Abstracts Archive - Page 2174 of 2425 - ACR Meeting Abstracts

Abstract Number: 1137 • 2013 ACR/ARHP Annual Meeting
Evaluating Indeterminate Quantiferon-TB Gold In-Tube Results in Patients With Chronic Inflammatory Diseases On Immunosuppressive Therapy
Cassandra Calabrese¹, Robert A. Overman^2,3, Stacie Dusetzina⁴ and Rula Hajj-Ali⁵, ¹Cleveland Clinic, Cleveland, OH, ²Eshelman School of Pharmacy - Division of Pharmaceutical Policy and Outcomes, University of North Carolina, Chapel Hill, NC, ³Rheumatology, Cleveland Clinic, Cleveland, OH, ⁴Epidemiology, School of Medicine and Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Raleigh-Durham, NC, ⁵Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: The Quantiferon test (QFT) is used to for screen for tuberculosis in patients with autoinflammatory conditions (IC) prior to the use of immunosuppressant medications. …
Abstract Number: 1138 • 2013 ACR/ARHP Annual Meeting
Tuberculin Skin Test and Booster Phenomenon In a Rheumatoid Arthritis Population. Differences Between Early and Established Disease
Lorena Perez-Barbosa¹, David Vega-Morales², Janett Carmen Luzmilla Riega-Torres¹, Octavio Ilizaliturri-Guerra¹ and Mario Alberto Garza-Elizondo¹, ¹Early Arthritis Clinic, Rheumatology Service, Hospital Universitario, Monterrey, Mexico, ²Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose: Tuberculosis (TB) remains a major global health problem. Chronic inflammation in Rheumatoid Arthritis (RA) and the use of immunosuppressive drugs, increase the risk of…
Abstract Number: 1139 • 2013 ACR/ARHP Annual Meeting
Pyogenic Arthritis: Clinical and Epidemiological Features Of 101 Cases At a University Hospital
Anne Riveros-Frutos¹, Lourdes Mateo¹, Melania Martínez-Morillo², Beatriz Tejera³, Samantha Rodriguez-Muguruza¹, Juana Sanint¹, Susana Holgado¹, Jerónima Cañellas¹, Xavier Tena¹, Alejandro Olivé¹ and Montserrat Gímenez⁴, ¹Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ²Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ³Rheumatology, University Hospital of Canary Islands, Santa Cruz de Tenerife, Spain, ⁴Microbiology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain
Background/Purpose: To describe the clinical characteristics, treatment and outcome of patients diagnosed with pyogenic septic arthritis. Methods: Design: retrospective (1984-2012). Location: University hospital. Referial area:…
Abstract Number: 1140 • 2013 ACR/ARHP Annual Meeting
Study Of The Antibody Titer By Influenza Vaccination In Rheumatoid Arthritis Patients Treated With Biologics In JAPAN
Hisato Ishikawa¹, Daihei Kida², Yosuke Hattori³, Atsushi Kaneko³ and Tomotaro Sato⁴, ¹Nagoya Medical Center, nagano, Japan, ²Department of Rheumatology and Orthopedic Surgery, Nagoya Medical Center, Nagoya, Japan, ³Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya, Japan, ⁴Orthopaedic Surgery and Rheumatology, Nagoya Medical Center, National Hospital Organization, Nagoya, Japan
Background/Purpose: Vaccination for influenza virus is recommended for patients with rheumatoid arthritis (RA) with underlying such as disease elderly people over the age of 65,…
Abstract Number: 1142 • 2013 ACR/ARHP Annual Meeting
Distinct Pathways Of Ly6C^hi Monocyte Development Identified By a Novel Dual-Reporter Murine Myeloid Progenitor Cell Line
Pui Lee¹, David Sykes², Sarah Ameri³, Demetrios Kalaitzidis², Peter A. Nigrovic⁴ and Astrid Cardona⁵, ¹Boston Children's Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Division of Immunology, Boston Children's Hospital, Boston, MA, ⁵University of Texas - San Antonio, San Antonio, MA
Background/Purpose: Monocytes are essential to innate immunity but also propagate the inflammatory response in autoimmune arthritis and crystal arthropathies. Development of inflammatory monocytes (Ly6Chi CCR2+)…
Abstract Number: 1143 • 2013 ACR/ARHP Annual Meeting
Increased Frequency Of Pratroling Monocytes In Experimental Arthritis and Rheumatoid Arthritis Patients In Response To IL6-R Blockade
Julie Quentin¹, Jessy Presumey², Florence Apparailly², Yves-Marie Pers³, Pascale Louis Plence⁴ and Christian Jorgensen³, ¹Inserm U844, Montpellier, France, ²U844, Inserm, Montpellier, France, ³Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ⁴INSERM U844 Montpellier, Montpellier, France
Background/Purpose: Monocytes represent a heterogeneous circulating population of immune cells that play important roles in the inflammatory response. Two main functional subsets of human monocytes…
Abstract Number: 1144 • 2013 ACR/ARHP Annual Meeting
Wnt Signaling Pathway Regulates Multi-Unconventional Differentiation and Function Of Human Dendritic Cells
Jia Wang¹, Yi Liu² and Yi Zhao², ¹General medical center, Sichuan Provincial People's Hospital, Chengdu, China, ²Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China
Background/Purpose: Dendritic cells (DCs) play a central role in regulating immune responses and govern T cell priming and polarization, mediating immunity and tolerance. Recent progress…
Abstract Number: 1145 • 2013 ACR/ARHP Annual Meeting
Regulation Of Plasmacytoid Dendritic Cells By Prostaglandin E2
Alice E. Wiedeman¹ and Keith B. Elkon², ¹Immunology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Plasmacytoid dendritic cells (pDCs) constitute a rare blood cell subset exquisitely attuned for production of large quantities of interferon-alpha (IFN-α), and these cells have…
Abstract Number: 1147 • 2013 ACR/ARHP Annual Meeting
Human Dendritic Cells Produce Thymic Stromal Lymphopoietin In Response To Pattern Recognition Receptor Ligation and This Secretion Is Augmented By Endoplasmic Reticulum Stress
Matthew J Elder¹, Anthony YKC Ng², Steven J Webster³, Michael J Bacon¹, JS Hill Gaston⁴ and Jane C Goodall¹, ¹Medicine, University of Cambridge, Cambridge, United Kingdom, ²Medicine, Level 5, University of Cambridge, Cambridge, United Kingdom, ³Dept Medicine Level 5 Box 157, University of Cambridge, Cambridge, United Kingdom, ⁴Dept Medicine Level 5 Box 157, University of Cambridge/Clin Med, Cambridge, United Kingdom
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is a cytokine that has an important role in inducing Th2 cell differentiation and has also been implicated as a…
Abstract Number: 1148 • 2013 ACR/ARHP Annual Meeting
Autologous Tolerogenic Dendritic Cells In Rheumatoid and Inflammatory Arthritis
Gillian Bell¹, Amy Anderson², Julie Diboll¹, Rachel Harry², Elaine McColl³, Anne Dickinson⁴, Catharien Hilkens¹ and John Isaacs⁵, ¹Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³Clinical Trials Unit, Institute of Health and Society, NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ⁴Haematological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁵National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle Upon Tyne, United Kingdom
Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease which results from a breakdown of immune tolerance. Current therapies include traditional DMARDs, anti-TNF, B cell depleting…
Abstract Number: 1149 • 2013 ACR/ARHP Annual Meeting
Phenotypic and Molecular Profile Of Innate Lymphoid Cells In Chronic Synovial Inflammation
Hulda S. Hreggvidsdottir^1,2, Maureen C. Turina¹, Troy Noordenbos^1,3, Marius Munneke⁴, Charlotte Peters², Jochem Bernink², Jenny Mjosberg⁵, Dominique L. Baeten⁶ and Hergen Spits², ¹Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Hematology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling. The family comprises several phenotypically…
Abstract Number: 1150 • 2013 ACR/ARHP Annual Meeting
Differential Regulation Of IL-10 and Dusp1 Production By Kinases In The p38 MAPK Pathway
Deepa Hammaker¹, Katharyn Topolewski² and G. S. Firestein³, ¹MC 0656, UCSD School of Medicine, La Jolla, CA, ²UCSD School of Medicine, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: MAPK kinases MKK3 and MKK6 regulate p38 function in inflammatory diseases like rheumatoid arthritis (RA). Targeting MKK3 or MKK6 might be superior to traditional…
Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting
Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation
Bo Shi¹, Qiquan Huang², Robert Birkett¹, Renee E. Koessler³, Andrea Dorfleutner⁴, Christian Stehlik⁴ and Richard M. Pope⁵, ¹Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…
Abstract Number: 1152 • 2013 ACR/ARHP Annual Meeting
Ligation Of TLR5 Promotes Myeloid Cell Infiltration and Differentiation Into Mature Osteoclasts In RA Patients and Experimental Arthritis
Seung-jae Kim¹, Zhenlong Chen¹, Nathan D. Chamberlain¹, Michael V. Volin², Suncica Volkov¹, William Swedler³, Shiva Arami⁴, Anjali Mehta⁵, Nadera J. Sweiss⁶ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵University of Illinois at Chicago, Chicago, IL, ⁶internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The aim of this study was to examine the importance of TLR5 ligation in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis. Methods:…
Abstract Number: 1128 • 2013 ACR/ARHP Annual Meeting
Validation Of a Rapid, Quantitative Method Of Magnetic Resonance Imaging-Detected Osteoarthritis-Related Bone Marrow Lesions In The Patellofemoral Joint
Charles Ratzlaff¹ and Jeffrey W. Duryea², ¹Harvard Medical School / Brigham and Women's Hospital, Boston, MA, ²Dept of Radiology, Brigham & Women, Boston, MA
Background/Purpose : We recently developed an efficient semi-automated measure of tibial and femoral BML volume and validated it against the Whole-Organ Magnetic Resonance Imaging Score…

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