Abstract Number: 684 • 2013 ACR/ARHP Annual Meeting
Clinical Characteristics Of Scleroderma Patients With Calcinosis In a Single-Center Cohort
Clinical characteristics of scleroderma patients with calcinosis in a single-center cohort Background/Purpose: Calcinosis is soft tissue deposition of calcium hydroxyapatite crystals in scleroderma spectrum disorder…Abstract Number: 685 • 2013 ACR/ARHP Annual Meeting
Lung Function and Survival In Systemic Sclerosis Associated Interstitial Lung Disease
Background/Purpose: We sought to assess for an association between baseline forced vital capacity (FVC) and diffusion capacity (DLCO) with mortality, and to identify threshold values…Abstract Number: 686 • 2013 ACR/ARHP Annual Meeting
Blood Flow In The Hands Of a Predefined Homogeneous Systemic Sclerosis Population: The Presence Of Digital Ulcers and The Improvement With Bosentan
Background/Purpose: Digital ulcers (DU) are complications of systemic sclerosis (SSc) and arise as a result of ischaemia due to vasculopathy of the digital arteries (1).…Abstract Number: 643 • 2013 ACR/ARHP Annual Meeting
Potential Immunopathological Roles Of The Novel Anti-Inflammatory Cytokine Interleukin-35 In Patients With Systemic Lupus Erythematous
Background/Purpose: IL-35, a dimeric protein with two subunits, IL-12A (p35) and Epstein-Barr virus induced 3, is a novel IL-12 cytokine family regulatory T-cells (Treg)-specific immunosuppressive/anti-inflammatory…Abstract Number: 644 • 2013 ACR/ARHP Annual Meeting
Expansion Of CD4+CXCR3+ T Cells In Patients With Systemic Lupus Erythematosus (SLE) Correlates With Subclinical Atherosclerosis
Background/Purpose: The mechanisms for accelerated atherosclerosis in SLE remain unclear. As atherosclerosis is itself immune-mediated, features of SLE-associated immunity might explain accelerated cardiovascular disease beside traditional…Abstract Number: 645 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Blood and Kidney Biopsies From Chinese Patients With Lupus Nephritis Reveals Concordant Activation Of Type I IFN Signaling In The Blood and Kidney, Reduced B Cell Presence In The Blood, and Increased Macrophages In The Kidney
Background/Purpose: Up-regulated expression of type I interferon-regulated genes has consistently been observed within the peripheral blood in a large proportion of patients with active systemic…Abstract Number: 646 • 2013 ACR/ARHP Annual Meeting
Expression Of Interferon-Inducible Gene (Lymphocyte Antigen 6 Complex Locus E) In Systemic Lupus Erythematosus Patients and Its Association With Disease Activity
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear and other autoantibodies, generation of…Abstract Number: 647 • 2013 ACR/ARHP Annual Meeting
Enhanced Expression of CCR Receptors in Healthy AA and SSc ILD Monocytes
Background/Purpose: Scleroderma-associated Interstitial Lung Disease (SSc ILD) is more prevalent and more severe in African Americans (AA) than in Caucasian (C) patients, but little is…Abstract Number: 648 • 2013 ACR/ARHP Annual Meeting
A Possible Contribution of Inducible Costimulator to the Development of Skin Sclerosis and Interstitial Lung Disease in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous disorder characterized by excessive fibrosis and microvascular damage of the skin and various internal organs. Cutaneous mononuclear cell…Abstract Number: 649 • 2013 ACR/ARHP Annual Meeting
Altered BMP Signalling In a TGFβ Dependent Murine Model Of Scleroderma May Contribute To Development Of Pulmonary Arterial Hypertension
Background/Purpose: Pulmonary arterial hypertension associated is an important complication of scleroderma (PAH-SSc) and has a poor prognosis compared to idiopathic (iPAH) or heritable (hPAH) forms…Abstract Number: 650 • 2013 ACR/ARHP Annual Meeting
Parental Influence On Systemic Sclerosis
Background/Purpose: A genealogic resource, the Utah Population Database (UPDB) has successfully identified systemic sclerosis (SSc) pedigrees and hereditable risk for this disease (1). We hypothesized…Abstract Number: 651 • 2013 ACR/ARHP Annual Meeting
Growth Differentation Factor-15, a Marker Of lung disease In Systemic Sclerosis, Is Involved In Fibrosis Development But Does Not Impair Fibrosis Development
Background/Purpose: It is generally known that members of the TGF-β superfamily are involved in the regulation of connective tissue biology in systemic sclerosis (SSc). Growth…Abstract Number: 652 • 2013 ACR/ARHP Annual Meeting
Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis
Background/Purpose: Pirfenidone (5-methyle-1-phenyl-2- [1H]-pyridone) and BIBF1120 (Nintedanib) are currently evaluated in clinical trials as a potential idiopathic pulmonary fibrosis (IPF). Pirfenidone was approved as the…Abstract Number: 653 • 2013 ACR/ARHP Annual Meeting
Norepinephrine-Induced IL-6 Regulates Fibrosis In Systemic Sclerosis
Background/Purpose: Raynaud phenomenon is freaquently observed in patients of systemic sclerosis (SSc) and characterized by episodic vasospasm and ischemia of extremities in response to cold or…Abstract Number: 654 • 2013 ACR/ARHP Annual Meeting
Effects Of Macitentan and Its Active Metabolite In Modulating Extracellular Matrix Synthesis In Cultured Human Systemic Sclerosis and Normal Skin Fibroblasts
Background/Purpose: Endothelin-1 (ET-1) has been shown to activate myofibroblasts and to enhance the synthesis of extracellular matrix proteins (ECM), such as collagen type I (COL-1)…