Abstracts Archive - Page 2211 of 2605 - ACR Meeting Abstracts

Abstract Number: 298 • 2014 ACR/ARHP Annual Meeting
Long-Term Impact of Juvenile Idiopathic Arthritis in the Greek adults’ Psychosocial Life
Despoina Dimopoulou¹, Maria Trachana², Polyxeni Pratsidou-Gertsi³, George Garyfallos⁴, Prodromos Sidiropoulos⁵, Athina Theodoridou⁶ and Alexandros Garyfallos⁶, ¹Nikolaou Manou Str. 20, 4th Department of Internal Medicine, Aristotle University, Hippocratio Hospital, Thessaloniki, Greece, ²Aristotle University, Thessaloniki, Greece, ³1st Department of Pediatrics, Aristotle University, 1st Department of Pediatrics, Aristotle University, Thessaloniki, Greece, ⁴2nd Department of Psychiatry Aristotle University, 2nd Department of Psychiatry Aristotle University, Thessaloniki, Greece, ⁵Rheumatology, Clinical Immunology, and Allergy, University of Crete, Heraklion, Greece, ⁶4th Department of Internal Medicine, Aristotle University, Hippocratio Hospital, 4th Department of Internal Medicine, Aristotle University, Hippocratio Hospital, Thessaloniki, Greece
Background/Purpose Juvenile idiopathic arthritis (JIA) seems to have a negative impact on patients’ life style mostly due to the disease chronicity. No relevant data have been…
Abstract Number: 316 • 2014 ACR/ARHP Annual Meeting
Cytokines in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Tipping the Balance Between Interleukin-18 and Interferon-Gamma
Karen Put¹, Anneleen Avau¹, Ellen Brisse¹, Tania Mitera¹, Stéphanie Put¹, Paul Proost², Brigitte Bader-Meunier³, Rene Westhovens⁴, Benoît Van den Eynde⁵, Ciriana Orabona⁶, Francesca Fallarino⁶, Lien De Somer⁷, Thomas Tousseyn⁸, Pierre Quartier³, Carine Wouters⁷ and Patrick Matthys¹, ¹University of Leuven, Laboratory of Immunobiology, Rega Institute, Leuven, Belgium, ²University of Leuven, Laboratory of Molecular Immunology, Rega Institute, Leuven, Belgium, ³Pediatric Rheumatology, IMAGINE Institute, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France, ⁴University of Leuven, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration; Rheumatology, University Hospital Leuven, Leuven, Belgium, ⁵Institut de Duve, Université catholique de Louvain, Brussels, Belgium, ⁶Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, ⁷University of Leuven, Laboratory of Pediatric Immunology, University Hospital Leuven, Leuven, Belgium, ⁸University of Leuven, Department of Imaging and Pathology, Leuven, Belgium
Background/Purpose To study the role of interferon-gamma (IFN-γ) in the pathogenesis of systemic juvenile idiopathic arthritis (sJIA) and macrophage activation syndrome (MAS) by searching for…
Abstract Number: 317 • 2014 ACR/ARHP Annual Meeting
Myeloid Related Proteins 8 and 14 (MRP 8/14) – Potential Biomarkers of Disease Activity of Arthritis in Children with Trisomy 21
Charlene Foley, Orla Killeen and Emma Jane MacDermott, The National Centre for Paediatric Rheumatology, Dublin, Ireland
Background/Purpose JIA is an umbrella term used to describe a heterogeneous group of diseases.To date no specific markers exist in clinical practice to predict disease…
Abstract Number: 315 • 2014 ACR/ARHP Annual Meeting
NLRC4-Related Macrophage Activation Syndrome (NLRC4-MAS): A Novel Primary Autoinflammatory Syndrome Caused By Activating Mutations in NLRC4
Scott Canna¹, Adriana Almeida de Jesus², Sushanth Gouni¹, Stephen Brooks³, Kristien J. Zaal⁴, Bernadette Marrero⁵, Yin Liu⁶, Michael Dimattia⁷, Gina A. Montealegre Sanchez⁶, Hanna Kim⁶, Dawn C. Chapelle⁶, Nicole Plass⁶, Yan Huang⁶, Angelique Biancotto⁸, J. Alex Duncan⁹, Susanne Benseler¹⁰, John J. O'Shea¹, Alexei A. Grom¹¹, Zuoming Deng¹², Ronald Laxer¹³ and Raphaela Goldbach-Mansky¹⁴, ¹Molecular Immunology and Inflammation Branch, NIAMS/NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ³NIAMS/NIH, Bethesda, MD, ⁴Light Imaging Section, NIAMS/NIH, Bethesda, MD, ⁵Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ⁶Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁷Laboratory of Structural Biology, NIAMS/NIH, Bethesda, MD, ⁸Center for Human Immunology, Autoimmunity and Inflammation, NHLBI/NIH, Bethesda, MD, ⁹Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, ¹⁰Alberta Children's Hospital Research Institute/University of Calgary, Calgary, AB, Canada, ¹¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹²Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ¹³Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ¹⁴Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: Macrophage Activation Syndrome (MAS) is a life-threatening systemic inflammatory complication of many rheumatic diseases and its causes are unknown. While genetic defects causing impaired…
Abstract Number: 314 • 2014 ACR/ARHP Annual Meeting
Next Generation Sequencing Reveals Restriction of the Treg Cell Repertoire and an Abundance of Shared Synovial Treg Clonotypes in JIA
Lauren A. Henderson¹, Stefano Volpi¹, Francesco Frugoni², Susan Kim¹, Robert P. Sundel¹, Fatma Dedeoglu³, Mindy S. Lo¹, Erin Janssen¹, Melissa M. Hazen¹, Mary Beth Son¹, Ronald Mathieu⁴, David Zurakowski⁵, Robert C. Fuhlbrigge¹, Jolan E. Walter⁶, Yu Nee Lee¹, Peter A. Nigrovic¹ and Luigi D Notarangelo⁷, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Immunology, Boston Children's Hospital, Boston, MA, ³Rheumatology, Boston Children's Hospital, Boston, MA, ⁴Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, ⁵Departments of Anesthesia and Surgery, Boston Children’s Hospital, Boston, MA, ⁶Division of Pediatric Allergy/Immunology, Massachusetts General Hospital for Children, Bpstpm, MA, ⁷Division of Immunology and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA
Background/Purpose Regulatory T cell (Treg) dysfunction has been documented in juvenile idiopathic arthritis (JIA), but the basis for this lapse in suppressive capacity is incompletely…
Abstract Number: 313 • 2014 ACR/ARHP Annual Meeting
Elevated Cardiovascular Disease Burden and Inflammatory Biomarker Levels in Adults with Juvenile Idiopathic Arthritis
Siobhan Crittenden¹, Elizabeth Coulson^1,2, Vijay Kunadian^3,4,5, Wan-Fai Ng^1,2,6 and H. E. Foster^7,8,9, ¹Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ²Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ³Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ⁴Cardiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁵Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁶Musculoskeletal Directorate, The Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁷Paediatric Rheumatology, Newcastle Hospitals NHS Trust and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, ⁸Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle Upon Tyne, United Kingdom, ⁹Paediatric Rheumatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
Background/Purpose: Rheumatoid Arthritis (RA) is associated with a 50 % greater cardiovascular mortality rate than the general population, attributable to the increased prevalence of traditional…
Abstract Number: 312 • 2014 ACR/ARHP Annual Meeting
Mutations in the MTHFR Gene Are Not Associated with Methotrexate Intolerance in Patients with Juvenile Idiopathic Arthritis
Andrea Scheuern¹, Nadine Fischer², Johannes-Peter Haas¹ and Boris Hugle¹, ¹German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ²Research, German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany
Background/Purpose: Methotrexate (MTX) is the drug used most frequently in the therapy of juvenile idiopathic arthritis (JIA). However, long-term treatment in children frequently leads…
Abstract Number: 311 • 2014 ACR/ARHP Annual Meeting
Inhibition of Natural Killer (NK) Cell Cytotoxicity By Interleukin-6 (IL-6): Implications for the Pathogenesis of Macrophage Activation Syndrome
Loredana Cifaldi¹, Giusi Prencipe², Ivan Caiello², Claudia Bracaglia², Raffaele Strippoli³ and Fabrizio De Benedetti Sr.², ¹Paediatric Haematology/Oncology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, ²Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, ³Cellular Biotechnologies and Haematology, Sapienza Rome University, Rome, Italy
Background/Purpose: MAS occurs frequently in patients with active systemic juvenile idiopathic arthritis(s-JIA) and because of the similarities with Haemophagocytic Lymphohistiocytosis (HLH) is classified among secondary…
Abstract Number: 310 • 2014 ACR/ARHP Annual Meeting
Differential Expression of microRNA in Monocytes from Children with Systemic Juvenile Idiopathic Arthritis: Implications for Polarized Phenotype
Grant Schulert¹, Ndate Fall², Nan Shen³ and Alexei Grom⁴, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, OH, China, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, and the predominant effector cells are mononuclear phagocytes rather than lymphocytes as in…
Abstract Number: 309 • 2014 ACR/ARHP Annual Meeting
Clinical Significance of Cytokine Profile with Interleukin-18 and -6 in Systemic Juvenile Idiopathic Arthritis
Masaki Shimizu, Natsumi Inoue, Yuko Tasaki, Sayaka Ishikawa, Kazuyuki Ueno and Akihiro Yachie, Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan
Background/Purpose Innate proinflammatory cytokines interleukin (IL)-6 and IL-18 are critical for perpetuating the inflammatory processes in systemic juvenile idiopathic arthritis (s-JIA) and macrophage activation syndrome…
Abstract Number: 307 • 2014 ACR/ARHP Annual Meeting
Sibling Exposure and Risk of Juvenile Idiopathic Arthritis
Jessica Miller¹, Anne-Louise Ponsonby^2,3, Angela Pezic², Jonathan Akikusa⁴, Roger Allen⁴, Jane Munro⁴ and Justine Ellis^5,6, ¹Murdoch Childrens Research Institute, Parkville, Australia, ²Environmental & Genetic Epidemiology Research, Murdoch Childrens Research Institute, Parkville, Australia, ³The University of Melbourne, Parkville, Australia, ⁴Rheumatology, Royal Children's Hospital, Parkville, Australia, ⁵Genes, Environment, and Complex Disease, Murdoch Childrens Research Institute, Parkville, Australia, ⁶Department of Paediatrics, The University of Melbourne, Parkville, Australia
Background/Purpose: Susceptibility to juvenile idiopathic arthritis (JIA) is presumed to be determined by the interplay of genes and environment. Our understanding of the genetic basis…
Abstract Number: 308 • 2014 ACR/ARHP Annual Meeting
Tenascin-C, a TLR4 Ligand Levels in Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis: Cross-Sectional and Longitudinal Study
Anuj Shukla¹, Priyanka Gaur² and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose Tenascin-C (TNC) is an extracellular matrix glycoprotein, which binds to TLR4 and leads to its activation. Monocytes of children with Enthesitis related arthritis (ERA)…
Abstract Number: 306 • 2014 ACR/ARHP Annual Meeting
Association of Kawasaki Disease with Tropospheric Winds in Central Chile: Is Wind-Borne Desert Dust a Risk Factor?
Arturo Borzutzky^1,2, Alvaro García³, Rodrigo Hoyos-Bachiloglu^1,2 and Hector Jorquera^4,5, ¹Pediatrics, Pontificia Universidad Católica de Chile School of Medicine, Santiago, Chile, ²Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Pontificia Universidad Católica de Chile School of Medicine, Santiago, Chile, ⁴Department of Chemical and Bioprocess Engineering, Pontificia Universidad Católica de Chile School of Engineering, Santiago, Chile, ⁵Centro de Desarrollo Urbano Sustentable (CEDEUS), Santiago, Chile
Background/Purpose: Kawasaki disease (KD) has been reported to have seasonal variations in many different countries, as well as geographical and temporal clustering. It has been…
Abstract Number: 305 • 2014 ACR/ARHP Annual Meeting
Understanding the Molecular Pathogenesis of and Response to Canakinumab Treatment in TNF Receptor-Associated Periodic Syndrome By Gene Expression Profiling of Whole Blood from Patients
R. Torene¹, M. Gattorno², H. Lachmann³, L. Obici⁴, A. Meini⁵, V. Tormey⁶, R. Caorsi⁷, L. Baeriswyl⁸, U. Affentranger⁸, S. Starck-Schwertz⁸, M. Letzkus⁸, N. Hartmann⁸, K. Abrams⁹ and N. Nirmala¹, ¹Novartis Institutes for BioMedical Research, Cambridge, MA, ²Pediatric Rheumatology, G. Gaslini Institute, Genova, Italy, ³Royal Free Hospital, London, United Kingdom, ⁴Amyloid Centre, IRCCS Policlinico San Matteo, Pavia, Italy, ⁵Pediatric Clinic, Spedali Civili, Brescia, Italy, ⁶Galway University Hospitals, Galway, Ireland, ⁷Second Division of Paediatrics, G. Gaslini Institute, Genova, Italy, ⁸Novartis Institutes for BioMedical Research, Basel, Switzerland, ⁹Novartis Pharmaceutical Corporation, East Hanover, NJ
Background/Purpose: TNF receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disease causing unprovoked fevers, myalgia, abdominal pain, rash, headaches, and, in severe cases, AA amyloidosis. It…
Abstract Number: 304 • 2014 ACR/ARHP Annual Meeting
Juvenile Rheumatoid Arthritis and Future Risk for Cardiovascular Disease; A Multicenter Population-Based Study
Jason Anderson¹, Katelyn Anderson¹, Hanne Aulie², Cynthia S. Crowson³, Thomas Mason II⁴, Stacy P. Ardoin⁵, Ann M. Reed⁶ and Berit Flato⁷, ¹Mayo Clinic, Rochester, MN, ²Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology - Department of Medicine, Mayo Clinic, Rochester, MN, ⁵Pediatric & Adult Rheumatology, Ohio State University College of Medicine, Columbus, OH, ⁶Rheumatology, Mayo Clinic, Rochester, MN, ⁷Department of Rheumatology, Oslo University Hospital, Oslo, Norway
Background/Purpose: Several studies suggest an increased frequency of cardiovascular disease (CVD) in patients with rheumatoid arthritis, but little is known about CVD risk in patients…

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