Abstracts Archive - Page 2204 of 2607 - ACR Meeting Abstracts

Abstract Number: 449 • 2014 ACR/ARHP Annual Meeting
Citrullinated-Vimentin-Specific Regulatory T-Cell Responses Associate with ACPA Positive Individuals with Non-Specific Musculoskeletal Symptoms
Aamir Aslam¹, Jackie L. Nam¹, Laura Hunt¹, Chadi Rakieh¹, Ann W. Morgan² and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: The pathogenesis of RA can be conceptualised by sequential phases that precede the development of synovitis. Autoimmune antibody responses, including ACPA, can precede clinical…
Abstract Number: 448 • 2014 ACR/ARHP Annual Meeting
Citrulline-Specific Autoimmunity Resides in Quiescent Circulating Memory B Cells in Rheumatoid Arthritis
Adam Pelzek, Caroline Grönwall, Jeffrey D. Greenberg and Gregg J. Silverman, Medicine, New York University School of Medicine, New York, NY
Background/Purpose . The detection of anti-citrullinated protein antibodies (ACPA) aids RA diagnosis, while B cell depletion by anti-CD20 can provide clinical benefits. We therefore undertook…
Abstract Number: 447 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Factor Isotypes in Relation to Antibodies Against Citrullinated Peptides in Individuals before Onset of Rheumatoid Arthritis
Mikael Brink¹, Monika Hansson², Linda Mathsson-Alm³, Johan Rönnelid³, Lars Klareskog² and Solbritt Rantapää-Dahlqvist⁴, ¹Public Health & Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Public Health & Clinical Medicine/Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden
Background/Purpose The presence of rheumatoid factor (RF) and antibodies against citrullinated peptides (ACPA) has been shown to precede the development of rheumatoid arthritis (RA) by…
Abstract Number: 453 • 2014 ACR/ARHP Annual Meeting
In a Periodontal Disease Cohort without RA, Indeterminate or Low-Positive Anti-CCP-2 Antibodies Are Associated with Multiple Distinct ACPA
Jerry A. Molitor¹, Bryan S. Michalowicz², Ryan T. Demmer³, Jane H. Buckner⁴, Mark H. Wener⁵ and William H. Robinson⁶, ¹Rheumatology, University of Minnesota, Minneapolis, MN, ²Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ³Epidemiology, Columbia Univ. Mailman School of Public Health, New York, NY, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁵Rheumatology & Lab Med, University of Washington, Seattle, WA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Periodontal disease (PD) and RA share the risk factors HLA DR B1 shared epitope (SE) and tobacco exposure (TE). PD may represent a risk…
Abstract Number: 426 • 2014 ACR/ARHP Annual Meeting
Exploring the DAS: What Is the Level of Agreement in the Classification of Remission and Low Disease Activity (LDA) Among the Various Versions of the Disease Activity Score (DAS) and Their Correlation? an Analysis from a Prospective, Observational Registry
WG Bensen¹, Edward Keystone², Philip Baer³, Jude Rodrigues⁴, J. Antonio Avina-Zubieta⁵, Wojciech Olszynski⁶, Denis Choquette⁷, Suneil Kapur⁸, Manisha Mulgund⁹, John S. Sampalis¹⁰, Emmanouil Rampakakis¹⁰, Francois Nantel¹¹, Allen J Lehman¹², May Shawi¹¹ and Susan Otawa¹², ¹St Josephs Hospital and McMaster University, Hamilton, ON, Canada, ²Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ³Private Practice, Scarborough, ON, Canada, ⁴Clinical Research and Arthritis Centre, Windsor, ON, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁶University of Saskatchewan, Saskatoon, SK, Canada, ⁷Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁸Rheumatology, University of Ottawa, Ottawa, ON, Canada, ⁹Private Practice, Hamilton, ON, Canada, ¹⁰JSS Medical Research, Montreal, QC, Canada, ¹¹Janssen Inc., Toronto, ON, Canada, ¹²Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Two versions of DAS28 are available, DAS28-4 comprising 4 variables [tender and swollen joint counts, acute phase reactant (APR), and patient global assessment] and…
Abstract Number: 423 • 2014 ACR/ARHP Annual Meeting
Circulating Anti-Citrullinated Peptide Antibodies and Cytokines As Biomarkers of Response to Disease-Modifying Antirheumatic Drugs Therapy in Early Rheumatoid Arthritis
Mahmood MTM Ally¹, Pieter Meyer², Bridget Hodkinson³, Eustasius Musenge⁴, Gregory Tintinger², Mohammed Tikly⁵ and Ronald Anderson¹, ¹University of Pretoria, Pretoria, South Africa, ²university of pretoria, pretoria, South Africa, ³Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ⁴University of Witwatersrand, Johannesburg, South Africa, ⁵Rheumatology Wits University, C H Baragwanath Hospital, Johannesburg, South Africa
Background/Purpose Serial measurement of circulating anti-citrullinated peptide antibodies (ACPA) and cytokines is of potential importance in the management of patients with rheumatoid arthritis (RA). However,…
Abstract Number: 424 • 2014 ACR/ARHP Annual Meeting
The Comparison Between Physical and Ultrasound Joint Examination for the Hand Joints in Patients with Rheumatoid Arthritis
Norihide Hayashi¹, Takehisa Ogura², Ayako Hirata², Rie Kujime³, Munetsugu Imamura¹, Sayaka Takenaka³, Kennosuke Mizushina³, Sumie Nakahashi³, Hideki Ito¹, Naoko Yamashita³ and Hideto Kameda¹, ¹Div Rheumatol, Dep Intern Med, Toho Univ, Tokyo, Japan, ²Department of Rheumatology, Toho Univ, Tokyo, Japan, ³Toho Univ, Tokyo, Japan
Background/Purpose To establish the importance of joint examination by ultrasound (US) in daily clinical practice of patients with rheumatoid arthritis (RA), we compared the US…
Abstract Number: 425 • 2014 ACR/ARHP Annual Meeting
Beyond Disease Activity: Patient Global Scores Also Reflect Treatment Expectations and Emotional Reactions to Living with Rheumatoid Arthritis
Susan J. Bartlett¹, Maria Celia Bazan Bardales² and Ines Colmegna³, ¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ²Rheumatology, McGill University, Montreal, QC, Canada, ³Rheumatology, McGill University - Royal Victoria Hospital, Montreal, QC, Canada
Background/Purpose: Illness perceptions (IP) are the beliefs and expectations that an individual has about medical conditions. IP have been found to cluster around five coherent…
Abstract Number: 422 • 2014 ACR/ARHP Annual Meeting
Correlation of RAPID3, DAS28 and CDAI in Disease Activity and Effects of Education Level and Co-Morbid Diseases on This Assesment in RA
Kubilay Sahin¹, Yasar Karaaslan^2,3, Zeynep Ozbalkan¹, Ahmet Omma¹ and Nesibe Yesil¹, ¹Rheumatology, Ankara Numune Education and Research Hospital, Ankara, Turkey, ²Rheumatology, Hitit University, Corum, Turkey, ³Ankara Numune Training and Research Hospital, Ankara, Turkey
Background/Purpose RAPID3 is an activity index based on only the patient's report in RA. It doesn’t require joint counts and it isn’t time consuming. Therefore…
Abstract Number: 421 • 2014 ACR/ARHP Annual Meeting
Prediction of Remission By Patients and Physicians: Does the Doctor Know Best?
WG Bensen¹, Boulos Haraoui², Carter Thorne³, Edward Keystone⁴, Michel Zummer⁵, Isabelle Fortin⁶, Rafat Faraawi⁷, Andrew Chow⁸, Milton Baker⁹, Niall Jones¹⁰, Emmanouil Rampakakis¹¹, John S. Sampalis¹¹, May Shawi¹², Francois Nantel¹², Allen J Lehman¹³ and Susan Otawa¹³, ¹St Josephs Hospital and McMaster University, Hamilton, ON, Canada, ²University of Montreal Hospital Centre, Montreal, QC, Canada, ³Southlake Regional Health Centre, Newmarket, ON, Canada, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Université de Montréal, Montreal, QC, Canada, ⁶Centre de Rhumatologie de l'Est du Québec, Rimouski, QC, Canada, ⁷Medicine, McMaster University, Hamilton, ON, Canada, ⁸McMaster University, Hamilton and Credit Valley Hospital, Mississauga, ON, Canada, ⁹University of Victoria, Victoria, BC, Canada, ¹⁰Dept of Rheumatology, University of Alberta, Edmonton, AB, Canada, ¹¹JSS Medical Research, Montreal, QC, Canada, ¹²Janssen Inc., Toronto, ON, Canada, ¹³Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Patient (PtGA) and physician (MDGA) assessment of global disease activity have been used as outcome measures individually or as part of composite scores in…
Abstract Number: 420 • 2014 ACR/ARHP Annual Meeting
Less Is More: The Shorter Physical Function Measure Promis-PF10a Outperforms HAQ in an Ethnically Diverse, Urban Rheumatoid Arthritis Clinic Population
Elizabeth R. Wahl¹, Andrew J. Gross², R Krishna Chaganti¹, Lianne S. Gensler³, Vladimir Chernitskiy¹, Laura Trupin², Patricia P. Katz² and Jinoos Yazdany², ¹Rheumatology, University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Patient-reported outcome measures are important tools that assess the impact of disease on patients' lives; in RA, patient-reported physical function is especially relevant. In…
Abstract Number: 419 • 2014 ACR/ARHP Annual Meeting
Comparative Dynamics of Rheumatoid Arthritis Disease Activity and Disease Severity Measures Using Rarbis, Ciras and DAS28 in a Population Based Cohort of Patients with RA
Arun K. Chandran¹, Cynthia S. Crowson², Birkan İlhan³, C. John Michet III¹, Eric L. Matteson¹ and Elena Myasoedova⁴, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey, ⁴Internal Medicine and Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: There is an extensive list of composite scores of rheumatoid arthritis (RA) activity status for the use in clinical practice including Disease Activity Score…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 437 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Heat Shock Protein 90 Antibodies Identified in Bronchoalveolar Lavage Fluid Are a Marker of Lung-Specific Immune Responses
Lisa Harlow¹, Bernadette Gochuico², Ivan Rosas³, Tracy Doyle⁴, Juan Osorio⁴, Timothy Travers⁵, Carlos Camacho⁶, Chester V. Oddis⁷ and Dana P. Ascherman⁸, ¹Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ²Medical Genetics Branch, National Institutes of Health, Bethesda, MD, ³Medicine/Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁴Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁵Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁶Compuational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Background/Purpose . Previous work has demonstrated an association between serum anti-citrullinated HSP90 antibodies and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). To further investigate this potential…
Abstract Number: 436 • 2014 ACR/ARHP Annual Meeting
Increasing Cartilage Turnover in Smokers Developing Rheumatoid Arthritis Is Associated with High Disease Activity in Early Disease
Carl Turesson¹, Christina Book², Ulf Bergström², Lennart Jacobsson^2,3 and Tore Saxne⁴, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, ⁴Dept of Rheumatology, Dept of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden
Background/Purpose Autoantibodies and other biomarkers of rheumatoid arthritis (RA) that may be detected years before disease onset in a subset of investigated individuals could be…

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