Abstracts Archive - Page 2358 of 2425 - ACR Meeting Abstracts

Abstract Number: 969 • 2012 ACR/ARHP Annual Meeting
Presence of Small Fiber Neuropathy in a Cohort of Patients with Fibromyalgia
Todd Levine¹, Victoria Lawson², Aidan Levine¹, Kevin V. Hackshaw³ and David Saperstein¹, ¹Phoenix Neurological Associates, Phoenix, AZ, ²Neurology, Ohio State University, Columbus, OH, ³Immunology/Rheumatology, The Ohio State University, Columbus, OH
Background/Purpose: The pain associated with fibromyalgia is classically described as deep, muscular, aching and flu-like; however, a significant percentage of patients with fibromyalgia also describe…
Abstract Number: 970 • 2012 ACR/ARHP Annual Meeting
Genetic Interactions Between SNP Variants in C3 Receptor Subunits in Patients with SLE
Jeffrey C. Edberg¹, Christine W. Duarte², Amit Patki², Elizabeth E. Brown MPH³, Kenneth M. Kaufman⁴, Jennifer A. Kelly⁵, Mary E. Comeau⁶, Marta E. Alarcon-Riquelme on behalf of BIOLUPUS and GENLES⁷, Sang-Cheol Bae⁸, Lindsey A. Criswell⁹, Barry I. Freedman¹⁰, Patrick M. Gaffney¹¹, Gary S. Gilkeson¹², Chaim O. Jacob¹³, Judith A. James⁵, Diane L. Kamen¹⁴, Kathy Moser Sivils⁵, Timothy B. Niewold¹⁵, Robert H. Scofield¹⁶, Betty P. Tsao¹⁷, Timothy J. Vyse¹⁸, John B. Harley¹⁹, Carl D. Langefeld²⁰, Hemant Tiwari² and Robert P. Kimberly²¹, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Wake Forest University Health Sciences, Winston-Salem, NC, ⁷Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, ⁸Hanyang University Hospital for Rheumatic Disease, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, ⁹Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ¹⁰Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ¹¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ¹³Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ¹⁴Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ¹⁵Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ¹⁶Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹⁷Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, ¹⁸Medical & Molecular Genetics, King's College London, London, United Kingdom, ¹⁹Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ²⁰Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Genome-wide and candidate gene studies have supported a role for genes involved in immune complex processing as being important contributors to development of SLE. …
Abstract Number: 971 • 2012 ACR/ARHP Annual Meeting
Association of adam33 Polymorphisms with Systemic Lupus Erythematosus
Seung Cheol Shim¹, Mi Kyoung Lim¹, Donghyuk Sheen² and Hyo Park¹, ¹Medicine, Eulji University Hospital, Daejeon, South Korea, ²Rheumatology, Eulji University Hospital, Daejeon, South Korea
Background/Purpose: A Disintegrin and Metalloprotease 33 (ADAM33) is a member of a family of genes that encode membrane-anchored proteins with a disintegrin and a metalloprotease…
Abstract Number: 972 • 2012 ACR/ARHP Annual Meeting
Associations of Genetic Polymorphisms of Microrna-146a and Its Target Interleukin-1-Receptor-Associated Kinase 1 with Ankylosing Spondylitis
Chun-Huang Huang¹, Jia-Yan Zhan², Kai-Jieh Yeo³, James C. Wei⁴, Chih-Shien Chuang² and Ruey-Hong Wong², ¹Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ²Department of Public Health, Chung Shan Medical University, Taichung, Taiwan, ³Division of Allergy, Immunology and Rheumatology, Chung Shan Med Univ Hospital, Taichung, Taiwan, ⁴Allergy/Immunology/Rheumatolog, Chung Shan Med Univ Hospital, Taichung, Taiwan
Background/Purpose: Tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) were important mediators of inflammation response in the development of ankylosing spondylitis (AS). Especially, microRNA (miR)-146a targets…
Abstract Number: 973 • 2012 ACR/ARHP Annual Meeting
New Genetic Risk Loci for the Radiographic Severity of Rheumatoid Arthritis
Diederik P.C. de Rooy¹, Sacha Zhernakova¹, Roula Tsonaka², Fina Kurreeman³, René E.M. Toes¹, Tom W. J. Huizinga⁴, Jeanine Houwing-Duistermaat⁵, Peter K. Gregersen⁶ and Annette H.M. van der Helm-van Mil¹, ¹Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Statistics, Statistics, Leiden University Medical Center, Leiden, Netherlands, ⁶Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: The severity of joint destruction is highly variable between Rheumatoid Arthritis (RA) patients; approximately 54% of this variance is explained by genetic factors. Many…
Abstract Number: 974 • 2012 ACR/ARHP Annual Meeting
Identification of Susceptibility Loci for Inflammatory Arthritis
K. J. A. Steel¹, Anne Hinks², John Bowes³, Joanna Cobb², Edward Flynn⁴, Carl D. Langefeld⁵, Sampath Prahalad⁶, Johannes Peter Haas⁷, John F. Bohnsack⁸, Stephen Guthery⁸, Anne Barton¹, Susan D. Thompson⁹ and Wendy Thomson¹, ¹Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁵Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁶Pediatrics, Emory Children's Center, Atlanta, GA, ⁷Childrens Hospital, Erlangen, Germany, ⁸Department of Pediatrics,, University of Utah, Salt Lake City, ⁹Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: One of the principal findings of genome wide association studies in autoimmune diseases has been the substantial overlap of genetic susceptibility loci identified. This…
Abstract Number: 934 • 2012 ACR/ARHP Annual Meeting
Direct Medical Cost Associated with Organ System Involvement in a Commercially Insured Population with Systemic Lupus Erythematosus in the United States
Alan Oglesby¹, Emily Durden², Siva Narayanan³, Paul Juneau⁴ and Kathleen L. Wilson⁵, ¹GlaxoSmithKline, Research Triangle Park, NC, ²Thomson Reuters, Austin, TX, ³Global Health Economics and Outcomes Research and Epidemiology, Human Genome Sciences, Inc., Rockville, MD, ⁴Truven Health Analytics, Washington, DC, ⁵Thomson Reuters Healthcare, Cambridge, MA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs including the heart, lungs, kidneys, as well as the joints and…
Abstract Number: 935 • 2012 ACR/ARHP Annual Meeting
Primary Care Preventive Services in Patients with Systemic Lupus Erythematosus Compared to Others in Their Community
Cristina Drenkard¹, Kimberley Rask², Gaobin Bao³, Gnanesh Patel⁴, Suparna Bagchi⁵ and S. Sam Lim⁶, ¹Medicine, Div Rheumatology, Emory University, Atlanta, GA, ²Health Policy and Management, Emory University, Atlanta, GA, ³Medicine, Emory University, Atlanta, GA, ⁴Emory University, Atlanta, GA, ⁵Georgia Department of Public Health, Atlanta, GA, ⁶Emory University School of Medicine, Division of Rheumatology, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic illness frequently complicated by infections, cardiovascular disease (CVD) and cancer. Primary care preventive services (PCS) are recommended…
Abstract Number: 936 • 2012 ACR/ARHP Annual Meeting
Autoimmune Diseases: Declining Mortality Between 1999 and 2008 However Continuing to be a Leading Cause of Death in Children-A 10-Year Retrospective Review
Eric Y. Yen¹ and Deborah K. McCurdy², ¹Pediatrics/Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, ²Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA
Background/Purpose: Autoimmune diseases are chronic illnesses that cause significant and chronic disability in children and may lead to death. Using mortality data from 1995, Walsh…
Abstract Number: 937 • 2012 ACR/ARHP Annual Meeting
Changes in Ten Year Survival Among SLE Patients At an Academic Center in North America (1970-2011)
Joseph F. Merola¹, Bonnie L. Bermas², Bing Lu¹, Peter Hsun Tsao¹, Tabatha Norton¹, Christina Iversen¹, Elizabeth W. Karlson², Peter H. Schur¹ and Karen H. Costenbader¹, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Data from other large SLE cohorts have suggested improving survival among SLE patients in recent years with protective effects from antimalarial use and less…
Abstract Number: 938 • 2012 ACR/ARHP Annual Meeting
Hospitalizations in Systemic Lupus Erythematosus: A Longitudinal Study
Hong Fang¹, Jie Xu² and Michelle Petri¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Hospitalizations are one of the major direct costs in SLE. A review of studies looking at the contributions of different medical components to the…
Abstract Number: 939 • 2012 ACR/ARHP Annual Meeting
Shared High Risk of Intensive Care Unit Admission in Three Autoimmune Inflammatory Diseases
Christine Peschken¹, Carol A. Hitchon², Allan Garland³, Charles N. Bernstein³, Randy Fransoo⁴ and Ruth Ann Marrie³, ¹Medicine & Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, ⁴Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Little is known about the influence of autoimmune inflammatory diseases on the risk of critical illness, as defined by Intensive care unit admissions (ICU).…
Abstract Number: 940 • 2012 ACR/ARHP Annual Meeting
Incidence of Systemic Lupus Erythematosus in England, 1998-2010
Herve Caspard¹, Amy Steffey², Jie Li² and Trung N. Tran², ¹Epidemiology, Clinical Development, MedImmune LLC, Gaithersburg, MD, ²Epidemiology, Clinical Development, MedImmune, Gaithersburg, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic auto-immune disease associated with a wide spectrum of clinical manifestations and increased mortality. The most recent data…
Abstract Number: 941 • 2012 ACR/ARHP Annual Meeting
Validity and Reliability of the Systemic Lupus Activity Questionnaire (SLAQ): A Prospective Study
Yuko Okamoto, Yasuhiro Katsumata, Yasushi Kawaguchi, Sayumi Baba, Kae Takagi, Hisae Ichida, Takahisa Gono, Masanori Hanaoka, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Traditional assessments of systemic lupus erythematosus (SLE) disease activity, such as the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus Activity Measure…
Abstract Number: 942 • 2012 ACR/ARHP Annual Meeting
Validity and Reliability of the Lupus Damage Index Questionnaire (LDIQ): A Prospective Study
Yuko Okamoto, Yasuhiro Katsumata, Yasushi Kawaguchi, Sayumi Baba, Kae Takagi, Hisae Ichida, Takahisa Gono, Masanori Hanaoka, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI) is a validated instrument for assessing organ damage in systemic lupus…

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