ACR Meeting Abstracts

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  • Abstract Number: 2236 • 2012 ACR/ARHP Annual Meeting

    Cross Cultural Validation of English and French Versions of a Disease Specific Patient Reported Outcome Measure for Lupus in Canada

    Josiane Bourré-Tessier1, Ann E. Clarke2, Rachel A. Mikolaitis3, Mark Kosinski4, Sasha Bernatsky5, Joel A. Block3 and Meenakshi Jolly6, 1Rheumatology, McGill University, Montréal, QC, Canada, 2Clinical Epidemiology, McGill University, Montreal, QC, Canada, 3Section of Rheumatology, Rush University Medical Center, Chicago, IL, 4QualityMetric Inc, Lincoln, RI, 5McGill University, Montreal, QC, Canada, 6Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: The LupusPRO, a disease targeted Patient Reported Outcome measure, was developed and validated in US patients with Systemic Lupus Erythematosus (SLE). We aimed to…
  • Abstract Number: 2237 • 2012 ACR/ARHP Annual Meeting

    Application and Feasibility of Proposed Systemic Lupus Erythematosus Reproductive Health Care Quality Indicators At a Public Urban Rheumatology Clinic

    Itziar Quinzanos1, Angela Keniston2, Joann Zell3, Jinoos Yazdany4, Alyssa Nash1, Rebecca Fransen1, Jennifer Stichman1 and Joel M. Hirsh5, 1Dept Medicine, Denver Health Med Ctr, Denver, CO, 2Department of Medicine, Denver Health and Hospital Authority, Denver, CO, 3Medicine, National Jewish Health, Denver, CO, 4Medicine, University of California, San Francisco, San Francisco, CA, 5Medicine, Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO

    Background/Purpose: Reproductive health quality indicators (QIs) for systemic lupus erythematosus (SLE) have recently been developed: anti-ssA, anti-ssB, and phospholipid antibody (aPL) screening prior to pregnancy;…
  • Abstract Number: 2238 • 2012 ACR/ARHP Annual Meeting

    Alpha-Chlorofatty Acid Does Not Correlate with Baseline Subclinical Cardiovascular Disease in Systemic Lupus Erythematosus

    Mary A. Mahieu1, Camelia Guild2, Carolyn J. Albert3, George Kondos4, James Carr5, Daniel Edmundowicz6, David A. Ford7 and Rosalind Ramsey-Goldman8, 1Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Pediatrics and Center for Outcomes Research, Saint Louis University, Saint Louis, MO, 3Saint Louis University, Saint Louis, MO, 4University of Illinois at Chicago, Chicago, IL, 5Northwestern University Feinberg School of Medicine, Chicago, IL, 6Temple University School of Medicine, Philadelphia, PA, 7Department of Biochemistry and Molecular Biology, Saint Louis University, Saint Louis, MO, 8Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Serum alpha-chlorofatty acid (α-ClFA) directly reflects in vivo myeloperoxidase activity, an important regulator of atherogenesis. The objective of our study was to investigate whether α-ClFA…
  • Abstract Number: 2239 • 2012 ACR/ARHP Annual Meeting

    Characterization of Pure Membranous Lupus Nephritis: A Cohort of 150 Patients

    Lucía Silva1, Teresa Oton1, Anca Askanase2, Patricia Carreira3, Francisco Javier López-Longo4, Anne Riveros5, Íñigo Rúa-Figueroa6, Javier Narvaez7, Esther Ruiz-Lucea8, Mariano Andres9, Enrique Calvo10, Francisco Toyos11, Juan J. Alegre12, Eva Tomero13, Carlos Montilla14, Antonio Zea15, Esther Uriarte-Isacelaya16, Jaime Calvo-Alen17, Carlos Marras18, Víctor M. Martínez-Taboada19, María Ángeles Belmonte20, Jose Rosas21, Enrique Raya22, Gema Bonilla23 and Mercedes Freire24, 1Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda (Madrid), Spain, 2NYU School of Medicine, New York, NY, 3Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 4Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, 5Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 6Rheumatology, Hospital Universitario Dr Negrín. Las Palmas, Las Palmas de Gran Canaria, Spain, 7Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 8Rheumatology, Hospital de Basurto, Bilbao, Spain, 9Seccion Reumatologia, Hospital General Universitario de Alicante, Alicante, Spain, 10Rheumatology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Spain, 11Rheumatology, Hospital Universitario Virgen Macarena, Sevilla, Spain, 12Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, 13Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 14Unit Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain, 15Rheumatology, Hospital Universitario Ramon y Cajal, Madrid, Spain, 16Rheumatology, Hospital Universitario de Donostia, Donosti, Spain, 17Rheumatology, Hospital Sierrallana. Torrelavega, Torrelavega, Spain, 18Rheumatology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain, 19Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 20Rheumatology, Hospital Universitario Carlos Haya, Málaga, Spain, 21Rheumatology, Hospital Marina Baixa. Villajoyosa, Villajoyosa, Spain, 22Rheumatology, University Hospital San Cecilio, Granada, Spain, 23Rheumatology, Hospital La Paz, Madrid, Spain, 24Rheumatology, Hospital Universitario Juan Canalejo, La Coruña, Spain

    Background/Purpose : Over 50% of patients with SLE develop renal involvement but only 20% of these are found to have pure membranous lupus neprhitis (MLN)…
  • Abstract Number: 2240 • 2012 ACR/ARHP Annual Meeting

    Systematic Review of Skin Nontuberculous Mycobacteria Infection in Systemic Lupus Erythematosus: An Unusual Skin Infection Mimicking Lupus Vasculitis

    Zahi Touma1, Amir Haddad2, Dafna D. Gladman3, Elizabeth Uleryk4 and Murray B. Urowitz5, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 3Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada, 4Hospital Library and Archives, The Hospital for Sick Children, Toronto, ON, Canada, 5Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Nontuberculous mycobacteria (NTM) have become pathogens frequently associated with skin infection in patients on immunosuppression. NTM is not unusual in lupus patients and the…
  • Abstract Number: 2241 • 2012 ACR/ARHP Annual Meeting

    Efficacy of Belimumab in Systemic Lupus Erythematosus Patients with High Baseline Disease Activity

    Ann E. Clarke1, Susan Manzi2, Michelle Petri3, Richard Furie4, Ronald F. van Vollenhoven5, Simon Cooper6, Z. John Zhong6, William W. Freimuth6 and Arthur Weinstein7, 1Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, 2Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4North Shore-LIJ Health System, Lake Success, NY, 5Karolinska University Hospital, Stockholm, Sweden, 6Human Genome Sciences, Inc., Rockville, MD, 7Washington Hospital Center, Washington, DC

    Background/Purpose: To assess the efficacy of belimumab in patients with SLE who had high disease activity at baseline, as defined by SELENA-SLEDAI score ≥10.  Methods: In…
  • Abstract Number: 2202 • 2012 ACR/ARHP Annual Meeting

    Classification Criteria for Sjögren’s Syndrome: Comparison of the Performance of the 2002 American-European Consensus Group Criteria (AECG) and the 2012 ACR Criteria

    Elke Theander1, Peter Olsson2 and Thomas Mandl3, 1Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden, 3Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden

    Background/Purpose: To assess level of agreement between 2002 AECC and 2012 ACR criteria for primary Sjögren's Syndrome syndrome (pSS) within the Malmö Sjögren's Syndrome RegistryMethods…
  • Abstract Number: 2203 • 2012 ACR/ARHP Annual Meeting

    Effects of Reclassification Using the American College of Rheumatology Criteria On a Large cohort Sjögren’s Syndrome Patients

    Astrid Rasmussen1, John A. Ice1, He Li2, Kiely Grundahl3, Jennifer A. Kelly4, Lida Radfar5, Kimberly S. Hefner6, Donald U. Stone7, Juan-Manuel Anaya8, Michael Rohrer9, Glen D. Houston10, David M. Lewis11, James Chodosh12, John B. Harley13, Pamela Hughes9, Jacen S. Maier-Moore5, Courtney G. Montgomery1, Nelson L. Rhodus14, A. Darise Farris15, Barbara M. Segal16, Christopher J. Lessard17, R. Hal Scofield18 and Kathy Moser Sivils4, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, oklahoma CIty, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5University of Oklahoma Health Sciences Center, Oklahoma City, OK, 6Hefner Eye Care and Optical Center, Oklahoma City, OK, 7Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 9Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 10Collage of Denistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 11College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 12Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 13Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 14University of Minnesota, Minneapolis, MN, 15Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, 16Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 17Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, 18Arthritis & Immunology, Oklahoma Medical Research Foun, Oklahoma City, OK

    Background/Purpose: There is no single clinical diagnostic test for primary Sjögren’s syndrome (pSS). For research purposes, multiple classification criteria have been proposed over the past…
  • Abstract Number: 2204 • 2012 ACR/ARHP Annual Meeting

    Overall Agreement Between Sjögrens’s Minor Salivary Gland Biopsy and 2002 and 2012 Classification Criteria

    Laura Aline Martinez1, Candido Flores2, Alberto Arana Fraustro3 and Luis H. Silveira4, 1Rheumatology, Instituto Nacional de Cardiologia Ignacion Chavez, Mexico City, Mexico, 2Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 3Pathology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 4Rheumatology, Instituto Nacional Cardiología Ignacio Chávez, Mexico City, Mexico

    Background/Purpose: Sjögren’s syndrome (SS) is an inflammatory autoimmune disease characterized by lymphoid infiltration of exocrine glands, although extraglandular involvement is frequently observed. Prevalence is around…
  • Abstract Number: 2205 • 2012 ACR/ARHP Annual Meeting

    Longitudinal Evaluation of the Performance of Different Classification Criteria in Patients with Primary Sjögren’s Syndrome

    Martina Plešivčnik Novljan1, ŽIga Rotar2, Aleš Ambrožič1, Gaj Vidmar3 and Matija Tomšič1, 1Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 3University Rehabilitation Institute, 1000 Ljubljana, Slovenia

    Background/Purpose: Over the past 3 decades, 10 different classification criteria for Sjögren's syndrome (SS) had been proposed. In 2001 and 2002 222 consecutive patients suspected…
  • Abstract Number: 2206 • 2012 ACR/ARHP Annual Meeting

    Patients Fulfilling the Imaging-Arm and Patients Fulfilling the HLA-B27+ Arm of the Assessment of Spondyloarthritis International Society Axial Spondyloarthritis Classification Criteria: Are They Similar?

    Rosaline van den Berg1, Manouk de Hooge1, Floris van Gaalen1, Monique Reijnierse2, Tom Huizinga1 and Désirée van der Heijde1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: It is possible to classify patients as having spondyloarthritis (SpA) according to the ASAS axial SpA (axSpA) criteria HLA-B27+ arm without any signs of…
  • Abstract Number: 2207 • 2012 ACR/ARHP Annual Meeting

    How Useful Is Imaging of the Sacroiliac Joints (MRI and/or X-ray) in Patients with Possible Spondyloarthritis in the Diagnostic Work-up?

    Rosaline van den Berg1, Manouk de Hooge1, Victoria Navarro-Compán1, Floris van Gaalen1, Monique Reijnierse2, Tom Huizinga1 and Désirée van der Heijde1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: In daily practice, the diagnostic work-up of patients with possible axial spondyloarthritis (axSpA) starts with clinical and laboratory data. In many patients MRI and/or…
  • Abstract Number: 2208 • 2012 ACR/ARHP Annual Meeting

    Referral Patterns and Diagnosis of Patients with Axial Spondyloarthritis: Results of an International Survey

    Désirée van der Heijde1, Joachim Sieper2, Dirk Elewaut3, Aileen L. Pangan4 and Dianne Nguyen5, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, 3Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, 4Abbott Laboratories, Abbott Park, IL, 5Abbott Laboratories, Singapore, Singapore

    Background/Purpose: This analysis compares referral patterns and diagnostic tools for axial spondyloarthritis (axSpA) used by rheumatologists working in academic centers and in community clinical practice…
  • Abstract Number: 2209 • 2012 ACR/ARHP Annual Meeting

    Assessing Active Inflammation in Sacroiliac Joints in Spondyloarthritis Patients: No Added Value of Gadolinium Compared to Short Tau Inversion Recovery Sequence

    Manouk de Hooge1, Rosaline van den Berg1, Victoria Navarro-Compán1, Floris van Gaalen1, Désirée van der Heijde1, Tom Huizinga1 and Monique Reijnierse2, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: MRI is used as a diagnostic tool to detect active disease of the sacroiliac joint. T1 weighted and STIR images are generally used and…
  • Abstract Number: 2210 • 2012 ACR/ARHP Annual Meeting

    The Canada-Denmark Fat Spondyloarthritis Spine Score: Validation of a New Scoring Method for the Evaluation of Fat Lesions in the Spine of Patients with Axial Spondyloarthritis

    Susanne Juhl Pedersen1, Zheng Zhao2, Robert GW Lambert3, Mikkel Østergaard4, Ulrich Weber5 and Walter P. Maksymowych6, 1Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 2Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, 3Radiology, University of Alberta, Edmonton, AB, Canada, 4Department of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, 5Rheumatology, Balgrist University Hospital, Zurich, Switzerland, 6Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Fat metaplasia has been shown to follow resolution of inflammation in axial SpA and this may be evident within one year (1). Fat metaplasia…
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