ACR Meeting Abstracts

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  • Abstract Number: 752 • 2012 ACR/ARHP Annual Meeting

    IFNg Production Is Intimately Associated with Clinical and Laboratory Features of CpG-Induced Secondary Hemophagocytic Lymphohistiocytosis (sHLH)/Macrophage Activating Syndrome (MAS) in Mice

    Vanessa Buatois1, Laurence Chatel1, Laura Cons1, Maureen Deehan1, Cristina de Min2, Marie Kosco-Vilbois1 and Walter Ferlin1, 1NovImmune S.A., Geneva, Switzerland, 2Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland

    Background/Purpose: Repeated TLR9 stimulation with CpG DNA has been found to result in a sHLH/MAS-like disease in mice (1). CpG-administered mice present with cytopenia, anemia,…
  • Abstract Number: 711 • 2012 ACR/ARHP Annual Meeting

    Myopathy Is a Poor Prognostic Feature in Systemic Sclerosis: Results From the Canadian Scleroderma Research Group

    MIchelle Jung1, Murray Baron2, Marie Hudson3, Ashley Bonner4, Janet E. Pope5 and Canadian Scleroderma Research Group6, 1Western University, London, ON, Canada, 2Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, 3Jewish General Hospital, McGill University, Montreal, QC, Canada, 4McMaster University, Hamilton, ON, Canada, 5Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, 6Montreal, QC, Canada

    Background/Purpose: Myopathy / myositis is associated with more severe systemic scleroderma (SSc).  The aim of this study was to determine such clinical information from the…
  • Abstract Number: 712 • 2012 ACR/ARHP Annual Meeting

    Autoantibodies to Survival of Motor Neuron (SMN) Complex Are Common in Patients with Anti-U1RNP/Sm and Are Associated with Features of Scleroderma and Myopathy

    Jason YF Chan1, Yi Li1, Angela Ceribelli2, Eric S. Sobel3, Westley H. Reeves4, Edward K.L. Chan2 and Minoru Satoh1, 1Medicine, University of Florida, Gainesville, FL, 2Oral Biology, University of Florida, Gainesville, FL, 3Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, 4Rheumatology & Clinical Imm, University of Florida, Gainesville, FL

    Background/Purpose: Survival of motor neuron (SMN) complex that plays a key role in small nuclear ribonucleoproteins (snRNPs) assembly and interacts with snRNPs has recently been…
  • Abstract Number: 713 • 2012 ACR/ARHP Annual Meeting

    Rpp25 Is a Major Target of Autoantibodies to the Th/to Complex As Measured by ELISA and a New Chemilumiscence Assay

    Michael Mahler1, Cristina Gascon2, Sima Patel2, Angela Ceribelli3, Edward K.L. Chan3 and Minoru Satoh4, 1Research, INOVA Diagnostics, San Diego, CA, 2Research, INOVA Diagnostics, Inc., San Diego, CA, 3Oral Biology, University of Florida, Gainesville, FL, 4Medicine, University of Florida, Gainesville, FL

    Background/Purpose: Anti-nuclear antibodies (ANA) play an important role in the diagnosis of systemic autoimmune diseases including systemic sclerosis (SSc). A significant portion of ANA in…
  • Abstract Number: 714 • 2012 ACR/ARHP Annual Meeting

    Line Blot Assay, a Screening Test for Autoantibodies in Systemic Sclerosis (SSc)

    Kae Takagi1, Yasushi Kawaguchi1, Sayuri Kataoka1, Yuko Ota2, Yuko Okamoto1, Masanori Hanaoka1, Hisae Ichida1, Takahisa Gono1, Yasuhiro Katsumata1 and Hisashi Yamanaka1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology,Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Detection of auto-antibody is informative for diagnosis of SSc. Line blot assay (LBA) provides a quantitative in vitro assay for detecting human IgG class…
  • Abstract Number: 716 • 2012 ACR/ARHP Annual Meeting

    Utility of Novel Patient-Reported Outcome Instruments in Predicting Cardiac Involvement and Pulmonary Hypertension in Patients with Systemic Sclerosis

    Monique E. Hinchcliff1, Mary A. Carns2, Sofia Podlusky2, John Varga3 and Sanjiv J. Shah4, 1Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Heart involvement in systemic sclerosis (SSc) includes left ventricular systolic and diastolic dysfunction, right ventricular dysfunction, pericardial disease, and pulmonary hypertension. We recently demonstrated…
  • Abstract Number: 717 • 2012 ACR/ARHP Annual Meeting

    Results From a Multi-Tiered Item Collection On Linking Systemic Sclerosis to the International Classification of Functioning, Disability and Health: A EULAR Scleroderma Trials and Research Initiative

    Lesley Ann Saketkoo1, Reuben Escorpizo2, Kevin J. Keen3, Kim Fligelstone4 and Oliver Distler5, 1LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 2ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications in Germany (DIMDI), Nottwil, Switzerland, 3Mathematics and Statistics, University of Northern British Columbia, Prince George, BC, Canada, 4Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom, 5Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Systemic Sclerosis (SSc) affects multiple organs with complex combinations of disability. Skin fibrosis, ischemic pain, ulceration, arthritis, joint contractures, myopathy and cardiopulmonary, renal as…
  • Abstract Number: 719 • 2012 ACR/ARHP Annual Meeting

    Biomarkers of Pulmonary Hypertension in Patients with Scleroderma: A Case-Control Study

    Zsuzsanna H. McMahan1, Florian Schoenhoff2, Jennifer van Eyk3, Fredrick M. Wigley4 and Laura K. Hummers4, 1Rheumatology, Johns Hopkins University, Baltimore, MD, 2Department of Cardiovascular Surgery, Berne, Switzerland, 3Johns Hopkins University and Cedars Sinai Medical Center, Los Angeles, CA, 4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The objective of this study was to evaluate for an association between various biomarkers and the presence or absence of pulmonary hypertension (PH) in…
  • Abstract Number: 720 • 2012 ACR/ARHP Annual Meeting

    Left-Heart Disease Is a Frequent Cause of Pulmonary Hypertension in Systemic Sclerosis, Is Associated with Increased Levels of MR-ProANP and MR-ProADM but Is Unrelated to Elevated NT-ProBNP Levels: A Retrospective Cohort Analysis

    Lada Miller1, Sandra Chartrand1, Martial Koenig2, Jean-Richard Goulet3, Eric Rich1, Michal Abrahamowicz4, Jean-Luc Senécal1 and Tamara Grodzicky1, 1Rheumatology, Hôpital Notre-Dame du CHUM, Montreal, QC, Canada, 2Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 3Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 4Centre Universitaire de Santé McGill (CUSM), Montreal, QC, Canada

    Background/Purpose: Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in systemic sclerosis (SSc). Pulmonary arterial hypertension (PAH) is reportedly the most frequent…
  • Abstract Number: 721 • 2012 ACR/ARHP Annual Meeting

    Measurement of Pulmonary Arteries by Cardiac Magnetic Resonance Imaging: A Simple and Useful Tool for the Detection of Pulmonary Hypertension in Systemic Sclerosis Patients without Overt Cardiac Microvascular Perfusion Defects or Fibrosis

    Sandra Chartrand1, Lada Miller1, Martial Koenig2, Jean-Richard Goulet1, Eric Rich1, Anne S. Chin3, Yves Provost3, Carl Chartrand-Lefebvre3, Pauline Gou1, Jean-Luc Senécal1 and Tamara Grodzicky1, 1Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 2Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 3Radiology, Hôtel-Dieu de Montréal du CHUM, Montréal, QC, Canada

    Background/Purpose: Pulmonary hypertension (PH) is a major complication of systemic sclerosis (SSc). We observed that a significant proportion of our SSc patients with PH as…
  • Abstract Number: 722 • 2012 ACR/ARHP Annual Meeting

    Systemic Sclerosis Associated Pulmonary Hypertension – Is Pulmonary Veno-Occlusive Disease As Common As They Say?

    Benjamin E. Schreiber1, Greg Keir2, D. Dobarro3, Clive Handler4, Svetlana Nihtyanova5, Jay Suntharaligam6, Nicola Sverzelatti7, Graham Robinson6, David Hansell8, Athol U. Wells9, Christopher P. Denton10 and John G. Coghlan11, 1Royal Free Hospital NHS Foundation Trust, National Pulmonary Hypertension Service, London, United Kingdom, 2Royal Brompton Hospital, United Kingdom, 3Pulmonary Hypertension, Royal Free Hospital, London, United Kingdom, 4Department of Pulmonary Hypertension, The Royal Free Hospital, London, United Kingdom, 5Department of Rheumatology, Royal Free Hospital, Medical School, London, England, 6Royal United Hospital, Bath, United Kingdom, 7University of Parma, Parma, Italy, 8Royal Brompton Hospital, London, United Kingdom, 9Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom, 10Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 11National Pulmonary Hypertension Service, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom

    Background/Purpose: Recent reviews have suggested a high prevalence of pulmonary veno-occlusive disease (PVOD) amongst patients with systemic sclerosis (SSc) associated pulmonary hypertension (PH). Interlobular septal…
  • Abstract Number: 723 • 2012 ACR/ARHP Annual Meeting

    Renal Dysfunction and Disease Severity in Scleroderma-Associated Pulmonary Arterial Hypertension

    Stephen C. Mathai1, Laura K. Hummers2 and Virginia D. Steen3, 1Medicine, Johns Hopkins University, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Rheumatology, Georgetown University Medical Center, Washington, DC

    Background/Purpose: Renal disease is a common complication of scleroderma (SSc).  Isolated reduction in glomerular filtration rate (GFR), a marker of impaired renal function, can occur…
  • Abstract Number: 724 • 2012 ACR/ARHP Annual Meeting

    Survival, Hospitalization or Need for Combination Therapy At One Year in Patients with Scleroderma-Associated Pulmonary Arterial Hypertension

    Robyn T. Domsic1, Lorinda Chung2, Jessica K. Gordon3, Yona Cloonan4, Virginia D. Steen5 and PHAROS Investigators6, 1Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 5Department of Rheumatology, Georgetown University Medical Center, Washington, DC, 6Washington, DC, DC

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of death in patients with systemic sclerosis (SSc).  Although survival has improved with PAH-specific medications in…
  • Abstract Number: 725 • 2012 ACR/ARHP Annual Meeting

    The Role of Interleukin-23 in Spondyloarthropathy

    Jonathan Sherlock1, Barbara Joyce-Shaikh1, Scott Turner1, Cheng-Chi Chao2, Manjiri Sathe1, Jeff Grein1, Dan Gorman1, Eddie P. Bowman2, Terrill McClanahan1, Jennifer Yearley1, Gerard Eberl3, Christopher D. Buckley4, Robert Kastelein1, Robert Pierce1, Drake LaFace1 and Daniel Cua5, 1Merck, Palo Alto, CA, 2Drug Discovery, Merck, Palo Alto, CA, 3Institut Pasteur, Paris, France, 4Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, 5Discovery Research, Merck Research Laboratory, Palo Alto, CA

    Background/Purpose: Spondyloarthropathy is characterized by inflammation and bony pathology at the entheseal insertion of tendons to bone.  Recent investigations have converged upon interleukin(IL)-23, demonstrating firstly…
  • Abstract Number: 726 • 2012 ACR/ARHP Annual Meeting

    Dynamic in Vivo Imaging of Th17-Mediated Osteoclastic Bone Resorption in Live Bones by Using Intravital Multiphoton Microscopy

    Junichi Kikuta and Masaru Ishii, Laboratory of Cellular Dynamics, Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint synovial inflammation and progressive cartilage/bone destruction. Although various kinds of cell types, such…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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