Abstract Number: 742 • 2012 ACR/ARHP Annual Meeting
Utility of HLA-B5801 Genotyping and Renal Dosing of the Starting Dose of Allopurinol in Preventing Allopurinol Hypersensitivity Syndrome: A Cost-Effectiveness Analysis
Background/Purpose: Allopurinol is the leading choice of urate-lowering therapy (~ 95%) for gout which affects 8.3 million US adults. However, allopurinol is associated with a…Abstract Number: 743 • 2012 ACR/ARHP Annual Meeting
Anemia and the Onset of Gout in a Population-Based Cohort of Adults: Atherosclerosis Risk in Communities Study
Background/Purpose: There is a growing prevalence of gout in the US and worldwide. Gout is a recognized risk factor for cardiovascular disease (CVD). It is…Abstract Number: 744 • 2012 ACR/ARHP Annual Meeting
Racial Differences in Reported Knee Pain Severity Persist Even After Adjustment for Knee Examination and Radiographic Findings: Data From the Osteoarthritis Initiative
Background/Purpose: African Americans have a higher prevalence of both radiographic and symptomatic radiographic knee osteoarthritis (OA) than Caucasians. In addition, African Americans with knee OA…Abstract Number: 745 • 2012 ACR/ARHP Annual Meeting
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data From the Osteoarthritis Initiative
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data from the Osteoarthritis InitiativeBackground/Purpose : Soft drink consumption has been associated with weight gain and…Abstract Number: 746 • 2012 ACR/ARHP Annual Meeting
Increased Risk of Acute and Chronic Renal Comorbidity in Ankylosing Spondylitis: Results From a Population-Based Study
Background/Purpose: Clinical evidence points to an increased risk of renal comorbidity in ankylosing spondylitis (AS) compared to the general population. However, there are no population-based…Abstract Number: 747 • 2012 ACR/ARHP Annual Meeting
Familial Mediterranean Fever: Inhibition of IL-6 Signalling As a New Therapeutic Option in a Frequent Autoinflammatory Syndrome.
Background/Purpose: Familial Mediterranean Fever (FMF) is the most prevalent episodic fever syndrome with more than 100.000 affected individuals worldwide. Colchicine is the established first-line therapy…Abstract Number: 748 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Canakinumab in Patients with Cryopyrin Associated Periodic Syndrome: Results From Meta-Analysis of 5 Studies
Background/Purpose: Canakinumab (CAN) is approved in over 60 countries for the treatment of CAPS. This meta-analysis evaluated the efficacy and safety of CAN and assessed…Abstract Number: 749 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Canakinumab in Patients with TNF Receptor Associated Periodic Syndrome
Background/Purpose: TNF-receptor associated periodic syndrome (TRAPS) is a rare dominantly inherited periodic fever syndrome due to mutations of the TNFRSF1A gene. It is characterized by…Abstract Number: 750 • 2012 ACR/ARHP Annual Meeting
Efficacy and Safety of Canakinumab in Adults with Colchicine Resistant Familial Mediterranean Fever
Background/Purpose: Familial Mediterranean fever (FMF) is associated with variations in the MEFV gene resulting in proteolytic activation of IL-1β through the inflammasome complex. FMF is…Abstract Number: 751 • 2012 ACR/ARHP Annual Meeting
Whole Transcriptome Analysis in Erdheim-Chester Disease: A Multicenter Collaborative Study of 58 Patients
Background/Purpose: To date, gene expression profiling has not been performed in Erdheim-Chester disease (ECD), a rare, non-Langerhans form of histiocytosis. The aim of this study…Abstract Number: 752 • 2012 ACR/ARHP Annual Meeting
IFNg Production Is Intimately Associated with Clinical and Laboratory Features of CpG-Induced Secondary Hemophagocytic Lymphohistiocytosis (sHLH)/Macrophage Activating Syndrome (MAS) in Mice
Background/Purpose: Repeated TLR9 stimulation with CpG DNA has been found to result in a sHLH/MAS-like disease in mice (1). CpG-administered mice present with cytopenia, anemia,…Abstract Number: 711 • 2012 ACR/ARHP Annual Meeting
Myopathy Is a Poor Prognostic Feature in Systemic Sclerosis: Results From the Canadian Scleroderma Research Group
Background/Purpose: Myopathy / myositis is associated with more severe systemic scleroderma (SSc). The aim of this study was to determine such clinical information from the…Abstract Number: 712 • 2012 ACR/ARHP Annual Meeting
Autoantibodies to Survival of Motor Neuron (SMN) Complex Are Common in Patients with Anti-U1RNP/Sm and Are Associated with Features of Scleroderma and Myopathy
Background/Purpose: Survival of motor neuron (SMN) complex that plays a key role in small nuclear ribonucleoproteins (snRNPs) assembly and interacts with snRNPs has recently been…Abstract Number: 713 • 2012 ACR/ARHP Annual Meeting
Rpp25 Is a Major Target of Autoantibodies to the Th/to Complex As Measured by ELISA and a New Chemilumiscence Assay
Background/Purpose: Anti-nuclear antibodies (ANA) play an important role in the diagnosis of systemic autoimmune diseases including systemic sclerosis (SSc). A significant portion of ANA in…Abstract Number: 714 • 2012 ACR/ARHP Annual Meeting
Line Blot Assay, a Screening Test for Autoantibodies in Systemic Sclerosis (SSc)
Background/Purpose: Detection of auto-antibody is informative for diagnosis of SSc. Line blot assay (LBA) provides a quantitative in vitro assay for detecting human IgG class…