Abstracts Archive - Page 2325 of 2425 - ACR Meeting Abstracts

Abstract Number: 1476 • 2012 ACR/ARHP Annual Meeting
Caveolin-1 Deficiency May Play a Role in the Predisposition of African Americans to SSc ILD
Elena Tourkina¹, Charles Reese¹, Beth Perry², Shanice Dyer¹, Michael Bonner³, Richard P. Visconti⁴, Jing Zhang⁵, Richard M. Silver¹ and Stanley Hoffman², ¹Rheumatology, Medical University of SC, Charleston, SC, ²Rheumatology, Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁵Cell Biology and Anatomy, Medical University of SC, Charleston, SC
Background/Purpose: Scleroderma-associated Interstitial Lung Disease (SSc-ILD) is more prevalent and more severe in African Americans (AA) than in Caucasian (C) patients, but little is known…
Abstract Number: 1436 • 2012 ACR/ARHP Annual Meeting
Application of European League Against Rheumatism Recommendations for the Management of Systemic Lupus Erythematosus Patients with Neuropsychiatric Involvement May Limit Unnecessary Diagnostic Testing and Curve Intensification of Immunosuppressive Therapy of Unclear Benefit
Cristina Pamfil¹, Antonios Fanouriakis², Argyro Repa³, Maria Melissourgaki², Prodromos Sidiropoulos³, Ileana Filipescu¹, Mirela Rinzis⁴, Simona Rednic⁴, George Bertsias³ and Dimitrios Boumpas⁵, ¹Rheumatology, University of Medicine and Pharmacy, Cluj-Napoca, Romania, ²Rheumatology, Clinical Immunology, and Allergy, University of Crete, Iraklion, Greece, ³Rheumatology, Clinical Immunology, and Allergy, University of Crete, Heraklion, Greece, ⁴Rheumatology, Emergency County Clinical Hospital Cluj Napoca, Cluj-Napoca, Romania, ⁵Panepistimio Kritis, Rethymnon, Greece
Background/Purpose: Systemic lupus erythematosus (SLE) patients may experience a wide variety of neurological and psychiatric manifestations (neuropsychiatric [NP] SLE [NPSLE]), which pose diagnostic and therapeutic…
Abstract Number: 1437 • 2012 ACR/ARHP Annual Meeting
Majority of Lupusqol Domains Are Negatively Correlated with Systemic Lupus Activity Questionnaire (SLAQ) Score
Wendy Marder¹, Martha Ganser¹, Margaret Hyzy² and Emily C. Somers³, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Universitiy of Michigan, Ann Arbor, MI, ³IntMed, Environmental Health, and OB/GYN, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) disease activity measures such as the SLEDAI and BILAG require real time physician and laboratory assessment of patients, making them…
Abstract Number: 1438 • 2012 ACR/ARHP Annual Meeting
Development of Systemic Lupus Erythematosus (SLE) in NZM 2328 Mice in the Absence of Any Single BAFF Receptor
Chaim O. Jacob¹, Ning Yu¹, Shunhua Guo¹, Noam Jacob¹, William J. Quinn III², Michael P. Cancro², Beatrice Goilav³, Chaim Putterman⁴, Thi-Sau Migone⁵ and William Stohl¹, ¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, ³Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵Human Genome Sciences, Rockville, MD
Background/Purpose: To determine the necessity for any individual BAFF receptor in the development of SLE. Methods: NZM 2328 wild-type (WT), NZM.Bcma-/-, NZM.Taci-/-, and NZM.Br3-/-mice were…
Abstract Number: 1439 • 2012 ACR/ARHP Annual Meeting
CTL-Promoting Effects of IL-21 Results in B Cell Elimination and Disease Improvement in a Murine Model of Lupus
Vinh Nguyen¹, Daniel Veizaga-Udaeta², Horea Rus³ and Violeta Rus⁴, ¹Medicine, University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland at Baltimore County, MD, ³Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ⁴Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD
Background/Purpose: IL-21 is a member of the type I cytokine family with pleiotropic activities. IL-21 enhances CD8 T cells maturation into cytotoxic T lymphocytes (CTL),…
Abstract Number: 1440 • 2012 ACR/ARHP Annual Meeting
Lupus-Prone Mice Demonstrate Enhanced Neutrophil Extracellular Trap Formation: Implications for Autoantibody Formation and Organ Damage
Jason S. Knight¹, Alexander A. O'Dell¹, Wenpu Zhao², Ritika Khandpur², Srilakshmi Yalavarthi² and Mariana J. Kaplan³, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Rheumatology, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation—the programmed release of chromatin fibers decorated with granular antimicrobial peptides—is as an important activator…
Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting
Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease
Melissa E. Munroe¹, Jourdan R. Anderson², Timothy F. Gross³, Laura L. Stunz⁴, Gail A. Bishop⁴ and Judith A. James⁵, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴The University of Iowa, Iowa City, IA, ⁵Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…
Abstract Number: 1442 • 2012 ACR/ARHP Annual Meeting
IRF-1 Deficient Lupus-Prone MRL/Lpr Mice Show Reduced Glomerulonephritis but Develop Severe Interstitial Nephritis, Renal Vasculitis and Pulmonary Granulomas with Propensity for Th2 Polarity
Hidemaru Sekine¹, Takeshi Machida¹, Natsumi Sakamoto¹, Eiji Suzuki², Xian Zhang³, Christopher Reilly⁴ and Gary S. Gilkeson⁵, ¹Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Medicine, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC, ⁴Virginia Tech, Blacksburg, VA, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: The transcription factor interferon regulatory factor-4 (IRF-4) and -1 (IRF-1) are members of the IRF family of transcription regulators and involved in the development…
Abstract Number: 1443 • 2012 ACR/ARHP Annual Meeting
Caspase-1 Modulates Endothelial Dysfunction and Vascular Repair in Murine Lupus
J. Michelle Kahlenberg¹, Wenpu Zhao², Srilakshmi Yalavarthi² and Mariana J. Kaplan³, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Rheumatology, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Premature cardiovascular disease (CVD) represents a significant cause of morbidity and mortality in systemic lupus erythematosus (SLE). We recently proposed that type I interferon…
Abstract Number: 1444 • 2012 ACR/ARHP Annual Meeting
HLA-DR3 Controls Autoantibody Response to Sm in NZM2328.DR3+.AE0 Transgenic Mice
Vaidehi R. Chowdhary¹, Chao Dai², Shu Man Fu² and Chella S. David³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Medicine/CIIR/Rheumatology, University of Virginia Health System, Charlottesville, VA, ³Departement of Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Large genome wide scans have confirmed the strong association of HLA -DR3 with risk of developing SLE and antibody response to Sm which is specific…
Abstract Number: 1445 • 2012 ACR/ARHP Annual Meeting
Shared and Unique Molecular Features of Nephritis in 3 Models of Murine SLE
Ramalingam Bethunaickan¹, Celine C. Berthier², Matthias Kretzler³ and Anne Davidson⁴, ¹Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Mouse models are useful for studying the pathogenesis of SLE nephritis but it is not clear which model is the most appropriate for understanding…
Abstract Number: 1446 • 2012 ACR/ARHP Annual Meeting
The Granulocyte Signature and Organ Inflammation in TLR7 Responsive Mice Is RNA and Type 1 Interferon Dependent
Xizhang Sun¹, Alice Wiedeman², Thomas H. Teal³, Nalini Agrawal³, Jeffrey Duggan², Matt B. Buechler⁴, Jeffrey A. Ledbetter³, Denny Liggitt⁵, Jessica A. Hamerman⁶ and Keith B. Elkon⁷, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Department of Immunology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, Seattle, ⁵Comparative Medicine, University of Washington, Seattle, WA, ⁶Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁷Rheumatology Box 356428, University of Washington, Seattle, WA
Background/Purpose: Microarray expression analysis of blood taken from patients with Systemic Lupus Erythematosus (SLE) has revealed two characteristic signatures: one that reflects exposure to type…
Abstract Number: 1447 • 2012 ACR/ARHP Annual Meeting
A Synthetic Triterpenoid CDDO-Me Prevents and Reverses Murine Lupus Nephritis
Tianfu Wu¹, Yujin Ye¹, Mei Yan¹, Xin J. Zhou², Michael Andreef³ and Chandra Mohan¹, ¹Division of Rheumatology/Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, ²Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ³Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Background/Purpose: Current treatment options for lupus are far from optimal. Previously, we have reported that PI3K/AKT/mTOR, MEK1/Erk1,2, p38, STAT3, STAT5, NF-κB, multiple Bcl-2 family members,…
Abstract Number: 1448 • 2012 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice
Kunihiro Ichinose¹, Atsushi Kawakami² and George C. Tsokos³, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice. Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with abnormal…
Abstract Number: 1449 • 2012 ACR/ARHP Annual Meeting
Numbers of Splenic Long-Lived Plasma Cells in Autoimmune and Pre-Autoimmune Lupus Mice Are Linked to a Hyper-Responsive Variant of the Thrombopoietin Receptor and Enhanced Megakaryopoiesis
Oliver Winter¹, Katrin Moser², Rudolf A. Manz³ and Falk Hiepe⁴, ¹Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ²German Arthritis Research Center (DRFZ Berlin), Berlin, Germany, ³Institute for Systemic Inflammation Research (ISEF), University of Lübeck, Lübeck, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Autoantibodies contribute to the pathogenesis of the autoimmune disease Systemic Lupus Erythematosus (SLE) by stimulating the immune response. Further, deposits of immune complexes in…

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