Abstracts Archive - Page 2270 of 2425 - ACR Meeting Abstracts

Abstract Number: 2297 • 2012 ACR/ARHP Annual Meeting
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biologic and pathologic processes. It is initiated by DNA…
Abstract Number: 2298 • 2012 ACR/ARHP Annual Meeting
The Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) Polymorphism Is Associated with Risk of Scleroderma-Related Interstitial Lung Disease: A Multicenter Study From the EULAR Scleroderma Trial and Research Group
Otylia M. Kowal-Bielecka¹, Sylwia Chwiesko-Minarowska², Pawel Bernatowicz², Yannick Allanore³, Timothy RD Radstake⁴, Jasper Broen⁵, Marco Matucci-Cerinic⁶, Roger Hesselstrand⁷, Dorota Krasowska⁸, Gabriela Riemekasten⁹, Madelon C. Vonk¹⁰, Oksana Kowalczuk², Marek Bielecki¹¹, Robert Milewski¹², Lech Chyczewski¹³, Jacek Niklinski² and Krzysztof Kowal¹⁴, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, Netherlands, ⁶Department of Biomedicine & Division of Rheumatology AOUC, University of Florence, Florence, Italy, ⁷Rheumatology, Lund University, Lund, Sweden, ⁸Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ¹⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹¹Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ¹²Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland, ¹³Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ¹⁴Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by chronic inflammation, vascular injury and profound fibrosis of the skin and internal organ. Leukotrienes…
Abstract Number: 2299 • 2012 ACR/ARHP Annual Meeting
Acroosteolysis Is Associated with Increased Propensity for Osteoclast Formation and Higher VEGF Levels in the Peripheral Blood of Systemic Sclerosis Patients
Jin Kyun Park¹, Andrea Fava², Antony Rosen³ and Francesco Boin⁴, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ²Internal Medicine, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Acroosteolysis (AO) secondary to bone resorption of distal phalanges affects up to 20% of systemic sclerosis (SSc) patients leading to shortening of the digits,…
Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
Qingmei Liu¹, Wenyu Wu², Wenzheng Tu³, Haiyan Chu¹, Yanyun Ma¹, Hejian Zou⁴, Xiaodong Zhou⁵ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…
Abstract Number: 2301 • 2012 ACR/ARHP Annual Meeting
The Interferon Type I Signature Is Increased in Monocytes From Systemic Sclerosis Patients
Zana Brkic¹, Lenny van Bon², Cornelia G. van Helden-Meeuwsen³, Madelon C. Vonk⁴, Hanneke Knaapen⁵, Wim van den Berg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Timothy Radstake² and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht/Radboud University Nijmegen Medical Center, Utrecht/Nijmegen, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁵Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: Systemic sclerosis (SSc) is a complex fibrosing disease of unknown etiology. The past decade clear indications for an aberrant immune system have been revealed.…
Abstract Number: 2302 • 2012 ACR/ARHP Annual Meeting
Secreted Frizzled-Related Protein 4 Induces a Profibrotic Phenotype in Systemic Sclerosis Fibroblasts by Activating a Non-Canonical WNT Signaling Pathway
Justin Gillespie¹, Paul Emery² and Francesco Del Galdo³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is a chronic fibrotic disease involving autoimmune activation, fibroproliferative vasculopathy and tissue fibrosis of skin and multiple internal organs. Several studies…
Abstract Number: 2262 • 2012 ACR/ARHP Annual Meeting
Hypogammaglobulinemia in Pediatric Systemic Lupus Erythematosus
Emilina Lim¹ and Megan A. Cooper², ¹Pediatric Rheumatology, Washington University in Saint Louis- St. Louis Children's Hospital, St. Louis, MO, ²Pediatrics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: : Systemic lupus erythematosus (SLE) is characterized by B cell activation, elevated serum IgG and prominent circulating immune complexes. However, hypogammaglobulinemia in SLE patients…
Abstract Number: 2263 • 2012 ACR/ARHP Annual Meeting
The Association Between Prior Pregnancy Morbidity and Cardiovascular Events in Women with Systemic Lupus Erythematosus
Megan E. B. Clowse¹, Eliza F. Chakarvarty², Jill P. Buyon³ and Gerald McGwin Jr.⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ³Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Adverse pregnancy outcomes have been associated with increased cardiovascular disease in healthy women. We hypothesized that women with SLE and a history of adverse…
Abstract Number: 2265 • 2012 ACR/ARHP Annual Meeting
Clinical Manifestations of Systemic Lupus Erythematosus Vary Based On Age of Disease Onset
Flora Simmons¹, Natasha M. Ruth², Gary S. Gilkeson³ and Diane L. Kamen⁴, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease which disproportionately affects women of child-bearing age. However, onset during childhood and late adult onset can…
Abstract Number: 2266 • 2012 ACR/ARHP Annual Meeting
Outcome of Renal Transplantation in Lupus Patients with Positive and Negative Serology: Survival of the Graft and Patients After Transplant
Zahi Touma¹, Murray B. Urowitz², Dominique Ibanez² and D. D. Gladman³, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Lupus nephritis (LN) occurs in 50-75% of adults with SLE and up to 20% of LN patients may advance to end stage renal disease…
Abstract Number: 2267 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Pathway Analysis of Genome-Wide Association Studies On Systemic Lupus Erythematosus
Young Ho Lee¹, Sung Jae Choi², Jong Dae Ji² and Gwan Gyu Song³, ¹Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Rheumatology, Korea University Medical Center, Seoul, South Korea, ³Div of Rheum, Dept of Int Med, Korea Univ College of Med, Seoul, South Korea
Background/Purpose: Genome-wide association studies (GWASs) have been successfully used to identify novel common genetic variants that contribute to susceptibility to complex diseases, but individual GWASs…
Abstract Number: 2268 • 2012 ACR/ARHP Annual Meeting
Hyperacetylation of Histone H4 in Systemic Lupus Erythematosus
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song², Zhe Zhang³, Michelle Petri⁴ and Kathleen E. Sullivan², ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease and is characterized by multi-systemic chronic inflammation. Epigenetic processes, such as posttranslational histone modifications, can…
Abstract Number: 2269 • 2012 ACR/ARHP Annual Meeting
The Differences of DNA Methylome and Transcriptome Among Diverse Clinical Manifestations of Systemic Lupus Erythematosus
Ming Zhao¹, Shuangyan Luo¹, Honglong Wu², Siyang Liu², Meini Tang¹, Wenjing Cheng¹, Qing Zhang¹, Xinhai Yu¹, Tak Mao Chan³, Yudong Xia², Na Yi², Fei Gao², Li Wang², Ning Li² and Qianjin Lu⁴, ¹Department of Dermatology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Medical Epigenomics, Changsha, China, ²Beijing Genomics Institute at Shenzhen, Shenzhen, China, Shenzhen, China, ³Division of Nephrology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Aberrant DNA methylation and gene expression have been observed in systemic lupus erythematosus (SLE). However, patterns of DNA methylation and gene expression associated with…
Abstract Number: 2270 • 2012 ACR/ARHP Annual Meeting
The DNA Methylome of Systemic Lupus Erythematosus (SLE) From Whole Peripheral Blood Mononuclear Cells (PBMCs)
Robert Shoemaker¹, Lou H. Bookbinder², David L. Boyle³, Gary S. Firestein⁴, Jonathan E. Lim⁵ and David W. Anderson⁶, ¹Bioinformatics, NexDx, Inc., San Diego, CA, ²Molecular Biology, NexDx, Inc., San Diego, ³Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Research and Development, NexDx, Inc., San Diego, ⁶Research and Development, NexDx, Inc., San Diego, CA
Background/Purpose: SLE is a disease where epigenetic mechanisms play a role. Methylation of DNA at CpG loci is known to influence the suppression or activation…
Abstract Number: 2271 • 2012 ACR/ARHP Annual Meeting
Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes
Olof Berggren¹, Andrei Alexsson², Gunnar V. Alm³, Ann-Christine Syvänen⁴, Lars Rönnblom² and Maija-Leena Eloranta², ¹Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ³Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, ⁴Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden
Background/Purpose: Many autoimmune diseases, e.g. systemic lupus erythematosus (SLE), have an activated type I interferon (IFN) system and about 40 SLE susceptibility loci, many within…

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