Abstracts Archive - Page 2115 of 2607 - ACR Meeting Abstracts

Abstract Number: 1776 • 2014 ACR/ARHP Annual Meeting
Factors Predictive of ANCA-Associated Vasculitis Relapse in Patients Given Rituximab-Maintenance Therapy
Benjamin Terrier¹, Christian Pagnoux², Guillaume Geri³, Alexandre Karras⁴, Chahéra Khouatra⁵, Olivier Aumaitre⁶, Pascal Cohen⁷, Francois Maurier⁸, Olivier Decaux⁹, Hélène Desmurs-Clavel¹⁰, Pierre Gobert¹¹, Thomas Quemeneur¹², Claire Blanchard-Delaunay¹³, Pascal Godmer¹⁴, Xavier Puéchal⁷, Luc Mouthon⁷ and Loïc Guillevin for the French Vasculitis Study Group⁷, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ²Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ³Intensive Care Unit, Cochin Hospital, Paris, France, ⁴Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, ⁵CHU Louis Pradel, Lyon, Lyon, France, ⁶Internal Medicine, CHU, Clermont-Ferrand, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Department of Internal Medicine, Rennes University Hospital, Rennes, France, ¹⁰University of Lyon, LYON, France, ¹¹Nephrology, Centre Hospitalier d'Avignon, Avignon, France, ¹²Internal Medicine, CH, Valenciennes, France, ¹³Internal Medicine, Hôpital de Niort, Niort, France, ¹⁴Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France
Background/Purpose Rituximab (RTX) was shown to be as effective as cyclophosphamide to induce remission in patients with ANCA-associated vasculitis (AAV). The prospective MAINRITSAN trial compared…
Abstract Number: 1775 • 2014 ACR/ARHP Annual Meeting
Predicting Relapse in Patients with Granulomatosis with Polyangiitis – the Potential Use of Monitoring in Vitro ANCA Production
Judith Land¹, Wayel H. Abdulahad¹, Coen A. Stegeman², Peter Heeringa³ and Abraham Rutgers¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose Patients with granulomatosis with polyangiitis (GPA) suffer from frequent disease relapses, with up to 50% of patients relapsing within 5 years. Several risk factors…
Abstract Number: 1774 • 2014 ACR/ARHP Annual Meeting
Granulomatosis with Polyangiitis (Wegener’s): Endoscopic Management of Tracheobronchial Stenosis – Results from a Multicenter Experience in 47 Patients
Benjamin Terrier¹, Agnes Dechartres², Charlotte Girard³, Stéphane Jouneau⁴, Jean-Emmanuel Kahn⁵, Robin Dhote⁶, Jean Cabane⁷, Estibaliz Lazaro⁸, Thomas Papo⁹, Nicolas Schleinitz¹⁰, Guillaume Le Guenno¹¹, Luc Mouthon¹² and Loïc Guillevin for the French Vasculitis Study Group¹², ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ²Biostatistics, Hotel Dieu, Paris, France, ³Internal Medicine, CHU, Lyon, France, ⁴Pulmonology, CHU, Rennes, France, ⁵Internal Medicine, Foch Hospital, Suresnes, France, ⁶Internal Medicine, Avicenne University Hospital, Bobigny, France, ⁷Internal Medicine, Saint-Antoine, Paris, France, ⁸Centre François Magendie, CHU, Pessac, France, ⁹Internal Medicine, Bichat Hospital, Paris, Paris, France, ¹⁰internal medicine, APHM, marseille, France, ¹¹Internal Medicine department, Clermont-Ferrand, France, ¹²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France
Background/Purpose Tracheobronchial stenosis (TBS) is noted in 12 to 23% in patients with granulomatosis with polyangiitis (GPA), and includes subglottic stenosis (SGS) and bronchial stenosis.…
Abstract Number: 1773 • 2014 ACR/ARHP Annual Meeting
Otolaryngologic Lesions Are Not Rare and Closely Related with Pachymeningitis and Cranial Neuropathy in MPO-ANCA Associated Vasculitis
Takahiro Nunokawa¹, Naoto Yokogawa², Kota Shimada¹ and Shoji Sugii², ¹Department of Rheumatic diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Background/Purpose: Recently several case reports of serous otitis media (SOM), hypertrophic pachymeningitis (HP) and cranial neuropathy (CN) have been reported in connection with MPO-ANCA associated…
Abstract Number: 1772 • 2014 ACR/ARHP Annual Meeting
Venous Thromboembolic Events in Eosinophilic Granulomatosis with Polyangiitis (EGPA)
Chiara Baldini¹, Francesco Ferro¹, Nicoletta Luciano¹, Antonio Tavoni², Francesca Sernissi¹, Daniela Martini¹, Sara L'Abbate¹, Marta Mosca³ and Stefano Bombardieri³, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²University of Pisa, Immunoallergology Unit, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Previous studies have documented an increased risk of venous thromboembolic events in patients with antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides (AAV) as compared to…
Abstract Number: 1771 • 2014 ACR/ARHP Annual Meeting
Arterial Thrombotic Events in Systemic Vasculitis
Alexander Tsoukas¹, Sasha Bernatsky², Lawrence Joseph³, David Buckeridge⁴, Patrick Belisle⁵ and Christian A. Pineau¹, ¹Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada, ⁵Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis. Methods Using large-cohort administrative…
Abstract Number: 1770 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Chronic Obstructive Pulmonary Disease in Granulomatosis with Polyangiitis: A General Population-Based Study
Neda Amiri¹, Mohsen Sadatsafavi², Eric C. Sayre³, John M. Esdaile⁴ and J. Antonio Avina-Zubieta^2,5, ¹Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose Chronic obstructive pulmonary disease (COPD) is increasingly recognized as an inflammatory condition. We aimed to identify the risk of newly recorded COPD among…
Abstract Number: 1769 • 2014 ACR/ARHP Annual Meeting
Abdominal Visceral Adipose Tissue Measured By DXA As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides
Bertrand Dunogué¹, Karine Briot², Sami Kolta³, Alexis Regent⁴, Pascal Cohen⁵, Alice Berezne⁶, Xavier Puéchal⁵, Claire Le Jeunne⁵, Luc Mouthon⁵, Christian Roux⁷, Loïc Guillevin for the French Vasculitis Study Group⁵ and Benjamin Terrier⁸, ¹Internal Medicine, Hôpital Cochin, Paris, France, ²Cochin Hospital, Paris Descartes University, Paris, France, ³Rheumatology B, Paris Descartes University, Cochin hospital, Paris, France, ⁴Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁶Paris Descartes University, Internal Medicine department, Cochin Hospital, Paris, France, ⁷Paris Descartes University, Cochin Hospital, Paris, France, ⁸National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France
Background/Purpose Studies have shown a strong prevalence of cardiovascular events among patients with primary necrotizing vasculitides. Recent studies indicate that visceral adipose tissue (VAT) is…
Abstract Number: 1768 • 2014 ACR/ARHP Annual Meeting
Cardiac Involvement in Granulomatosis with Polyangiitis: A Magnetic Resonance Imaging Study of 31 Consecutive Patients
Grégory Pugnet^1,2, Xavier Puéchal¹, Benjamin Terrier¹, Hervé Gouya³, Andre Kahan⁴, Paul Legmann³, Loïc Guillevin¹ and Olivier Vignaux⁵, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ²Toulouse University Hospital, Internal Medicine Department, Toulouse, France, ³AP-HP Cochin Hospital, Department of Radiology B, Paris, France, ⁴Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁵Radiology, Cochin University Hospital, Paris, France
Background/Purpose Cardiac manifestations in granulomatosis with polyangiitis (GPA) patients are usually considered to be rare but may be life-threatening. However specific cardiac involvement in GPA is…
Abstract Number: 1767 • 2014 ACR/ARHP Annual Meeting
Granulomatosis with Polyangiitis (Wegener’s) According to Geographic Origin and Ethnicity: Clinical-Biological Presentation and Outcome
Benjamin Terrier¹, Christophe Deligny², Xavier Puéchal³, Pascal Godmer⁴, Pierre Charles⁵, Gilles Hayem⁶, Bertrand Dunogué⁷, Pascal Cohen³, Serge Arfi⁸, Luc Mouthon³ and Loïc Guillevin for the French Vasculitis Study Group³, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ²Internal Medicine, CHU Fort de France, Fort de France, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁴Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France, ⁵Internal Medicine, Institut Mutualiste Montsouris, Paris, France, ⁶Rhumatologie, Hopital Bichat, Paris Cedex 18, France, ⁷Internal Medicine, Hôpital Cochin, Paris, France, ⁸Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique
Background/Purpose Granulomatosis with polyangiitis (Wegener’s) (GPA) is an ANCA-associated vasculitis (AAV) predominantly affecting small-sized vessels, involving mainly the upper and lower respiratory tracts and kidneys.…
Abstract Number: 1766 • 2014 ACR/ARHP Annual Meeting
Comparison of Clinicopathologically- and Serologically-Based Classification Systems for ANCA-Associated Vasculitis
Sebastian Unizony¹, Eli M. Miloslavsky¹, Miguel Villarreal², Peter A. Merkel³, Paul Monach⁴, E. William St. Claire⁵, Cees Kallenberg⁶, David Ikle², Robert F. Spiera⁷, Nadia Tchao⁸, Deborah J. Phippard⁸, Linna Ding⁹, Carol A. Langford¹⁰, Philip Seo¹¹, Gary S. Hoffman¹², John H. Stone¹ and Ulrich Specks¹³, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Rho, Chapel Hill, NC, ³University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology, Boston University, Boston, MA, ⁵Rheumatology, Duke University School of Medicine, Durham, NC, ⁶Rheumatology and Clinical Immunology, University of Groningen, Groningen, Netherlands, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Immune Tolerance Network, Bethesda, MD, ⁹NIAID, Bethesda, MD, ¹⁰Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ¹¹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹²Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ¹³Frederichs Dr NW, Mayo Clinic, Rochester, MN
Background/Purpose Genome-wide association studies suggest that PR3-ANCA-positive ANCA-associated vasculitis (AAV) is genetically distinct from MPO-ANCA AAV. We evaluated patients enrolled in the RAVE trial according…
Abstract Number: 1765 • 2014 ACR/ARHP Annual Meeting
Comparison of Clinical Characteristics of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis By the Serotype Specificity to Myeloperoxidase and Proteinase-3
Takamasa Murosaki, Takeo Sato, Yoichiro Akiyama, Katsuya Nagatani and Seiji Minota, Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan
Background/Purpose: To correlate the clinical characteristics of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with myeloperoxidase (MPO)-ANCA and proteinase-3 (PR3)-ANCA, and to detect clinical characteristics of…
Abstract Number: 1784 • 2014 ACR/ARHP Annual Meeting
Prognostic Factors for Interstitial Lung Disease with Microscopic Polyangiitis
Takeshi Shoda, Tohru Takeuchi, Takaaki Ishida, Hideyuki Shiba, Youhei Fujiki, Daisuke Wakura, Shuzo Yoshida, Takuya Kotani, Shigeki Makino and Toshiaki Hanafusa, Department of Internal Medicine (I), Osaka medical college, Osaka, Japan
Background/Purpose Many patients with interstitial lung disease (ILD) complicated by microscopic polyangiitis (MPA) show a UIP pattern on chest CT. The prognosis is poorer than…
Abstract Number: 1783 • 2014 ACR/ARHP Annual Meeting
The Importance of Histopathological Classification of ANCA-Associated Glomerulonephritis in Renal Function and Renal Survival
Valeria Scaglioni¹, Marina Scolnik¹, Luis J. Catoggio¹, Carlos Federico Varela², Gustavo Greloni², Silvia Christiansen³ and Enrique R. Soriano¹, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Nephrology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Pathology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose : Histological changes in renal biopsy are the gold standard for establishing the diagnosis of antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). In 2010 a…
Abstract Number: 1782 • 2014 ACR/ARHP Annual Meeting
Long-Term Follow-up of Non-HBV Polyarteritis Nodosa and Microscopic Polyangiitis with Poor-Prognosis Factors
Maxime Samson¹, Xavier Puéchal², Hervé Devilliers³, Pascal Cohen², Boris Bienvenu⁴, Kim Heang Ly⁵, Alain Bruet⁶, Brigitte Gilson⁷, Marc Ruivard⁸, Edouard Pertuiset⁹, Mohamed Hamidou¹⁰, Benjamin Terrier², Christian Pagnoux¹¹, Luc Mouthon², Loic Guillevin¹² and The French Vasculitis Study Group (FVSG)¹², ¹Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ³Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, ⁴Médecine interne, CHU Côte de Nacre, CAEN, France, ⁵CHU Dupuytren, Limoges, Limoges, France, ⁶Department of Nephrology and Internal Medicine, CH de Poissy Saint-Germain-en-Laye, Poissy, France, ⁷Department of Nephrology and Internal Medicine, CH de Verdun, Verdun, France, ⁸CHU Estaing, Clermont–Ferrand, Clermont–Ferrand, France, ⁹Rheumatology, René Dubos Hospital, Pontoise, France, ¹⁰CHU Hôtel Dieu, Nantes, Nantes, France, ¹¹Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ¹²Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose To study the long-term outcomes of 65 patients with non-HBV polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA) enrolled in a prospective, randomized, open-label trial,1…

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