Abstract Number: 655 • 2013 ACR/ARHP Annual Meeting
DNA Methylation and Systemic Sclerosis
DNA Methylation and Systemic SclerosisBackground/Purpose: Epigenetic modifications are stable and heritable alterations in gene expression and cellular function that do not involve changes to the…Abstract Number: 656 • 2013 ACR/ARHP Annual Meeting
Gene Expression Variation and The Role Of Interferon In Patients With Morphea From The Morphea In Adults and Children Cohort
Background/Purpose: Localized scleroderma (morphea) is characterized by inflammation and sclerosis of the dermis and underlying tissue and may be associated with significant morbidity. Overproduction of…Abstract Number: 657 • 2013 ACR/ARHP Annual Meeting
Lipoic Acid Plays a Crucial Role In Scleroderma Dermal Fibroblasts
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived…Abstract Number: 658 • 2013 ACR/ARHP Annual Meeting
Elevated 8-Isoprostane In Scleroderma: Implications Of Its Role In Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive disposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…Abstract Number: 659 • 2013 ACR/ARHP Annual Meeting
Circulating Cell-free microRNAs in Systemic Sclerosis
Background/Purpose: microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression through target mRNAs and are involved in important physiological and pathological…Abstract Number: 660 • 2013 ACR/ARHP Annual Meeting
Bleomycin Delivery By Mini-Osmotic Pump: A Novel Multi-Organ Murine Model For Fibrosis
Background/Purpose: Systemic sclerosis (SSc, Scleroderma) is a rare but severe systemic connective tissue disorder involving the skin and multiple internal organs, in particular lung, kidney,…Abstract Number: 661 • 2013 ACR/ARHP Annual Meeting
Topoisomerase-1 Specific T Cells Exhibit a Proinflammatory Th17 Phenotype and Are Associated With Interstitial Lung Disease In Scleroderma
Background/Purpose: Anti-topoisomerase-1 (Topo-1 or Scl70) autoantibodies are present in 30-45% of scleroderma (SSc) patients and identify a more aggressive disease phenotype with worse clinical outcome…Abstract Number: 662 • 2013 ACR/ARHP Annual Meeting
Oxidative Stress-Dependent Activation Of Collagen Synthesis Is Induced In Human Pulmonary Vascular Smooth Muscle Cells By Scleroderma Sera and Predicts Pulmonary Vascular Disease
Background/Purpose: Vascular disease is a dominant component of Systemic Sclerosis (SSc) pathogenesis. Hypoxia and oxidative stress have been linked to endothelial injury, intimal hyperplasia and…Abstract Number: 625 • 2013 ACR/ARHP Annual Meeting
Smoking and Secondhand Smoke Exposure Among Patients With Systemic Lupus Erythematosus and Controls: Associations With Disease and Disease Damage
Background/Purpose: Previous reports suggest smoking may be a risk factor for developing systemic lupus erythematosus (SLE), however the significance of this relationship varies among studies.…Abstract Number: 642 • 2013 ACR/ARHP Annual Meeting
Serum Concentrations Of Type I Interferon-Regulated Chemokines Are Associated With Disease Activity In Systemic Lupus Erythematosus
Background/Purpose: Expression array studies suggest the activity of Type I interferon (IFN), as reflected in IFN-induced genes, is associated with phenotypic subsets in SLE. Three…Abstract Number: 622 • 2013 ACR/ARHP Annual Meeting
Serum Anti-Apolipoprotein 1 Antibodies Are Present In a Quarter Of Patients With Systemic Lupus Erythematosus At The Time Of Diagnosis and Are Associated With Earlier Mortality
Background/Purpose: A large number of different autoantibodies have been reported in patients with systemic lupus erythematosus but not all have been related to clinical outcomes.…Abstract Number: 623 • 2013 ACR/ARHP Annual Meeting
Lupus Patients Have a High Prevalence Of Abnormalities On Resting Electrocardiogram That Are Associated With Increased Risk For Cardiovascular Events
Background/Purpose: Patients with lupus are at increased risk for cardiovascular disease (CVD). Abnormalities detected on resting electrocardiography (ECG) that may be associated with an increased…Abstract Number: 624 • 2013 ACR/ARHP Annual Meeting
Extremely High Coronary Artery Calcium Scores Among Patients With Systemic Lupus Erythematosus
Background/Purpose: Investigations of major lupus-cohorts have demonstrated cardiovascular disease to have major impact on morbidity and mortality (Am J Epidemiol 1997;145:408-15). The aim of this…Abstract Number: 626 • 2013 ACR/ARHP Annual Meeting
Ultrasound Assessment Of Both Carotid and Femoral Arteries In Patients With Systemic Lupus Erythematosus Increases Sensitivity For Detecting Asymptomatic Atherosclerosis
Background/Purpose: SLE is an independent risk factor for cardiovascular disease (CVD). Traditional risk assessment tools underestimate the actual CVD risk of these patients limiting the…Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…