Abstracts Archive - Page 2260 of 2607 - ACR Meeting Abstracts

Abstract Number: 2601 • 2013 ACR/ARHP Annual Meeting
Modified Rodnan Ultrasound Skin Score: An Ultrasound Skin Scoring Approach In Systemic Sclerosis
Ingeborg Sacksen¹, P. Scott Pollock² and Mark H. Wener³, ¹Rheumatology, University of Washington, Seattle, WA, ²Internal Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology & Lab Med, University of Washington, Seattle, WA
Background/Purpose: Systemic sclerosis (SSc) is a multi-organ disease characterized by thickening, hardening and tightening of the skin. Skin thickening is described by physical exam…
Abstract Number: 2602 • 2013 ACR/ARHP Annual Meeting
Reduced Frequencies Of Circulating CD8 T Cells In Early Diffuse Cutaneous Systemic Sclerosis Is Associated With Worse Skin Scores
Marie Hudson¹, Maximilien Lora², Christopher Di Ioia³, Solene Tatibouet⁴, Sasha Bernatsky⁵ and Ines Colmegna⁶, ¹Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ²Rheumatology, McGill University Health Centre, Montréal, QC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada, ⁶Rheumatology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Diffuse cutaneous systemic sclerosis (dcSSc) is associated with significant morbidity and mortality. Measurement of skin thickness (modified Rodnan skin score (mRss)) is a surrogate…
Abstract Number: 2603 • 2013 ACR/ARHP Annual Meeting
Are There Differences In Limited Systemic Sclerosis According To Extension Of Skin Involvement?
Marina Scolnik¹, Eliana Lancioni², Luis J. Catoggio¹, Mirtha Sabelli³, Zaida Bedran⁴, Carla Saucedo⁴, Josefina Marin³ and Enrique Soriano¹, ¹Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: There is consensus in classifying Systemic Sclerosis (SSc) according to extension of skin involvement as limited and diffuse, using the elbows and knees as…
Abstract Number: 2604 • 2013 ACR/ARHP Annual Meeting
Longitudinal Assessment Of Scleroderma Skin By Optical Coherence Tomography: Preliminary Validation Of Sensitivity To Change Over-Time
Giuseppina Abignano¹, Lesley-Anne Bissell¹, Jason Britton², Daniel Woods³, Maya H. Buch¹, Dennis McGonagle¹, Paul Emery¹ and Francesco Del Galdo¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Medical Physics Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Michelson Diagnostics Ltd, Kent, United Kingdom
Background/Purpose: Optical coherence tomography (OCT) has been shown to be a quantitative reliable tool to assess skin involvement in Systemic Sclerosis (SSc) (1). However the…
Abstract Number: 2605 • 2013 ACR/ARHP Annual Meeting
Quality Of Life and Psychosocial Aspects In Juvenile Localized Scleroderma
Roberta Culpo¹, Marco Ricca², Fabio Vittadello³, Giuseppina Sequi², Francesco Zulian⁴ and Giorgia Martini⁵, ¹Department of Pediatrics., University of Padua, Padua, Italy, ²University of Padua, Padua, Italy, ³Department of Pediatrics, University of Padua, Padua, Italy, ⁴PRINTO, Genoa, Italy, ⁵Department of Pediatrics,, University of Padua, Padua, Italy
Background/Purpose: Juvenile Localized Scleroderma (JLS) is a chronic, autoimmune disease, characterized by skin and subcutaneous tissues fibrosis, which can cause a poor quality of life…
Abstract Number: 2607 • 2013 ACR/ARHP Annual Meeting
Evaluation Of The Construct Validity Of The Patient-Reported Outcomes Measurement Information System (PROMIS®) Gastrointestinal (GI) Symptoms Measures In Systemic Sclerosis (SSc)
Dinesh Khanna¹, Puja Khanna¹, Brennan Spiegel², Lin Chang³, Gil Y. Melmed⁴, Roger Bolus⁵ and Ron Hays⁶, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Gastroenterology; Health Policy and Management, Cedars-Sinai Health System and UCLA School of Medicine and Public Health, Los Angeles, CA, ³Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, ⁴Inflammatory Bowel Disease Center, Cedar-Sinai Medical Center, Los Angeles, CA, ⁵Research Solutions Group, Encinitas, CA, ⁶Medicine, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: As part of the National Institutes of Health PROMIS¨ roadmap initiative, we developed GI Symptoms measures that assess 8 domains: Gastroesophageal reflux (13 items),…
Abstract Number: 2608 • 2013 ACR/ARHP Annual Meeting
Coeliac Disease In Scleroderma – Clinical Features, Frequency and Impact Of Screening In Scleroderma
Alfredo Guillén-Del Castillo¹, Vincent Sobanski², Jennifer Harvey³, Christopher Denton⁴ and Voon H. Ong⁵, ¹Systemic Autoimmune Disease Unit, Department of Internal Medicine, Hospital Universitari Vall d’Hebron, Barcelona, Spain, ²Department of Rheumatology, Royal Free Hospital, London, United Kingdom, ³Clinical Immunology, Royal Free Hospital, London, United Kingdom, ⁴Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁵Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom
Background/Purpose: Recent studies suggest that coeliac disease (CD) affects 4-7% of Scleroderma (SSc) patients. This association however has not been well characterized in a large…
Abstract Number: 2609 • 2013 ACR/ARHP Annual Meeting
Dutch Translation and Validation Of The University of California, Los Angeles scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0
Jessica Meijs¹, Daisy Pors¹, Theodora P.M. Vliet Vlieland², Tom W.J. Huizinga¹ and Annemie J.M. Schuerwegh¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Gastrointestinal tract (GIT) involvement occurs in approximately 90% of the patients with systemic sclerosis (SSc) and leads to a decrease in health-related quality of…
Abstract Number: 2610 • 2013 ACR/ARHP Annual Meeting
A New Pathogenic Role Of BAFF As a Critical Mediator Of Skin and Lung Fibrosis In Experimental Bleomycin-Induced Pulmonary Fibrosis, Systemic Sclerosis and Idiopathic Pulmonary Fibrosis
Antoine Francois¹, Pascal Schneider², Anne Davidson³, Emmanuel Chatelus⁴, Jérôme Avouac⁵, Yannick Allanore⁶, Bérengère Villeret⁷, Aurélie Gombault⁷, Paméla Gasse⁸, Sylvain Marchand Adam⁹, Bernhard Ryffel¹⁰, Siamak Bahram¹¹, Philippe Georgel¹², Jean Sibilia¹³, Isabelle Couillin⁸ and Jacques-Eric Gottenberg¹⁴, ¹Laboratory of Physiopathology of Arthritises, University of Strasbourg, Illkirch-Strasbourg, France, ²Department of Biochemistry, University of Lausanne, Lausanne, Switzerland, ³Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁴Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁷Molecular Immunology and Embryology, University of Orleans and National Center for Scientific Research, Orléans, France, ⁸Molecular Immunology and Embryology, University of Orleans and National Center for Scientific Research, Orleans, France, ⁹Francois Rabelais University, National institute of the health and the medical research, Tours, France, ¹⁰UMR6218, Molecular Immunology, University and CNRS, 3b rue de la Ferollerie, Orleans, France, ¹¹Fédération of Translational Medicine of Strasbourg (FMTS), Immunorhumatology Molécular, Strasbourg, France, ¹²Université de Strasbourg, Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France, ¹³Rheumatology, CHU Hautepierre, Strasbourg, France, ¹⁴Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Interstitial pneumonitis and lung fibrosis are frequent systemic complications of inflammatory arthritides, including systemic sclerosis (SSc), rheumatoid arthritis, or primary Sjögren’s syndrome. B lymphocytes…
Abstract Number: 2612 • 2013 ACR/ARHP Annual Meeting
Epidemiology Of Cancer In Systemic Sclerosis. Systematic Review and Meta-Analysis Of Cancer Incidence, Predictors and Mortality
Tatiana Nevskaya¹, Shelly Chandran², Adrienne M. Roos¹, Christopher Pasarikovski¹, Amie T. Kron³, Cathy Chau⁴ and Sindhu R. Johnson⁵, ¹Medicine, Toronto Scleroderma Research Program, Toronto Western Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, ²Medicine, Toronto Scleroderma Research Program, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada, ⁴Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Medicine, Toronto Western Hospital, Toronto General Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada
Background/Purpose: To improve our understanding of the epidemiology of cancer in systemic sclerosis (SSc) by evaluating the incidence, prevalence, relative risk of overall and site-specific…
Abstract Number: 2613 • 2013 ACR/ARHP Annual Meeting
NF-κB Pathway Is Depleted In Phagocytes From Behçet´s Disease Patients Secondarily To Constitutive Phosphorylation Of The p65 Subunit
Sandro F. Perazzio^1,2, Paulo Vitor Soeiro Pereira³, Alexandre W.S. Souza^4,5, Antonio Condino-Neto³ and Luis Eduardo C. Andrade⁶, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Fleury Medicine and Health, Sao Paulo, Brazil, ³Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, ⁴University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁶Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: : Increased neutrophil activation has been previously shown in Behçet’s disease (BD) patients and it is unclear whether neutrophil activation occurs constitutively or if…
Abstract Number: 2614 • 2013 ACR/ARHP Annual Meeting
Plasma Of Active Behçet´s Disease Increases Oxidative Metabolism Profile Of Normal and Patients Phagocytes
Sandro F. Perazzio^1,2, Paulo Vitor Soeiro Pereira³, Alexandre W.S. Souza^4,5, Antonio Condino-Neto³ and Luis Eduardo C. Andrade⁶, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Fleury Medicine and Health, Sao Paulo, Brazil, ³Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, ⁴University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁶Rheumatology Division, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: Behçet’s disease (BD) exhibits several features suggestive of neutrophil hiperactivity. It is unclear whether neutrophil activation occurs constitutively or if it is secondary to…
Abstract Number: 2582 • 2013 ACR/ARHP Annual Meeting
Treatment Of Pulmonary Hypertension In Scleroderma Patients With Restricitive Lung Disease.Observations From The Pulmonary Hypertension Assessment and Recognition Of Outcomes In Scleroderma Cohort
Virginia D. Steen¹ and Robyn T. Domsic², ¹Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ²Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Trials of therapy in pulmonary hypertension(PH) have generally excluded patients with significant interstitial lung disease, but many patients with systemic sclerosis(SSc) and PH have…
Abstract Number: 2572 • 2013 ACR/ARHP Annual Meeting
An Atypical Cyclin-Dependent Kinase Mediates Fibrosis and Is a Novel Target In Scleroderma
Jun Wei¹, Roberta G. Marangoni², Wenxia Wang³, Jingang Huang⁴, Joerg H. W. Distler⁴ and John Varga⁵, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Cyclin-dependent kinase 5 (CDK5), expressed primarily in the central nervous system, plays important roles in axonal guidance, dopaminergic signaling, neuronal migration, and pain sensing.…
Abstract Number: 2573 • 2013 ACR/ARHP Annual Meeting
The Role Of STAT-3 In The Development Of Pulmonary and Dermal Fibrosis
Mesias Pedroza¹, Sarah To¹, Anuh T. George¹, David J. Tweardy² and Sandeep K. Agarwal¹, ¹Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis is the accumulation of excessive extra-cellular matrix in tissues, leading to tissue damage. In systemic sclerosis, the trigger is postulated to be an…

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