Abstracts Archive - Page 2316 of 2607 - ACR Meeting Abstracts

Abstract Number: 1756 • 2013 ACR/ARHP Annual Meeting
Trends In Incidence and Mortality In Rheumatoid Arthritis and Systemic Autoimmune Rheumatic Diseases In Quebec, Canada: A Population-Based Study
Sonia Jean¹, Philippe Gamache², Marie Hudson³, Louis Bessette⁴, Paul R. Fortin⁵, Gilles Boire⁶ and Sasha Bernatsky⁷, ¹Chronic disease surveillence division, National Institute of public health of Quebec, Quebec, QC, Canada, ²Chronic disease surveillance division, National institute of public health of Quebec, Quebec, QC, Canada, ³Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁴Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, ⁵Medicine, Centre de Recherche du Chu de Québec et Université Laval, Quebec City, QC, Canada, ⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada
Background/Purpose: Health administrative data (HAD) are a potentially efficient to conduct population-based research and are increasingly used to develop chronic disease surveillance indicators. Examining trends…
Abstract Number: 1757 • 2013 ACR/ARHP Annual Meeting
Does Foot Pain Mediate The Effect Of Knee Osteoarthritis and Risk Of Indoor and Outdoor Falls In Older Men and Women?
Uyen Sa D.T. Nguyen¹, Yuqing Zhang², Jingbo Niu³, Robert H. Shmerling⁴, Douglas P. Kiel⁵, Suzanne G. Leveille⁶, Carol A. Oatis⁷ and Marian T. Hannan⁸, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Beth Israel Deaconess Medical Center, Boston, MA, ⁵Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶University of Massachusetts-Boston, Boston, MA, ⁷Physical Therapy, Arcadia University, Glenside, PA, ⁸Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Knee osteoarthritis (OA), foot pain, and falls are common in older adults and limit mobility. We previously showed that knee OA increases the risk…
Abstract Number: 1759 • 2013 ACR/ARHP Annual Meeting
The Effect Of Knee Replacement On Self-Reported Participation and Gait Speed: The Multicenter Osteoarthritis Study and The Osteoarthritis Initiative
Jessica L. Maxwell, Physical Therapy & Athletic Training, Boston Univ Sargent College, Boston, MA
The Effect of Knee Replacement on Self-Reported Participation and Gait Speed: The MOST Study and the Osteoarthritis InitiativeBackground/Purpose: Little research has explored participation outcomes, defined…
Abstract Number: 1758 • 2013 ACR/ARHP Annual Meeting
Low Literacy Decision Aid Enhances Knowledge and Reduces Decisional Conflict Among Diverse Population Of Adults With Rheumatoid Arthritis: Results Of a Pilot Trial
Jennifer Barton¹, Laura Trupin², Gina Evans-Young³, John B. Imboden⁴, Dean Schillinger⁵, Victor M. Montori⁶ and Edward H. Yelin⁷, ¹Medicine, University of California, San Francisco, San Francisco, CA, ²Medicine, UC San Francisco, San Francisco, CA, ³Rheumatology, UCSF, San Francisco, CA, ⁴Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, ⁵Medicine and Center for Vulnerable Populations, UCSF, San Francisco, CA, ⁶Divisions of Endocrinology and Diabetes and Health Care and Policy Research, Mayo Clinic, Rochester, MN, ⁷Arthritis Research Group, University of California, San Francisco, San Francisco, CA
Background/Purpose: Vulnerable populations with rheumatoid arthritis (RA) have poorer outcomes and report suboptimal shared decision-making communication. Patient involvement in the choice of disease modifying anti-rheumatic…
Abstract Number: 1760 • 2013 ACR/ARHP Annual Meeting
Relationships Between Driving Distance, Rheumatoid Arthritis Diagnosis, and Disease-Modifying Anti-Rheumatic Drug Receipt
Jennifer M. Polinski¹, M. Alan Brookhart², John Z. Ayanian³, Jeffrey N. Katz⁴, Seo Young Kim⁵, Chris Tonner⁶, Edward H. Yelin⁷ and Daniel H. Solomon^8,9, ¹Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ²University of North Carolina, Chapel Hill, NC, ³Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology; Division of Pharmacoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁶Medicine, University of California, San Francisco, San Francisco, CA, ⁷Arthritis Research Group, University of California, San Francisco, San Francisco, CA, ⁸Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, ⁹Division of Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) are recommended for all patients with rheumatoid arthritis (RA). Some studies estimate that almost half of patients with RA do…
Abstract Number: 1761 • 2013 ACR/ARHP Annual Meeting
The Link Of Foot Structure and Foot Function With Falls: The Johnston County Osteoarthritis Project
Yvonne M. Golightly¹, Marian T. Hannan², Howard J. Hillstrom³, Alyssa B. Dufour⁴, Amanda E. Nelson⁵, Adam Dore⁶ and Joanne M. Jordan⁷, ¹Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ²Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rehabilitation, Hospital Special Surgery (HSS), New York, NY, ⁴Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, ⁵University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Nearly 1/3 of older adults experience at least one fall annually in the United States. Foot type (static and dynamic arch height) is…
Abstract Number: 1762 • 2013 ACR/ARHP Annual Meeting
Endogenous IL-22 Regulates Th1 Responses and Plays a Pathogenic Role After the Onset of Arthritis
Shivali Justa¹, Xiaoqun Zhou² and Sujata Sarkar³, ¹Rheumatology & Arizona Arthritis Center, University of Arizona, Tucson, AZ, ²Rheumatology, University of Arizona, Tucson, AZ, ³Rheumatology and Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: IL-22,belongs to the IL-10 family of cytokines and is primarily produced by CD4 T, NK and LTi cells. IL-22 plays a dual role depending…
Abstract Number: 1763 • 2013 ACR/ARHP Annual Meeting
IL4-10 Synerkine: A Novel Immunoregulatory Drug To Prevent Immunopathology In Rheumatic Diseases
Sarita Hartgring¹, Cristine Steen-louws², C.E. Hack³, Martin De Smet⁴, Floris Lafeber⁵ and J.A.G. van Roon⁶, ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology & Clinical Immunology/Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ³Immunology, UMC Utrecht, Utrecht, Netherlands, ⁴Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ⁵Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ⁶Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: A considerable percentage of patients shows a limited response to biologics targeting one specific inflammatory mediator, largely because of redundancy of these mediators. An…
Abstract Number: 1764 • 2013 ACR/ARHP Annual Meeting
Binding Of Apoptotic Fetal Cardiocytes By Anti-Ro Antibodies Stimulates uPA/uPAR- Dependent Macrophage Infiltration and M2 Type Phenotype
Paraskevi Briasouli¹, Savvas Pavlides², Leslie Gold³, Mark Halushka⁴ and Jill P. Buyon⁵, ¹Rheumatology, New York University Medical Center, New York, NY, ²New York University Medical Center, new York, NY, ³new York University Medical Center, new York, NY, ⁴Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, ⁵Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Organ injury induced by antibodies characteristic of Sjogren's Syndrome and Systemic Lupus Erythematosus, while varied in the adult and fetus, may share in common…
Abstract Number: 1765 • 2013 ACR/ARHP Annual Meeting
Complement Component C5a Permits The Co-Existence Of Pathogenic Th17 Cells and Type I Interferon In Lupus
Marc C. Levesque¹, Sudesh Pawaria², Kelly Maers² and Partha Biswas³, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Dept. of Medicine, University of Pittsburgh, Pittsburgh, PA, ³Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic lupus erythematosus (SLE) is a type I interferon (IFN-I)-driven autoimmune disorder with exaggerated B and T-helper (Th) cell responses. Th17 cells, a recently…
Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting
Role Of IL33 In The Inflammation Of Takayasu Arteritis
David Saadoun¹, Marlène Garrido², Julien Gaudric³, Cloé Comarmond⁴, Michele Rosenzwacjg⁵ and Patrice Cacoub⁶, ¹Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ²I3 laboratory, Pitié-Salpétrière, Paris, France, ³Department of Vascular surgery GHPS, Paris, France, ⁴Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, ⁵Department of Immunology GHPS, Paris, France, ⁶Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France
Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
Abstract Number: 1767 • 2013 ACR/ARHP Annual Meeting
Gender, Race, and Soluble Mediators Distinguish Blood Relatives Who Develop Incomplete Lupus Or Classified SLE In The Lupus Autoimmunity In Relatives (LAUREL) Study
Melissa E. Munroe¹, Kendra A. Young², Jill M. Norris², Joel M. Guthridge³, Diane L. Kamen⁴, Timothy B. Niewold⁵, Gary S. Gilkeson⁴, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J. Wallace⁷, David R. Karp⁸, John B. Harley^9,10 and Judith A. James^11,12, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ⁹Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁰US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and identify individuals for prevention trials. Healthy blood relatives (FDRs) of lupus…
Abstract Number: 1728 • 2013 ACR/ARHP Annual Meeting
Amelioration Of Collagen-Induced Arthritis By Modulation Of Inhibitory Apoptosis Stimulating Protein Of p53 To Activate Transcription Factor p73
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Chia-Tse Weng⁵, I-Ming Jou⁶, Ming-Fei Liu⁷ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ⁶Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, ⁷Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Background/Purpose: Our previous studies have demonstrated p53 mutations competent for the inactivation of wild type p53 in synovial fibroblasts (SF) from either rheumatoid arthritis patients…
Abstract Number: 1729 • 2013 ACR/ARHP Annual Meeting
Cell Cycle Regulation Therapy Combined With Cytokine Blockade Enhances Anti-Arthritic Effects Without Increase Of Immune Suppression
Tadashi Hosoya¹, Hideyuki Iwai¹, Yu Yamaguchi², Nobuyuki Miyasaka² and Hitoshi Kohsaka², ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ²Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is characterized by infiltration of immune cells to the synovial tissues and their hyperplasia. Aim of the current…
Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting
Novel Role For Ly6C^– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis
Alexander Misharin¹, Carla M. Cuda², Rana Saber³, Angelica K. Gierut⁴, G. Kenneth Haines III⁵, Steffen Jung⁶ and Harris R. Perlman⁷, ¹Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern Med Faculty Found, Chicago, IL, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Immunology, Weizmann Institute, Rehovot, Israel, ⁷Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…

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