ACR Meeting Abstracts

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  • Abstract Number: 1541 • 2013 ACR/ARHP Annual Meeting

    Spinal Mobility Gets Impaired In a Fixed Order In Patients With Ankylosing Spondylitis: 12-Year OASIS Results

    Sofia Ramiro1, Robert Landewé2, Désirée van der Heijde3, Carmen Stolwijk4, Maxime Dougados5, Filip Van den Bosch6 and A.M. van Tubergen7, 1Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 5Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 6Ghent University Hospital, Ghent, Belgium, 7Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose: Spinal mobility is impaired in patients with ankylosing spondylitis (AS) compared to normal subjects. However, the extent of impairment and the relative contribution of…
  • Abstract Number: 1542 • 2013 ACR/ARHP Annual Meeting

    Regular Exercise Is Associated With Better Functional Outcomes In Ankylosing Spondylitis

    Lianne S. Gensler1, John D. Reveille2, MinJae Lee3, Mohammad Rahbar4, Manouchehr Ardjomand-Hessabi5, Matthew A. Brown6, Michael H. Weisman7 and Michael M. Ward8, 1Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 2Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 3Medicine, University of Texas Health Science Center at Houston, Houston, TX, 4The University of Texas Health Science Center at Houston, Houston, TX, 5Medicine, The University of Texas, Health Science Center at Houston, Houston, TX, 6Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, 7Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA, 8Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD

    Background/Purpose: Exercise and physical therapy are the cornerstones of non-pharmacologic therapy in Ankylosing Spondylitis.  The long-term association of exercise on function has not been evaluated.…
  • Abstract Number: 1543 • 2013 ACR/ARHP Annual Meeting

    Patients With Ankylosing Spondylitis Are Substantially Undertreated For Hypertension and Hypercholesterolemia

    Sjoerd C. Heslinga1,2,3, Inge A.M. van den Oever1, Alper M. van Sijl2,4, Irene E. Van der Horst-Bruinsma4,5 and Michael. T. Nurmohamed2,4, 1Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 2Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 3Internal Medicine, VU University Medical Center, Amsterdam, Netherlands, 4Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 5Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Patients with ankylosing spondylitis (AS) have a decreased life expectancy due to an increased cardiovascular (CV) risk. The general inflammatory process is held responsible…
  • Abstract Number: 1544 • 2013 ACR/ARHP Annual Meeting

    Good Agreement Between The Ankylosing Spondylitis Disease Activity Scores Based On C-Reactive Protein and Erythrocyte Sedimentation Rate

    Dilek Solmaz, Pinar Cetin, Ismail Sari, Merih Birlik, Servet Akar, Fatos Onen and Nurullah Akkoc, Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey

    Background/Purpose: Recently, ASDAS has been developed as a disease activity measuring tool for ankylosing spondylitis (AS), using a similar methodology to that used for the…
  • Abstract Number: 1545 • 2013 ACR/ARHP Annual Meeting

    Serum Periostin: a New Marker Of Local Bone Formation In Early Inflammatory Back Pain: results From The DESIR Cohort

    Karine Briot1, Simon Paternotte2, Didier Borderie3, Corinne Miceli-Richard4, Maxime Dougados2 and Christian Roux1, 1Cochin hospital, Paris Descartes University, Paris, France, 2Cochin Hospital, Paris Descartes University, Paris, France, 3Laboratoire de Biochimie, Hopital Cochin, Paris Descartes University, Pris, France, 4Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France

    Background/Purpose: Periostin is a secreted, homodimeric protein that is synthesized by mesenchymal cells of the periosteum, which is involved in osteoblast homeostasis of the periosteum…
  • Abstract Number: 1546 • 2013 ACR/ARHP Annual Meeting

    Patient-Reported Outcomes of Etanercept in Early Non-Radiographic Axial Spondyloarthritis: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

    Maxime Dougados1, Wen-Chan Tsai2, Diego Luis Saaibi3, Randi Bonin4, Jack Bukowski5, Ronald Pedersen6, Bonnie Vlahos7 and Sameer Kotak8, 1Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, 2Chung-Ho Memorial Hospital, Kaohsiung, 807, Taiwan, 3MEDICITY S.A.S, Bucaramanga, Santander 681001, Colombia, 4Pfizer Inc, Collegeville, PA, 5Department of Specialty Care, Pfizer Inc, Collegeville, PA, 6Specialty Care, Pfizer Inc, Collegeville, PA, 7Department of Specialty Care, Pfizer Inc., Collegeville, PA, 8Specialty Care, Pfizer Inc., New York, NY

    Background/Purpose: Limited data are available on the efficacy of anti-TNF agents in non-radiographic axial spondyloarthritis (nr-axSpA). This analysis compares the impact of etanercept (ETN) vs…
  • Abstract Number: 1547 • 2013 ACR/ARHP Annual Meeting

    How The Delay In Diagnosis Impacts On The Clinical, Functional and Radiographic Status Of Patients With Ankylosing Spondylitis. Is There a Window Of Opportunity?

    luis Alejandro Cayetti1, Emilce Schneeberger1, Natalia Zamora2, Fernando Sommerfleck2 and Gustavo Citera2, 1Instituto de Rehabilitacion Psicofisica, Buenos Aires, Argentina, 2Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina

    Background/Purpose: The delay in diagnosis has deleterious effects in patients with Rheumatoid Arthritis. This fact has not been fully investigated in patients with Ankylosing Spondylitis…
  • Abstract Number: 1548 • 2013 ACR/ARHP Annual Meeting

    Effect Of TNF Inhibitors On Bone Mineral Density In Patients With Ankylosing Spondylitis- a Systematic Review and Meta-Analysis

    Nisha Nigil Haroon1, Jeevitha Srighanthan2, Nayef AL Ghanim3, Robert D. Inman4,5,6,7,8,9 and Angela Cheung10, 1Medicine, University of Toronto, Toronto, ON, Canada, 2Osteoporosis Program, University of Toronto, Ontario, ON, Canada, 3Rheumatology, University of Toronto, Toronto, ON, Canada, 4Toronto Western Hospital, Toronto, ON, Canada, 5Rheumatology, Toronto Western Research Institute. University of Toronto, Toronto, ON, Canada, 6University of Toronto, Toronto, ON, Canada, 7Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 8U of Toronto, Toronto, ON, Canada, 9Dept of Medicine/Rheumatology, The Arthritis Program, Toronto Western Hospital and Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 10Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with ankylosing spondylitis (AS) are susceptible to osteoporosis (OP) and have high fracture risk. Currently, no specific strategies are established to treat OP…
  • Abstract Number: 1549 • 2013 ACR/ARHP Annual Meeting

    Prevalence Of Syndesmophytes In Patients With Chronic Back Pain Suspected Of Axial Spondyloarthritis (axSpA) Not Fulfilling The Modified New York (mNY) Criteria

    Manouk de Hooge1, Rosaline van den Berg2, Floris van Gaalen2, Monique Reijnierse3, Victoria Navarro-Compán2, Karen Fagerli4, Maureen C. Turina5, Maikel van Oosterhout6, Roberta Ramonda7, Tom Huizinga2 and Désiréé van der Heijde1, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Rheumatology, GHZ Hospital, Gouda, Netherlands, 7Rheumatology Unit, University of Padova, Padova, Italy

    Background/Purpose: The mNY criteria1, which indicate sacroiliitis of at least grade 2 bilaterally or grade 3 or 4 unilaterally, are used to classify patients as…
  • Abstract Number: 1550 • 2013 ACR/ARHP Annual Meeting

    Validation Of The Ankylosing Spondylitis Disease Activity Score and Effectiveness Of Infliximab In The Treatment Of Ankylosing Spondylitis Over 4 Years: The Canadian Experience

    Proton Rahman1, Denis Choquette2, Majed M. Khraishi3, William G. Bensen4, Saeed A. Shaikh5, Dalton E. Sholter6, Maqbool K. Sheriff7, Emmanouil Rampakakis8, John S. Sampalis8, Francois Nantel9, Susan M. Otawa10, Allen J. Lehman10 and May Shawi11, 1Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 2Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 3Nexus Clinical Research, St John's, NF, Canada, 4Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, 5Medicine, McMaster University, St Catharines, ON, Canada, 6Rheumatology Associates, Edmonton, AB, Canada, 7Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 8JSS Medical Research, Montreal, QC, Canada, 9Janssen Inc., Toronto, ON, Canada, 10Medical Affairs, Janssen Inc., Toronto, ON, Canada, 11Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada

    Background/Purpose: The efficacy of anti-TNF in the management of Ankylosing Spondylitis (AS) has been demonstrated in numerous controlled clinical trials. The objective of this study…
  • Abstract Number: 1551 • 2013 ACR/ARHP Annual Meeting

    The Minimum Clinically Important Improvement and Patient Acceptable Symptom State In Basdai and BASFI For Patients With Ankylosing Spondylitis

    Milla Kviatkovsky1, Sofia Ramiro2, Robert Landewé3, Florence Tubach4,5, Maxime Dougados6 and D. van der Heijde7, 1College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, 2Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 4Département d'Epidémiologie Biostatistique et Recherche Clinique, APHP, Hôpital Bichat, Paris, France, 5INSERM, Universite Paris Diderot, Paris, France, 6Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, 7Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The minimum clinically important improvement (MCII) and patient acceptable symptom state (PASS) are clinically relevant measures that report the patient response and condition. We…
  • Abstract Number: 1552 • 2013 ACR/ARHP Annual Meeting

    Effective Prevention Of New Osteitis On Magnetic Resonance Imaging In Patients With Early Axial Spondyloarthritis During 3 Years Of Continous Treatment With Etanercept – Data Of The Esther Trial

    In-Ho Song1, Kay-Geert A. Hermann2, Hildrun Haibel3, Christian Althoff4, Denis Poddubnyy3, Joachim Listing5, Anja Weiss6, Ekkehard Lange7, Bruce Freundlich8, Martin Rudwaleit9 and Joachim Sieper10, 1Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, 2Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, 3Charité Universitätsmedizin Berlin, Berlin, Germany, 4Radiology, Charite Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, 5German Rheumatism Research Center, Berlin, Germany, 6German Rheumatism Research Centre, Berlin, Germany, 7BU Specialty Care, Pfizer Pharma AG, Berlin, Germany, 8University of Pennsylvania, Philadelphia, PA, 9Endokrinologikum, Berlin, Germany, 10Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin-Franklin, Berlin, Germany

    Background/Purpose:   In patients with early axial spondyloarthritis (SpA) with a disease duration of
  • Abstract Number: 1553 • 2013 ACR/ARHP Annual Meeting

    Responsiveness Of Health Related Quality Of Life Questionnaires To Treatment With Anti-TNF Therapy In Psoriatic Arthritis

    Zahi Touma1, Arane Thavaneswaran1, Vinod Chandran2 and Dafna D. Gladman2, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Patient-reported outcomes (PRO) on Health Related Quality of Life (HRQoL) are increasingly used to assess responsiveness after treatment.  This study aimed to determine the…
  • Abstract Number: 1554 • 2013 ACR/ARHP Annual Meeting

    Real-World Effectiveness Of Infliximab In The Treatment Of Psoriatic Arthritis Over 12 Months: The Canadian Experience

    Proton Rahman1, Majed M. Khraishi2, William Bensen3, John T. Kelsall4, Brian D. Hanna5, Craig Watts6, Emmanouil Rampakakis7, John S. Sampalis7, May Shawi8, Susan M. Otawa9 and Allen J. Lehman9, 1Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 2Nexus Clinical Research, St John's, NF, Canada, 3St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, 4Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, 5Rheumatology, McMaster University, Ontario, Kitchener, ON, Canada, 6Department of Rheumatology, McGill University and Montreal General Hospital, Sainte-Anne-de-Bellevue, QC, Canada, 7JSS Medical Research, Montreal, QC, Canada, 8Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada, 9Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose: The efficacy of anti-TNF in the management of psoriatic arthritis (PsA) has been demonstrated in numerous controlled clinical trials. Longitudinal observational studies assessing the…
  • Abstract Number: 1555 • 2013 ACR/ARHP Annual Meeting

    Anti-TNF Drug Survival In Psoriatic Arthritis Patients Treated In Ordinary Clinical Practice

    Glenn Haugeberg1, Andreas P. Diamantopoulos1, Agnete Gulati2, Mari Hoff3 and Arthur Kavanaugh4, 1Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 2Rheumatology, St.Olavs Hospital, Trondheim, Norway, 3Rheumatology, St Olavs Hospital, Trondheim, Norway, 4University of California San Diego, San Diego, CA

    Background/Purpose: The use of TNF-inhibitors in psoriatic arthritis (PsA) has been shown to improve clinical and radiographic outcome in randomized controlled trials (RCT) and shown…
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