Abstracts Archive - Page 2241 of 2605 - ACR Meeting Abstracts

Abstract Number: 2865 • 2013 ACR/ARHP Annual Meeting
Gene Expression Profiles Of Fibroblast-Like Synoviocytes In Early Stage Of Oligoarticular Juvenile Idiopathic Arthritis Are Different In Extended Versus Persistent Course
AnneMarie C. Brescia¹, Megan M. Simonds², Suzanne M. McCahan², Paul T. Fawcett² and Carlos D. Rose¹, ¹Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, ²Nemours Research, Nemours/AI duPont Hospital for Children, Wilmington, DE
Background/Purpose: Our goal is the identification of informative synovial biomarkers to predict persistent vs extended course in oligoarticular JIA patients. Methods: Stored remnant synovial fluid…
Abstract Number: 2866 • 2013 ACR/ARHP Annual Meeting
Determining The Absolute Change In The Clinical Disease Activity Index (CDAI) To Define a Minimally Important Difference
Jeffrey R. Curtis¹, Shuo Yang², Lang Chen³, Janet E. Pope⁴, Edward C. Keystone⁵, Boulos Haraoui⁶, Gilles Boire⁷, J. Carter Thorne⁸, Diane Tin⁹, Carol A. Hitchon¹⁰, Clifton O. Bingham III¹¹ and Vivian P. Bykerk¹², ¹University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴St Joseph Health Care, London, ON, Canada, ⁵Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, ⁶Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁷Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ¹¹Rheumatology, Johns Hopkins University, Baltimore, MD, ¹²Divison of Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Simplified measures to quantify rheumatoid arthritis (RA) disease activity are increasing in use in clinical practice. However, the absolute minimally important difference (MID) in…
Abstract Number: 2867 • 2013 ACR/ARHP Annual Meeting
Using Patient Reported Outcomes Measurement Information System Instruments To Identify Disease Flares In People With Rheumatoid Arthritis
Susan J. Bartlett^1,2, Ana-Maria Orbai³, Trisha Duncan³ and Clifton O. Bingham III³, ¹Clinical Epidemiology, McGill University, Montreal, QC, Canada, ²Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Rheumatoid arthritis (RA) is associated with unpredictable episodes of disease worsening that may prompt consideration of treatment change. Core RA Flare domains have been…
Abstract Number: 2868 • 2013 ACR/ARHP Annual Meeting
Reliability and Validity Of Patient-Reported Joint Counts and Determinants Of Disagreement With The Physician In Recent Onset Rheumatoid Arthritis
Karen Visser¹, Janet E. Pope², Ernest Choy³, Clifton O. Bingham III⁴, Susan J. Bartlett^5,6, Gilles Boire⁷, Carol A. Hitchon⁸, J. Carter Thorne⁹, Boulos Haraoui¹⁰, Diane Tin¹¹, Edward Keystone¹² and Vivian P. Bykerk¹³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, St Joseph Health Centre, London, ON, Canada, ³Section of Rheumatology, Cardiff University, Cardiff, ENGLAND, United Kingdom, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Clinical Epidemiology, McGill University, Montreal, QC, Canada, ⁶Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, ⁷Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, ¹¹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, ¹³Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Patient-reported joint counts (JCs) might improve the efficiency and consistency of disease monitoring, self-management and early recognition of changes in disease activity in rheumatoid…
Abstract Number: 2869 • 2013 ACR/ARHP Annual Meeting
Changes In Patient-Reported Joint Counts and Composite Indices Can Identify Flare Of Disease Activity In Recent Onset Rheumatoid Arthritis
Karen Visser¹, Susan J. Bartlett^2,3, Clifton O. Bingham III⁴, Ernest Choy⁵, Daming Lin⁶, Juan Xiong⁷, Gilles Boire⁸, Boulos Haraoui⁹, Carol A. Hitchon¹⁰, Edward Keystone¹¹, Janet E. Pope¹², J. Carter Thorne¹³, Diane Tin¹⁴ and Vivian P. Bykerk¹⁵, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, McGill University, Montreal, QC, Canada, ³Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Section of Rheumatology, Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ⁶Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷Mount Sinai Hospital, Toronto, ON, Canada, ⁸Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁹Department of Medicine, Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada, ¹⁰Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ¹¹Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, ¹²St Joseph Health Care, London, ON, Canada, ¹³Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁴The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁵Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Patient-reported joint counts (JCs) have been identified as core domains for assessment of flare in rheumatoid arthritis (RA).[1] To assess the responsiveness and discriminative…
Abstract Number: 2870 • 2013 ACR/ARHP Annual Meeting
Higher Disease Activity and Serum Levels Of Angiogenic Factors In Patients With Rheumatoid Arthritis In Clinical Remission With Synovitis On Ultrasound
Julio Ramirez¹, Virginia Ruiz-Esquide², Isaac Pomés³, Raquel Celis⁴, Jaume Pomés³, Sonia Cabrera¹, M. Victoria Hernández⁵, Oscar M Epis⁶, Jose L. Pablos⁷, Raimon Sanmarti¹ and Juan D. Cañete², ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clinic, Barcelona, Spain, ³Radiology, Hospital Clínic, Barcelona, Spain, ⁴Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ⁵Arthritis Unit, Department of Rheumatology, Hospital Clinic, Barcelona, Barcelona, Spain, ⁶A.O. Ospedale Niguarda Cà Granda, Milan, Italy, ⁷Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose: To identify and characterize subclinical synovitis in patients with rheumatoid arthritis in clinical remission using power Doppler ultrasound and serum levels of angiogenic factors.…
Abstract Number: 2871 • 2013 ACR/ARHP Annual Meeting
Validation Of The FLARE Self-Report Questionnaire For Assessing FLARE Out Of The Clinical Visit In Rheumatoid Arthritis
Jacques Morel¹, Jean-Marie Berthelot², Arnaud L. Constantin³, Michel De Bandt⁴, Philippe Gaudin⁵, Olivier Vittecoq⁶, Jean Francis Maillefert⁷, Olivier Meyer⁸, Thao Pham⁹, Alain Saraux¹⁰, Elisabeth Solau Gervais¹¹, Elisabeth Spitz¹², Daniel Wendling¹³, Francis Guillemin¹⁴ and Bruno Fautrel¹⁵, ¹Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ²Rheumatology Unit, Nantes University Hospital, Nantes, France, ³Rheumatology, Purpan University Hospital, Toulouse, France, ⁴Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ⁵Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, ⁶Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, ⁷University Hospital, Department of Rheumatology, Dijon, France, ⁸Rheumatology, Bichat University Hospital, Paris, France, ⁹Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ¹⁰Rhumatologie, CHU de la Cavale Blanche, Brest Cedex, France, ¹¹Departement of Rheumatology, CHU de Poitiers, Poitiers, France, ¹²UFR Sciences Humaines et Arts, APEMAC-EA4360, Metz, France, ¹³Rheumatology, University Hospital, Besancon, France, ¹⁴CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ¹⁵Paris 6 – Pierre et Marie Curie University; AP-HP, Rheumatology, Pitié-Salpêtrière Hospital, - GRC-UPMC 08 – EEMOIS, Paris, France
Background/Purpose: Defining flare in rheumatoid arthritis (RA) raises a complex issue related to the difference in perception or concept of flare between patients or health…
Abstract Number: 2872 • 2013 ACR/ARHP Annual Meeting
Long Noncoding RNA Nron Regulates The Cytoplasmic-Nuclear Shuttling and Activity Of NFAT5 In Rheumatoid Arthritis Synovial Fibroblast
Kunihiko Umekita¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴, Steffen Gay¹ and Mojca Frank Bertoncelj⁵, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) are critical regulators of gene expression and of major biological processes, such as cell migration, proliferation and invasion. The lncRNA…
Abstract Number: 2873 • 2013 ACR/ARHP Annual Meeting
The Ion Channel TRPV2 Is New Suppressor of Arthritis Severity and Joint Damage
Teresina Laragione^1,2, Max Brenner^1,2, Christine Beeton³ and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY, ³Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic disease associated with increased risk of developing disability. Disease remission is still rarely achieved and better…
Abstract Number: 2874 • 2013 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts
Munitta Muthana¹, Holly Davies², Sachin Khetan³, Gbadebo Adeleke Adeleke⁴, Sarah Hawtree¹ and Anthony G. Wilson⁵, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, Sheffield, United Kingdom, ³Infection and immunity, Dr, Sheffield, United Kingdom, ⁴Infection and Immunity, Dr, Sheffield, United Kingdom, ⁵Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first intron of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility…
Abstract Number: 2875 • 2013 ACR/ARHP Annual Meeting
Metabolic Profiles of Synovial Fibroblasts
Sabrina Kapoor¹, Andrew Filer², Christopher D. Buckley³, Karim Raza⁴ and Stephen Young⁵, ¹Rheumatology, University of Birmingham, Birmingham, United Kingdom, ²Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ³Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁴Centre for Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom, ⁵Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Synovial fibroblasts play a key role in the persistence of inflammation and joint destruction in rheumatoid arthritis (RA). Cell function and proliferation are highly…
Abstract Number: 2876 • 2013 ACR/ARHP Annual Meeting
Key Rheumatoid Arthritis-Associated Pathogenic Pathways Revealed By Integrative Analysis Of RA Omics Datasets
John Whitaker¹, Wei Wang² and Gary S. Firestein³, ¹Chemistry, UCSD School of Medicine, La Jolla, CA, ²Chemistry, UCSD, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Genome-wide analysis of RA has independently evaluated DNA sequence variation, differential RNA expression, and differential DNA methylation. Each approach alone implicates promising pathways…
Abstract Number: 2877 • 2013 ACR/ARHP Annual Meeting
Potential Of Integrating Human Genetics and Electronic Medical Records For Drug Discovery: The Example Of TYK2 and Rheumatoid Arthritis
Dorothee Diogo¹, Katherine P. Liao², Robert S. Fulton³, Robert R. Graham⁴, Jing Cui⁵, Jeffrey D. Greenberg⁶, Stephen Eyre⁷, John Bowes⁸, Annette T. Lee⁹, Dimitrios A. Pappas¹⁰, Joel M. Kremer¹¹, Anne Barton⁷, Marieke J.H. Coenen¹², Xavier Mariette¹³, Corrine Richard-Miceli¹⁴, Helena Canhão¹⁵, João E. Fonseca¹⁶, Niek de Vries¹⁷, Fina Kurreeman¹⁸, Ted R. Mikuls¹⁹, Yukinori Okada¹, Isaac Kohane²⁰, Joshua C. Denny²¹, Jane Worthington²², Soumya Raychaudhuri¹, Timothy W. Behrens²³, Michael F. Seldin²⁴, Peter K. Gregersen²⁵, Elaine R. Mardis³ and Robert M. Plenge²⁶, ¹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³The Genome Institute, Washington University School of Medicine, Saint Louis, MO, ⁴ITGR Human Genetics, Genentech, Inc., South San Francisco, CA, ⁵Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶NYU Hospital for Joint Diseases, New York, NY, ⁷Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁸Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁹Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰Department of Medicine, Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ¹¹Center for Rheumatology, Albany Medical College, Albany, NY, ¹²Human Genetics (855), Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹³Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ¹⁴Hôpital Bicêtre, Université Paris-sud, Paris, France, ¹⁵Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisboa, Portugal, ¹⁶Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ¹⁷Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ¹⁸Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²⁰on behalf of i2b2 ; Brigham and Women's Hospital, Boston, MA, ²¹Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, ²²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ²³Genentech, Inc, South San Francisco, CA, ²⁴Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, ²⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Human genetics has the potential to identify promising drug targets for complex traits such as rheumatoid arthritis (RA). Genes with a series of disease-associated…
Abstract Number: 2837 • 2013 ACR/ARHP Annual Meeting
Higher Disease Activity Leads To More Damage In The Early Phases Of Ankylosing Spondylitis: 12-Year Data From The OASIS Cohort
Sofia Ramiro¹, A.M. van Tubergen², Désirée van der Heijde³, Carmen Stolwijk⁴, Maxime Dougados⁵, Filip Van den Bosch⁶ and Robert Landewé⁷, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: For years, it was unclear if inflammation and radiographic progression were related in ankylosing spondylitis (AS), but studies were only of short follow-up and…
Abstract Number: 2838 • 2013 ACR/ARHP Annual Meeting
Relationship Between Active Inflammatory Lesions In The Spine and Sacroiliac Joints and Development Of Fatty Lesions On Whole-Body MRI In Patients With Early Axial Spondyloarthritis- Long-Term Data Of The Esther Trial
In-Ho Song¹, Kay-Geert A. Hermann², Hildrun Haibel³, Christian Althoff⁴, Denis Poddubnyy³, Joachim Listing⁵, Anja Weiss⁶, Ekkehard Lange⁷, Bruce Freundlich⁸, Martin Rudwaleit⁹ and Joachim Sieper¹⁰, ¹Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ²Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Radiology, Charite Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ⁵German Rheumatism Research Center, Berlin, Germany, ⁶German Rheumatism Research Centre, Berlin, Germany, ⁷BU Specialty Care, Pfizer Pharma AG, Berlin, Germany, ⁸University of Pennsylvania, Philadelphia, PA, ⁹Endokrinologikum, Berlin, Germany, ¹⁰Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin-Franklin, Berlin, Germany
Background/Purpose : In patients with early axial spondyloarthritis (SpA) with evidence of active inflammation on magnetic resonance imaging (MRI) in the spine and/or sacroiliac (SI-)joints…

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