Abstract Number: 933 • 2013 ACR/ARHP Annual Meeting
Characterizing The Expression and Function Of CCL28 and Its Corresponding Receptor CCR10 In The Pathogenesis Of RA
Background/Purpose: This study was conducted to determine the expression pattern and function of CCL28 and its corresponding receptor CCR10 in the pathogenesis of rheumatoid arthritis…Abstract Number: 934 • 2013 ACR/ARHP Annual Meeting
Interleukin-12B Is Up-Regulated By Decoy Receptor 3 In Specifically Rheumatoid Synovial Fibroblasts
Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand (FasL), LIGHT,…Abstract Number: 935 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptor Activates The Pro-Fibrotic Wnt / β-Catenin Signaling In Human Dermal Fibroblasts
Background/Purpose: Upon adenosine formation in stress conditions, the adenosine A2A Receptor (A2AR) activation promotes wound healing, but it is also detrimental in fibrotic conditions such…Abstract Number: 936 • 2013 ACR/ARHP Annual Meeting
Decreased Plasma Levels Of Soluble CD18 Link Leukocyte Migration and Disease Activity In Spondyloarthritis
Background/Purpose: Spondyloarthritis (SpA) comprise a group of diseases characterized by inflammation of the entheses and joints of the axial skeleton primarily driven by innate immune…Abstract Number: 937 • 2013 ACR/ARHP Annual Meeting
Inhibitor Of DNA Binding 1 Mediates Angiogenesis In Rheumatoid Arthritis By Recruitment Of Endothelial Progenitor Cells
Background/Purpose: Endothelial progenitor cells (EPCs) are known to induce vasculoproliferative responses within rheumatoid arthritis (RA) synovial tissue (ST). Inhibitor of DNA-Binding 1 (Id1) is a…Abstract Number: 938 • 2013 ACR/ARHP Annual Meeting
A Disintegrin and Metalloprotease-17 (ADAM-17) Is Expressed In Rheumatoid Arthritis and Mediates Monocyte Migration
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized byinflammation and joint destruction. Migration of monocytes/macrophages into the synovium is important in a variety…Abstract Number: 940 • 2013 ACR/ARHP Annual Meeting
Novel Function Of Soluble Interleukin-6 Receptor As An Antagonist Of Interleukin-27-Mediated Anti-Inflammatory Responses
Background/Purpose: The immunological roles of interleukin 27 (IL-27) have been reported in various rheumatic diseases, such as rheumatoid arthritis (RA), lupus, systemic sclerosis and psoriasis.…Abstract Number: 941 • 2013 ACR/ARHP Annual Meeting
Mir-34a In Rheumatoid Arthritis: Characterisation Of Elevated Synovial Expression and Association With Treatment Resistance
Background/Purpose: Cells of the monocyte/macrophage lineage are critical to RA pathogenesis: unravelling mechanisms underlying macrophage inflammatory gene expression should elucidate novel disease-associated pathways and thereby…Abstract Number: 942 • 2013 ACR/ARHP Annual Meeting
CXCL13 Is a Marker Of Joint Involvement In Early Rheumatoid Arthritis
Background/Purpose: CXCL13 is central in the formation of lymphoid follicles in secondary and tertiary lymphoid tissue. It attracts CXCR5-expressing B cells and follicular helper T…Abstract Number: 943 • 2013 ACR/ARHP Annual Meeting
Synergism Between Granulocyte-Macrophage Colony Stimulating Factor and Interleukin-17 Causes Joint Damage Via The Production Of Interleukin-23, Receptor Activator Of NF-κB Ligand and S100A8
Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…Abstract Number: 944 • 2013 ACR/ARHP Annual Meeting
Mir-125a: A Novel Regulator Of IL-6 and TLR Driven Pathways In RA Pathogenesis
Background/Purpose: Molecular mechanisms driving disease initiation and chronicity in RA are incompletely understood. There is increasing interest in the role played therein by microRNAs –…Abstract Number: 945 • 2013 ACR/ARHP Annual Meeting
Non-Canonical NF-Kappa B Signaling Enhances Angiogenesis In a Novel 3D Spheroid Model Of Rheumatoid Arthritis Synovial Inflammation
Background/Purpose: Angiogenesis plays a crucial role in rheumatoid arthritis (RA) synovitis and is regarded as a switch from acute to chronic inflammation. Previously, we have…Abstract Number: 946 • 2013 ACR/ARHP Annual Meeting
Interleukin-34 Regulates Angiogenesis and Cell Proliferation In Inflammatory Arthritis, This Effect Is Potentiated By Hypoxia
Background/Purpose: Interleukin-34 (IL-34) is a cytokine implicated in macrophage differentiation, angiogenesis and osteoclastogenesis in inflammatory arthritis (IA). IA is characterized by synovial hypoxia, increased oxidative…Abstract Number: 948 • 2013 ACR/ARHP Annual Meeting
Dual Neutralization Of TNF and IL-17 Provides Greater Efficacy In Collagen Induced Arthritis Through Regulation Of a Gene Transcription Program That Includes CXCL1 and CXCL5
Background/Purpose: Dual neutralization of TNF and IL-17 is hypothesized to provide greater efficacy in rheumatoid arthritis (RA) and inflammatory diseases compared to either monotherapy as…Abstract Number: 908 • 2013 ACR/ARHP Annual Meeting
Appearance Dissatisfaction, Social Discomfort, and Helplessness In Patients With Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a progressive, autoimmune disease with no known cure. It is related to a wide spectrum of adverse health outcomes including…