
Prolonged improvement of systemic lupus erythematosus following systematic administration of rituximab and cyclophosphamide. Background/Purpose: We report sustained improvement in 15 patients with corticosteroid dependent SLE…Abstract Number: 622 • 2012 ACR/ARHP Annual Meeting
Headache in Systemic Lupus Erythematosus (SLE): Results From a Prospective, International, Inception Cohort Study
Background/Purpose: Headache is common in SLE patients and in the general population. We examined the frequency, characteristics and attribution of headaches in a large, prospective,…Abstract Number: 623 • 2012 ACR/ARHP Annual Meeting
Endothelial Microparticles As a Biomarker for Endothelial Dysfunction in Active Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is associated with an increased risk of clinical and subclinical cardiovascular disease (CVD) including endothelial dysfunction, in part due to…Abstract Number: 624 • 2012 ACR/ARHP Annual Meeting
Excess Health Care Utilization Prior to Diagnosis of Systemic Lupus Erythematosus in England
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic auto-immune disease resulting in significant excess morbidity and health care utilization. Since time of disease onset is…Abstract Number: 625 • 2012 ACR/ARHP Annual Meeting
Control of Hypertension and Hypercholesterolemia Is Not Associated with a Decreased Rate of Atherosclerotic Vascular Events in Patients with Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology. It has been shown that patients with SLE are at a higher…Abstract Number: 626 • 2012 ACR/ARHP Annual Meeting
The Interferon Alpha Gene Signature Is Not Associated with Nor Does It Predict Progression of Coronary Artery Calcium (CAC) or Carotid Intima-Media Thickness (IMT) in Systemic Lupus Erythematosus (SLE)
Background/Purpose: Accelerated atherosclerosis is the major cause of late mortality in SLE. Interferon alpha plays a role in atherosclerosis by deleting endothelial progenitor cells and…Abstract Number: 627 • 2012 ACR/ARHP Annual Meeting
Zostavax Vaccine Is Safe in Lupus Patients with Low Disease Activity
Background/Purpose: The Zostavax vaccine was FDA approved in 2006 for the prevention of herpes zoster in healthy adults over age 50. Because it is…Abstract Number: 628 • 2012 ACR/ARHP Annual Meeting
Urinary Heparanase Activity Is Elevated in Patients with Lupus Nephritis and Correlate with Protein Excretion
Background/Purpose: The heparin sulphate proteoglycans (HSPGs) in the glomerular basement membrane (GBM) play an important role in the charge-selective permeability of the glomerular filter. The…Abstract Number: 629 • 2012 ACR/ARHP Annual Meeting
Inflammatory Biomarkers of Atherosclerosis and Oxidative Stress Are Associated with Disease Flare in SLE
Background/Purpose: Although our current serologic measures of disease activity are useful for predicting flare in some patients, other patients experience disease flare in the absence…Abstract Number: 630 • 2012 ACR/ARHP Annual Meeting
Risk Factors Associated with Early Central Nervous System Damage Detected Through Diffusion Tensor Imaging (DTI) in Patients with Systemic Lupus Erythematosus
Background/Purpose: Antiphosholipid antibodies, SLICC-DI and some cardiovascular risk factors have been identified as risk factors for neuropsychiatric lupus (NPSLE). Diffusion tensor imaging (DTI) is an…Abstract Number: 591 • 2012 ACR/ARHP Annual Meeting
Structural Progression of Ankylosing Spondylitis Associated with Elevation in Two NOVEL, Inflammatory Biomarkers; Matrix Metalloproteinase and Cathepsin-Derived
Background/Purpose: Current inflammatory biomarkers, such as CRP, have insufficient sensitivity and specificity to be broadly accepted for diagnosis and prognosis of AS. We hypothesized, that…Abstract Number: 592 • 2012 ACR/ARHP Annual Meeting
Two Novel Diagnostic Biomarkers of Cartilage Degradation and Connective Tissue Inflammation Are Predictive of Disease Progression in Ankylosing Spondylitis
Background/Purpose: Cartilage degradation and inflammation of synovial and connective tissue are key events in inflammatory arthropathies such as SpA. Presently there are no prognostic tools…Abstract Number: 593 • 2012 ACR/ARHP Annual Meeting
DKK1 Serum Level Is Increased in Recent Spondyloarthritis and Is Associated with Higher Prevalence of Syndesmophytes. Sclerostin Is Highly Correlated with Age. Data From the DESIR Cohort
Background/Purpose: Dickkopf-1 (DKK-1) and sclerostin (SOST) are 2 inhibitory proteins of the Wnt signalling pathway that could rationally be involved either in AS osteoporosis or…Abstract Number: 594 • 2012 ACR/ARHP Annual Meeting
Evidence of Human Leucozyte Antigen-B27 in Healthy Individuals and Patients with Uveitis Is a Risk Factor for Alterations in Bone Metabolism
Background/Purpose: To test whether positivity for HLA-B27 per se is associated with changes of biomarkers of the Wnt pathway. HLA-B27 is strongly associated with the…