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  • Abstract Number: 2131 • 2014 ACR/ARHP Annual Meeting

    the Impact of Patient-Reported Flares on Radiographic Progression in Rheumatoid Arthritis Patients with Low-Disease Activity: Secondary Analyses from a Randomized Trial

    Dorota Kuettel1, Jette Primdahl2,3,4,5, Lykke Midtbøll Ørnbjerg6, Hans Christian Horn7, Robin Christensen8 and Kim Hørslev-Petersen9, 1Rheumatological, King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark, 2Rheumatology, King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark, 3Institute for Regional Health Research, University of Southern Denmark, Graasten, Denmark, 4Hospital of Southern Jutland, Soenderborg, Denmark, 5Danbio Registry, Glostrup, Denmark, 6Copenhagen Center for Arthritis Reasearch, Center for Rheumatology and Spine diseases, Glostrup Hospital, Copenhagen, Denmark, 7Internal Medicine/Rheumatology, Odense University Hospital, Odense, Denmark, 8Rheumatology, MSU, The Parker Institute, Copenhagen University Hospital, Frederiksberg, Denmark, 9Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark

    Background/Purpose Flares, potentially disabling and disease worsening even when a patient is in low disease activity, are common features in patients with rheumatoid arthritis (RA)…
  • Abstract Number: 2132 • 2014 ACR/ARHP Annual Meeting

    What Is Associated with X- Ray Progression at 5 Years in Rheumatoid Arthritis (RA) Patients in Low Disease Activity?

    Violaine Foltz1, Lisa Biale2, Frederique Gandjbakhch1, Laure Gossec1, Pierre Bourgeois1, Benjamin Granger3 and Bruno Fautrel1, 1Rheumatology, UPMC Paris 06 University, GRC 08, Paris France and Pitié Salpétrière Hospital Paris France, Paris, France, 2Rheumatology, Instruction des Armées Begin hospital, Saint-mande, France, 3Departement de santé publique, information medicale et biostatistiques, unite biotstatistiques, UPMC Paris 06 University, GRC 08, Paris France and Pitié Salpétrière Hospital Paris France, Paris, France

    Background/Purpose Persistent inflammation on Power Doppler (PD) by ultrasound (US) was associated with relapse and structural progression after one year of follow up in a…
  • Abstract Number: 2133 • 2014 ACR/ARHP Annual Meeting

    Efficacy of Tocilizumab Therapy in Patients with Rheumatoid Arthritis Based on FDG-PET/CT

    Koichi Okamura1, Yukio Yonemoto1, Chisa Okura2 and Kenji Takagishi1, 1Orthopaedic Surgery, Gunma University, Maebashi, Japan, 2Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan

    Background/Purpose: A humanized anti-interleukin-6 receptor (anti-IL-6R) antibody, tocilizumab (TCZ), is one of the biologics and the C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR)…
  • Abstract Number: 2134 • 2014 ACR/ARHP Annual Meeting

    Baseline Scintigraphic Detection of TNFá As a Predictor of Therapy Response after Treatment with Certolizumab Pegol in Rheumatoid Arthritis and Spondyloarthritis Patients

    Philippe Carron1, Bieke Lambert2, Filip De Vos3, Gust Verbruggen1, Dirk Elewaut1 and Filip van Den Bosch1, 1Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, 2Department of Nuclear Medicine Ghent University Hospital, Department of Nuclear Medicine Ghent University Hospital, Ghent, Belgium, 3Radiopharmacy, Department of Radiopharmacy Ghent University, Ghent, Belgium

    Background/Purpose: A major challenge in the biologic era is to predict clinical response. A large variability in the level of TNFα expression has been recognized…
  • Abstract Number: 2135 • 2014 ACR/ARHP Annual Meeting

    Patients with Moderate Disease Activity in the First 5 Years of Rheumatoid Arthritis Still Progress Radiographically Despite Conventional Disease Modifying Therapy

    Lewis Carpenter1, Elena Nikiphorou2, Sam Norton3, Keeranur Jayakumar4, Josh Dixey5 and Adam Young6, 1Centre for Lifespan & Chronic Illness Research, University of Hertfordshire, Hatfield, United Kingdom, 2School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 3Institute of Psychiatry, King's College London, London, United Kingdom, 4Rheumatology, Heart of England NHS Foundation Trust, Birmingham, United Kingdom, 5Rheumatology, New Cross Hospital, Wolverhampton, United Kingdom, 6Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom

    Background/Purpose:  Patients with moderate disease are an important, and often poorly studied, patient subgroup. The extent to which traditional DMARD therapies adequately control the disease…
  • Abstract Number: 2136 • 2014 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography

    Stephanie Finzel1, Cheryl Barnabe2, Kathryn Stok3, A. Scharmga4, Andrew J. Burghardt5, Ellen-Margrethe Hauge6, Hubert Marotte7, Stephanie Boutroy8, Klaus Engelke9, Dominique Toepfer10, Sebastian Kraus11, Roland Kocijan12, Xiaojuan Li13 and J. de Jong4, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 3Hpi F 26, Worfgang-Paul Str. 1, ETH Zurich Institute for Biomechanics, Zurich, Switzerland, 4Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 5Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 6Reumatologisk Afdeling, Aarhus Universitetshospital, Aarhus C, Denmark, 7Rheumatology, University Hospital of Saint Etienne, Saint Etienne, France, 8INSERM U1033 and University of Lyon, Hôpital Edouard Herriot, Lyon, France, 9Henkestr. 91, Institute of Medcial Physics Synarc, Hamburg, Germany, 10Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany, 11Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 12Medical Department II, St. Vincent Hospital, Vienna, Austria, 13Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA

    Background/Purpose An operational case definition for identification of erosions imaged by HR-pQCT was achieved and tested in a first reliability exercise (RELEX-1) using cross-sectional data.…
  • Abstract Number: 2137 • 2014 ACR/ARHP Annual Meeting

    Linear Extrapolation of Missing Radiographic Progression Scores Does Not Spuriously overestimate overall Radiographic Progression in Rheumatoid Arthritis

    Iris Markusse1, Robert Landewé2,3, Meilien Ho4, Martin Jenkins4 and Desiree van der Heijde5, 1Leiden University Medical Center, Leiden, Netherlands, 2Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Atrium Medical Center, Heerlen, Netherlands, 4AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, 5Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose : Linear Extrapolation (LE) is a frequently applied method to impute missing radiographic data in trials. However, there is frequent critique that LE overestimates…
  • Abstract Number: 2138 • 2014 ACR/ARHP Annual Meeting

    Radiological Outcomes after Two Years of Remission Steered Treatment in Early Arthritis Patients

    G. Akdemir1, L. Heimans1, K.V.C. Wevers-de Boer1, M.K. Verheul2, A.a. Schouffoer3, M. van Oosterhout4, J.B. Harbers5, C. Bijkerk6, G.M. Steup-Beekman7, L.R. Lard8, T. W. J. Huizinga1, L.a. Trouw1 and C.F. Allaart1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Haga Hospital, The Hague, Netherlands, 4Rheumatology, GHZ Hospital, Gouda, Netherlands, 5Rheumatology, Franciscus Hospital, Roosendaal, Netherlands, 6Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, 7Rheumatology, Bronovo Hospital, The Hague, Netherlands, 8Rheumatology, MCH Antoniushove Hospital, Leidschendam, Netherlands

    Background/Purpose: We investigated whether early, remission steered treatment can prevent damage progression in patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA), and aimed…
  • Abstract Number: 2139 • 2014 ACR/ARHP Annual Meeting

    Predictors of Radiologic Disease Progression during the Rheumatoid Arthritis Comparison of Active Therapies Trial

    Alan Erickson1, Denis Rybin2, Mary Brophy3, Robert Lew3, Ted R. Mikuls1, Timothy Moore4, Keri Hannagan2, Edward Keystone5 and James O' Dell1, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2MAVERIC, VA Boston Heathcare System, Boston, MA, 3VA Boston Heathcare System, Boston, MA, 4Radiology, University of Nebraska Medical Center, Omaha, NE, 5University of Toronto and Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose Halting joint damage is a central goal in the treatment of rheumatoid arthritis.  Much research has been conducted to identify factors associated with progressive…
  • Abstract Number: 2140 • 2014 ACR/ARHP Annual Meeting

    Agreement Among FDG-PET/CT, Ultrasound and Physical Examination in Patients with Inflammatory Arthritis

    Alexis Ogdie1, Shiv Sehra2, Viviane Khoury3, Yihui Jiang4, Shawn Rose5, Nehal N. Mehta6, Sally W. Pullman-Mooar7, Abass Alavi8, Joel Gelfand9 and Joshua Baker10, 1Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, 2Rheumatology, University of Pennsylvania, Philadelphia, PA, 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, 4Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 6Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, 7Rheumatology, University of Pennsylvania and Philadelphia Veterans Hospital, Philadelphia, PA, 8Department of Radiology/Division of Nuclear Medicine, University of Pennsylvania, Philadelphia, PA, 9Dermatology and Epidemiology, University of Pennsylvania., Philadelphia, PA, 10Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA

    Background/Purpose: The lack of tools to accurately measure and quantify joint inflammation is a challenging problem in the study of inflammatory arthritis. No gold standard…
  • Abstract Number: 2141 • 2014 ACR/ARHP Annual Meeting

    Sensitivity to Change of Joint Space Width Measurements in Hand Osteoarthritis in a Two Year Follow-up Study

    W. Damman1, S.E. de Bruin1, B.C. Stoel2, R. van 't Klooster2 and M. Kloppenburg1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Cartilage loss, represented by joint space width (JSW) on radiographs, is an important outcome measure in hand OA disease course. JSW can be assessed…
  • Abstract Number: 2142 • 2014 ACR/ARHP Annual Meeting

    Sensitivity and Precision of Automated Osteophyte Volumetric Measurement in Knee Osteoarthritis over Four Years

    Michael Hakky1, Charles Ratzlaff2, Mohamed Jarraya3, Ali Guermazi4 and Jeffrey Duryea5, 1Radiology, Lahey Clinic, Burlington, MA, 2Harvard Medical School / Brigham and Women's Hospital, Boston, MA, 3Boston University School of Medicine, Boston, MA, 4Radiology, Boston University School of Medicine, Boston, MA, 5Dept of Radiology, Brigham & Women, Boston, MA

    Background/Purpose: Osteophyte formation and evolution is a hallmark of knee OA, and their radiographic identification and progression is fundamental in clinical practice, observational research and…
  • Abstract Number: 2143 • 2014 ACR/ARHP Annual Meeting

    Cortical Breaks and Bone Erosions in the Hand Joints: A Cadaver Study Comparing Conventional Radiography with High-Resolution and Micro-Computed Tomography

    A. Scharmga1, A. van Tubergen1, J. van den Bergh1, J. de Jong1, M. Peters1, B. van Rietbergen2 and P. Geusens1, 1Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

    Background/Purpose . Conventional radiography (CR) is considered the gold standard for diagnosing bone erosions in rheumatic diseases. However, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) and…
  • Abstract Number: 2144 • 2014 ACR/ARHP Annual Meeting

    Cuantification of Hand Bone Mineral Density By Radiogrammetry and Dual X-Ray Absorptiometry in Early Arthritis Patients

    Irene Llorente Cubas*1, Leticia Merino-Meléndez*1, Saturnino González Ortega2, Ana M. Ortiz-García1, Eugenio Escolano2, Esther Vicente-Rabaneda1, Rosario Garcia-Vicuña3, Isidoro González-Alvaro3 and Santos Castañeda-Sanz4, 1Rheumatology Department, Hospital Universitario de La Princesa, Madrid, Spain, 2Radiology Department, Hospital Universitario de la Princesa, Madrid, Spain, 3Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 4Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain

    Background/Purpose: The evaluation of cortical bone mineral density (BMD) on metacarpal bones by digital radiogrammetry (DXR) has been proven to be a simple, reliable and…
  • Abstract Number: 2145 • 2014 ACR/ARHP Annual Meeting

    Diagnostic Performance and Disease Activity Assessment By FDG-PET in Large-Vessel Vasculitis: A Systematic Literature Review and Meta-Analysis

    Michael Soussan1, Patrick Nicolas2, Catherine Schramm3, Sandrine Katsahian3, Veronique Eder4, Olivier Fain5 and Arsene Mekinian6, 1Nuclear Medicine, Avicennes Hospital, Bobigny, France, 2Pharmacology, Avicenne Hospital, 93000, France, 3Inserm U1138, Centre de Recherche des Cordeliers, Equipe 22, Paris 5, Paris 6, Paris, France, paris, France, 4Nuclear Medicine, Avicenne Hospital, Bobigny, France, 5Hôpital Saint Antoine, DHU i2B, Service de Médecine Interne, paris, France, 6Internal Medicine, DHUi2B Saint Antoine Hospital, paris, France

    Background/Purpose: FDG-PET is increasingly used in the work up of large-vessel vasculitis (LVV). The purpose of this study is to perform a systematic review and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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