Abstracts Archive - Page 2191 of 2605 - ACR Meeting Abstracts

Abstract Number: 611 • 2014 ACR/ARHP Annual Meeting
Autophagy and Unfolded Protein Response: A Fine Balance That Can Influence the Pathogenesis of Ankylosing Spondylitis and Inflammatory Bowel Disease
Nigil Haroon¹, Giuliana Guggino², Zhenbo Zhang¹, Kirby Yee³, Hasan Abdullah⁴, Ricardo Alessandro⁵, Stefania Raimondo⁵, Giovanni Triolo⁵ and Francesco Ciccia², ¹Toronto Western Research Institute, Toronto, ON, Canada, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³McMaster University, Hamilton, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Palermo, Palermo, Italy
Background/Purpose We have shown an increase in the unfolded protein response (UPR) with decreased ERAP1 or ERAP2 function in an in vitrosystem. Similarly UPR has…
Abstract Number: 610 • 2014 ACR/ARHP Annual Meeting
Functional Implications of the Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Association with Ankylosing Spondylitis and Crohn’s Disease: Impact on the Unfolded Protein Response
Zhenbo Zhang¹, Francesco Ciccia², Kirby Yee³, Giuliana Guggino², Hasan Abdullah⁴, Ricardo Alessandro⁵, Stefania Raimondo⁵, Giovanni Triolo⁵ and Nigil Haroon^1,6,7, ¹Toronto Western Research Institute, Toronto, ON, Canada, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³McMaster University, Hamilton, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Palermo, Palermo, Italy, ⁶Rheumatology, University Health Network, Toronto, ON, Canada, ⁷Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) has found to be associated with AS and Crohn’s Disease (CD). The functional implications of this association have not…
Abstract Number: 609 • 2014 ACR/ARHP Annual Meeting
Induced Pluripotent Stem Cells (iPSCs) As a Tool for Unraveling the Role of Different Cell Types in the Disease Process of Spondyloarthritis Pathogenesis
Gerlinde Layh-Schmitt¹, Shjia Lu², Fatemeh Navid², Massimo Gadina² and Robert A. Colbert², ¹10 Center Drive., NIAMS/NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Many genetic factors and cell types contribute to the axial inflammation, trabecular bone loss, and aberrant bone formation that result in ankylosing spondylitis. The…
Abstract Number: 608 • 2014 ACR/ARHP Annual Meeting
Identification of Novel Autoantibodies in Patients with Ankylosing Spondylitis Using Human Protein Microarray
Matthew Presby¹, Mark J. Soloski¹, John A. Flynn², Clifton O. Bingham III¹, Michael M. Ward³ and Grant H. Louie⁴, ¹Johns Hopkins University, Baltimore, MD, ²Dept of Medicine, Johns Hopkins University, Baltimore, MD, ³Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Ankylosing spondylitis (AS) is an immune-mediated disease for which the search for autoantibodies has been elusive. Conventional immunoserological approaches are slow and limited…
Abstract Number: 607 • 2014 ACR/ARHP Annual Meeting
The HLA-B27 Peptidome in Vivo in Transgenic Rats
Joel D. Taurog¹, Yael Haimovich², Eilon Barnea³, Michal Bassani-Sternberg³, Shira Yair-Sabag², Martha L. Dorris¹, Nimman Satumtira¹, Mylinh Nguyen⁴, Robert E. Hammer⁴, Tri M. Tran⁵, Robert A. Colbert⁵ and Arie Admon³, ¹Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ²Technion-Israel Institute of Technology, Haifa, Israel, ³Biology, Technion-Israel Institute of Technology, Haifa, Israel, ⁴Biochemistry, UT Southwestern Medical Center, Dallas, TX, ⁵NIAMS/NIH, Bethesda, MD
Background/Purpose . In all current hypotheses for the association of B27 with SpA, the B27 peptide repertoire (peptidome) is likely to play a key role.…
Abstract Number: 605 • 2014 ACR/ARHP Annual Meeting
Decreased Frequencies of Circulating Follicular Helper T Cell Counterparts and Plasmablasts in Ankylosing Spondylitis Patients Naïve for TNF Blockers
M. Belén Bautista-Caro¹, Irene Arroyo-Villa¹, Concepcion Castillo-Gallego¹, Eugenio De Miguel², Diana Peiteado¹, Chamaida Plasencia-Rodriguez¹, Alejandro Villalba¹, Paloma Sanchez-Mateos³, Amaya Puig-Kröger⁴, Emilio Martín-Mola¹ and Maria Eugenia Miranda-Carus¹, ¹Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ²Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain, ³Immunology, Hospital Gregorio Marañon, Madrid, Spain, ⁴Laboratorio de Inmuno-Metabolismo, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
Background/Purpose: Follicular helper T cells (Tfh), localized in lymphoid organs, promote B cell differentiation and function. Circulating CD4 T cells expressing CXCR5, ICOS and/or PD-1…
Abstract Number: 604 • 2014 ACR/ARHP Annual Meeting
Characterisation of Mucosal-Associated Invariant T (MAIT) Cells in Ankylosing Spondylitis Patients
Ibrahim Almaghlouth¹, Eric Gracey², Zoya Qaiyum², Robert D. Inman³ and Ammepa Anton⁴, ¹Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Immunology, University of Toronto, Toronto, ON, Canada, ³Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose: Ankylosing spondylitis (AS) is chronic inflammatory disease of unknown origin. Studies into the molecular basis of AS have demonstrated exaggerated innate and adaptive immune…
Abstract Number: 603 • 2014 ACR/ARHP Annual Meeting
Periostin May Have a Role in Ankylosing Spondylitis and It Is Associated with Wnt Signalling Pathway Regulators
Servet Akar¹, Saadettin Uslu², Leyla Didem Kozaci³, Gercek Can⁴, Neslihan Karaca⁵, Emine Figen Tarhan⁴, Mustafa Ozmen⁶ and Dilek Solmaz⁷, ¹Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine,, Izmir, Turkey, ²Department of Internal Medicine, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ³Department of Medical Biochemistry, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁴Internal Medicine Clinic, Division of Rheumatology, Izmir Ataturk Education and Reseach Hospital, Izmir, Turkey, ⁵Adnan Menderes University, Science Thecnology Research and Application Center, Aydin, Turkey, ⁶Internal Medicine Clinic, D,v,s,on of Rheumatology, Izmir Ataturk Education and Reseach Hospital, Izmir, Turkey, ⁷Department of Internal Medicine, Division of Rheumatology, Namik Kemal University School of Medicine, Tekirdag, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is a chronic rheumatic disease characterized by sacroiliac and spinal inflammationand new bone formation (syndesmophyte). Molecular mechanisms underlying this process have…
Abstract Number: 602 • 2014 ACR/ARHP Annual Meeting
A Phase 3, Randomized, Controlled Trial of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, for Treatment of Psoriatic Arthritis: Long-Term (52-Week) Improvements in Physical Function
Alvin Wells¹, Jacob A. Aelion², Adewale O. Adebajo³, Alan Kivitz⁴, Paul Bird⁵, ChiaChi Hu⁶, Randall M. Stevens⁶ and Christopher J. Edwards⁷, ¹Rheumatology & Immunotherapy Center, Franklin, WI, ²West Tennessee Research Institute, Jackson, TN, ³University of Sheffield, Sheffield, United Kingdom, ⁴Altoona Center for Clinical Research, Duncansville, PA, ⁵Combined Rheumatology Practice, Kogarah, Australia, ⁶Celgene Corporation, Warren, NJ, ⁷University Hospital Southampton, Southampton, United Kingdom
Background/Purpose: Apremilast (APR) is a phosphodiesterase 4 inhibitor that helps regulate the immune response that causes inflammation and skin disease associated with psoriatic arthritis (PsA).…
Abstract Number: 601 • 2014 ACR/ARHP Annual Meeting
Combined Hip Abduction Angle Measured By Using Iphone Compass Application; A Novel Measurement Tool to Asses Hip Mobility
Handan Yarkan, Berrin Zengin, Gokce Kenar, Pinar Cetin, Ismail Sari, Fatos Onen and Nurullah Akkoc, Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey
Background/Purpose Intermalleolar distance (IMD) is a component of the Bath ankylosing spondylitis metrology index (BASMI) and measures abduction of the hips. New generations of smartphones…
Abstract Number: 600 • 2014 ACR/ARHP Annual Meeting
Differing Patterns of Axial Spondyloarthritis in Females and Males
Ibrahim Almaghlouth^1,2, Arane Thava³, Nigil Haroon⁴ and Robert D. Inman⁵, ¹Internal medicine, University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, Toronto, ON, Canada, ⁴Toronto Western Research Institute, Toronto, ON, Canada, ⁵Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Sex effects have been noted in axial spondyloarthritis (AS) however controversy still exists regarding male and female clinical manifestations of AS. This includes uncertainty…
Abstract Number: 618 • 2014 ACR/ARHP Annual Meeting
A Gender Bias in Gut Microbiota of SKG Mice Colonized with a Limited Bacterial Consortium Associated with Severity of Spondyloarthritis and Ileitis Triggered By Beta-Glucan
Linda Rehaume, Olga Zbarskaya, Alicia Kang, Helen Benham, Paraic O Cuiv, Mark Morrison and Ranjeny Thomas, University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose Beta-glucan (curdlan)-treated BALB/c ZAP-70W163C(SKG) mutant mice develop IL-23-dependent spondyloarthritis, and curdlan promotes ileitis in SKG mice housed under specific pathogen-free (SPF) but not germ-free…
Abstract Number: 619 • 2014 ACR/ARHP Annual Meeting
Effect of ERAP1 Knockdown on Conformation of HLA-B27 and Other HLA Class I Molecules in Human Monocytic Cells
Tri M. Tran¹, Sohee Hong¹, Jehad H. Edwan² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS NIH, Bethesda, MD
Background/Purpose Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with ankylosing spondylitis, Behcet’s disease, and psoriasis/psoriatic arthritis, where HLA class I alleles are…
Abstract Number: 617 • 2014 ACR/ARHP Annual Meeting
Shared HLA Class I and II Alleles in Susceptibility to Ankylosing Spondylitis Among Three Ethnic Groups
Mark Hwang¹, Xiaodong Zhou², Michael H. Weisman³, Michael M. Ward⁴, Jiucun Wang⁵, Lianne S. Gensler⁶, Hejian Zou⁵, Dongyi He⁷, Matthew A. Brown⁸, Paul Scheet⁹ and John D. Reveille^10,11, ¹Medicine, University of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁵Rheumatology, Huashan Hospital, Shanghai, China, ⁶Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷No.540 xinhua Road .Shanghai, Shanghai Guanghua Hospital, Shanghai, China, ⁸University of Queensland Diamantina Institute, Brisbane, Australia, ⁹MD Anderson Cancer Center, Houston, TX, ¹⁰Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹¹Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose : The purpose of this study is to examine associations of HLA class I and class II alleles with AS in different patients populations of…
Abstract Number: 606 • 2014 ACR/ARHP Annual Meeting
The Immunological Basis of the Sex-Bias in Ankylosing Spondylitis: Th17 Expansion Is Restricted to Male Patients and Correlates with Sex-Related Alteration in Vitamin D Metabolism
Eric Gracey^1,2, Blerta Green², Paul Yip³, Renise Ayearst⁴, Ammepa Anton⁵, Aifeng Lin² and Robert D. Inman⁶, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, University Health Network, Toronto, ON, Canada, ³Clinical Biochemistry, University Health Network, Toronto, ON, Canada, ⁴University Health Network, Toronto, ON, Canada, ⁵Rheumatology, University Health Network, Toronto, ON, Canada, ⁶Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose : Ankylosing spondylitis (AS) is an inflammatory arthritis of the spine, which has a major impact on function and quality of life. AS is…

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