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  • Abstract Number: 678 • 2013 ACR/ARHP Annual Meeting

    Quantifying Change In Pulmonary Function As a Prognostic Marker In Systemic Sclerosis-Related Interstitial Lung Disease

    Owen Moore1,2, Susanna Proudman3, Nicole Goh4, Tamera Corte5, Hannah Rouse6, Oliver Hennessy6, Vivek Thakkar7, Joanne Sahhar8, Janet E. Roddy9, Peter Youssef10, Eli Gabbay11, Peter Nash12, Jane Zochling13, Wendy Stevens14 and Mandana Nikpour15, 1Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, 2Rheumatology, Derriford Hospital, Plymouth, United Kingdom, 3Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 4Department of Respiratory Medicine, Alfred Hospital, Melbourne, Australia, 5Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia, 6Department of Radiology, St. Vincent’s Hospital, Melbourne, Australia, 7St Vincent's Hospital, Melbourne, Australia, 8Rheumatology Unit, Monash Medical Centre, Clayton, Australia, 9Royal Perth Hospital, Perth, Australia, 10Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, Australia, 11Advanced Lung Disease Unit, Royal Perth Hospital, Perth, Australia, 12Rheumatology Research Unit, Nambour Hospital, Sunshine Coast, Australia, 13Menzies Research Institute Tasmania, Hobart, Australia, 14Rheumatology, St Vincent's Hospital, Melbourne, Australia, 15Department of Medicine (St Vincent's Hospital), University of Melbourne, Fitzroy, Australia

    Background/Purpose: Interstitial lung disease (ILD) is a leading cause of mortality in systemic sclerosis (SSc) but it is not severe or progressive in all patients.…
  • Abstract Number: 679 • 2013 ACR/ARHP Annual Meeting

    Validation Of a Novel Radiographic Scoring System For Calcinosis Affecting The Hands Of Patients With Systemic Sclerosis

    Lorinda Chung1, Antonia Maria Valenzuela Vergara2, David Fiorentino3, Kate Stevens2, Shufeng Li4, Jonathan Harris5, Charles E. Hutchinson6, Shervin Assassi7, Lorenzo Beretta8, Santhanam Lakshminarayanan9, Tatiana Rodriguez Reyna10, Christopher P. Denton11, Rebecca G. Taillefer12, Solene Tatibouet13, Ariane Herrick14 and Murray Baron15, 1Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, 2Stanford University School of Medicine, Stanford, CA, 3Dermatology, Stanford University School of Medicine, Redwood City, CA, 4Dermatology, Stanford University School of Medicine, Palo Alto, CA, 5Salford Royal Hospital, Manchester, United Kingdom, 6Warwick Medical School, University of Warwick, Coventry, United Kingdom, 7Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 8Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 9Dept of Med/Div Rheum Diseases, University of Connecticut School of Medicine, Farmington, CT, 10Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico, 11Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 12University of Montreal, Montreal, QC, Canada, 13Jewish General Hospital, McGill University, Montreal, QC, Canada, 14Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, 15Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada

    Background/Purpose:   Calcinosis affects approximately 25% of patients with systemic sclerosis (SSc) and is associated with substantial morbidity.  There are currently no validated outcome measures…
  • Abstract Number: 680 • 2013 ACR/ARHP Annual Meeting

    Diastolic Dysfunction Amongst Autoantibody Subgroups Of Patients With Diffuse Scleroderma

    Cory Perugino1, John Stephens2, Colin O'Rourke3 and Soumya Chatterjee4, 1Internal Medicine, Cleveland Clinic, Cleveland, OH, 2Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 4Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Scleroderma or systemic sclerosis (SSc) is an autoimmune disease characterized by microangiopathy, tissue hypoxia, and fibrosis. At least seven different autoantibodies have been identified…
  • Abstract Number: 682 • 2013 ACR/ARHP Annual Meeting

    Effects Of Extracoporeal Shock Wave Therapy To The Digital Ulcers Of Scleroderma:a Pilot Study

    Shinichiro Saito1, Yukiko Kamogawa2, Kyohei Nakamura3, Ryu Watanabe3, Tsuyoshi Shirai2, Yoko Fujita4, Hiroshi Fujii3, Yuko Shirota5, Tomonori Ishii3, Hideo Harigae3, Katsuko Kikuchi6 and Yasushi Kawaguchi7, 1Department of hematology and rheumatology, Tohoku University, Sendai, Japan, 2Tohoku University, Sendai, Japan, 3Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, 4Department of Hematolgy and rheumatolgy, Tohoku University, Sendai, Japan, 5Department of Hematology and Rheumatolgy, Tohoku University, Sendai, Japan, 6Department of Dermatology, Tohoku University, Sendai, Japan, 7Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Vasculopathy, immunological abnormalities and excessive tissue fibrosis are key elements in the pathogenesis of Scleroderma (SSc). In winter,  patients often display Raynaud syndrome, which…
  • Abstract Number: 683 • 2013 ACR/ARHP Annual Meeting

    HRCT Predictors Of Decline In FVC% predicted—Implications For Cohort Enrichment For Scleroderma Lung Disease (SLD) Trials

    Dinesh Khanna1, Chi-hong Tseng2, Robert D. Suh3, Fereidoun Abtin4, Athol U. Wells5, Donald Tashkin6 and Jonathan Goldin7, 1University of Michigan, Ann Arbor, MI, 2Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 3UCLA Department of Radiological Sciences, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 4Radiology, University of California Los Angeles Medical Center, Santa Monica, CA, 5Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom, 6Medicine, University of California at Los Angeles, Los Angeles, CA, 7Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Moderate-to-severe HRCT-defined lung involvement (total lung involvement or fibrosis) is a predictor of decline in FVC% predicted and mortality in SLD. Various staging systems…
  • Abstract Number: 684 • 2013 ACR/ARHP Annual Meeting

    Clinical Characteristics Of Scleroderma Patients With Calcinosis In a Single-Center Cohort

    Danielle Velez1 and Vivien M. Hsu2, 1RWJMS, South Plainfield, NJ, 2Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ

    Clinical characteristics of scleroderma patients with calcinosis in a single-center cohort Background/Purpose: Calcinosis is soft tissue deposition of calcium hydroxyapatite crystals in scleroderma spectrum disorder…
  • Abstract Number: 685 • 2013 ACR/ARHP Annual Meeting

    Lung Function and Survival In Systemic Sclerosis Associated Interstitial Lung Disease

    Samar M. Shadly1, Sindhu R. Johnson2, Cathy Chau3 and Theodore K. Marras4, 1Medicine, University Health Network Interstitial Lung Diseases Program, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada, 2Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, 3Medicine, Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 4Medicine, University Health Network Interstitial Lung Diseases Program, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: We sought to assess for an association between baseline forced vital capacity (FVC) and diffusion capacity (DLCO) with mortality, and to identify threshold values…
  • Abstract Number: 686 • 2013 ACR/ARHP Annual Meeting

    Blood Flow In The Hands Of a Predefined Homogeneous Systemic Sclerosis Population: The Presence Of Digital Ulcers and The Improvement With Bosentan

    Jessica Meijs1, Annemie J.M. Schuerwegh1, Alexandre E. Voskuyl2, Joanne P.J. Bloemsaat-Minekus3 and Madelon C. Vonk4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 3Actelion, Woerden, Netherlands, 4Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Digital ulcers (DU) are complications of systemic sclerosis (SSc) and arise as a result of ischaemia due to vasculopathy of the digital arteries (1).…
  • Abstract Number: 643 • 2013 ACR/ARHP Annual Meeting

    Potential Immunopathological Roles Of The Novel Anti-Inflammatory Cytokine Interleukin-35 In Patients With Systemic Lupus Erythematous

    Zhe Cai1, Chun-Kwok Wong2 and Lai Shan Tam3, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 3Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: IL-35, a dimeric protein with two subunits, IL-12A (p35) and Epstein-Barr virus induced 3, is a novel IL-12 cytokine family regulatory T-cells (Treg)-specific immunosuppressive/anti-inflammatory…
  • Abstract Number: 644 • 2013 ACR/ARHP Annual Meeting

    Expansion Of CD4+CXCR3+ T Cells In Patients With Systemic Lupus Erythematosus (SLE) Correlates With Subclinical Atherosclerosis

    Karim Sacre1, Brigitte Escoubet2, Nicolas Charles3, Antoine Dossier4, Marie-Paule Chauveheid5 and Thomas Papo1, 1Internal Medicine, University Paris-7, INSERM U699, APHP, Bichat Hospital, Paris, France, 2Cardiology, University Paris-7, INSERM U872, APHP, Bichat Hospital, Paris, France, 3INSERM U699, Paris, France, 4Internal Medicine, University Paris-7, APHP, Bichat Hospital, Paris, France, 5Internal Medicine,, University Paris-7, APHP, Bichat Hospital, Paris, France

    Background/Purpose: The mechanisms for accelerated atherosclerosis in SLE remain unclear. As atherosclerosis is itself immune-mediated, features of SLE-associated immunity might explain accelerated cardiovascular disease beside traditional…
  • Abstract Number: 645 • 2013 ACR/ARHP Annual Meeting

    Transcript Profiling Of Blood and Kidney Biopsies From Chinese Patients With Lupus Nephritis Reveals Concordant Activation Of Type I IFN Signaling In The Blood and Kidney, Reduced B Cell Presence In The Blood, and Increased Macrophages In The Kidney

    Zheng Liu1, Chris, A. Morehouse1, Xinfang Huang2, Philip Brohawn1, Nan Shen2, Yihong Yao1 and Brandon W. Higgs1, 1Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 2Dept of Rheumatology, Shanghai Ren Ji Hospital, Shanghai, China

    Background/Purpose:  Up-regulated expression of type I interferon-regulated genes has consistently been observed within the peripheral blood in a large proportion of patients with active systemic…
  • Abstract Number: 646 • 2013 ACR/ARHP Annual Meeting

    Expression Of Interferon-Inducible Gene (Lymphocyte Antigen 6 Complex Locus E) In Systemic Lupus Erythematosus Patients and Its Association With Disease Activity

    Eman Omran1, Tayseer M Khidre2, Eman Alkady3, Eman Mosaad4 and Mona Hussein Abd Elsamea3, 1Rheumatology and Clincal Immunology, Assiut University- Faulty of Medicne, Assiut, Egypt, 2Assiut University, Faculty of Medicine, Assiut, Egypt, 3Assiut University- Faculty of Medicine, Assiut, Egypt, 4AssiutUniversity- Faculty of Medicine, Assiut, Egypt

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear and other autoantibodies, generation of…
  • Abstract Number: 647 • 2013 ACR/ARHP Annual Meeting

    Enhanced Expression of CCR Receptors in Healthy AA and SSc ILD Monocytes

    Rebecca Lee1, Charles Reese2, Beth Perry3, Jonathan Heywood2, Michael Bonner1, Richard P. Visconti4, Richard M. Silver5, Stanley Hoffman3 and Elena Tourkina2, 1Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 2Rheumatology, Medical University of SC, Charleston, SC, 3Rheumatology, Medical University of South Carolina, Charleston, SC, 4Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, 5Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC

    Background/Purpose: Scleroderma-associated Interstitial Lung Disease (SSc ILD) is more prevalent and more severe in African Americans (AA) than in Caucasian (C) patients, but little is…
  • Abstract Number: 648 • 2013 ACR/ARHP Annual Meeting

    A Possible Contribution of Inducible Costimulator to the Development of Skin Sclerosis and Interstitial Lung Disease in Systemic Sclerosis

    Koichi Yanaba1, Yoshihide Asano2 and Shinichi Sato2, 1Dermatology, The University of Tokyo, Tokyo, Japan, 2Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous disorder characterized by excessive fibrosis and microvascular damage of the skin and various internal organs. Cutaneous mononuclear cell…
  • Abstract Number: 649 • 2013 ACR/ARHP Annual Meeting

    Altered BMP Signalling In a TGFβ Dependent Murine Model Of Scleroderma May Contribute To Development Of Pulmonary Arterial Hypertension

    Adrian J Gilbane1, Emma C. Derrett-Smith2, Sarah Trinder3, Andrew Pearce4, Christopher P. Denton1 and Alan M. Holmes5, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, 3Centre for Rheumatology and Connective Tissue Disease, UCL Medical School, London, United Kingdom, 4Respiratory Disease Area, Novartis, London, United Kingdom, 5Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom

    Background/Purpose: Pulmonary arterial hypertension associated is an important complication of scleroderma (PAH-SSc) and has a poor prognosis compared to idiopathic (iPAH) or heritable (hPAH) forms…
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