Session Type: Abstract Submissions (ACR)
A prior study showed an association between osteoarthritis (OA) and increased mortality from dementia. Recent preclinical studies suggest a possible association between OA and the development of dementia. The objective of this analysis was to determine if older adults with OA have a higher risk of cognitive impairment (CI).
We used data from the Health Aging and Body Composition (HABC) study, a multicenter prospective cohort study of community dwelling adults, ages 70-79, to determine if participants with OA at baseline (self-reported OA or OA defined by HABC prevalent disease algorithm) have an increased risk of developing CI. CI was defined as a Modified Mini-Mental State examination (3MS) score<80. Participants with 3MS scores of <80 at baseline were excluded. Baseline and year 3, 5, 8, and 10 scores were analyzed.
There were 2577 participants with 3MS scores of >=80 at baseline (n=1277 with OA, n=1300 without OA). The OA group had more women (54% vs 44%, p<0.001), higher baseline CES-Depression scores (4.9 SD 5.4 vs 4.2, SD4.9, p=0.003) and hypertension (46% vs 40%, p=0.028).There was no significant difference in development of CI after 9 years amongst those with OA (n=165, 12.9%) versus without OA (n=197, 15.1%). χ 2(1, n= 2577) =2.66, p >0.10. The results of the multiple variable logistic regression analysis (adjusted for age, race, education and gender) suggest a protective effect that did not reach statistical significance (odds ratio= 0.8; 95% CI 0.6-1.0; P-value = 0.10). There was no significant association between baseline OA and the development of CI at the 3, 5, 8 and 10 year time points. No differences were found upon sensitivity analysis using race and education adjusted cut-points for 3MS scores.
These results do not support the hypothesis that there is a causal association between OA and CI.
M. C. Nevitt,
M. C. Hochberg,
« Back to 2014 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/older-adults-with-osteoarthritis-do-not-have-an-increased-risk-of-cognitive-impairment/