Abstracts Archive - Page 2373 of 2425 - ACR Meeting Abstracts

Abstract Number: 752 • 2012 ACR/ARHP Annual Meeting
IFNg Production Is Intimately Associated with Clinical and Laboratory Features of CpG-Induced Secondary Hemophagocytic Lymphohistiocytosis (sHLH)/Macrophage Activating Syndrome (MAS) in Mice
Vanessa Buatois¹, Laurence Chatel¹, Laura Cons¹, Maureen Deehan¹, Cristina de Min², Marie Kosco-Vilbois¹ and Walter Ferlin¹, ¹NovImmune S.A., Geneva, Switzerland, ²Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland
Background/Purpose: Repeated TLR9 stimulation with CpG DNA has been found to result in a sHLH/MAS-like disease in mice (1). CpG-administered mice present with cytopenia, anemia,…
Abstract Number: 711 • 2012 ACR/ARHP Annual Meeting
Myopathy Is a Poor Prognostic Feature in Systemic Sclerosis: Results From the Canadian Scleroderma Research Group
MIchelle Jung¹, Murray Baron², Marie Hudson³, Ashley Bonner⁴, Janet E. Pope⁵ and Canadian Scleroderma Research Group⁶, ¹Western University, London, ON, Canada, ²Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁴McMaster University, Hamilton, ON, Canada, ⁵Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁶Montreal, QC, Canada
Background/Purpose: Myopathy / myositis is associated with more severe systemic scleroderma (SSc). The aim of this study was to determine such clinical information from the…
Abstract Number: 712 • 2012 ACR/ARHP Annual Meeting
Autoantibodies to Survival of Motor Neuron (SMN) Complex Are Common in Patients with Anti-U1RNP/Sm and Are Associated with Features of Scleroderma and Myopathy
Jason YF Chan¹, Yi Li¹, Angela Ceribelli², Eric S. Sobel³, Westley H. Reeves⁴, Edward K.L. Chan² and Minoru Satoh¹, ¹Medicine, University of Florida, Gainesville, FL, ²Oral Biology, University of Florida, Gainesville, FL, ³Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, ⁴Rheumatology & Clinical Imm, University of Florida, Gainesville, FL
Background/Purpose: Survival of motor neuron (SMN) complex that plays a key role in small nuclear ribonucleoproteins (snRNPs) assembly and interacts with snRNPs has recently been…
Abstract Number: 713 • 2012 ACR/ARHP Annual Meeting
Rpp25 Is a Major Target of Autoantibodies to the Th/to Complex As Measured by ELISA and a New Chemilumiscence Assay
Michael Mahler¹, Cristina Gascon², Sima Patel², Angela Ceribelli³, Edward K.L. Chan³ and Minoru Satoh⁴, ¹Research, INOVA Diagnostics, San Diego, CA, ²Research, INOVA Diagnostics, Inc., San Diego, CA, ³Oral Biology, University of Florida, Gainesville, FL, ⁴Medicine, University of Florida, Gainesville, FL
Background/Purpose: Anti-nuclear antibodies (ANA) play an important role in the diagnosis of systemic autoimmune diseases including systemic sclerosis (SSc). A significant portion of ANA in…
Abstract Number: 714 • 2012 ACR/ARHP Annual Meeting
Line Blot Assay, a Screening Test for Autoantibodies in Systemic Sclerosis (SSc)
Kae Takagi¹, Yasushi Kawaguchi¹, Sayuri Kataoka¹, Yuko Ota², Yuko Okamoto¹, Masanori Hanaoka¹, Hisae Ichida¹, Takahisa Gono¹, Yasuhiro Katsumata¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology,Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Detection of auto-antibody is informative for diagnosis of SSc. Line blot assay (LBA) provides a quantitative in vitro assay for detecting human IgG class…
Abstract Number: 716 • 2012 ACR/ARHP Annual Meeting
Utility of Novel Patient-Reported Outcome Instruments in Predicting Cardiac Involvement and Pulmonary Hypertension in Patients with Systemic Sclerosis
Monique E. Hinchcliff¹, Mary A. Carns², Sofia Podlusky², John Varga³ and Sanjiv J. Shah⁴, ¹Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Heart involvement in systemic sclerosis (SSc) includes left ventricular systolic and diastolic dysfunction, right ventricular dysfunction, pericardial disease, and pulmonary hypertension. We recently demonstrated…
Abstract Number: 717 • 2012 ACR/ARHP Annual Meeting
Results From a Multi-Tiered Item Collection On Linking Systemic Sclerosis to the International Classification of Functioning, Disability and Health: A EULAR Scleroderma Trials and Research Initiative
Lesley Ann Saketkoo¹, Reuben Escorpizo², Kevin J. Keen³, Kim Fligelstone⁴ and Oliver Distler⁵, ¹LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ²ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications in Germany (DIMDI), Nottwil, Switzerland, ³Mathematics and Statistics, University of Northern British Columbia, Prince George, BC, Canada, ⁴Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom, ⁵Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Systemic Sclerosis (SSc) affects multiple organs with complex combinations of disability. Skin fibrosis, ischemic pain, ulceration, arthritis, joint contractures, myopathy and cardiopulmonary, renal as…
Abstract Number: 719 • 2012 ACR/ARHP Annual Meeting
Biomarkers of Pulmonary Hypertension in Patients with Scleroderma: A Case-Control Study
Zsuzsanna H. McMahan¹, Florian Schoenhoff², Jennifer van Eyk³, Fredrick M. Wigley⁴ and Laura K. Hummers⁴, ¹Rheumatology, Johns Hopkins University, Baltimore, MD, ²Department of Cardiovascular Surgery, Berne, Switzerland, ³Johns Hopkins University and Cedars Sinai Medical Center, Los Angeles, CA, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The objective of this study was to evaluate for an association between various biomarkers and the presence or absence of pulmonary hypertension (PH) in…
Abstract Number: 720 • 2012 ACR/ARHP Annual Meeting
Left-Heart Disease Is a Frequent Cause of Pulmonary Hypertension in Systemic Sclerosis, Is Associated with Increased Levels of MR-ProANP and MR-ProADM but Is Unrelated to Elevated NT-ProBNP Levels: A Retrospective Cohort Analysis
Lada Miller¹, Sandra Chartrand¹, Martial Koenig², Jean-Richard Goulet³, Eric Rich¹, Michal Abrahamowicz⁴, Jean-Luc Senécal¹ and Tamara Grodzicky¹, ¹Rheumatology, Hôpital Notre-Dame du CHUM, Montreal, QC, Canada, ²Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ³Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ⁴Centre Universitaire de Santé McGill (CUSM), Montreal, QC, Canada
Background/Purpose: Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in systemic sclerosis (SSc). Pulmonary arterial hypertension (PAH) is reportedly the most frequent…
Abstract Number: 721 • 2012 ACR/ARHP Annual Meeting
Measurement of Pulmonary Arteries by Cardiac Magnetic Resonance Imaging: A Simple and Useful Tool for the Detection of Pulmonary Hypertension in Systemic Sclerosis Patients without Overt Cardiac Microvascular Perfusion Defects or Fibrosis
Sandra Chartrand¹, Lada Miller¹, Martial Koenig², Jean-Richard Goulet¹, Eric Rich¹, Anne S. Chin³, Yves Provost³, Carl Chartrand-Lefebvre³, Pauline Gou¹, Jean-Luc Senécal¹ and Tamara Grodzicky¹, ¹Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ²Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ³Radiology, Hôtel-Dieu de Montréal du CHUM, Montréal, QC, Canada
Background/Purpose: Pulmonary hypertension (PH) is a major complication of systemic sclerosis (SSc). We observed that a significant proportion of our SSc patients with PH as…
Abstract Number: 722 • 2012 ACR/ARHP Annual Meeting
Systemic Sclerosis Associated Pulmonary Hypertension – Is Pulmonary Veno-Occlusive Disease As Common As They Say?
Benjamin E. Schreiber¹, Greg Keir², D. Dobarro³, Clive Handler⁴, Svetlana Nihtyanova⁵, Jay Suntharaligam⁶, Nicola Sverzelatti⁷, Graham Robinson⁶, David Hansell⁸, Athol U. Wells⁹, Christopher P. Denton¹⁰ and John G. Coghlan¹¹, ¹Royal Free Hospital NHS Foundation Trust, National Pulmonary Hypertension Service, London, United Kingdom, ²Royal Brompton Hospital, United Kingdom, ³Pulmonary Hypertension, Royal Free Hospital, London, United Kingdom, ⁴Department of Pulmonary Hypertension, The Royal Free Hospital, London, United Kingdom, ⁵Department of Rheumatology, Royal Free Hospital, Medical School, London, England, ⁶Royal United Hospital, Bath, United Kingdom, ⁷University of Parma, Parma, Italy, ⁸Royal Brompton Hospital, London, United Kingdom, ⁹Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom, ¹⁰Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ¹¹National Pulmonary Hypertension Service, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Recent reviews have suggested a high prevalence of pulmonary veno-occlusive disease (PVOD) amongst patients with systemic sclerosis (SSc) associated pulmonary hypertension (PH). Interlobular septal…
Abstract Number: 723 • 2012 ACR/ARHP Annual Meeting
Renal Dysfunction and Disease Severity in Scleroderma-Associated Pulmonary Arterial Hypertension
Stephen C. Mathai¹, Laura K. Hummers² and Virginia D. Steen³, ¹Medicine, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Rheumatology, Georgetown University Medical Center, Washington, DC
Background/Purpose: Renal disease is a common complication of scleroderma (SSc). Isolated reduction in glomerular filtration rate (GFR), a marker of impaired renal function, can occur…
Abstract Number: 724 • 2012 ACR/ARHP Annual Meeting
Survival, Hospitalization or Need for Combination Therapy At One Year in Patients with Scleroderma-Associated Pulmonary Arterial Hypertension
Robyn T. Domsic¹, Lorinda Chung², Jessica K. Gordon³, Yona Cloonan⁴, Virginia D. Steen⁵ and PHAROS Investigators⁶, ¹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ⁶Washington, DC, DC
Background/Purpose: Pulmonary arterial hypertension (PAH) is a leading cause of death in patients with systemic sclerosis (SSc). Although survival has improved with PAH-specific medications in…
Abstract Number: 725 • 2012 ACR/ARHP Annual Meeting
The Role of Interleukin-23 in Spondyloarthropathy
Jonathan Sherlock¹, Barbara Joyce-Shaikh¹, Scott Turner¹, Cheng-Chi Chao², Manjiri Sathe¹, Jeff Grein¹, Dan Gorman¹, Eddie P. Bowman², Terrill McClanahan¹, Jennifer Yearley¹, Gerard Eberl³, Christopher D. Buckley⁴, Robert Kastelein¹, Robert Pierce¹, Drake LaFace¹ and Daniel Cua⁵, ¹Merck, Palo Alto, CA, ²Drug Discovery, Merck, Palo Alto, CA, ³Institut Pasteur, Paris, France, ⁴Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁵Discovery Research, Merck Research Laboratory, Palo Alto, CA
Background/Purpose: Spondyloarthropathy is characterized by inflammation and bony pathology at the entheseal insertion of tendons to bone. Recent investigations have converged upon interleukin(IL)-23, demonstrating firstly…
Abstract Number: 726 • 2012 ACR/ARHP Annual Meeting
Dynamic in Vivo Imaging of Th17-Mediated Osteoclastic Bone Resorption in Live Bones by Using Intravital Multiphoton Microscopy
Junichi Kikuta and Masaru Ishii, Laboratory of Cellular Dynamics, Immunology Frontier Research Center, Osaka University, Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint synovial inflammation and progressive cartilage/bone destruction. Although various kinds of cell types, such…

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