Abstracts Archive - Page 2165 of 2607 - ACR Meeting Abstracts

Abstract Number: 1023 • 2014 ACR/ARHP Annual Meeting
Chronic PTHrP Treatment Promotes Hypertrophic Differentiation and Inflammatory Gene Expression in Chondrocytes
Bin Wang, Center for Translational Medicine, Department of Medicine, Thomas Jefferson University Medical College, Philadelphia, PA
Background/Purpose Parathyroid hormone-related protein (PTHrP) binds to the type 1 PTH receptor (PTH1R), a member of the superfamily of G protein-coupled receptors (GPCRs). Activation of…
Abstract Number: 1021 • 2014 ACR/ARHP Annual Meeting
Transthyretin and Amyloid in Cartilage Aging and Osteoarthritis
Yukio Akasaki¹, Oscar Alvarez-Garcia¹, Natalia Reixach², Joel Buxbaum², Yukihide Iwamoto³ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ³Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Background/Purpose Deposition of amyloid is a common aging-associated phenomenon and a key factor in the pathogenesis of several aging-related diseases. Osteoarthritis is the most prevalent…
Abstract Number: 1040 • 2014 ACR/ARHP Annual Meeting
Dysregulated Serum Interleukin 16 Concentration Associated with Clinical Disease Activity in Patients with Rheumatoid Arthritis Is Efficiently Corrected By Immunological Intervention
Atsuko Murota¹, Katsuya Suzuki¹, Yoshiaki Kassai², Takahiro Miyazaki³, Rimpei Morita⁴, Akihiko Yoshimura⁴ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Takeda Pharmaceutical Company, Fujisawa, Japan, ³Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan, ⁴Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: IL-16 is a chemoattractant factor that evokes massive infiltration of mononuclear cells in the synovial tissue in patients rheumatoid arthritis (RA). IL-16 concentrations are…
Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting
Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity
Ladislav Senolt¹, Klara Prajzlerova¹, Hana Hulejova², David Veigl³, Karel Pavelka¹ and Jiri Vencovsky¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³1st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
Abstract Number: 1037 • 2014 ACR/ARHP Annual Meeting
Anti-MDA5 Antibody Associated Myositis Compared to DM Patient: A Distinct Muscular Pattern Associated with a shared IFN Signature
Yves Allenbach^1,2,3, Gaelle Leroux⁴, Aude Rigolet², Baptiste Hervier⁵, Nicolas Limal⁶, Peter Hufnagl⁷, Norman Zerbe⁸, Thierry Maisonobe⁹, Alain Meyer¹⁰, Yurdagul Uzunhan¹¹, Kuberaka Mariampillai¹², Romain Gherardi¹³, Serge Herson¹², Olivier Benveniste^2,3 and Werner Stenzel¹⁴, ¹Neuropathology, Charite Hospital, Berlin, Germany, ²Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ³UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ⁴Department of Internal Medicine and Clinical Immunology, Hospital University Department: inflammation, immunopathology and biotherapy (DHU i2B), DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁵Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, PARIS, France, ⁶Department of Internal Medicine, Hôpital Henri Mondor, APHP, Creteil, France, ⁷Pathology departmen, Charite Hospital, Berlin, Germany, ⁸Department of Pathology, Charite Hospital, Berlin, Germany, ⁹Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ¹⁰Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹¹Pneumology, APHP Avicenne Hospital, Bobigny, France, ¹²Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ¹³Pathology, APHP Henri Mondor Hospital, Creteil, France, ¹⁴Department of Neuropathology, Charite Hospital, Berlin, Germany
Background/Purpose Anti-MDA5 auto-antibodies are thought to be specifically associated with dermatomyositis (DM). Nevertheless anti-MDA5 auto-antibody positive patients (MDA5+ DM) predominantly suffer from extra-muscular involvement with severe…
Abstract Number: 1036 • 2014 ACR/ARHP Annual Meeting
Synergism Between GM-CSF and IL-17 Causes Enhanced Joint Pathology Via the Production of IL-6 and IL-23
Annemarie E.M. van Nieuwenhuijze¹, Debbie M. Roeleveld², Birgitte Walgreen², Miranda Bennink¹, Monique M. Helsen¹, Liduine van den Bersselaar¹, Ian P. Wicks³, Wim B. van den Berg¹, Fons A. van de Loo¹ and Marije I. Koenders¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
Abstract Number: 1035 • 2014 ACR/ARHP Annual Meeting
TNF-á Modulates the Expression of Circadian Clock Genes Via Calcium Signaling in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Nao Shibanuma², Teppei Hashimoto^3,4, Yoshiko Kawasaki⁴, Naonori Hashimoto¹, Ayako Nakai¹, Kenta Kaneshiro¹, Koji Tateishi⁵, Natsuko Nakagawa⁵ and Akira Hashiramoto^1,4,6, ¹Faculty of Health Sciences, Kobe University School of Medicine, Kobe, Japan, ²Department of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ³Department of General Internal Medicine, Kobe University School of Medicine, Kobe, Japan, ⁴Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁶Clinical Immunology, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 1038 • 2014 ACR/ARHP Annual Meeting
Macrophage-Fibroblast Crosstalk Pathways Amplify RA Joint Pathology
Laura T. Donlin¹, Jennifer Ding¹ and Lionel B. Ivashkiv^1,2, ¹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ²Weill Cornell Graduate School of Medical Sciences, New York, NY
Background/Purpose Macrophages and synovial fibroblasts represent key cellular drivers of RA. The goal of this study was to define how the complex cellular programs of…
Abstract Number: 1022 • 2014 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cells and Monocytes Team up in the Organization and the Dynamic Modelling of the Synovial Tissue
Ruth Byrne¹, Karolina von Dalwigk², Thomas Karonitsch¹, Gunter Steiner³, Johannes Holinka⁴, Reinhard Windhager⁴, Josef Smolen⁵, Hans Peter Kiener¹ and Clemens Scheinecker⁶, ¹Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ⁵Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Divison of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
Abstract Number: 1017 • 2014 ACR/ARHP Annual Meeting
BMP9-Induced pSmad1/5/8 Signaling and Chondrocyte Hypertrophy Are Effectively Inhibited By TGFβ1
Arjan van Caam, Esmeralda Blaney Davidson, Ellen W. van Geffen, Wim B. van den Berg and Peter M. van der Kraan, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Osteoarthritis is characterized by degradation of articular cartilage. TGFβ-superfamily signaling via Smad phosphorylation (pSmad) plays a crucial role in cartilage maintenance. Two distinct pSmad…
Abstract Number: 1016 • 2014 ACR/ARHP Annual Meeting
Reduced Expression of Circadian Rhythm Genes in Human Osteoarthritis Cartilage: NR1D1 Suppression Alters Chondrocyte Response to IL-1β Stimulation
Ryuichiro Akagi¹, Kathleen M. Fisch¹, Oscar Alvarez-Garcia¹, Takeshi Teramura¹, Yuta Muramatsu¹, Masahiko Saito², Takahisa Sasho³, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ³Orthopaedic Surgery, Chiba University School of Medicine, Chiba, Japan
Background/Purpose NR1D1 is a negative regulator of BMAL1, a core clock gene that regulate circadian rhythmicity. Involvement of NR1D1 in inflammatory process has been reported,…
Abstract Number: 1015 • 2014 ACR/ARHP Annual Meeting
Mir-9/MCPIP1 Axis Mediated Regulation of IL-6 Expression in Osteoarthritis Chondrocytes
Tariq Haqqi¹, Abdul Haseeb² and Mohammad Shahidul Makki², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH
Background/Purpose Post-transcriptional regulation of cytokine expression is important for maintaining tissue integrity. MCPIP1 was identified as a novel protein, which destabilizes inflammatory cytokines mRNAs via…
Abstract Number: 1014 • 2014 ACR/ARHP Annual Meeting
Harpagide, a Low Molecular Weight Natural Product, Suppresses IL-1â-Induced IL-6 Expression By Blocking the Activation of p38 MAPK and Transcription Factors CEBPâ and AP-1 in Primary Human Osteoarthritis Chondrocytes
Abdul Haseeb¹ and Tariq Haqqi², ¹Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: There is growing evidence that shows the involvement of IL-6 in cartilage degradation during OA. Significant correlation between IL-6 levels in serum as well…
Abstract Number: 1013 • 2014 ACR/ARHP Annual Meeting
Mitochondrial Function Is Impaired in Human Knee Osteoarthritic (OA) Chondrocytes and Improved By Pharmacologic AMPK Activation Via SIRT1 and PGC-1α
Ru Bryan¹, Yun Wang², Xianling Zhao³, Martin Lotz⁴ and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ³VAMC, San Diego, CA, ⁴Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Chondrocyte mitochondrial abnormalities have been identified in OA, and have the potential to mediate disease progression by promoting oxidative stress and inflammation-driven cartilage matrix…
Abstract Number: 1012 • 2014 ACR/ARHP Annual Meeting
Role of High Glucose Environment on Chondrocyte Activation and Characterization of Diabetic Osteoarthritic Cartilage: Toward Pathophysiological Delineation of Diabetes Mellitus-Related Osteoarthritis
Marie-Charlotte Laiguillon¹, Alice Courties^1,2, Xavier Houard¹, Martine Auclair¹, Alain Sautet³, Bruno Fève¹, Jacqueline Capeau¹, Francis Berenbaum² and Jérémie Sellam², ¹Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ²AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ³AP-HP, Saint-Antoine Hospital, Orthopaedic Surgery Department, Paris, France
Background/Purpose: Recent epidemiological studies have suggested an association between type 2 diabetes/hyperglycemia and osteoarthritis (OA) but experimental evidences are lacking (1). We aimed i) to…

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