Abstract Number: 1164 • 2013 ACR/ARHP Annual Meeting
Both Endosomal and Surface Toll-Like Receptors Can Act As Biomarkers In Lupus
Background/Purpose: Toll-like receptors (TLR) are a major class of pathogen detectors in the cell that can trigger the innate defense and lead to activation of…Abstract Number: 1165 • 2013 ACR/ARHP Annual Meeting
Systems Approach To The Study Of the Microbiome and Inflammatory Pathways In Oral Ulcer Tissue From Patients With Active Behςet’s Syndrome (BS)
Background/Purpose: Behcet's syndrome (BS) exhibits features of both innate and acquired immunity. Oral ulceration is the cardinal lesion which usually precedes other manifestations. Despite the…Abstract Number: 1166 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammatory Property Of HDL In NOD1 Ligand Induced Kawasaki Arteritis In Mice
Background/Purpose: Atherosclerosis is a chronic metabolic disease of inflammatory processes. Immune cells including monocytes are recruited to the subintimal lesion of the vascular wall and…Abstract Number: 1168 • 2013 ACR/ARHP Annual Meeting
Innate Immune Cell Production Of Interleukin-12 Drives CpG-Induced Macrophage Activation Syndrome
Background/Purpose: Hemophagocytic syndromes are caused by an uncontrolled systemic inflammatory response resulting in cytopenias, multisystem organ failure, and rapid death, often despite aggressive therapy. Macrophage…Abstract Number: 1169 • 2013 ACR/ARHP Annual Meeting
A Novel Pro-Inflammatory Signaling Pathway Regulated By Follistatin-Like Protein 1
Background/Purpose: Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein produced mainly by cells of the mesenchymal lineage. The function of FSTL1 is still unclear, but…Abstract Number: 1170 • 2013 ACR/ARHP Annual Meeting
Expression and Function Of Human Mfg-E8 In The Clearance Of Apoptotic Cells and Suppression Of Inflammation
Background/Purpose: Effective clearance of apoptotic cells (AC) is necessary for the maintenance of tolerance to self. MFG-E8 is one of ~20 different opsonins reported to…Abstract Number: 1171 • 2013 ACR/ARHP Annual Meeting
Treatment Of Psoriasis Patients With IMO-3100 Shows Improvement In Gene Expression Patterns Of Meta-Analysis Derived-3 Transcriptome and IL-17 Pathway
Background/Purpose: IMO‑3100, an antagonist of TLRs 7 and 9, has shown significant improvement in Psoriasis Area and Severity Index (PASI) scores in a randomized, double‑blind,…Abstract Number: 1172 • 2013 ACR/ARHP Annual Meeting
Molecular Characterisation Of The Killer Cell Immunoglobulin-Like Receptor 3DL2 Binding To Aberrant HLA-B27 Heavy Chains In Spondyloarthritis
Background/Purpose: KIR3DL2 is a Killer cell Immunoglobulin-like Receptor which binds to HLA class I including HLA-B27 (B27) β2m-free heavy chains (FHC) and HLA-A3/A11. KIR3DL2 is…Abstract Number: 1173 • 2013 ACR/ARHP Annual Meeting
A Clinically Significant Interaction Between Furosemide and Allopurinol: Potential Implications for Clinical Practice
Background/Purpose: The xanthine oxidase (XO) inhibitor allopurinol is the most commonly used urate lowering therapy in gout. Allopurinol is metabolized to oxypurinol, which is responsible…Abstract Number: 1133 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of a New Method Of Computer Measurement Of Hip Joint Space Width: Performance Of Location-Specific Measures Obtained At a 48 Month Interval
Background/Purpose : Responsive measures of radiographic joint space width (JSW) in hip osteoarthritis (OA) are a major requirement for the evaluation of treatment interventions. The…Abstract Number: 1134 • 2013 ACR/ARHP Annual Meeting
More Evidence For Breaking The ‘law Of valgus’: Imaging Evidence For Higher Prevalence and Volume Of Bone Marrow Lesions In The Medial Patellofemoral Joint
Background/Purpose : We recently developed an efficient semi-automated measure of tibial and femoral BML volume and validated it against the Whole-Organ Magnetic Resonance Imaging Score…Abstract Number: 1135 • 2013 ACR/ARHP Annual Meeting
Synovial Fluid Vascular Endothelial Growth Factor Could Predict Progression Of Osteoarthritis According To Radiological and Ultrasonographic Findings
Background/Purpose: Vascular endothelial growth factor (VEGF) may have important contribution in the pathogenesis of knee osteoarthritis. MMP-13 is expressed by chondrocytes and synovial cells, and…Abstract Number: 1141 • 2013 ACR/ARHP Annual Meeting
Response To H. Pylori Treatment and Autoantibody In Chronic Thrombocytopenia
Background/Purpose: Helicobacter pylori (H. pylori) infection has been linked to pathogenesis of autoimmune disease including chronic idiopathic thrombocytopenic purpura (ITP). Prior studies showed platelet counts…Abstract Number: 1132 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of Radiographic Fixed-Location and Magnetic Resonance Imaging-Based Cartilage Thickness Measures In The Lateral Compartment Of Knees With Radiographic Osteoarthritis – Data From The Osteoarthritis Initiative
Background/Purpose: Radiographic joint space width (JSW) is frequently employed to indirectly assess structural progression in the medial femorotibial compartment, but it is unclear whether assessment…Abstract Number: 1136 • 2013 ACR/ARHP Annual Meeting
MR T1ρ and T2 Of Meniscus After Acute Anterior Cruciate Ligament Injuries
Background/Purpose: Acute anterior cruciate ligament (ACL) injuries are high-risk factors for post-traumatic osteoarthritis. Cartilage changes in such cases have been widely studied; however, there are…
ACR Meeting Abstracts