Abstracts Archive - Page 2265 of 2605 - ACR Meeting Abstracts

Abstract Number: 2499 • 2013 ACR/ARHP Annual Meeting
Analysis Of Inflammatory Markers Within Facet Joints Of Patients Within Ankylosing Spondylitis
Uta Syrbe¹, Janine Bleil², Rene Maier³, Heiner Appel¹ and Joachim Sieper⁴, ¹Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ²Charité, Berlin, Germany, ³Charite, Berlin, Germany, ⁴Charitè Campus Benjamin Franklin, Berlin, Germany
Background/Purpose: Inflammation within sacroiliac joints and within the spine is a hallmark of ankylosing spondylitis (AS). Apart from nonsteroidal anti-rheumatic drug (NSAID) treatment, inhibition of…
Abstract Number: 2500 • 2013 ACR/ARHP Annual Meeting
Mast Cells Are a Major Source Of IL-17 In Synovium and Extra-Articular Tissues In Spondyloarthritis Related Diseases
T. Noordenbos¹, I. Gofita¹, M. Alsina², E.W.M. Vogels³, A. A. te Velde³, J. D. Cañete⁴, Dominique L. Baeten⁵ and N. Yeremenko¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain, ³Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre/University of Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain, ⁵Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: IL-17 plays a key role in the pathogenesis of spondyloarthritis (SpA) as demonstrated by a recent proof-of-concept trial with the anti-IL17A mAb secukinumab. The…
Abstract Number: 2501 • 2013 ACR/ARHP Annual Meeting
Validation Of Gene Expression Biomarkers Of Psoriatic Arthritis
Fatima Abji¹, Remy Pollock¹, Fawnda Pellett², Kun Liang³, Vinod Chandran² and Dafna D. Gladman², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a seronegative immune mediated arthritis that develops in about a third of patients with cutaneous psoriasis (PsC). The cellular pathways…
Abstract Number: 2502 • 2013 ACR/ARHP Annual Meeting
Contributions Of Skin and Joint Manifestations To The Parent-Of-Origin Effect In Psoriatic Disease
Remy Pollock¹, Arane Thavaneswaran², Vinod Chandran³, Art Petronis⁴, Al Amin P. Rahman⁵ and Dafna D. Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada, ⁵Medicine, Memorial University, St Johns, NE, Canada
Background/Purpose: Excessive paternal transmission has been previously documented in psoriatic disease. Our objective is to delineate the differential contributions of skin and joint manifestations to…
Abstract Number: 2503 • 2013 ACR/ARHP Annual Meeting
IL-17+ CD8+ T Cells Are Enriched In The Joints Of Patients With Psoriatic Arthritis and Correlate With Markers Of Disease Activity and Joint Damage Progression
Bina Menon^1,2, Nicola J. Gullick³, Hayley G. Evans⁴, Gina J. Walter⁴, Megha Rajasekhar⁴, Toby Garrood², Leonie S. Taams⁴ and Bruce W. Kirkham², ¹Centre for Cellular and Molecular Biology of Inflammation, King's College London, London, United Kingdom, ²Rheumatology, Guy's and St. Thomas' Foundation Hospital NHS Trust, London, United Kingdom, ³Rheumatology, King's College Hospital Foundation NHS Trust, London, United Kingdom, ⁴Centre for Molecular and Cellular Biology of Inflammation, King's College London, London, United Kingdom
Background/Purpose: Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) have clear differences in clinical, radiological and genetic features, suggesting that the immunopathology of the conditions may…
Abstract Number: 2504 • 2013 ACR/ARHP Annual Meeting
Male Children With Higher SLE Disease Activity In An US Cohort
Lakshmi N. Moorthy¹, Elizabeth Roy², Margaret Peterson³, Afton L. Hassett⁴, Alexa B. Adams⁵, Laura V. Barinstein⁶, Elizabeth C. Chalom⁷, Karen Onel⁸, Linda Ray⁹, Jorge Lopez-Benitez¹⁰, Kathleen A. Haines¹¹, Philip Hashkes¹², Daniel J. Kingsbury¹³, Victoria Cartwright¹⁴, Nora G. Singer¹⁵, Ingrid Tomanova-Soltys¹⁶, Andreas Reiff¹⁷, Sandy D. Hong¹⁸ and Thomas J. A. Lehman¹⁹, ¹Pediatric Rheumatology, Robert Wood Johnson Medical School-Rutgers University, New Brunswick, NJ, ²RWJMS-UMDNJ, New Brunswick, NJ, ³Hospital for Special Surgery, New York, NY, ⁴Anesthesiology, University of Michigan, Ann Arbor, MI, ⁵Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Pediatric Rheumatology, Mount Sinai Med Ctr, New York, NY, ⁷Pediatrics, St. Barnabas Medical Center, Livingston, NJ, ⁸Pediatric Rheumatology, University of Chicago Hospitals, Chicago, IL, ⁹Pediatric Rheumatology, University of Mississippi Medical Center, Jackson, MS, ¹⁰Pediatric Rheumatology Program Centro Medico La Costa, Asuncion, Paraguay, ¹¹Department of Pediatrics, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ¹²Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, ¹³Randall Children's Hospital at Legacy Emanuel, Portland, OR, ¹⁴Legacy Emanuel Children's Hospital, Portland, OR, ¹⁵Medicine, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, ¹⁶Winthrop University Hospital, Mineola, NY, ¹⁷Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, ¹⁸Pediatrics-Rheumatology, U of Iowa Children's Hosp, Iowa City, IA, ¹⁹Chief Div Ped Rheum PTD, Hospital for Special Surgery, New York, NY
Background/Purpose: Although systemic lupus erythematosus (SLE) is more common in females, males tend to have more severe disease. We compared age at SLE diagnosis, duration,…
Abstract Number: 2505 • 2013 ACR/ARHP Annual Meeting
Higher Disease Damage Among African Americans With Familial Versus Sporadic Systemic Lupus Erythematosus
April Barnado¹, Lee Wheless², Stephanie Slan¹, Gary S. Gilkeson¹ and Diane L. Kamen¹, ¹Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Public Health Sciences, Medical University of South Carolina, Charleston, SC
Background/Purpose: Studies in predominantly Caucasian cohorts have found no significant clinical or serologic differences in systemic lupus erythematosus (SLE) patients with a family history of…
Abstract Number: 2506 • 2013 ACR/ARHP Annual Meeting
Systemic LUPUS Erythematosus Patients Presenting With Immune Thrombocytopenia and The Association Between Two Diseases
Omer Nuri Pamuk¹, Gulsum Emel Pamuk² and Mehmet Sevki Uyanik², ¹Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey, ²Hematology, Trakya University Medical Faculty, Edirne, Turkey
Background/Purpose: We evaluated the features of our systemic lupus erythematosus (SLE) patients who presented with immune thrombocytopenia (ITP) and compared them to other SLE patients.…
Abstract Number: 2507 • 2013 ACR/ARHP Annual Meeting
What Is The Risk Of Having a Total Hip Or Knee Replacement for Patients With Lupus?
Sandeep Mukherjee¹, David Culliford², Nigel K. Arden³ and Christopher J. Edwards¹, ¹NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, ²Faculty of Medicine, University of Southampton, Southampton, United Kingdom, ³NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: Individuals with systemic lupus erythematosus (SLE) frequently have arthralgia, but joint damage leading to surgery is thought to be less common. In addition to…
Abstract Number: 2508 • 2013 ACR/ARHP Annual Meeting
Clinical and Serological Discordance In The Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) Cohort
Murray B. Urowitz¹, Dafna D. Gladman¹, Nicole Anderson¹ and Systemic Lupus Erythematosus International Collaborating Clinics SLICC², ¹Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Anti-DNA antibodies and serum complement levels are considered important biomarkers for disease activity in SLE. Despite this many SLE patients present serologically active (positive…
Abstract Number: 2509 • 2013 ACR/ARHP Annual Meeting
Long Term Natural History Of Asymptomatic Avascular Necrosis In a Cohort Of Patients With Systemic Lupus Erythematosus Treated With Corticosteroids
Eileen J. Lydon¹ and H. Michael Belmont², ¹Rheumatology, NYU Hospital for Joint Diseases, New York, NY, ²NYU School of Medicine, New York, NY
Background/Purpose: Avascular necrosis (AVN) is cellular death of bone components due to interruption of the blood supply resulting in area of ischemic necrosis but may…
Abstract Number: 2510 • 2013 ACR/ARHP Annual Meeting
The Epidemiology Of Systemic LUPUS Erythematosus and Clinical Features Of Patients At A Single Center In Northwestern Turkey
Omer Nuri Pamuk¹, Salim Dönmez², Gokce Busra Calayir³ and Cigdem Mengus⁴, ¹Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey, ²Rheumatology, Yüzüncü Yıl University Medical Faculty, Edirne, Turkey, ³Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ⁴Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey
Background/Purpose: We evaluated the clinical features, treatment modalities, treatment responses and prognosis of patients diagnosed with systemic lupus erythematosus (SLE). We also estimated the prevalence…
Abstract Number: 2511 • 2013 ACR/ARHP Annual Meeting
Multicenter Validation Of The Lupus Activity Scoring Tool (LAST) As Compared To The Selena Sledai (SS) Modification
Majed M. Khraishi¹, Rana Aslanov², Sanjay Dixit³, Krista Fudge⁴, Vandana Ahluwalia⁵ and Sarah Khraishi⁶, ¹Nexus Clinical Research, St John's, NF, Canada, ²Clinical Epidemiology Department, Faculty of Medicine, Memorial University of Newfoundland, St.John's, NF, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Medical Consultants of West Newfoundland, Western Memorial Hospital, Corner Brook, NF, Canada, ⁵Past President, Ontario Rheumatology Association, Brampton, ON, Canada, ⁶Nexus Clinical Research, Memorial University of Newfoundland, St.John's, NF, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic immune modulated disease with variable clinical manifestations. New advances in the management of SLE mandated closer monitoring…
Abstract Number: 2473 • 2013 ACR/ARHP Annual Meeting
Comparison Of The Two Subtypes Of Axial Spondyloarthritis Patients Fulfilling The Imaging Arm Based On Radiographic and MRI Findings
Dilek Solmaz, Servet Akar, Ismail Sari, Pinar Cetin, Fatos Onen and Nurullah Akkoc, Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey
Background/Purpose: New Axial Spondyloarthritis Classification Criteria include an imaging arm and a clinical arm. The imaging arm includes radiographic ax-SpA patients who have radiographic sacroilitis…
Abstract Number: 2478 • 2013 ACR/ARHP Annual Meeting
Clinical Characteristics Of Patients With Early Spondyloarthritis. Results From a Specialized Consultation In a Clinical Hospital
Juan Jose Aznar Sánchez, Eugenio Chamizo Carmona, Adela Gallego Flores, Raul Veroz Gonzalez and Tamara Libertad Rodriguez Araya, Rheumatology, Hospital de Mérida, Mérida, Spain
Background/Purpose: The classification criteria for spondyloarthritis (SpA) intend to identify patients with this disease from the initial stages. The nonspecific characteristics, symptoms, signs, and additional…

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