Abstracts Archive - Page 2117 of 2607 - ACR Meeting Abstracts

Abstract Number: 1749 • 2014 ACR/ARHP Annual Meeting
Molecular Mechanisms Underlying 1,25(OH)₂D₃-Mediated Suppression of Th17 Cell Activity
Wendy Dankers^1,2, Jan Piet van Hamburg^2,3, Wida Razawy^1,2, Nadine Davelaar^1,2, Anne-Marie Mus^1,2, Patrick Asmawidjaja^1,2, Johannes van Leeuwen⁴, Edgar Colin⁵ and Erik Lubberts^1,2, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, Th17 cells play a crucial role in the…
Abstract Number: 1748 • 2014 ACR/ARHP Annual Meeting
CCR6⁺CD4⁺ Cells Are Counterparts of Follicular T-Cells Supporting Autoantibody Production in Rheumatoid Arthritis
Karin ME Andersson¹, Dan Hu², Ron Cialic², Nicola Cavallini³, Vijay K. Kuchroo⁴, Malin Erlandsson¹, Howard Lee Weiner² and Maria Bokarewa⁵, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Department of Neurology, Brigham and Women's Hospital, Boston, MA, ⁵Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose CCR6 has been associated with rheumatoid arthritis (RA) in genome-wide association studies. CCR6 expression characterises Th17 cells recruited to inflamed joints of RA patients.…
Abstract Number: 1746 • 2014 ACR/ARHP Annual Meeting
Involvement of IL-17-Producing MAIT Cells in the Pathogenesis of Rheumatoid Arthritis
Eri Hayashi¹, Asako Chiba², Mie Kitagaichi³, Kurisu Tada³, Ken Yamaji⁴, Naoto Tamura¹, Yoshinari Takasaki³ and Sachiko Miyake², ¹Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Immunology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes which are restricted by the MHC-related molecule-1 (MR1) and express a semi-invariant TCRα…
Abstract Number: 1745 • 2014 ACR/ARHP Annual Meeting
Memory Stem T Cells Are Selectively Enriched in Patients with Rheumatoid Arthritis, Contract upon Anti-TNF Treatment, and May Provide a Long-Term Reservoir of Arthritogenic Lymphocytes
Nicoletta Cieri¹, Giacomo Oliveira¹, Raffaella Greco², Mattia Baldini³, Elena Baldissera⁴, Fabio Ciceri² and Chiara Bonini¹, ¹Division of Immunology, Infectious Diseases and Transplants, Experimental Hematology Unit, San Raffaele Scientific Institute, Milan, Italy, ²Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy, ³Division of Immunology, Infectious Diseases and Transplants, Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy, ⁴Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy
Background/Purpose: the T-cell memory compartment is multi-faceted and encompasses multiple subsets with divergent properties. In addition to central memory (TCM) and effector memory (TEM) cells,…
Abstract Number: 1764 • 2014 ACR/ARHP Annual Meeting
Clinical and Other Differences Observed Between Cocaine Induced and Non-Cocaine Induced Anti-Neutrophil Cytoplasmic Antibody Positive Vasculitis
Santhi Penmetsa¹, N. Suzanne Emil², Joshua Duchesne¹, Wilmer Sibbitt Jr.³, Arthur Bankhurst⁴ and Roderick Fields⁵, ¹Rheumatology, University of New Mexico Health sciences center, Albuquerque, NM, ²Rheumatology, Presbyterian Medical Group, Rio Rancho, NM, ³Rheumatology, University of New mexico health sciences center, Albuquerque, NM, ⁴Rheum/ MSC 105550, University of NM Med Ctr, Albuquerque, NM, ⁵Division of Rheumatology, University of New Mexico health Sciences center, Albuquerque, NM
Background/Purpose Objective: To compare various factors including clinical manifestations, laboratory data and mortality in between two groups of patients with anti-neutrophil cytoplasmic antibody (ANCA) positive…
Abstract Number: 1763 • 2014 ACR/ARHP Annual Meeting
Tobacco Differentially Affects the Clinical-Biological Phenotype of ANCA-Associated Vasculitides at Diagnosis
Lucas Benarous¹, Benjamin Terrier², Bertrand Dunogué³, Pascal Cohen⁴, Xavier Puéchal⁴, Claire Le Jeunne⁴, Luc Mouthon⁴ and Loïc Guillevin for the French Vasculitis Study Group⁴, ¹Cochin Hospital, Paris, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ³Internal Medicine, Hôpital Cochin, Paris, France, ⁴National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France
Background/Purpose Occupational and non-occupational exposures may play a role in the occurrence of ANCA-associated vasculitides (AAV) and affect their initial clinical-biological phenotype. Among these potential…
Abstract Number: 1762 • 2014 ACR/ARHP Annual Meeting
The Muscle Biopsy Is a Useful and Noninvasive Procedure in Diagnosing Systemic Vasculitis Affecting Small-to-Medium-Sized Vessels: A Prospective Evaluation
Takahiro Nunokawa¹, Takayasu Kise¹, Naoto Yokogawa², Kota Shimada¹ and Shoji Sugii², ¹Department of Rheumatic diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Background/Purpose: Histopathological confirmation is required for the diagnosis of systemic vasculitis. However, patients suspected of vasculitis often only have lesions with a low diagnostic yield…
Abstract Number: 1761 • 2014 ACR/ARHP Annual Meeting
Standardisation of Disease Assesment in Systemic Vasculitis: Use of a Novel Web-Based Software Training Application
Jan Sznajd^1,2, Joe Rosa¹, David Gray³, Jennifer O'Donoghue¹, Joanna Robson¹, Surjeet Singh¹, Richard Philipson⁴, Judith Brown⁴, Thor Ostenfeld⁴ and Raashid Luqmani⁵, ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Jagiellonian University Medical College, Krakow, Poland, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ⁴GlaxoSmithKline R&D, Brentford, United Kingdom, ⁵Oxford NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom
Background/Purpose The Birmingham Vasculitis Activity Score (BVAS) and Vasculitis Damage Index (VDI) are validated clinical assessment tools for the systemic vasculitides. However use of BVAS…
Abstract Number: 1744 • 2014 ACR/ARHP Annual Meeting
CD4+ T Cell Subpopulations in Blood and Synovial Fluid Defined By Differential Expression of Integrins
Deepak A. Rao¹, Adam Chicoine², Peter A. Nigrovic³, Soumya Raychaudhuri⁴, Michael B. Brenner⁵ and ACR Authors 2014, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard University, Cambridge, MA, ⁴Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁵Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose CD4+ T cells are important mediators of inflammation in rheumatoid arthritis; however, the specific CD4+ T cell populations most important in driving disease pathology…
Abstract Number: 1743 • 2014 ACR/ARHP Annual Meeting
Antigen-Specificity Regulates Peripheral Homeostasis of Regulatory T Cells
Laura Su¹ and Mark Davis², ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Microbiology, Stanford, Stanford, CA
Background/Purpose One key mechanism of peripheral tolerance involves regulatory T cells (Tregs). Tregs are best known for the expression of the transcription factor Foxp3 that…
Abstract Number: 1742 • 2014 ACR/ARHP Annual Meeting
Depletion of Reactive Oxygen Species Biases T Cells to Proinflammatory Cytokine Production in Rheumatoid Arthritis
Zhen Yang¹, Eric L. Matteson², Jorg J. Goronzy¹ and Cornelia M. Weyand³, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease, genetically associated with polymorphisms in HLA class II molecules. CD4 cells produce proinflammatory cytokines and orchestrate…
Abstract Number: 1741 • 2014 ACR/ARHP Annual Meeting
Anti-TNFα Treatment Increases IL-17A+ and IL-22+ T Cells in Spondyloarthritis Regardless of Concomittant Gut Inflammation
Thomas Andersen¹, René Østgård^1,2, Bent Deleuran^1,2, Malene Hvid³ and Henning Glerup⁴, ¹Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, ²Dept. of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁴Dept. of Gastroenterology, Regional Hospital of Silkeborg, Silkeborg, Denmark
Background/Purpose The pro-inflammatory Th17 associated cytokines IL-17A and IL-22 have been proposed as important mediators of the inflammation seen in spondyloarthritis (SpA) and inflammatory bowel…
Abstract Number: 1740 • 2014 ACR/ARHP Annual Meeting
Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: Can T-Cell Subsets Model Help?
Laura Hunt¹, Agata Burska², Elizabeth M.A. Hensor¹, Jackie L. Nam¹, Frederique Ponchel¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom
Background/Purpose: ACPA+ individuals with non-specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss…
Abstract Number: 1739 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Properties of CD271+ and CD271- Synovial Mesenchymal Cells
Alicia Usategui¹, Manuel J. Del Rey¹, Regina Faré¹, Gabriel Criado², Vanessa Miranda¹, Juan D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain
Background/Purpose Mesenchymal stem cells (MSC) have been isolated from synovium and represent a fraction of synovial fibroblast (SF) cultures. CD271+ is considered a MSC surface…
Abstract Number: 1738 • 2014 ACR/ARHP Annual Meeting
Prominent Role of CCR6+ T Helper Cells in the Pathogenesis of ACPA+ Patients with Early RA
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar², Heleen Vroman³, Johanna MW Hazes⁴, P.H.P. de Jong⁵ and Erik Lubberts², ¹Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology and Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ⁵Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Presence of serum anti-citrullinated protein antibodies (ACPAs) in patients with rheumatoid arthritis (RA) predicts worse disease course and a more erosive disease. In the…

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