Abstract Number: 898 • 2012 ACR/ARHP Annual Meeting
Nuclear Receptor Related 1 Induces Synovial Hyperplasia Via Transcriptional Regulation of Novel Target Genes
Background/Purpose: Nuclear receptor related 1 (NURR1 / NR4A2) is an orphan member of the nuclear receptor super-family that functions as a constitutively active transcription factor.…Abstract Number: 899 • 2012 ACR/ARHP Annual Meeting
A Role for Soluble Interleukin-6 Receptor As an Antagonist of Interleukin-27 Signaling
Background/Purpose: Recently, it has been reported that interleukin (IL)-27 treatment reduces inflammation and ameliorates arthritis in collagen-induced arthritis mice. IL-27 is a heterodimeric cytokine composed…Abstract Number: 900 • 2012 ACR/ARHP Annual Meeting
Deletion of RBP-J in a Murine Model of Inflammatory Arthritis Reveals Differential Pro-Inflammatory Cytokine and FoxP3 Gene Expression
Background/Purpose: The DNA-binding protein RBP-J serves as the central transcriptional regulator of the Notch signaling pathway. Prior work done using a knockdown approach of RBP-J…Abstract Number: 901 • 2012 ACR/ARHP Annual Meeting
Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis
Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…Abstract Number: 902 • 2012 ACR/ARHP Annual Meeting
Activation of NF-Kb Via Poly(I:C)-Induced Monocyte-Derived Microparticles Decreases TRAIL-Induced Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts
Background/Purpose: Decreased sensitivity of rheumatoid arthritis (RA) synovial fibroblasts (SF) to apoptosis leads to synovial hyperplasia and destruction of joints in RA. Activation of NF-kB…Abstract Number: 903 • 2012 ACR/ARHP Annual Meeting
NR4A1 Mediates Anti-Inflammatory Effects of Apoptotic Cells
Background/Purpose: The nuclear receptor NR4A1 has been implicated as negative feedback regulator of NF kappa B signalling and as key regulator during the differentiation of…Abstract Number: 904 • 2012 ACR/ARHP Annual Meeting
Perinatal Characteristics, Maternal Reproductive History and Juvenile Idiopathic Arthritis: A Case-Control Study
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a heterogeneous group of chronic inflammatory arthritis conditions in children with onset before 16 years of age, and is the…Abstract Number: 905 • 2012 ACR/ARHP Annual Meeting
The Association Between Lower Body Mass Index and Increased Risk of Giant Cell Arteritis Is Not Explained by Differences in Physical Activity
Background/Purpose: There is limited data on predictors of giant cell arteritis (GCA). Low body mass index (BMI), a history of smoking and several hormonal factors…Abstract Number: 906 • 2012 ACR/ARHP Annual Meeting
Patient-Rheumatologist Communication Concerning Medication and Disease Risks
Background/Purpose: Medications play an important role in the management of rheumatoid arthritis. Principles of informed consent, informed and shared decision-making, and professional ethics highlight the importance…Abstract Number: 907 • 2012 ACR/ARHP Annual Meeting
Use of Patient Preferences to Inform the Development of Disease Modifying Drugs for Osteoarthritis
Background/Purpose: Considerable efforts are currently being directed at developing robust and efficient trial designs to study the efficacy of disease modifying drugs (DMOADs) for osteoarthritis…Abstract Number: 908 • 2012 ACR/ARHP Annual Meeting
Race, Gender and Total Knee Replacement Consideration: The Role of Social Support
Background/Purpose: There is marked variation in patient preference (i.e. willingness) regarding total knee replacement (TKR), an effective treatment option for end-stage osteoarthritis (OA). Studies have…Abstract Number: 909 • 2012 ACR/ARHP Annual Meeting
Determinants of Patient Preferences for Total Knee Replacement: A Comparison of Whites and African-Americans
Background/Purpose: TKR is a cost-effective treatment option for end-stage knee osteoarthritis (OA). Although it is one of the fastest growing elective surgeries, there are marked…Abstract Number: 910 • 2012 ACR/ARHP Annual Meeting
The Cost-Effectiveness of Total Joint Arthroplasty: A Systematic Review of Published Literature
Background/Purpose: Utilization of total hip arthroplasty (THA) and total knee arthroplasty (TKA) has nearly doubled in the last decade. These procedures are increasingly performed in…Abstract Number: 911 • 2012 ACR/ARHP Annual Meeting
Race- and Sex-Specific Estimates of 10-, 20-, 30-Year, and Lifetime Risk of Diagnosed Symptomatic Knee Osteoarthritis and the Need for TKR in the US
Background/Purpose: A growing body of evidence suggests that females are more likely to be diagnosed with knee osteoarthritis (OA) and that obesity increases the risk…Abstract Number: 912 • 2012 ACR/ARHP Annual Meeting
Clinical Features Associated with Progression of Knee Radiographic Osteoarthritis: Data From the Osteoarthritis Initiative
Background/Purpose: A better understanding of the factors associated with structural progression of knee osteoarthritis (OA) may help identify individuals not only at risk for more…