Abstracts Archive - Page 2310 of 2605 - ACR Meeting Abstracts

Abstract Number: 1809 • 2013 ACR/ARHP Annual Meeting
Topline Results Of The Biomarkers Of Lupus Disease (BOLD) Study: Clinical and Mechanistic Perplexities Of Lupus Treatment Trials Can Be Mitigated By Eliminating Background Immune Suppressants
Joan T. Merrill¹, Frederick W. Immermann², Tianhui Zhou³, Margot O'Toole⁴, Maryann Whitley⁵, Andrew A. Hill⁵, Ying Zhang⁵, David von Schack⁵, Padmalatha S. Reddy⁵, Jaime L. Masferrer⁴, Stan Kamp¹, Joel M. Guthridge⁶, Aikaterini Thanou⁷, Paul Wu⁵, Theresa Paradis⁵, William M. Mounts⁵, Judith A. James⁸ and Sudhakar T. Sridharan², ¹Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²BioTherapeutics R&D, Pfizer Inc, Collegeville, PA, ³BioTherapeutics R&D, Bristol Myers Squibb, Princeton, NJ, ⁴independent consultant, Cambridge, MA, ⁵Pfizer Inc, Cambridge, MA, ⁶Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Arthritis and Clinical Immmunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The BOLD study was designed to test the discriminatory capacity and safety of a trial design eliminating background immune suppressants (IS) in SLE patients…
Abstract Number: 1810 • 2013 ACR/ARHP Annual Meeting
Evaluation Of The New American College Of Rheumatology/European League Against Rheumatism Criteria For The Classification Of Systemic Sclerosis In The Canadian Scleroderma Research Group Cohort
Hebah Alhajeri¹, Marie Hudson², Marvin J. Fritzler³, Janet E. Pope⁴, Canadian Scleroderma Research Group -⁵ and Murray Baron⁶, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Medicine, University of Calgary, Calgary, AB, Canada, ⁴St Joseph Health Care, London, ON, Canada, ⁵Jewish General Hospital, Montreal, QC, Canada, ⁶Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: New classification criteria for systemic sclerosis (SSc) have recently been developed. In this study, we aimed to assess the sensitivity of this classification in…
Abstract Number: 1811 • 2013 ACR/ARHP Annual Meeting
Validation Of The ICD-CM-9 Code For Systemic Sclerosis Using Updated ACR/EULAR Classification Criteria
Aaliya Yaqub¹, Lorinda Chung², David Fiorentino³ and Eswar Krishnan⁴, ¹Stanford Univ Medical Center, Stanford, CA, ²Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Dermatology, Stanford University School of Medicine, Redwood City, CA, ⁴Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease associated with substantial morbidity. Epidemiologic studies using large administrative databases often rely on the accuracy of…
Abstract Number: 1812 • 2013 ACR/ARHP Annual Meeting
Adverse Events In Connective Tissue Disease-Associated Pulmonary Arterial Hypertension Compared To Idiopathic Pulmonary Arterial Hypertension
Rennie L. Rhee¹, Nicole B. Gabler², Amy Praestgaard², Peter A Merkel³ and Steven M. Kawut⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ³Division of Rheumatology, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁴Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Whether the risk of treatment-related adverse events (AEs) in patients with pulmonary arterial hypertension (PAH) differs based on diagnosis, either connective tissue disease (CTD-PAH)…
Abstract Number: 1814 • 2013 ACR/ARHP Annual Meeting
The Risk Of Pulmonary Embolism and Deep Venous Thrombosis In Systemic Sclerosis: A Population-Based Cohort Study
J. Antonio Avina-Zubieta¹, Iman Hemmati², Eric C. Sayre³, Kamran Shojania^3,4 and Hyon Choi^3,5,6, ¹Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁶Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Data on the risk of pulmonary embolism (PE) and deep venous thrombosis (DVT) in patients with systemic sclerosis (SSc) is lacking. To fill this…
Abstract Number: 1815 • 2013 ACR/ARHP Annual Meeting
Asymmetric Dimethylarginine Levels In The Early Detection Of Systemic Sclerosis-Related Pulmonary Arterial Hypertension
Vivek Thakkar¹, Wendy Stevens², David Prior³, Joanne Sahhar⁴, Janet E. Roddy⁵, Jane Zochling⁶, Peter Nash⁷, Peter Youssef⁸, Susanna Proudman⁹ and Mandana Nikpour¹⁰, ¹St Vincent's Hospital, Melbourne, Australia, ²Rheumatology, St Vincent's Hospital, Melbourne, Australia, ³Cardiology, St Vincent's Hospital, Melbourne, Australia, ⁴Rheumatology Unit, Monash Medical Centre, Clayton, Australia, ⁵Royal Perth Hospital, Perth, Australia, ⁶Menzies Research Institute Tasmania, Hobart, Australia, ⁷Rheumatology Research Unit, Nambour Hospital, Sunshine Coast, Australia, ⁸Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, Australia, ⁹Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ¹⁰Department of Medicine (St Vincent's Hospital), University of Melbourne, Fitzroy, Australia
Background/Purpose: Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc), and alterations in nitric oxide (NO) metabolism and endothelial cell…
Abstract Number: 1816 • 2013 ACR/ARHP Annual Meeting
Exercise Therapy Reduces Pain Sensitivity In Patients With Knee Osteoarthritis: A Randomized Controlled Trial
Marius Henriksen¹, Louise Klokker², Thomas Graven-Nielsen³, Cecilie Bartholdy², Tanja Schjoedt Joergensen⁴, Elisabeth Bandak¹, Bente Danneskiold-Samsøe⁵, Robin Christensen⁶ and Henning Bliddal¹, ¹Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark, ²The Parker Institute, Copenhagen, Denmark, ³Center for Sensori-Motor Interaction, Aalborg University, Aalborg, Denmark, ⁴The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen F, Denmark, ⁵Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark, ⁶Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark
Background/Purpose: Exercise has beneficial effects on pain in patients with knee osteoarthritis (OA), yet the underlying analgesic mechanisms are ambiguous. A deeper understanding of the…
Abstract Number: 1817 • 2013 ACR/ARHP Annual Meeting
The Clinical Burden Of Generalized Osteoarthritis Represented By Activity Limitations and Health Related Quality Of Life: A Cross-Sectional Study
Nienke Cuperus¹, Thea Vliet Vlieland², Elien Mahler¹, Clarinda Kersten¹, Thomas Hoogeboom³ and Els van den Ende¹, ¹Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Department of Orthopaedics, University Medical Center Leiden, Leiden, Netherlands, ³Department of Epidemiology, CAPHRI school for public health and primary care, CCTR centre for Care Technology Research, Maastricht University, Maastricht, Netherlands
Background/Purpose: A growing body of evidence shows that generalized osteoarthritis (GOA) is fairly common, however research and clinical practice recommendations are mainly focused on a…
Abstract Number: 1818 • 2013 ACR/ARHP Annual Meeting
Automated Telephone-Linked Communication: A Novel Approach To Enhance Long-Term Adherence To Resistance Training Exercise Among People With Knee Osteoarthritis
Kristin Baker¹, Aileen Ledingham¹, Michael P. Lavalley², Julie J. Keysor¹ and David T. Felson³, ¹Physical Therapy, Boston University Sargent College, Boston, MA, ²Biostatistics, Boston University, Boston, MA, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose: Knee Osteoarthritis (OA) is one of the most common chronic musculoskeletal conditions and is a leading cause of disability. Strengthening exercise is well known…
Abstract Number: 1819 • 2013 ACR/ARHP Annual Meeting
Effectiveness Of Pilates Method For The Treatment Of Chronic Mechanical Neck PAIN
Luciana A. Cazotti¹, Anamaria Jones¹, Diego Roger Silva², Luiza H. C. Ribeiro¹ and Jamil Natour³, ¹Unifesp-EPM, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: The neck pain comes from multifactorial origin and affects approximately 70% of individuals at some point in their lives being considered a frequent problem…
Abstract Number: 1820 • 2013 ACR/ARHP Annual Meeting
Assessing 24-Hour Physical (In)Activity and Sleep In People With Early Rheumatoid Arthritis
Christopher Feehan¹, Eric C. Sayre², Erin Carruthers² and Lynne M. Feehan³, ¹Medicine, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: For people with inflammatory arthritis, the health benefits of physical activity (PA) and negative impact of sedentary lifestyle are clear. However, it is unclear…
Abstract Number: 1821 • 2013 ACR/ARHP Annual Meeting
Benefits Of Progressive Muscle Strengthening Using a Swiss Ball In Patients With Ankylosing Spondylitis: A Randomized Controlled Trial
Marcelo Souza¹, Fabio Jennings², Hisa Morimoto¹ and Jamil Natour³, ¹Division of Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Ankylosing spondylitis (AS) is a systemic inflammatory disease that affects the physical capacity of patients globally. Exercises are recommended to the management of patients…
Abstract Number: 1822 • 2013 ACR/ARHP Annual Meeting
Oleanolic Acid Acetate Inhibits Osteoclast Differentiation By Downregulating Phospholipase Cγ² –calcium ion oscillation-Nuclear Factor Of Activated T Cell c1 Signaling, and Suppresses Bone Loss In Mice
Chang-Hoon Lee¹, Myeung Su Lee¹, Won Seok Lee², Wan-Hee Yoo³, Ju-Young Kim⁴, Jae-Min Oh⁴ and Yong-Geun Jeong⁵, ¹Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ²Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ³Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁴Department of Anatomy, School of Medicine, Wonkwang University, Iksan, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Changwon Fatima Hospital, Changwon, South Korea
Background/Purpose: we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis(azuki bean) to discover anti-bone resorptive agents. Many studies have identified and…
Abstract Number: 1823 • 2013 ACR/ARHP Annual Meeting
IL-6 Suppresses Osteoblast Differentiation Through The SHP2/MEK2 and SHP2/Akt2 Pathways In Vitro
Shoichi Kaneshiro¹, Kosuke Ebina¹, Kenrin Shi¹, Chikahisa Higuchi², Hideki Yoshikawa¹, Jun Hashimoto³ and Makoto Hirao⁴, ¹Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Osaka University Graduate School of Medicine, Suita, Japan, ³Dept of Rheumatology, Osaka-Minami Medical Center, Kawachinagano City, Japan, ⁴Orthopaedic Surgery, Osaka Minami Medical Center, Osaka, Japan
Background/Purpose: Interleukin-6 (IL-6), a potent inflammatory cytokine, plays a key role in the pathogenesis of rheumatoid arthritis (RA), including osteoporosis not only in inflamed joints…
Abstract Number: 1826 • 2013 ACR/ARHP Annual Meeting
Immune Complex Formation By Adalimumab Contributes Significantly To Its Inhibitory Effect On TNF-Enhanced Human Osteoclast Development Even In The Absence Of Fc Receptor Binding
Bohdan P. Harvey and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast development. …

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