ACR Meeting Abstracts

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  • Abstract Number: 953 • 2013 ACR/ARHP Annual Meeting

    Baseline Serum Interleukin-34 Levels Predict Radiographic Progression In Rheumatoid Arthritis Patients

    Sung Hae Chang1,2, Byoung Youg Choi3, Hyon Joung Cho4, Hye Jin Oh5, Eun Ha Kang3, Yeong Wook Song2,6 and Yun Jong Lee2,7, 1Internal Medicine Rheumatology, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 2Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 3Internal Medicine, Rheumatology, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 4Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 5Internal Medicine, Rheumatology, Seoul National University Hospital, Seoul, South Korea, 6Internal Medicine,Rheumatology, Seoul National University Hospital, Seoul, South Korea, 7Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea

    Background/Purpose: Interleukin-34 (IL-34), a novel cytokine playing a critical role in osteoclastogenesis, recently was reported that its expression increases in the synovial tissue and sera…
  • Abstract Number: 954 • 2013 ACR/ARHP Annual Meeting

    Correlating The In Vivo Production Of IFNγ To Disease Parameters In TLR9-Induced Macrophage Activation Syndrome (MAS) In Mice

    Vanessa Buatois1, Laurence Chatel1, Laura Cons1, Sabrina Lory1, Maureen Deehan1, Jennifer Sims2, Cristina de Min3, Marie Kosco-Vilbois1 and Walter Ferlin1, 1NovImmune S.A., Geneva, Switzerland, 2Integrated Biologix GmBH, Basel, Switzerland, 3Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland

    Background/Purpose: Cytokine release is the hallmark feature in mice given repeated injections of the TLR9 agonist, CpG-containing oligodeoxynucleotides (CpG-ODN), resulting in pathology resembling the human…
  • Abstract Number: 955 • 2013 ACR/ARHP Annual Meeting

    Myeloid Deletion Of SIRT1 Aggravates Serum Transfer Arthritis But Ameliorate Collagen-Induced Arthritis

    Sang-Il Lee1, Yun-Hong Cheon2, Won Seok Lee2 and Ji-Min Kim3, 1Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, 2Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea

    Background/Purpose: SIRT1 plays a pivotal role in regulating the inflammatory response. Thus, we assessed the role of SIRT1 in K/BxN serum transfer arthritis as a…
  • Abstract Number: 957 • 2013 ACR/ARHP Annual Meeting

    The Role Of S100A4 As a Biological Marker Of Immune Response In Early Rheumatoid Arthritis

    Lucie Andrés Cerezo1, Klára Prajzlerová2, Martina Remáková1, Herman F. Mann3, Michal Tomcík2, Karel Pavelka4, Jiri Vencovsky2 and Ladislav Senolt2, 1Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Institute of Rheumatology, Prague, Czech Republic, 2Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    Background/Purpose: We have previously demonstrated that S100A4 is up-regulated in established rheumatoid arthritis (RA) and that S100A4 regulates apoptosis and synthesis of matrix degrading enzymes…
  • Abstract Number: 958 • 2013 ACR/ARHP Annual Meeting

    Serum Cytokine Changes In Rituximab-Treated Rheumatoid Arthritis Patients

    Tamarah D. de Jong1, Saskia Vosslamber1, Wilco de Jager2, Hennie G. Raterman3, Alexandre E. Voskuyl4, Kyra A. Gelderman1 and Cornelis L. Verweij5, 1Pathology, VU University Medical Center, Amsterdam, Netherlands, 2Pediatric Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 4Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 5Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Although rituximab therapy is successful in the majority of rheumatoid arthritis (RA) patients, 30-40% of patients do not respond. The mechanism behind this is…
  • Abstract Number: 959 • 2013 ACR/ARHP Annual Meeting

    Interleukin 10 Negatively Correlates With Glycoprotein VI-Related Platelet Activation In Rheumatoid Arthritis (RA): A Novel Potential Target Of Cardiovascular Morbidity In RA

    Leann Bell1, Anne M. Madigan1, Paul A. MacMullan1, Eimear Dunne2, Paola M. Bagaglia1, Laura J. Durcan1, Dermot Kenny2 and Geraldine M. McCarthy1, 1Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, 2Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland

    Background/Purpose: Patients with rheumatoid arthritis (RA) die prematurely of cardiovascular disease (CVD). Platelet mediated thrombosis is a major cause of CVD.  Platelets amplify inflammation in RA via the collagen receptor,…
  • Abstract Number: 960 • 2013 ACR/ARHP Annual Meeting

    Self-Perceived Efficacy of a Workshop On Musculoskeletal Clinical Anatomy

    Miguel A. Saavedra1, José E. Navarro-Zarza2, J. Alvarez-Nemegyei3, Juan J. Canoso4, Robert A. Kalish5, Pablo Villaseñor-Ovies6 and Cristina Hernández-Díaz7, 1Rheumatology, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico, 2Mexican Taskforce for the Advancement of Clinical Anatomy, Mexico, Mexico, 3Instituto Mexicano del Seguro Social, Merida, Mexico, 4Medicine/Rheumatology, ABC Medical Center and Tufts University, Mexico City, Mexico, 5Div of Rheumatology, Tufts Medical Center, Boston, MA, 6Hospital Angeles Tijuana, Tijuana, Mexico, 7Musculoskeletal Ultrasound, Instituto Nacional de Rehabilitación, Mexico City, Mexico

    Background/Purpose: Knowledge of musculoskeletal anatomy is suboptimal at many levels of rheumatology training and practice. In a recent practical anatomy pre-test administered prior to a…
  • Abstract Number: 961 • 2013 ACR/ARHP Annual Meeting

    Assessment and Promotion of a National Immunology Curriculum for Adult Rheumatology Residents

    Dharini Mahendira1, Shirley L. Chow2, Sari Herman-Kideckel3 and Heather McDonald-Blumer4, 1Rheumatology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada, 2Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 3Allergy and Immunology, University of Toronto, North York, ON, Canada, 4Rheumatology, Division of Rheumatology, Mount Sinai Hospital; Osteoporosis Program, Toronto General Hospital, Toronto, ON, Canada

    Background/Purpose:  Immunologic mechanisms play an integral role in understanding the pathogenesis and management of rheumatic conditions. Currently, there is limited access to standardized formal instruction…
  • Abstract Number: 962 • 2013 ACR/ARHP Annual Meeting

    Electronic Learning Module Enhances Rheumatology Education

    Malini Juyal1, Avis Ware1, John Houk1 and Rina Mina2, 1Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, OH, 2Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Electronic-learning (e-learning) has recently increased in use. Blended learning combines e-learning with traditional training. At the University of Cincinnati Division of Rheumatology, only traditional…
  • Abstract Number: 963 • 2013 ACR/ARHP Annual Meeting

    Impact Of a Nurse-Led Program On Comorbidity Management In Rheumatoid Arthritis (RA): Results Of a Prospective, Multicenter, Randomized, Controlled Trial

    Martin Soubrier1, Elodie Perrodeau2, Melanie Gilson3, Alain G. Cantagrel4, Xavier le Loet5, René-Marc Flipo6, Sandrine Guis7, Gael Mouterde8, Liana E. Euller-Ziegler9, Thierry Schaeverbeke10, Bruno Fautrel11, Alain Saraux12, Isabelle Chary-Valckenaere13, Gérard Chales14, Emmanuelle Dernis15, Pascal Richette16, Xavier Mariette17, Francis Berenbaum18, Jean Sibilia19, Philippe Ravaud20 and Maxime Dougados21, 1Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, 2Epidemiologist, Paris, France, 3CH Grenoble Hopital Sud, Grenoble, France, 4Dept of Rheumatology, Hopital Purpan, Toulouse CEDEX 9, France, 5Rheumatology Department, CHU de ROUEN, Rouen, France, 6Hôpitaux Universitaires de Lille, France, France, 7Rheumatology1, CRMBM UMR CNRS 7339, Aix Marseille Univ; AP-HM, Marseille, France, 8Rheumatology, Montpellier 1 University, Lapeyronie Hospital, Montpellier, France, 9Service de Rhumatologie, L Archet Hospital (University), Nice CEDEX 3, France, 10Rhumatology departement, Groupe Hospitalier Pellegrin, Bordeaux, France, 11Rheumatology, UPMC - Paris 6 University, Paris, France, 12Rhumatologie, CHU de la Cavale Blanche, Brest Cedex, France, 13Rheumatology, Nancy Teaching Hospital, Nancy, France, 14CHU RENNES, Rennes, France, 15Centre Hospitalier, Le Mans, France, 16Centre Viggo Petersen / Service de Rhumatologie, Hôpital Lariboisière, Paris, France, 17Paris-Sud University, Paris, France, 18Rheumatology, AP-HP, St Antoine Hospital, Paris, France, 19Rheumatology, CHU Hautepierre, Strasbourg, France, 20Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 21Cochin Hospital, Paris, France

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk of developing numerous comorbid conditions that affect both mortality and RA outcome. Objectives: To…
  • Abstract Number: 964 • 2013 ACR/ARHP Annual Meeting

    Redesign Of a Rheumatology Curriculum For Internal Medicine Residents: Results Of Needs Assessment Survey

    Susan F. Kroop1, Cecilia P. Chung2 and Charlene M. Dewey3, 1Medicine/Rheumatology, Vanderbilt University Medical School, Nashville, TN, 2Medicine, Vanderbilt University, Nashville, TN, 3Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN

    Background/Purpose: We plan to improve internal medicine (IM) resident competence in caring for patients with rheumatologic disease and increase resident interest in rheumatology as a…
  • Abstract Number: 965 • 2013 ACR/ARHP Annual Meeting

    The “Mini-Residency” In Musculoskeletal Care: An Efficient and Effective Mixed Method Model For Continuing Professional Education

    Michael J. Battistone1, Andrea M. Barker2, Marissa Grotzke3, J Peter Beck4, Robert Z. Tashjian5, Timothy A. Huhtala6, Grant W. Cannon1 and Patrice Kennedy7, 1Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 2General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, 3Division of Endocrinology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 4Salt Lake City VA and University of Utah, Salt Lake City, UT, 5Division of Orthopaedics, Salt Lake City VA and University of Utah, Salt Lake City, UT, 6Division of General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, 7500 Foothill Boulevard, Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: The societal burden of musculoskeletal (MSK) disease is amplified by the limited number of subspecialists. Developing knowledge and skills of primary providers is projected…
  • Abstract Number: 966 • 2013 ACR/ARHP Annual Meeting

    Less Is More? A Targeted Intervention Results In Substantial Improvement In rheumatologists’ Ordering Of Anti Nuclear Antibodies (ANA) In Patients With Rheumatic Complaints

    Nienke Lesuis1, Ester Piek2, Hatice Demirel1, Ronald F. van Vollenhoven3 and Alfons A. den Broeder1, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Laboratory, Sint Maartenskliniek, Nijmegen, Netherlands, 3Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), the Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Anti-Nuclear Antibodies (ANA) are found both in patients with (non-)rheumatic diseases and in healthy controls1. ANA testing is useful in the diagnostic process of…
  • Abstract Number: 967 • 2013 ACR/ARHP Annual Meeting

    ‘Bending’ Ethical Norms To Serve Patients’ Interests:  Tensions In Medical Professionalism

    C. Ronald MacKenzie1, Inmaculada de Melo-Martin2, Michele Meltzer3 and Elizabeth A. Kitsis4, 1Medicine, Hospital for Special Surgery, New York, NY, 2Weill Cornell Medical College, New York, NY, 3Rheumatology, Jefferson Universtiy, Philadelphia, PA, 4Epidemiology & Medicine, Albert Einstein College of Med, Bronx, NY

    Background/Purpose: The rheumatic diseases are a common cause of short and long-term disability. Affecting all sectors of the population, they diminish wellbeing, affect quality of…
  • Abstract Number: 930 • 2013 ACR/ARHP Annual Meeting

    The Endocannabinoid Anandamide Modulates Adhesion, Proliferation and The Production Of Inflammatory Mediators In Rheumatoid Arthritis Synovial Fibroblasts By Activating CB1, TRPV1, TRPA1 and Non-Cannabinoid Receptor Targets

    Torsten Lowin, Angelika Graeber and Rainer H. Straub, Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany

    Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs…
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