Abstracts Archive - Page 2153 of 2607 - ACR Meeting Abstracts

Abstract Number: 1203 • 2014 ACR/ARHP Annual Meeting
NK/NKT Cells from Early and Definite Systemic Sclerosis Patients Show Different Immunological Responses after IL-2 Stimulation
Marta Cossu¹, Lenny van Bon¹, Stefan Nierkens², Alessandro Santaniello³, Lorenzo Beretta⁴ and Timothy Radstake⁵, ¹Department of Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²U-DAIR- Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ³Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁴Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁵Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The innate immune system may be implicated in the fibrotic processes of systemic sclerosis (SSc); to date little has been done to unravel the…
Abstract Number: 1202 • 2014 ACR/ARHP Annual Meeting
Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE
Bo Qu¹, Jianchang Cao², Feifei Zhang² and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, ³The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…
Abstract Number: 1201 • 2014 ACR/ARHP Annual Meeting
Hypoxia Modulates Peptidyl Arginine Deiminase 4 Activity and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous¹, Luke W. Thomas³, Margaret Ashcroft³, Joanna C. Porter² and Ian Giles¹, ¹Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ³Centre for Cell Signalling and Molecular Genetics, Centre for Cell Signalling and Molecular Genetics, University College London, London, United Kingdom
Background/Purpose RA is an autoimmune rheumatic disease characterised by ACPA, endothelial dysfunction, platelet activation, synovial hyperplasia and hypoxia in affected joints. ACPA recognise citrullinated proteins,…
Abstract Number: 1220 • 2014 ACR/ARHP Annual Meeting
Higher Inflammatory Response in Elderly Patients during Gout Attack
Ji Ae Yang¹, Jae Hyun Lee¹, Eun Young Lee², Eun Bong Lee¹, Yeong Wook Song³ and Jin Kyun Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ²Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Higher inflammatory response in elderly patients during gout attack Background/Purpose Clinical experiences suggest that gout attacks in elderly patients are accompanied by stronger systemic inflammatory…
Abstract Number: 1219 • 2014 ACR/ARHP Annual Meeting
Lack of Gene-Diuretic Interactions on Risk of Incident Gout: The Nurses’ Health Study and Health Professionals Follow-up Study
Ying Bao¹, Tony R. Merriman², Gary Curhan³, Eli A. Stahl⁴, David B. Mount⁵, Robert M. Plenge⁶, Peter Kraft⁷ and Hyon K. Choi⁸, ¹Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Renal Division, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁸Boston University School of Medicine, Boston, MA
Background/Purpose: Diuretics, particularly thiazide and loop diuretics, increase the risk of gout, likely through urate transporters (e.g., OAT4) and volume depletion promoting urate reabsorption. As…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 1217 • 2014 ACR/ARHP Annual Meeting
The Random Urine Uric Acid to Creatinine Ratio As a Predictor of 24-Hour Urine Uric Acid Excretion in Gout Patients
Sang Tae Choi¹, Jung-Soo Song² and Eun-Hye Park², ¹Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea, ²Chung-Ang University College of Medicine, Seoul, South Korea
Background/Purpose: Gout is an inflammatory disease resulted from an increased body pool of uric acid. The measurement of 24-hour uric acid excretion is important to…
Abstract Number: 1216 • 2014 ACR/ARHP Annual Meeting
The Relationship Between Serum Homocysteine, Uric Acid and Renal Function in Chronic Gouty Patients: 2 Year Follow-up Results
Eun-Hye Park¹, Sang Tae Choi² and Jung-Soo Song¹, ¹Chung-Ang University College of Medicine, Seoul, South Korea, ²Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea
Background/Purpose: Hyperhomocysteinemia is one of the important factors for the endothelial cell damage and also a risk factor for cardiovascular events. Gout is known to…
Abstract Number: 1215 • 2014 ACR/ARHP Annual Meeting
Circulating Mediators of Bone Remodeling in Patients with Tophaceous Gout
Ashika Chhana¹, Opetaia Aati², Gregory Gamble², Karen E. Callon¹, Anthony Doyle³, Mark Roger⁴, Fiona M. McQueen⁵, Anne Horne², Ian R. Reid², Jillian Cornish¹ and Nicola Dalbeth², ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Auckland, Auckland, New Zealand, ⁴Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Disordered bone remodeling has been implicated in the development of bone erosion in tophaceous gout. The function of bone cells in the skeleton is…
Abstract Number: 1197 • 2014 ACR/ARHP Annual Meeting
Febuxostat Inhibits Monosodium Urate Crystal-Induced IL-1beta Secretion and Cell Death Via ROS- and Intracellular ATP-Dependent Pathways
Johji Nomura¹, Nathalie Busso², Mizuho Tamura¹, Tsunefumi Kobayashi¹ and Alexander So³, ¹Pharmaceutical Development Research Laboratories, Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan, ²Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, ³Rheumatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
Background/Purpose: In gout, monosodium urate (MSU) crystals trigger acute inflammation. MSU has been reported to activate NLRP3 inflammasome via ROS-dependent pathways, which result in IL-1beta…
Abstract Number: 1196 • 2014 ACR/ARHP Annual Meeting
Inflammation Develops in a Toll-like Receptor 9-Independent Manner in Experimental Arthritis and Rheumatoid Arthritis
Julie Mussard¹, Matthieu Ribon¹, Gaelle Clavel², Marie-Christophe Boissier³ and Patrice Decker¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology. Toll-like receptor (TLR) 9 recognizes pathogen-derived DNA and even self DNA under certain circumstances.…
Abstract Number: 1195 • 2014 ACR/ARHP Annual Meeting
Activation of the nlrp3 Inflammasome By an Endogenous TLR2 Ligand in Rheumatoid Arthritis
Mary Connolly, Trudy McGarry, Monika Biniecka, Douglas J. Veale and Ursula Fearon, Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: The inflammasome is a large multiprotein complex which plays a key role in innate immunity by mediating the production of pro-inflammatory cytokines interleukin-1β (IL-1β)…
Abstract Number: 1194 • 2014 ACR/ARHP Annual Meeting
Cofilin-1 Is a ROS Sensor in Regulating the NLRP3 Inflammasome
Yong Hwan Park¹, Daniel L. Kastner² and Jae Jin Chae¹, ¹Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD
Background/Purpose NLRP3 (NOD-like receptor family, pyrin domain containing 3) has a pivotal role in nucleating inflammasome, cytoplasmic multiprotein complexes that mediate the maturation of the…
Abstract Number: 1193 • 2014 ACR/ARHP Annual Meeting
Diagnostic value of Contrast-Enhanced MR-Angiography in diagnosing large Vessel Vasculitis
Sabine Adler¹, Marco Sprecher¹, Harald Bonel², Thorsten Klink² and Peter M. Villiger³, ¹Rheumatology, Immunology, Allergology, University Hospital Bern, Bern, Switzerland, ²Diagnostic, Interventional and Pediatric Radiology, University Hospital Bern, Bern, Switzerland, ³Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland
Background/Purpose Diagnosis of large-vessel vasculitis (LVV) remains difficult despite clinical and serological signs and symptoms. Detection by histology might be unavailable in exclusive thoracic or…
Abstract Number: 1192 • 2014 ACR/ARHP Annual Meeting
Erosions Detected By Magnet Resonance Imaging in Patients with Juvenile Idiopathic Arthritis (JIA) Are True Erosions As Visualized By Computed Tomography
Stephanie Finzel¹, Georg A. Schett² and Nikolay Tzaribachev³, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Pediatric Rheumatology, Bad Bramstedt, Germany
Background/Purpose Chronic arthritis occurs relatively frequent in childhood. Patients with polyarticular disease might have a destructive disease course and thus a worse outcome. In adult…

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