Abstract Number: 1291 • 2013 ACR/ARHP Annual Meeting
COVA322: Overcoming Limitations Of Current Biologics In Rheumatoid Arthritis By a Novel, Bispecific Tumor-Necrosis-Factor-Alpha / Interleukin-17A (TNF/IL-17A) Inhibitor Moving Towards The Clinic
Background/Purpose: Biologic treatment options such as TNF inhibitors have revolutionized the treatment of inflammatory diseases, such as rheumatoid arthritis (RA), psoriasis and psoriatic arthritis. However, there…Abstract Number: 1292 • 2013 ACR/ARHP Annual Meeting
The Spatial Energy Expenditure Configuration and Possible Applications In An Experimental Model Of Arthritis
Background/Purpose: An autoimmune response with differentiation and proliferation of immune cells and the subsequent tissue-directed inflammatory process in the symptomatic phase of the disease are…Abstract Number: 1294 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammatory Effect Of Resveratrol As a Dietary Supplement In An Antigen-Induced Arthritis Rat Model
Background/Purpose: Inflammatory cells like macrophages, lymphocytes and neutrophils in hyperplasic synovial tissue have been identified as key players in the onset and development of rheumatoid…Abstract Number: 1295 • 2013 ACR/ARHP Annual Meeting
Mechanisms For Fostamatinib-Induced Blood Pressure Elevation
Background/Purpose: Fostamatinib is a kinase inhibitor with activity at spleen tyrosine kinase. In clinical studies in patients with rheumatoid arthritis, fostamatinib treatment was associated with…Abstract Number: 1255 • 2013 ACR/ARHP Annual Meeting
Ovarian Dysfunction In Adult Childhood-Onset Systemic Lupus Erythematosus Patients: A Possible Role Of Methotrexate?
Background/Purpose: Reduction of ovarian reserve has been observed in childhood-onset SLE (c-SLE) and adult SLE populations, and most of them were limited to follicle stimulating…Abstract Number: 1256 • 2013 ACR/ARHP Annual Meeting
Depression, Anxiety and Suicidal Thoughts In a Cohort Of Pediatric Lupus and Mixed Connective Tissue Disease Patients
Background/Purpose: Emerging data reveals that depression and anxiety disorders are highly prevalent in adult patients with systemic lupus erythematosus (SLE). These disorders are associated with…Abstract Number: 1257 • 2013 ACR/ARHP Annual Meeting
Feasibility and Clinical Implications Of The Pediatric Automated Neuropsychological Assessment Metrics for Screening Of Childhood-Onset Neuropsychiatric Systemic Lupus Erythematosus
Background/Purpose: Neuropsychiatric disease is common in childhood-onset Systemic Lupus Erythematosus (cSLE). Signs of cNPSLE can be subtle and difficult to ascertain in daily clinical practice.…Abstract Number: 1258 • 2013 ACR/ARHP Annual Meeting
Cognitive Functions In Childhood-Onset Systemic Lupus Erythematosus
Background/Purpose: To determine differences in cognitive functions in childhood-onset systemic lupus erythematosus (cSLE). Methods: We performed a cross-sectional study including patients with age of onset…Abstract Number: 1259 • 2013 ACR/ARHP Annual Meeting
Cognitive Dysfunction In Childhood Systemic Lupus Erythematosus: Comparison Of Different Classification Criteria
Background/Purpose: Cognitive deficits are frequently observed in systemic lupus erythematosus (SLE), in both adult and childhood (cSLE) onset. However there are several different cutoff levels…Abstract Number: 1260 • 2013 ACR/ARHP Annual Meeting
Serum S100β Is Associated With Neuropsychiatric Manifestations In Childhood-Onset Systemic Lupus Erythematosus
Background/Purpose: Involvement of the central nervous system (CNS) in systemic lupus erythematosus (SLE) is an important source of morbidity and mortality. S100β has been considered…Abstract Number: 1261 • 2013 ACR/ARHP Annual Meeting
The Usefulness Of Traditional Neurocognitive Testing and N-Methyl-D-Aspartate Receptor Antibodies In Pediatric Lupus Patients
Background/Purpose: In order to identify lupus patients at risk for CNS disease, and specifically, cognitive dysfunction, the ACR recommended a standard battery of tests for…Abstract Number: 1262 • 2013 ACR/ARHP Annual Meeting
Comparison Of Remission Rates For Pediatric Membranous Plus Proliferative Lupus Nephritis Versus Isolated Proliferative Lupus Nephritis: An Analysis Of The Childhood Arthritis and Rheumatism Research Alliance Registry
Background/Purpose: Lupus nephritis (LN) affects many patients with pediatric systemic lupus erythematosus (pSLE) and is a significant cause of disease morbidity. Inability to achieve remission…Abstract Number: 1263 • 2013 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus In Ontario: Long Term Outcomes In a Population-Based Cohort With Universal Health Care Coverage
Background/Purpose: Little is known about the long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care; however, linking clinical data to administrative…Abstract Number: 1264 • 2013 ACR/ARHP Annual Meeting
Evaluation Of Quality Indicators and Disease Damage In Childhood-Onset Systemic Lupus Erythematosus Patients
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect virtually every organ system and may lead to significant morbidities. A…Abstract Number: 1265 • 2013 ACR/ARHP Annual Meeting
Initial Benchmarking Of The Quality Of Medical Care Of Children and Adolescents With Lupus
Background/Purpose: Recently, 26 quality indicators (QI) for childhood-onset systemic lupus erythematous (cSLE) have been developed based on international consensus and scientific evidence. QI are defined…