Abstracts Archive - Page 2091 of 2425 - ACR Meeting Abstracts

Abstract Number: 2430 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis as An Etiological Clue To The Development Of Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis
Nastya Kharlamova¹, Natalia Sherina¹, Anne-Marie Quirke², Kaja Eriksson³, Lena Israelsson⁴, Jan Potempa⁵, Patrick Venables⁶, Tulay Yucel-Lindberg³ and Karin Lundberg⁷, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Department of Dentistry, Karolinska Institutet, Stockholm, Sweden, ⁴Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Microbiology Department, Jagiellonian University, Krakow, Poland, ⁶Kennedy Institute of Rheumatology, Oxford, United Kingdom, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the production of autoantibodies to citrullinated proteins (ACPA). Citrullinated proteins are generated by the actions of peptidyl arginine…
Abstract Number: 2395 • 2013 ACR/ARHP Annual Meeting
Plasma Short-Talin Is a New Rheumatoid Arthritis Monitoring Biomarker Independent Of The Inflammatory Markers
Kensei Tsuzaka, Masako Takao and Jiro Nishida, Dept of Internal Medicine, Ichikawa General Hospital,TDC, Ichikawa, Chiba, Japan
Methods: ). Sixteen (31.4 %) of these 51 patients were untreated, and 18 patients (35.3%) were treated with biologics DMARD at the time of collecting…
Abstract Number: 2391 • 2013 ACR/ARHP Annual Meeting
Pathogenic Pro-Inflammatory Cytokine Production Induced By Synovial Fluid From RA Patients Is Related To Levels Of Endogenous TLR4 Ligands and Is Blocked By a Novel Therapeutic Anti-Human TLR4 Monoclonal Antibody, NI-0101
Limin Shang¹, Greg Elson¹, Jeremy Sokolove², Iain B. McInnes³, James Reilly⁴, Eric Hatterer¹, Marie Kosco-Vilbois⁵, Walter Ferlin⁵, Emmanuel Monnet⁵ and Cristina de Min⁶, ¹NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵NovImmune S.A., Geneva, Switzerland, ⁶Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland
Background/Purpose: Deregulation of Toll-Like Receptor 4 (TLR4) signaling is thought to play a role in the pathogenesis of certain autoimmune diseases. In rheumatoid arthritis (RA),…
Abstract Number: 2392 • 2013 ACR/ARHP Annual Meeting
Impact Of CT-P13 and Originator Infliximab Treatment On Quality Of Life Derived From The Health Assessment Questionnaire (HAQ) and Short-Form 36 (SF-36) From a Randomized, Double-Blind Trial In Patients With Active RA
Dae-Hyun Yoo¹, Andriy Yagensky², Antoaneta Toncheva³, Osca Ruiz Santacruz⁴, Fidencio Cons Molina⁵, Yunju Bae⁶, Taek Kwon⁶, SinHye Kim⁶, Peter Lacouture⁷, Teresa Kok⁸ and Won Park⁹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Lutsk City Hospital, Lutsk, Ukraine, ³National Multiprofile Transport Hospital, Sofia, Bulgaria, ⁴Centro Integral de Reumatología e Inmunología - CIREI S.A.S, Bogotá, Colombia, ⁵Centro de Investigacion en Artritis y Osteoporosis, Mexicali, Mexico, ⁶Celltrion Inc., Incheon, South Korea, ⁷Hospira Inc, Lake forest, IL, ⁸Hospira Inc., Lake Forest, IL, ⁹Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea
Background/Purpose: Quality of life and functionality are important outcome metrics in understanding the value of therapeutic interventions in RA. Biological products have become an established…
Abstract Number: 2393 • 2013 ACR/ARHP Annual Meeting
Involvement Of Transitional T Follicular Like Helper Cells Bearing Triple Phenotypes Of Tfh/Th1/Th17 In The Pathogenesis Of Rheumatoid Arthritis
Shingo Nakayamada¹, Satoshi Kubo², Naoki Yunoue², Maiko Yoshikawa², Shunsuke Fukuyo², Kazuyoshi Saito² and Yoshiya Tanaka², ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: T follicular helper (Tfh) cells are a new subset of T helper cells that regulate B cell function and promote autoantibody production. We previously…
Abstract Number: 2394 • 2013 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Smoking Is Not Primarily Associated With Anti-Citrullinated Protein Antibodies, But With The Presence Of Multiple Autoantibodies
Ammar Muhammad¹, Tineke van Wesemael², Yuta Kochi³, Maria Mjaavatten⁴, Kirsten Wevers-de-Boer¹, Cornelia F. Allaart¹, Leendert A. Trouw¹, Akari Suzuki³, Kazuhiko Yamamoto⁵, Annette H.M. van der Helm-van Mil¹, Tom W.J. Huizinga¹, René E.M. Toes¹ and Diane van der Woude¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Department of Allergy and Rhaumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose: Smoking is associated with the presence of several autoantibodies in various autoimmune diseases. In rheumatoid arthritis (RA), smoking has been described to be specifically…
Abstract Number: 2396 • 2013 ACR/ARHP Annual Meeting
PI3Kdelta Regulates Invadosome Formation and Invasiveness Of Fibroblast-Like Synoviocyte In Rheumatoid Arthritis
Beatrix Bartok¹ and G. S. Firestein², ¹Rheumatology, UCSD School of Medicine, La Jolla, CA, ²Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the intimal lining are major effectors of cartilage damage in rheumatoid arthritis (RA). PI3Kdelta, a member of the Class IA…
Abstract Number: 2397 • 2013 ACR/ARHP Annual Meeting
To Which Extent May The Familial Risk Of Rheumatoid Arthritis Be Explained By Established Risk Factors?
Xia Jiang¹, Thomas Frisell², Johan Askling³, Lars Klareskog⁴, Lars Alfredsson¹ and Henrik Källberg¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a complex inflammatory disease known to aggregate within families, implicating the crucial role of shared genetic and/or environmental factors in…
Abstract Number: 2398 • 2013 ACR/ARHP Annual Meeting
Redox Mediated Angiogenesis In The Hypoxic Joint Of Inflammatory Arthritis
Monika Biniecka¹, Chin Teck Ng¹, Emese Balogh¹, Douglas J. Veale² and Ursula Fearon³, ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ³Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: To investigate whether in vivo synovial hypoxia and TNF blocking therapy determine expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase (Nox2) - a key source of…
Abstract Number: 2399 • 2013 ACR/ARHP Annual Meeting
Altered Histone Methylation Is Associated With IL-6 Dependent Matrix Metalloproteinases Gene Transcriptional Activation In Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^1,2, Kojiro Sato¹, Kazuhiro Yokota¹, Fumihiko Miyoshi¹, Yu F. Asanuma³, Yuji Akiyama¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which causes progressive joint destruction. In spite of the modern medications including biologic reagents, it…
Abstract Number: 2400 • 2013 ACR/ARHP Annual Meeting
Targeted Exon Resequencing For Korean Rheumatoid Arthritis
So-Young Bang¹, Kwangwoo Kim², Young-Ji Na², Jaemoon Lee³, Youngho Park⁴, Sun Young Lee⁵, Adnan Ahmad Ansari⁵, Chan-Bum Choi⁶, Yoon-Kyoung Sung², Tae-Hwan Kim⁷, Jae-Bum Jun⁸, Dae-Hyun Yoo⁸, Junghee Jung⁹, Hwanseok Rhee¹⁰, Jong-Young Lee¹¹, Bok-Ghee Han¹², Sung-Min Ahn¹³, Sungho Won³, Hye-Soon Lee¹⁴ and Sang-Cheol Bae⁸, ¹Hanyang University Guri Hospital, Guri, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Department of Applied Statistics, Chung-Ang University, Seoul, South Korea, ⁴Chung-Ang University, Seoul, South Korea, ⁵Gachon University, Incheon, South Korea, ⁶Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁸Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁹Bioinfomatics Center, Macrogen Inc, Seoul, South Korea, ¹⁰Bioinfomatics Center, Macrogen Inc, Seoul, South Korea, ¹¹Center for Genome Science, Korea National Institute of Health, Osong, South Korea, ¹²Korea National Institute of Health, Osong, South Korea, ¹³Deapartment of Translational Medicine, Gachon University, Incheon, South Korea, ¹⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disorder with heritability estimated at 65% characterized by arthritis and autoantibodies formation against citrullinated peptides (ACPA). Although…
Abstract Number: 2401 • 2013 ACR/ARHP Annual Meeting
Disease Activity (DAS-28CRP) In Rheumatoid Arthritis Correlates With Synovial Expression Of Tumor-Associated and IL-6-Dependent Genes
Bernard Lauwerys¹, Julie Ducreux², Adrien Nzeusseu Toukap¹, Valérie Badot³, Frédéric A. Houssiau² and Patrick Durez¹, ¹Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ³Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Background/Purpose: The molecular mechanisms that regulate disease activity in rheumatoid arthritis (RA) are unknown. Using high-throughput transcriptomic data sets generated in knee synovial biopsies from…
Abstract Number: 2402 • 2013 ACR/ARHP Annual Meeting
Association Between Life Events and Rheumatoid Arthritis, Results From The EIRA Case Control Study
Annmarie Wesley¹, Camilla Camilla Bengtsson¹, Marie Holmqvist², Töres Theorell³, Saedis Saevarsdottir⁴, Eva Skillgate¹, Lars Klareskog⁵, Lars Alfredsson⁶ and Sara Wedrén⁷, ¹Institute of Enviornmental Medicine, Karolinska Insitutet, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Public Health Sciences, Karolinska Insitutet, Stockholm, Sweden, ⁴Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Institute of Enviornmental Medicine/Cardiovascular epidemiology, Karolinska Insitutet, Stockholm, Sweden, ⁷Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The association between life events and rheumatoid arthritis (RA) has previously been studied with contradicting results. No previous study have investigated the impact of…
Abstract Number: 2403 • 2013 ACR/ARHP Annual Meeting
The Incidence Of Factor V Leiden A1691G, Methylene Tetrahydrofolate Reductase C677T, and Prothrombin G20210A Mutation In Patients With Rheumatoid Arthritis
Taskin Senturk¹, Zahit Bolaman², Sabri Batun³, Irfan Yavasoglu⁴ and Gurhan Kadikoylu², ¹Adnan Menderes University, Department of Rheumatology, Professor, Aydin, Turkey, ²Adnan Menderes University, Department of Hematology, Professor, Aydin, Turkey, ³Dicle University, Department of Hematology, Professor, Diyarbakır, Turkey, ⁴Adnan Menderes University, Department of Hematology, Associated Professor, Aydin, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic and inflammatory disease. Thromboembolic phenomenas are more frequent in patients with RA than healthy individuals and several…
Abstract Number: 2404 • 2013 ACR/ARHP Annual Meeting
CXCL13-Producing CD4 T-Cells In Rheumatoid Synovitis Are a Distinct Subset
Shio Kobayashi¹, Koichi Murata², Hideyuki Shibuya², Masahiro Ishikawa², Moritoshi Furu³, Hiromu Ito³, Shuichi Matsuda², Takeshi Watanabe⁴ and Hiroyuki Yoshitomi⁵, ¹Center for Innovation in Immunoregulative Technology ant Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁴Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Innovation Center for Immunoregulation Technologies and Drugs, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Ectopic lymphoid structures are frequently formed in synovial tissues of patients with rheumatoid arthritis (RA). Several reports suggested that CD4 T-cells have a crucial…

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