Abstracts Archive - Page 2068 of 2425 - ACR Meeting Abstracts

Abstract Number: 2770 • 2013 ACR/ARHP Annual Meeting
Complex Functional Effects Within The HLA Contribute To Sjögren’s Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding
Christopher J. Lessard^1,2, He Li¹, Indra Adrianto¹, John A. Ice¹, Mikhail G. Dozmorov³, Roland Jonsson⁴, Maureen Rischmueller⁵, Gunnel Nordmark⁶, Xavier Mariette⁷, Corinne Miceli-Richard⁸, Marie Wahren-Herlenius⁹, Torsten Witte¹⁰, Michael T. Brennan¹¹, Roald Omdal¹², Lars Rönnblom¹³, Patrick M. Gaffney¹, Wan-Fai Ng¹⁴, Nelson L. Rhodus¹⁵, Barbara M. Segal¹⁶, Jonathan D. Wren¹, R. Hal Scofield^1,17,18, Juan-Manuel Anaya¹⁹, John B. Harley^20,21, Courtney G. Montgomery¹ and Kathy L. Sivils^1,2, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ⁶Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁷Paris-Sud University, Paris, France, ⁸Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁹Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁰Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹¹Nidcr NIH, Carolinas Medical Center, Charlotte, NC, ¹²Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹³Department of Medical Science, Uppsala University, Uppsala, Sweden, ¹⁴Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ¹⁵University of Minnesota, Minneapolis, MN, ¹⁶Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁷Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹⁹School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ²⁰Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²¹US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a common, heterogeneous exocrinopathy. Etiology involves complex environmental, genetic and genomic influences driving innate and adaptive autoimmune responses. This…
Abstract Number: 2771 • 2013 ACR/ARHP Annual Meeting
The NKp30/B7H6 Axis Contributes To Pathogenesis In Primary Sjögren’s Syndrome
Gaetane Nocturne¹, Sylvie Rusakiewicz², Damien Sene³, Gunnel Nordmark⁴, Maija-Leena Eloranta⁵, Per Eriksson⁶, Elke Theander⁷, Helena Forsblad-d'Elia⁸, Roald Omdal⁹, Marie Wahren-Herlenius¹⁰, Roland Jonsson¹¹, Lars Rönnblom⁵, Joanne Nititham¹², Kimberly E. Taylor¹³, Christopher J. Lessard¹⁴, Kathy L. Moser¹⁵, Jacques-Eric Gottenberg¹⁶, Lindsey A. Criswell¹², Corinne Miceli-Richard¹⁷, Laurence Zitvogel¹⁸ and Xavier Mariette¹⁹, ¹INSERM U1012, Université Paris Sud, Le Kremlin Bicêtre, France, ²IGR INSERM U1015, Villejuif, France, ³Internal Medecine, Pitie-Salpetriere Hospital, Paris, France, ⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁵Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ⁶Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden, ⁷Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁸Rheumatology, University of Gothenburg, Gothenburg, Sweden, ⁹Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹⁰Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹¹Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹²Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ¹³University of California, San Francisco, San Francisco, CA, ¹⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Strasbourg University Hospital, Strasbourg, France, ¹⁷Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ¹⁸IGR INSERM U1015, Villejuif, France, ¹⁹Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France
Background/Purpose: NK cells are an important subset of cells involved in innate immunity. Their possible role has never been studies in pSS pathogeny. We aimed…
Abstract Number: 2772 • 2013 ACR/ARHP Annual Meeting
Identification Of a Sjögren’s Syndrome-Associated Variant That Influences OAS1 Isoform Switching
He Li^1,2, John A. Ice³, Jennifer A. Kelly³, Indra Adrianto¹, Stuart B. Glenn³, Kimberly S. Hefner⁴, Evan G. Vista⁵, Donald U. Stone⁶, Raj Gopalakrishnan⁷, Glen D. Houston⁸, David M. Lewis⁹, Michael Rohrer⁷, Pamela Hughes⁷, John B. Harley^10,11, Courtney G. Montgomery³, James Chodosh¹², James A. Lessard¹³, Juan-Manuel Anaya¹⁴, Barbara M. Segal¹⁵, Nelson L. Rhodus¹⁶, Lida Radfar², R. Hal Scofield¹⁷, Christopher J. Lessard^3,18 and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁵Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, ⁶Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ⁸Collage of Denistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹¹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹²Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹³Valley Bone and Joint Clinic, Grand Forks, ND, ¹⁴Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ¹⁵Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a common, progressive autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth present in 0.7-1% of the European population.…
Abstract Number: 2773 • 2013 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Patterns In naïve CD4+ T Cells From Patients With Primary Sjögren’s Syndrome
Nezam I. Altorok¹, Patrick S. Coit², Travis Hughes², Kristi A. Koelsch³, R. Hal Scofield⁴, Kathy L. Sivils⁵, A. Darise Farris⁶ and Amr H. Sawalha², ¹Internal Medicine and Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK
Background/Purpose: Primary Sjögren’s syndrome (PSS) is a systemic autoimmune disease characterized by inflammation of the lacrimal and salivary glands and dryness of the eyes and mouth.…
Abstract Number: 2774 • 2013 ACR/ARHP Annual Meeting
Distinct Role Of Plasmacytoid Dendritic Cells and Mast Cells In The Pathogenesis Of Sjӧgren’s Syndrome
Jidong Zhao¹, Kunihiro Yamaoka¹, Satoshi Kubo¹, Shingo Nakayamada² and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Sjögren’s Syndrome (SS) is characterized by the destruction of the lacrimal and salivary grands due to autoreactive lymphocyte infiltration in the early phase and…
Abstract Number: 2775 • 2013 ACR/ARHP Annual Meeting
Adenosine A2b Receptor Agonist Bay60-6583 Restores Salivary Gland Function In a Mouse Model For Sjögren’s Syndrome
Barbara Szczerba¹, Paulina Rybakowska¹, Paromita Dey¹, Harini Bagavant¹ and Umesh Deshmukh², ¹Department of Medicine, University of Virginia, Charlottesville, VA, ²Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder mainly affecting the exocrine glands. However, it is now clear that both immune and non-immune…
Abstract Number: 2746 • 2013 ACR/ARHP Annual Meeting
A Novel Autoinflammatory Disorder Characterized By Ectodermal Dysplasia, Metaphyseal Chondrodysplasia, Growth Failure and Hyper-IgD In a Single Family
Edward J. Oberle^1,2 and James W. Verbsky^1,3, ¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, ²Rheumatology, Children's Hospital of Wisconsin, Milwaukee, WI, ³Children's Hospital of Wisconsin, Milwaukee, WI
Background/Purpose: Autoinflammatory disorders are characterized by chronic inflammation, and a variety of systemic complaints. Defects in the NF-kb essential modifier, or NEMO, are associated…
Abstract Number: 2747 • 2013 ACR/ARHP Annual Meeting
Canakinumab Treatment In Schnitzler’s Syndrome: A Multi-Center Randomized Placebo-Controlled 4-Month Study
Karoline Krause, Karsten Weller, Martin Metz and Marcus Maurer, Dept. of Dermatology and Allergy, Allergie-Centrum-Charité, Charité – Universitätsmedizin Berlin, Germany, Berlin, Germany
Background/Purpose: Schnitzler’s syndrome (SchS) is an adult-onset autoinflammatory disease characterized by urticarial exanthema and monoclonal gammopathy in combination with episodes of fever, arthralgia, fatigue, and…
Abstract Number: 2736 • 2013 ACR/ARHP Annual Meeting
High Density Microarray Analysis Identifies Novel Differentially Expressed Long Noncoding RNAs In Rheumatoid Arthritis Synovial Fibroblasts
Mojca Frank Bertoncelj¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴ and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression. Recently, several new susceptibility loci were identified for rheumatoid arthritis (RA), mapping…
Abstract Number: 2737 • 2013 ACR/ARHP Annual Meeting
In Vivo MiR-146a Administration Ameliorates Murine Lupus Nephritis
Dong Liang¹, Shiyu Zhou², Zheng Liu³, Zhengyuan Shan¹, Philip Brohawn³, Yihong Yao³, Indu Raman⁴, Quan-Zhen Li⁴, John B. Harley^5,6 and Nan Shen^1,2,7, ¹Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ⁴Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁶US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁷Shanghai Institute of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Background/Purpose: New Zealand black and white F1 (NZBW/F1) is a classic mouse model of systemic lupus erythematosus (SLE). Type I interferon (IFN) infusion accelerates lupus…
Abstract Number: 2738 • 2013 ACR/ARHP Annual Meeting
Microrna-Mediated Regulation Explains Allelic Risk Of TLR7 Variant Predisposing To Systemic Lupus Erythematosis
Yun Deng¹, Jian Zhao¹, Jennifer M. Grossman² and Betty P. Tsao¹, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ²Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: We identified a genome-wide significant association of the TLR7 variant (rs3853839) with SLE susceptibility in multiple ancestries (Pmeta =2.0×10-19, OR =1.25), and the risk…
Abstract Number: 2739 • 2013 ACR/ARHP Annual Meeting
Immunochip Analysis Identifies New Susceptibility Loci For Systemic Sclerosis: Implications For Pathogenesis
Maureen D. Mayes for the US Scleroderma GWAS Group¹, Lara Bossini-Castillo for the Spanish Scleroderma Group², Olga Gorlova³, Jose Ezequiel Martin⁴, Xiaodong Zhou¹, Wei Chen⁵, Shervin Assassi¹, Jun Ying⁵, John D. Reveille¹, Peter K. Gregersen⁶, Annette T. Lee⁷, Maria Teruel⁸, Francisco David Carmona⁴, Bobby P.C. Koeleman⁹, Matthew A. Brown and the Immunochip Consortium¹⁰, Christopher P. Denton¹¹, Murray Baron for the Canadian Scleroderma Research Group¹², Jasper Broen¹³, T.R.D.J. Radstake¹³ and Javier Martin⁴, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ³Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, ⁴Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ⁵Department of Epidemiology, UT M.D. Anderson Cancer Center, Houston, TX, ⁶Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁷Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁸Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁰Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ¹¹Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ¹²Rheumatology, Jewish General Hospital, Montreal, QC, Canada, ¹³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose : The purpose of this study was to identify SSc risk loci shared with other autoimmune diseases on the Immunochip and to fine-map previously…
Abstract Number: 2740 • 2013 ACR/ARHP Annual Meeting
High Efficacy Of Toll-Like Receptor 4 Targeting In Murine and Humanized Models Of Rheumatoid Arthritis In Comparison With IL-1 and TNF Inhibitors
Shahla Abdollahi-Roodsaz¹, Marije I. Koenders², Leo A. Joosten³, Fons A. van de Loo⁴ and Wim B. van den Berg¹, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Increased expression of Toll-like Receptor (TLR) 4 and its endogenous agonists in rheumatoid joints suggest involvement in rheumatoid arthritis (RA). The aim of this…
Abstract Number: 2741 • 2013 ACR/ARHP Annual Meeting
Evidence That STAT3 controls NLRP3 inflammasome–dependent Release Of IL-1β and Pyronecrosis Through Regulation of mitochondrial activity
Jehad H. Edwan¹, Jae Jin Chae², Raphaela T. Goldbach-Mansky³ and Robert A. Colbert⁴, ¹NIAMS NIH, Bethesda, MD, ²Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁴NIAMS/NIH, Bethesda, MD
Background/Purpose: Self-activating NLRP3 mutations are responsible for cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID). Spontaneous…
Abstract Number: 2742 • 2013 ACR/ARHP Annual Meeting
Blau Syndrome-Associated NOD2 Mutations Limit Production Of IL-6 and KC/IL-8 In Knock-In Mice and In Patients Suggesting a Loss Of Function Disease Mechanism
Jae Dugan¹, Eric Griffiths¹, Paige Snow¹, Holly L. Rosenzweig¹, Carlos D. Rose², Daniel Carr¹, James T. Rosenbaum³ and Michael Davey¹, ¹Dept. of Veterans Affairs Medical Center, Portland, OR, ²Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, ³Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR
Background/Purpose: Blau syndrome is an autosomal dominant disorder caused by mutations in nucleotide-binding oligomerization domain 2 (Nod2) and characterized by arthritis, dermatitis and uveitis. Nod2…

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