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  • Abstract Number: 700 • 2014 ACR/ARHP Annual Meeting

    Decreased Lung Diffusion Capacity in Asymptomatic Patients with Systemic Lupus Erythematosus Does Not Predict Future Lung Disease

    Ofir Elalouf1, Elizabeth Fireman2, David Levartovsky1, Ilana Kaufman1, Ori Rogovski3, Ori Elkayam1, Dan Caspi1 and Daphna Paran1, 1Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 2Pulmonary and Allergic diseases, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Internal Medicine ward, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Background/Purpose In a previous study, performed 9±3.6 years ago 74 asymptomatic patients with systemic lupus erythematosus (SLE) and or antiphospholipid syndrome (APS) who fulfilled the…
  • Abstract Number: 719 • 2014 ACR/ARHP Annual Meeting

    Target Modulation of a Type I Interferon (IFN) Gene Signature with Sifalimumab or Anifrolumab in Systemic Lupus Erythematosus (SLE) Patients in Two Open Label Phase 2 Japanese Trials

    Chris Morehouse1, Linda Chang2, Liangwei Wang3, Philip Brohawn1, Shinya Ueda4, Gabor Illei5, Warren Greth3, Stephen Yoo6, Lorin Roskos7, Yihong Yao8, Gabriel Robbie9 and Brandon W. Higgs1, 1Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 2Translational Sciences, MedImmune, Hayward, CA, 3MedImmune, LLC, Gaithersburg, MD, 4PK, Astrazeneca, Osaka, Japan, 5Clinical Development, Medimmune, Gaithersburg, MD, 6Clinical Development, MedImmune, LLC, Gaithersburg, MD, 7One MedImmune Way, Medimmune, Gaithersburg, MD, 8Translational Sciences, MedImmune, Gaithersburg, MD, 9Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, MD

    Background/Purpose The pharmacokinetic (PK) and pharmacodynamic (PD) effects of two investigational monoclonal antibodies inhibiting type I IFN signaling -  sifalimumab or anifrolumab, specific for IFN-α…
  • Abstract Number: 718 • 2014 ACR/ARHP Annual Meeting

    Safety of Gardasil® Vaccine in Systemic Lupus Erythematosu, Trial Update

    J. Patricia Dhar1,2, Lynnette Essenmacher3, Renee Dhar4,5, Ardella Magee6, Harpreet Sagar2, Malini Venkatram7 and Robert Sokol8, 1Internal Medicine, Central Michigan University College of Medicine, Saginaw, MI, 2Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, 3Wayne State University, Detroit, MI, 4Clinical Research Center, Wayne State University, Detroit, MI, 5CMED medical student,, Central Michigan University College of Medicine, Mount Pleasant, MI, 6Clinical Research Center, Wayne State University, Detroit, MI, 7Division of Rheumatology, Wayne State University, Detroit, MI, 8Obstetrics and Gynecology, Wayne State University, Detroit, MI

    Background/Purpose: Cervical neoplasia is increased in women with SLE presumably due to cervical infection with oncogenic Human Papillomavirus (HPV) types which persist in an immunosuppressed…
  • Abstract Number: 717 • 2014 ACR/ARHP Annual Meeting

    Comparison of Responsiveness of Lupus Impact Tracker with Lupus Quality of Life to Selena Responder Index

    Hervé Devilliers1, Narender Annapureddy2, Winston Sequeira3, Joel A Block4 and Meenakshi Jolly2, 1Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, 2Rheumatology, Rush University Medical Center, Chicago, IL, 3rush university, chicago, IL, 4Rush University, Chicago, IL

    Background/Purpose: Lupus Impact Tracker (LIT) is a 10-item patient reported outcome tool to measure the impact of Systemic Lupus Erythematosus (SLE) or its treatment on…
  • Abstract Number: 716 • 2014 ACR/ARHP Annual Meeting

    Simple Disease Assessment for People with Lupus Erythematosus

    Meenakshi Jolly1, Winston Sequeira2, Sergio Toloza3, Ana M. Bertoli4, Luis M. Vilá5, Ivana Blazevic6, Ioana Moldovan7, Karina D Torralba8, Berna Goker9, Josiane Bourré-Tessier10, Sandra V. Navarra11, Daniel Wallace12, Michael H. Weisman13, Ann E. Clarke14, Chi Chiu Mok15 and Joel A. Block1, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Medicine/Rheumatology, Rush University, Chicago, IL, 3Hospital San Juan Bautista, San Fernando del Valle de Catamarca, Argentina, 4Instituto Reumatológico Strusberg, Cordoba, Cordoba, Argentina, 5Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 6University of Buenos Aires, Buenos Aries, Argentina, 7Rheumatology, Beaver Medical Group, Redlands, CA, 8University of Southern California, LA, CA, 9Department of Internal Medicine- Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 10Department of Medicine, Division of Rheumatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 11University of Santo Tomas Hospital, Manila, Philippines, 12UCLA, LA, CA, 13Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 14Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 15Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose: Community rheumatologists treating patients with Systemic Lupus Erythematosus (SLE) typically lack user-friendly tools to effectively track SLE disease activity. Current disease activity tools in…
  • Abstract Number: 715 • 2014 ACR/ARHP Annual Meeting

    The REAL Life with Lupus Study: Developing a Patient Reported Outcome Measure for Use in Clinical Trials and Clinical Care

    R. Paola Daly1, Sarah Gilman2, Joan T. Merrill3, Leslie M. Hanrahan4, Alisha Ladenburg2 and Anca Askanase5, 1Research & Education, Lupus Foundation of America, Washington, DC, 2Lupus Foundation of America, Washington, DC, 3Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Education & Research, Lupus Foundation of America, Washington, DC, 5Columbia University Medical Center, New York, NY

    Background/Purpose: The goal of this study is to better understand how people with systemic lupus erythematosus (SLE) in the United States experience the disease. Results…
  • Abstract Number: 714 • 2014 ACR/ARHP Annual Meeting

    The Validity of Patient and Physician Global Disease Activity Assessments of Systemic Lupus Erythematosus: Results from the Lupus Activity Scoring Tool (LAST) As Compared to the Selena Sledai (SS) Modification Multicentre Study

    Majed Khraishi1, Rana Aslanov2, Sanjay Dixit3, Ramin Yazdani4, Vandana Ahluwalia5 and Sarah Khraishi6, 1Nexus Clinical Research, St John's, NF, Canada, 2Clinical Epidemiology Department, Faculty of Medicine, Memorial University of Newfoundland, St.John's, NF, Canada, 3McMaster University, Hamilton, ON, Canada, 4Rheumatology, St. Clare' Mercy Hospital, St. John's, NF, Canada, 5Rheumatology, William Osler Health Center, Brampton, ON, Canada, 6NL Research Technologies (NLRT), St. John's, NF, Canada

    Background/Purpose In our centre, new tools for the assessment of SLE activity: the  Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST)…
  • Abstract Number: 713 • 2014 ACR/ARHP Annual Meeting

    Lupuspro Is Responsive to Changes in Disease Activity over Time

    David Giangreco1, Hervé Devilliers2, Narender Annapureddy1, Joel A. Block3 and Meenakshi Jolly1, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, 3Section of Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Patient reported outcome (PRO) tools are important to understand, educate, manage, and follow patients with systemic lupus erythematosus (SLE). Disease targeted PRO for SLE…
  • Abstract Number: 712 • 2014 ACR/ARHP Annual Meeting

    Mapping the Disease-Specific Lupusqol to the SF-6D

    Rachel Meacock1, Mark Harrison2, Kathleen McElhone3, Janice Abbott4, Sahena Haque5, Ian N. Bruce6 and Lee- Suan Teh7, 1Centre for Health Economics, The University of Manchester, Manchester, United Kingdom, 2University of British Columbia, Vancouver, BC, Canada, 3Royal Blackburn Hospital, Blackburn, United Kingdom, 4University of Central Lancashire, Preston, United Kingdom, 5University Hospital of South Manchester, Manchester, United Kingdom, 6NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, 7Department of Rheumatology, Royal Blackburn Hospital, Blackburn, United Kingdom

    Background/Purpose: The LupusQoL is a measure of health-related quality of life (HRQoL) developed specifically to assess the impact of systemic lupus erythematosus (SLE) and its…
  • Abstract Number: 711 • 2014 ACR/ARHP Annual Meeting

    Is the Disease-Specific Lupusqol Sensitive to Changes of Disease Activity in SLE Patients after Treatment of a Flare?

    Kathleen McElhone1, Jane Burnell2, Chris Sutton2, Janice Abbott3, Peter Lanyon4, Anisur Rahman5, Chee-Seng Yee6, Mohammed Akil7, Yasmeen Ahmad8, Ian Bruce9, Caroline Gordon10 and Lee-Suan Teh11, 1Rheumatology, Royal Blackburn Hospital, Blackburn, United Kingdom, 2School of Health, University of Central Lancashire, Preston, United Kingdom, 3University of Central Lancashire, Preston, United Kingdom, 4Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, 5Centre for Rheumatology Research, University College London, London, United Kingdom, 6Department of Rheumatology, Doncaster and Bassetlaw Hospitals NHS Foundation Trust, Doncaster, United Kingdom, 7Sheffield Center Rheumatic Dis, Sheffield South Yorkshire, United Kingdom, 8Department of Rheumatology, Peter Maddison Research Centre, Bangor, United Kingdom, 9Kellgren Centre for Rheum, Arthritis Research UK Epidemiology Unit, Institution of Inflammation and Repair, University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 10Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 11Department of Rheumatology, Royal Blackburn Hospital, Blackburn, United Kingdom

    Background/Purpose With improving survival in SLE patients, patient-reported health-related quality of life (HRQoL) has become an important outcome.  The LupusQoL is a disease-specific patient-derived HRQoL measure…
  • Abstract Number: 710 • 2014 ACR/ARHP Annual Meeting

    Splenectomy in Systemic LUPUS Erythematosus and  AUTOIMMUNE Hematological Diseases. a Comparative Analysis

    Luis J. Jara1, Nahim Barron2, Jesús Arenas-Osuna3, Arturo Vélazquez-García4, Arturo González-Zúñiga4, Miguel A Saavedra5 and Pilar Cruz-Domínguez6, 1Direction of Education and Research, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico, 2General Surgery, Hospital de Especialidades Centro Médico La Raza, México, Mexico, 3Division of Education, Hospital de Especialidades Centro Médico La Raza, Mexico, Mexico, 4General Surgery, Hospital de Especialidades Centro Médico La Raza, Mexico, Mexico, 5Reumathology, Hospital de Especialidades Centro Médico La Raza, Mexico, Mexico, 6Division of Research, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico

    Background/Purpose Acute presentation of severe autoinmune thrombocytopenia, and hemolytic anemia in systemic lupus erythematosus (SLE) is associated with high mortality. Splenectomy is the second line…
  • Abstract Number: 709 • 2014 ACR/ARHP Annual Meeting

    Impact of Sleep Disorders in Quality of Life, Pain and Disease Activity Using Actigraphy and  Pittsburgh Sleep Quality Index (PSQI)in Female with Systemic Lupus Ertyhematosus (SLE).

    Lilian Reis1, Marco Tulio de Mello2 and Virginia M. Trevisani3, 1Internal medicine and therapy, Federal University of Sao Paulo - UNIFESP, SAO PAULO, Brazil, 2Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil, 3Federal University of São Paulo, São Paulo Brazil, Brazil

    Background/Purpose Despite the fact that sleep disorders are poorly studied, they´re a frequent complain by patients with SLE (62 to 80% related) and others found…
  • Abstract Number: 708 • 2014 ACR/ARHP Annual Meeting

    Determining Risk Factors That Increase Hospitalizations in Patients with Systemic Lupus Erythematosis

    Hareth M. Madhoun1, Wael N. Jarjour2, Peter J. Embi3, Erinn M. Hade4 and W Neal Roberts Jr5, 1Rheumatology/Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 3Biomedical Informatics & Internal Medicine, The Ohio State University, Columbus, OH, 4College of Medicine Department of Biomedical Informatics, The Ohio State University Wexner Medical Center, Columbus, OH, 5Dept of Internal Medicine, Division of Rheumatology, University of Louisville, Louisville, KY

    Background/Purpose Systemic lupus erythematosis (SLE) is a complex heterogeneous disease which can be associated with significant morbidity and mortality. Hospitalization and readmissions have garnered significant…
  • Abstract Number: 707 • 2014 ACR/ARHP Annual Meeting

    Characteristics of Lupus Patients with Interstitial Lung Disease and Relationship with Jo-1 Antibody

    Samera Vaseer1, Judith A. James2, Aikaterini Thanou3 and Joan T. Merrill4, 1Rheumatology, University Of Oklahoma, Oklahoma City, OK, 2Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology Reseach Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose Pulmonary involvement is frequent in systemic lupus erythematosus (SLE) and can affect the pleura, pulmonary vasculature, and parenchyma. The prevalence of ILD is lower…
  • Abstract Number: 681 • 2014 ACR/ARHP Annual Meeting

    Hydroxychloroquine Use Is Associated Independently with Improved Quality of Life in Systemic Lupus Erythematosus

    Meenakshi Jolly1, Winston Sequeira2, Sarfraz Hasni3, Zulfiqar Ali4, Sergio Toloza5, Ana M. Bertoli6, Ivana Blazevic7, Luis M. Vila8, Ioana Moldovan9, Karina D Torralba10, Berna Goker11, Josiane Bourré-Tessier12, S. Navarra13, Daniel Wallace14, Michael H. Weisman15, Ann E. Clarke16 and Chi Chiu Mok17, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Medicine/Rheumatology, Rush University, Chicago, IL, 3NIH, BETHESDA, MD, 4NIH, Bethesda, MD, 5Hospital San Juan Bautista, San Fernando del Valle de Catamarca, Argentina, 6Instituto Reumatológico Strusberg, Cordoba, Cordoba, Argentina, 7University of Buenos Aires, Buenos Aries, Argentina, 8Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 9Rheumatology, Beaver Medical Group, Redlands, CA, 10University of Southern California, LA, CA, 11Department of Internal Medicine- Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 12Department of Medicine, Division of Rheumatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 13University of Santo Tomas Hospital, Manila, Philippines, 14UCLA, LA, CA, 15Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 16Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 17Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose: Hydroxychloroquine (HCQ) has been shown to be beneficial to patients with Systemic Lupus Erythematosus (SLE), however, its effects on the quality of life (QOL)…
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