Abstract Number: 705 • 2012 ACR/ARHP Annual Meeting
Adipose Derived Stem Cells As an Alternative Source of Cellular Repair for Vascular Dysfunction in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is autoimmune disease characterized by autoimmunity, diffuse fibrosis in the skin and internal organs, and vasculopathy in moderate size arteries and…Abstract Number: 706 • 2012 ACR/ARHP Annual Meeting
Excess Mortality From Atherosclerotic Cardiovascular Disease in Systemic Sclerosis Compared to Lupus and Rheumatoid Arthritis
Background/Purpose: Patients with autoimmune connective tissue diseases (CTD), including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are at increased risk for atherosclerotic cardiovascular disease…Abstract Number: 707 • 2012 ACR/ARHP Annual Meeting
Risk of Cancer in Systemic Sclerosis: Meta-Analysis of Population-Based Cohort Studies
Background/Purpose: The risk of cancer compared with general population has been elevated in several connective tissue diseases. However, the standardized incidence ratios (SIRs) for overall…Abstract Number: 708 • 2012 ACR/ARHP Annual Meeting
Histological Features of Localized Scleroderma‘en Coup De Sabre‘: A Study of 16 Cases
Background/Purpose: Scleroderma is a chronic disease of unknown etiology characterized by skin fibrosis and is divided into two clinical entities: localized scleroderma and systemic sclerosis.…Abstract Number: 709 • 2012 ACR/ARHP Annual Meeting
Fingertip Skin Hardness in Limited Scleroderma: Durometry versus Manual Assessment
Background/Purpose: Skin manifestations of scleroderma involve the digits in nearly all patients. Assessment of change at the level of digital skin involvement is difficult. The Modified…Abstract Number: 710 • 2012 ACR/ARHP Annual Meeting
Optical Density Measure of the Papillary Dermis Discriminates As Abnormal Clinically Uninvolved Skin in Systemic Sclerosis and Correlates with Severity of Skin Thickness
Background/Purpose: Skin involvement in systemic sclerosis (SSc) is often primary outcome in clinical trials and its severity inversely correlates with prognosis. Nevertheless, an objective quantitative…Abstract Number: 671 • 2012 ACR/ARHP Annual Meeting
Differences in the SLE Clinical Phenotype by Age of Diagnosis
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is characterized by the presence of antinuclear autoantibodies, complement activation and the formation and…Abstract Number: 672 • 2012 ACR/ARHP Annual Meeting
Immune Complexes and Autoantibodies to Oxidized Lipids in Systemic Lupus Erythematosus
Background/Purpose: SLE is a chronic autoimmune inflammatory disease. Increasing evidence suggest that excess production of reactive oxygen species (ROS) may cause oxidative stress and favor…Abstract Number: 673 • 2012 ACR/ARHP Annual Meeting
Altered Soluble Mediators in Individuals with Incomplete Lupus (ILE) in the Lupus Autoimmunity in Relatives (LAUREL) Study
Background/Purpose: SLE is a complex autoimmune disease marked by autoantibody production and immune dysregulation. Identification of at-risk populations is essential to minimize morbidity and mortality…Abstract Number: 674 • 2012 ACR/ARHP Annual Meeting
Altered Response to B Cell Receptor (BCR) Crosslinking in SLE: Correlation with Genetic Risk Variants Predicted to Impact BCR Signaling
Background/Purpose: Altered B cell signaling has been proposed to play an important role in susceptibility to SLE. In mice, genetic manipulations or polymorphisms that attenuate…Abstract Number: 675 • 2012 ACR/ARHP Annual Meeting
Differential Impairment of Serum Cholesterol Efflux Capacity in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus
Background/Purpose: Accelerated atherosclerosis associated with autoimmune diseases is partly due to immune system dysregulation aggravating cardiovascular damage, but little is known on lipid metabolism derangement…Abstract Number: 676 • 2012 ACR/ARHP Annual Meeting
A Novel Biomarker: Nucleotide-Binding Oligomerization Domain 27 in Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease in which a variety of autoantibodies contribute to the diversified disease phenotypes. In our previous…Abstract Number: 677 • 2012 ACR/ARHP Annual Meeting
Antibodies to Oxidized Low Density Lipoprotein or Anti-Lipoprotein Lipase May Lead to More Atherosclerotic Plaque in a Sub-Set of SLE Patients
Background/Purpose: Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). Oxidized low density lipoproteins (oxLDL) are important in atherosclerosis and have been reported in SLE…Abstract Number: 678 • 2012 ACR/ARHP Annual Meeting
Estrogen Modulation of ZAS3 Is Mediated Through Estrogen Receptor α: An Underlying Mechanism of Gender-Bias in Systemic Lupus Erythematosus?
Background/Purpose: Global population data has indicated that post-pubertal females have decreased rates of infectious diseases when compared to male counterparts and preadolescent or postmenopausal females. …Abstract Number: 679 • 2012 ACR/ARHP Annual Meeting
ZAP70+ B Cells and Plasmablasts As Markers of Disease Activity and Remission in Systemic LUPUS Erythematosus Nephritis
Background/Purpose: To analyze differences in B cells subsets distribution in patients with renal systemic lupus erythematosus (SLE). To define possible cellular biomarkers of active nephritis…