Abstracts Archive - Page 2123 of 2607 - ACR Meeting Abstracts

Abstract Number: 1656 • 2014 ACR/ARHP Annual Meeting
Rate of Histological Transformation to Higher Grade Nephritis in Class II Mesangial Proliferative Lupus Glomerulonephritis
Andrea Zacarias¹, Javier Narváez², Gloria Albert¹, Milagros Ricse¹, Paula Estrada¹, Melany Pestaña³, Chema Mora³, Jesus Rodriguez Moreno¹, Xavier Fulladosa⁴, Manel Rubio Rivas³ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: Class II mesangial proliferative lupus nephritis has generally been considered a mild form of the condition, with a good response to glucocorticoid treatment. However,…
Abstract Number: 1655 • 2014 ACR/ARHP Annual Meeting
Lupus Nephritis: Clinicopathological Correlation in 126 Biopsies
Milagros Ricse¹, Javier Narváez², Gloria Albert¹, Paula Estrada¹, Helena Borrell¹, Eugenia de Lama³, Xavier Fulladosa⁴, Manel Rubio Rivas⁵, Olga Capdevila⁵, Francesca Mitjavila⁵, Xavier Juanola⁶ and Joan Miquel Nolla¹, ¹Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ³Radiology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁴Nephrology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁵Internal Medicine, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁶Rheumatology, University Hospital Bellvitge, Barcelona, Spain
Background/Purpose: To analyze the correlation between clinical and laboratory data and type of histological injury in a cohort of patients with lupus nephritis (LN). Methods:…
Abstract Number: 1654 • 2014 ACR/ARHP Annual Meeting
Thrombotic Microangiopathy and Poor Renal Outcome in Lupus Patients Is Not Associated with Antiphospholipid Syndrome and/or Other Lupus Conventional Features
Gabriela Hernandez-Molina¹, Paola García-Trejo², Norma Uribe³ and Antonio R. Cabral⁴, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ³Pathology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
Background/Purpose: To assess acute thrombotic microangiopathy (aTMA) and chronic vascular lesions (cTMA) in lupus nephropathy and to evaluate their association with extrarrenal lupus features, antiphospholipid…
Abstract Number: 1653 • 2014 ACR/ARHP Annual Meeting
Serum Cystatin C As a Biomarker for Clinical Practice in Patients with Lupus Nephritis
Hua Zhou¹, Di Lu², Hairong Tang² and Lining Wang², ¹Nephrology, The First Hospital of China Medical University, Shenyang, China, ²The First Hospital of China Medical University, Shenyang, China
Background/Purpose: Cystatin C has been developed as a novel biomarker of renal function in last decade and thought as more sensitive than serum creatinine (sCr).…
Abstract Number: 1652 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Lupus Nephritis and Ethnic Disparities in Systemic Lupus Erythematosus
Adnan Kiani¹, Laurence S. Magder² and Michelle Petri³, ¹1830 E Monument St, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Lupus nephritis eventually occurs in 50% of Caucasian SLE patients and 75% of African-Americans. African Americans have a more severe presentation of SLE and…
Abstract Number: 1651 • 2014 ACR/ARHP Annual Meeting
Association of Glomerular Macrophage Phenotypes and Urine Soluble CD163 with Disease Activity in Human Lupus Nephritis
Naotake Tsuboi¹, Nobuhide Endo¹, Seiichi Matsuo² and Shoichi Maruyama¹, ¹Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Background/Purpose: In addition to the effector roles of classically activated macrophages for tissue injury, recent studies have shown that alternatively activated (M2) macrophages are involved…
Abstract Number: 1649 • 2014 ACR/ARHP Annual Meeting
High Specificity of Skin Immunoglobulin Deposits for diagnosing SLE in Patients with Lupus Nephritis
Marco Ulises Martinez-Martinez¹, Maria Daniela De Avila², Mario Perales³, Lourdes Baranda⁴, Susana Román Acosta⁵, Jaime Antonio Borjas García⁵ and Carlos Abud-Mendoza¹, ¹Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ²Regional Unit Rheumatology and Osteoporosis, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ³Regional Unit of Rheumatology and Osteoporosis, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁴Regional Unit of Rheumatology and Osteoposis, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁵Nephrology Department, Hospital Central y Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Background/Purpose: Deposit of different classes of immunoglobulins is the main feature of lupus nephritis;1 because of its high specificity, a patient is classified as having…
Abstract Number: 1650 • 2014 ACR/ARHP Annual Meeting
Prevalence and Prognostic Implications of IgG4 in Membranous Lupus Nephritis
David Herrera Van Oostdam¹, Marco Ulises Martinez-Martinez¹, Cuauhtémoc Oros-Ovalle², David Martínez-Galla², Gerardo Tonatiu Jaimes-Piñón¹, Natalia Alemán-Sánchez² and Carlos Abud-Mendoza¹, ¹Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ²Patología, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Background/Purpose: Patients with membranous lupus nephritis (MLN) have increased risk of thrombosis and different prognosis than other classes of lupus nephritis (LN). Previous studies demonstrated…
Abstract Number: 1648 • 2014 ACR/ARHP Annual Meeting
Urinary T Cells and Macrophages Strongly Reflect the Disease Activity, Kidney Function, and the Histopathologic Classification in Patients with Lupus Nephritis
Yoko Wada¹, Minoru Sakatsume², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ³School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Lupus nephritis (LN) is one of the common manifestations of systemic lupus erythematosus (SLE), and the occurrence of LN is considered to be a…
Abstract Number: 1647 • 2014 ACR/ARHP Annual Meeting
Relationship Between Apom/S1P Levels and Atherosclerosis in Women with Systemic Lupus Erythematosus
Sonali Narain¹, Sylvain Galvani², Christina Christoffersen³, Peiying Yang⁴, Maureen A. McMahon⁵, Timothy Hla² and Jane E. Salmon¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Vascular Biology, Weill Cornell College of Medicine, New York, NY, ³Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Gen Oncology Research, University of Texas MD Anderson Cancer Center, Houston, TX, ⁵Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: SLE patients are at risk for atherosclerotic cardiovascular disease (ASCVD). In some SLE patients, high density lipoprotein (HDL) has impaired vasoprotective effects, and this…
Abstract Number: 1646 • 2014 ACR/ARHP Annual Meeting
Molecular, Cellular and Histopathologic Assessment of Baseline Characteristics of Sixteen Subjects with Discoid Lupus Erythematosus Prior to Treatment with AMG 811 (anti-IFNγ)
Barbara Sullivan¹, Roberto Guzman², Christopher B. Russell³, Greg Arnold⁴, Michael Boedigheimer¹, Connie Ma⁵, James Chung¹, Victoria P. Werth^6,7 and David A. Martin³, ¹Amgen, Thousand Oaks, CA, ²Pathology, Amgen, Thousand Oaks, CA, ³Medical Sciences, Amgen, Seattle, WA, ⁴Medical Sciences, Amgen, Thousand Oaks, CA, ⁵Clinical Immunology, Amgen, Thousand Oaks, CA, ⁶Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA, ⁷University of Pennsylvania, Philadelphia, PA
Background/Purpose Discoid Lupus Erythematosus (DLE), the most common chronic cutaneous form seen in LE, includes inflammation leading to scarring, telangiectasias, atrophy, and/or dyspigmentation. Elevated levels…
Abstract Number: 1645 • 2014 ACR/ARHP Annual Meeting
Interferon Gene Signature Expression and Serological Differences in Japanese and Non-Japanese SLE Patients
Hitoshi Kohsaka¹, Kosuke Kotani², Tomonori Ishii³, Tomoya Miyamura⁴, Masato Okada⁵, Toshihiko Aranishi², R. Maciuca⁶, William P. Kennedy⁶ and Junko Ohata², ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ²Chugai Pharmaceutical co., ltd, Tokyo, Japan, ³Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ⁴Department of Internal Medicine and Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, ⁵Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ⁶Genentech, Inc, South San Francisco, CA
Background/Purpose: Elevated expression of interferon(IFN)-regulated genes in peripheral blood cells has been reported in systemic lupus erythematosus (SLE) patients and is known as the IFN…
Abstract Number: 1644 • 2014 ACR/ARHP Annual Meeting
Mycophenolic Acid and Ribavirin Induces Cytoplasmic Autoimmunogenic Rods and Rings Structures in Vivo
Gerson D Keppeke Sr.¹, Eunice Nunes², Maria Lucia Ferraz³, Sandro F. Perazzio¹, Mônica Prado¹, Edward K.L. Chan⁴ and Luis Eduardo C. Andrade⁵, ¹Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Gastroenterology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, ³Gastroenterology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ⁴Oral Biology, University of Florida, Gainesville, FL, ⁵Fleury Laboratories, Sao Paulo, Brazil
Background/Purpose Autoantibodies to IMPDH2 occur in Hepatitis C patients receiving ribavirin (RBV) & interferon-α (IFN-α). Anti-IMPDH2 antibodies recognize “rods and rings” (RR) cytoplasmic structures in…
Abstract Number: 1643 • 2014 ACR/ARHP Annual Meeting
Role of Inflammasome Activation in Systemic Lupus Erthematosus: Are Innate Immune Cells Activated?
Rodolfo Perez Alamino¹, Raquel Cuchacovich², Arnold Zea³ and Luis R. Espinoza⁴, ¹internal Medicine, LSUHSC, New Orleans, LA, ²Rheumatology, LSU Medical Center, New Orleans, LA, ³Stanley Scott Cancer Center, New Orleans, LA, ⁴Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA
Background/Purpose Systemic lupus erythematosus (SLE) presents with a wide spectrum of clinical and immunologic abnormalities. On the other hand, exciting data is emerging about the…
Abstract Number: 1662 • 2014 ACR/ARHP Annual Meeting
Lupus Nephritis Patients Who Stopped Maintenance Immunosuppressive Therapy without Relapse
Robert S. Katz¹ and Lauren Kwan², ¹Rush Medical College, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: The current guidelines from both the American College of Rheumatology and the American Society of Nephrology suggest initiating induction therapy for Class III and…

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