Abstracts Archive - Page 2349 of 2425 - ACR Meeting Abstracts

Abstract Number: 1115 • 2012 ACR/ARHP Annual Meeting
Relation Between Hip Dysplasia, Pain, and Osteoarthritis in a Cohort of Patients with Hip Symptoms
Johanne Morvan¹, Ronan Bouttier², Bernard Mazieres³, Evelyne Verrouil³, Jacques Pouchot⁴, Anne-Christine Rat⁵, Joel Coste⁶ and Alain Saraux⁷, ¹Rheumatology, CH Quimper, Quimper, France, ²Radiology, CHU Brest, Brest, ³Rhumatologie, Hopital de Rangueil, Toulouse, FRANCE, France, ⁴Medecine Interne, Hopital Louis Mourier, Colombes, FRANCE, France, ⁵Rheumatology, Nancy Teaching Hospital, Nancy, France, ⁶Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, F- 54 000, France, Nancy, France, ⁷Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France
Background/Purpose: The relationship between acetabular dysplasia (HD) and hip osteoarthritis remains unclear, especially for mild forms of dysplasia. Our objectives were to estimate the prevalence…
Abstract Number: 1076 • 2012 ACR/ARHP Annual Meeting
FLIP in Dendritic Cells May Regulate Hematopoietic Homeostasis and Modulating Inflammation and Immunity
Qi Quan Huang¹, Robert Birkett², Harris R. Perlman³ and Richard M. Pope⁴, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: We previously demonstrated that FLIP in myeloid linage cells is necessary for neutrophil homeostasis and macrophage differentiation. Therefore studies were performed to determine the…
Abstract Number: 1077 • 2012 ACR/ARHP Annual Meeting
p21 Promotes Inflammatory Arthritis Resolution by Facilitating Alternative Activation of Macrophages
Angelica K. Gierut¹, Carla M. Cuda², Alexander V. Misharin³, Rana Saber³ and Harris R. Perlman⁴, ¹Rheumatology, Northwestern Med Faculty Found, Chicago, IL, ²Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Current understanding of pathogenesis suggests that RA is mainly a Th1 mediated process that promotes robust inflammatory cytokine production by “classically” activated macrophages. …
Abstract Number: 1078 • 2012 ACR/ARHP Annual Meeting
Prolactin Is Increased in Responders to Anti-TNFá Treatment and the Role of the Prolactin Receptor in Rheumatoid Arthritis
Man Wai Tang¹, Danielle Marie Gerlag², Veronica Codullo³, Elsa Vieira-Sousa⁴, Anne Q. Reuwer⁵, Marcel T. Twickler⁵, Robert B. M. Landewé⁶ and Paul Peter Tak⁷, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ³Rheumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ⁴Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ⁵Vascular Medicine, Academic Medical Center/University of Amsterdam, Amsterddam, Netherlands, ⁶Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁷Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is the most common rheumatic disease which mainly affects women. In the last decade, it is known that prolactin (PRL) is…
Abstract Number: 1079 • 2012 ACR/ARHP Annual Meeting
Polyclonal CD4⁺Foxp3⁺treg Cells Induce TGFb-Dependent Tolerogenic Dendritic Cells That Suppress Murine Lupus-Like Syndrome
Qin Lan¹ and Song G. Zheng², ¹Medicine, University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine of USC, Los Angeles, CA
Background/Purpose: Interplay between Foxp3+ regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are…
Abstract Number: 1080 • 2012 ACR/ARHP Annual Meeting
Effect of Anti-NKG2A Antibody Treatment On NK Cell Receptor Expression in Rheumatoid Arthritis Patients
Joseph Wahle, John Bui and Kristen Bontadelli, Biopharmaceuticals Research Unit, Novo Nordisk, Seattle, WA
Background/Purpose: This study explored the effect of in vitroblockade of the NKG2A HLA-E interaction on peripheral NK cells from rheumatoid arthritis patients. To block this…
Abstract Number: 1081 • 2012 ACR/ARHP Annual Meeting
Toll-Like Receptor 7, 8 and 9 Activation of Primary Human Cells by Lupus Immune Complexes Is Dependent On Interleukin 1 Receptor Associated Kinase 4 Activity
Aaron Winkler¹, Weiyong Sun¹, Ken Dower², Elizabeth A. Murphy¹, Julia Shin¹, Michael Luong¹, Michael J. Primiano¹, Varenka A. Rodriguez², Tatyana Souza¹, Lih-Ling Lin³, J. Perry Hall¹, Katherine Lee⁴, Vikram R. Rao¹ and Margaret Fleming¹, ¹Inflammation & Remodeling, Pfizer, Cambridge, MA, ²Inflammation and Remodeling, Pfizer, Cambridge, MA, ³Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA, ⁴Worldwide Medicinal Chemistry, Pfizer, Cambridge, MA
Background/Purpose: Genetic, in vitro and in vivo evidence strongly implicate the activation of nucleic acid sensing toll like receptors (TLR) 7, 8, and 9 in…
Abstract Number: 1082 • 2012 ACR/ARHP Annual Meeting
Predictors of Persistence in People with Subacute Low Back Pain
Souraya Torbey¹, Ali Mansour¹, Kristina Herrmann¹, Marwan Baliki², Thomas J. Schnitzer³ and A. Vania Apkarian², ¹Northwestern University, Chicago, IL, ²Physiology, Northwestern University, Chicago, IL, ³PM&R and Int Med, Northwestern University, Chicago, IL
Background/Purpose: Acute pain is a vital adaptive and protective mechanism. Conversely, chronic pain is a persistent, maladaptive response that outlasts the normal healing period of…
Abstract Number: 1083 • 2012 ACR/ARHP Annual Meeting
Physicians’ Recommendations for Total Knee Arthroplasty in Younger Persons with Moderate Osteoarthritis
Liana Fraenkel¹, Lawrence Weis² and Lisa Suter³, ¹Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ²Medicine, Yale University, New Haven, CT, ³Medicine, Rheumatol, TAC S541, Yale University, New Haven, CT
Background/Purpose: Rates of total knee arthroplasty (TKA) are increasing among all age groups. The most rapidly growing population of patients undergoing TKA are those under…
Abstract Number: 1084 • 2012 ACR/ARHP Annual Meeting
In Vivo Kinematics of Three-Component Mobile-Bearing Total Ankle Replacement for Rheumatoid Arthritis
Keiji Iwamoto¹, Tetsuya Tomita², Takaharu Yamazaki³, Kenrin Shi⁴, Norimasa Shimizu¹, Masahiro Kurita¹, Kazuma Futai¹, Yasuo Kunugiza⁵, Hideki Yoshikawa⁶ and Kazuomi Sugamoto¹, ¹Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan, ²Dept of Orthopaedics, Osaka University Graduate School of Medicine, Osaka, Japan, ³The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan, ⁴Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan, ⁶Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: The standard treatment for end-stage arthritis of the ankle joint due to rheumatoid arthritis (RA) has been an ankle arthrodesis. Patients with RA who…
Abstract Number: 1085 • 2012 ACR/ARHP Annual Meeting
Differences in Baseline Characteristics Between TKR and THR Patients: Results From a National Research Consortium
Patricia D. Franklin¹, Benjamin Snyder², Jeroan Allison³, Wenjun Li¹, Milagros Rosal⁴, Leslie R. Harrold⁵, Bruce Barton³ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Orthopedics, University of Massachusetts Medical School, Worcester, MA, ³Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ⁴Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, ⁵Dept of Medicine, UMass Medical School, Worcester, MA
Background/Purpose: Both total knee replacement (TKR) and total hip replacement (THR) reliably relieve pain, restore function, and ensure mobility in patients with advanced joint arthritis;…
Abstract Number: 1086 • 2012 ACR/ARHP Annual Meeting
Has the Level of Disability At Time of TKR Changed Over the Past 10 Years?: Results From Two National Cohorts
Patricia D. Franklin¹, Wenjun Li¹, Benjamin Snyder², Courtland Lewis³, Philip Noble⁴ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Orthopedics, University of Massachusetts Medical School, Worcester, MA, ³CT Joint Replacement Institute, St. Francis Hospital, Hartford, CT, ⁴Baylor College of Medicine, Houston, TX
Background/Purpose: A growing numbers of younger adults report knee pain consistent with OA, although parallel analyses of knee x-rays show no increase in classic radiographic…
Abstract Number: 1087 • 2012 ACR/ARHP Annual Meeting
Do Younger TKR Patients Have Similar Disability At Time of Surgery As Older Adults?
Patricia D. Franklin¹, Wenjun Li¹, Leslie R. Harrold², Benjamin Snyder³, Courtland Lewis⁴, Philip Noble⁵ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Dept of Medicine, UMass Medical School, Worcester, MA, ³Orthopedics, University of Massachusetts Medical School, Worcester, MA, ⁴CT Joint Replacement Institute, St. Francis Hospital, Hartford, CT, ⁵Baylor College of Medicine, Houston, TX
Background/Purpose: The trend toward greater numbers of working-aged patients choosing TKR has raised concerns that younger patients may receive surgery prematurely. We compared the severity…
Abstract Number: 1088 • 2012 ACR/ARHP Annual Meeting
Factors Influencing Long-Term Recovery of Total Knee Arthroplasty
C. Allyson Jones¹, Gian S. Jhangri² and Maria E. Suarez-Almazor³, ¹Departments of Physical Therapy and School of Public Health, University of Alberta, Edmonton, AB, Canada, ²School of Public Health, University of Alberta, Edmonton, AB, Canada, ³The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Although a number of studies have examined short term outcomes after total knee arthroplasty (TKA), few have prospectively examined the long term trajectory of…
Abstract Number: 1089 • 2012 ACR/ARHP Annual Meeting
The Number of Ruptured Tendons As a Prognostic Factor for Reconstructing Extensor Tendon Rupture in Patients with Rheumatoid Arthritis
Yu Sakuma¹, Kensuke Ochi¹, Takuji Iwamoto¹, Shinji Yoshida², Asami Saitou¹, Katsunori Ikari¹ and Shigeki Momohara¹, ¹Department of orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Extensor tendon rupture seen in patients with rheumatoid arthritis (RA) is usually surgically treated in combination with extensor tendon reconstruction and wrist arthroplasty. However,…

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