Abstract Number: 924 • 2013 ACR/ARHP Annual Meeting
B Cell Subsets and Dysfunction Of Regulatory B Cells In IgG4-Related Diseases and Primary Sjögren Syndrome: The Similarities and Differences
Background/Purpose: IgG4 related disease (IgG4-RD) is a chronic, multisystem-involved autoimmune disease. Abnormally activated and differentiated B cells may play important roles. Regulatory B cells (Breg)…Abstract Number: 925 • 2013 ACR/ARHP Annual Meeting
B Cell Subset Phenotypes In Patients With Granulomatosis With Polyangiitis (Wegener’s)
Background/Purpose: B cells are pathogenic in granulomatosis with polyangiitis (Wegener’s) (GPA). Rituximab (RTX), an anti-CD20 monoclonal antibody, is effective therapy however B cell reconstitution patterns…Abstract Number: 926 • 2013 ACR/ARHP Annual Meeting
Autoantibodies to the Th/To Complex Are the Most Common Antibodies in Systemic Sclerosis (SSc) Patients Without Other Autoantibodies
Background/Purpose: Antinuclear antibodies (ANA) play an important role in the diagnosis of systemic sclerosis (SSc) being present in about 80-90% of the patients. In the…Abstract Number: 927 • 2013 ACR/ARHP Annual Meeting
The Role of HIF-1 and HIF-2 During Angiogenesis and Metabolic Adaptation of Human Microvascular Endothelial Cells Towards Hypoxia
Background/Purpose: Hypoxia is a feature of RA synovitis. In the present study, we focused on the two transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2.…Abstract Number: 888 • 2013 ACR/ARHP Annual Meeting
Role of Calcium/Calmodulin Kinase IV On Podocyte Function in Lupus Nephritis
Role of calcium/calmodulin kinase IV on podocyte function in lupus nephritis Background/Purpose: Kidney podocytes and their slit diaphragms settle the integrity of renal basement membrane…Abstract Number: 889 • 2013 ACR/ARHP Annual Meeting
Podocytes Take Up Adsdna Autoantibody Complexes
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, resulting in inflammation and tissue damage in several organs. This autoimmune reaction is caused by autoantibodies,…Abstract Number: 890 • 2013 ACR/ARHP Annual Meeting
Quantitative Cell Distance Mapping In Human Nephritis Reveals Organization Of In Situ Adaptive Immune Responses
Background/Purpose: Inflammatory infiltrates contain multiple cell types that could interact in myriad ways to amplify in situ immune responses. However, there currently are no methods…Abstract Number: 891 • 2013 ACR/ARHP Annual Meeting
A Single Amino Acid In The β1 Chain Of HLA-DR Explains The Majority Of The HLA Association With Giant Cell Arteriti
Background/Purpose: Giant cell arteritis (GCA) is a polygenic inflammatory disease affecting medium- and large-sized blood vessels in people elder than 50-years old. Although it is…Abstract Number: 892 • 2013 ACR/ARHP Annual Meeting
The Functional PTPN22 Variant R620W Is Strongly Associated With Giant Cell Artetitis Predisposition
Background/Purpose: The PTPN22/CSK signaling represents one of the common susceptibility pathways in autoimmunity. Considering that the genetic basis of giant cell arteritis (GCA), an autoimmune…Abstract Number: 893 • 2013 ACR/ARHP Annual Meeting
Association Between Human Leukocyte Antigen-B’s Amino Acid Variation and Disease-Susceptibility To Takayasu’s Arteritis
Background/Purpose: HLA-B52 and HLA-B51 are frequently seen in Asian population and are almost identical except two amino acid residues(the 63rd and 67th), but HLA-B52 is…Abstract Number: 894 • 2013 ACR/ARHP Annual Meeting
Intermittent Fever, Immune Dysregulation, and Systemic Vasculopathy Due To Loss-Of-Function Mutations In Adenosine Deaminase2
Background/Purpose: We observed a syndrome characterized by intermittent fevers and livedoreticularis, systemic inflammation, hepatosplenomegaly, cytopenias, vasculopathy, and early-onset lacunar strokes in five unrelated patients. We…Abstract Number: 895 • 2013 ACR/ARHP Annual Meeting
The Relative Risk Of Aortic Aneurysm In Patients With Giant Cell Arteritis Compared With The General Population
Background/Purpose: To evaluate the risk of aortic aneurysm in patients with giant cell arteritis (GCA) when compared with age, gender and location matched controls from…Abstract Number: 896 • 2013 ACR/ARHP Annual Meeting
Increased Rho Kinase (ROCK) Activity In Temporal Artery Biopsies From Patients With Giant Cell Arteritis (GCA)
Background/Purpose: ROCKs are implicated in the pathogenesis of many vascular diseases. ROCK activation is associated with Th17 differentiation and production of Th17-associated cytokines, IL-17 and…Abstract Number: 897 • 2013 ACR/ARHP Annual Meeting
Characterization Of Low Back Symptoms In a Community-Based Sample Of Older Adults: The Johnston County Osteoarthritis Project
Background/Purpose: The majority of research in low back pain has focused on the middle-aged segment of the population. As such, there is a gap in…Abstract Number: 898 • 2013 ACR/ARHP Annual Meeting
Sex-Specific Employment Participation Restriction Across Occupational Groups Among Working-Age (18-64 years) U.S. Adults With and Without Arthritis
Background/Purpose: Previous research has shown arthritis-attributable work limitation to be high (~30%) among U.S. adults with arthritis and for employment to be ~20% lower among…