Abstracts Archive - Page 2064 of 2425 - ACR Meeting Abstracts

Abstract Number: 2831 • 2013 ACR/ARHP Annual Meeting
Increased Risk Of Autism Spectrum Disorders In Children Born To Women With SLE: Preliminary Data From The O S L E R Cohort
Evelyne Vinet¹, Susan Scott², Christian A. Pineau³, Lawrence Joseph⁴, Ann E. Clarke⁵, Eric Fombonne⁶, Robert W. Platt⁴ and Sasha Bernatsky⁷, ¹McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, ⁶Oregon Health and Sciences University, Portland, OR, ⁷Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for autism spectrum disorders (ASD). Interestingly, women with…
Abstract Number: 2832 • 2013 ACR/ARHP Annual Meeting
The Effect Of Maternal Antimalarial Intake During Pregnancy On The Risk Of Neonatal Lupus
Julie Barsalou¹, Edgar Jaeggi² and Earl D. Silverman¹, ¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ²Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Background/Purpose: Neonatal Lupus (NLE) results from passive transfer of anti-Ro and/or anti-La antibodies to the fetus during gestation. It has been suggested that prenatal exposure…
Abstract Number: 2833 • 2013 ACR/ARHP Annual Meeting
Increased Cardiac Septal Defects In Children Born To Women With Systemic Lupus Erythematosus: Results From The O S L E R Study
Evelyne Vinet¹, Susan Scott², Christian A. Pineau³, Ann E. Clarke⁴, Robert W. Platt⁴ and Sasha Bernatsky⁵, ¹McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Cardiac septal defects, which include atrial septal defects (ASD) and ventricular septal defects (VSD), are the most frequent congenital heart anomalies in the general…
Abstract Number: 2834 • 2013 ACR/ARHP Annual Meeting
Maternal data Analysis Of The French Registry Of 205 Cases Of Immune Congenital Heart Block (neonatal lupus)
Kateri Levesque¹, Nathalie Morel², Gaëlle Guettrot-Imbert³, Mohamed Hamidou⁴, Jean Loup Pennaforte⁵, Pauline Orquevaux⁵, Jean-Charles Piette⁶, Christophe Deligny⁷, Zahir Amoura⁸, Olivier Meyer⁹, Olivier Fain¹⁰, Agathe Masseau¹¹, Holly Bezanahary¹², Pascal Cathebras¹³, Elizabeth Diot¹⁴, Yves Dulac¹⁵, Loic Guillevin¹⁶, Eric Hachulla¹⁷, Jean-Louis Pasquali¹⁸, Anne Besancon-Bergelin¹⁹, Bernard Bonnotte²⁰, Jérome Lebidois²¹, Alice Maltret²², Elisabeth Villain²² and Nathalie Costedoat-Chalumeau²³, ¹Medicine Interne, Hopital Cochin, Paris, France, ²Internal Medicine, COCHIN, Paris, France, ³Internal Medicine, Centre Hospitalier de Clermont-Ferrand, Clermont-Ferrand, France, ⁴CHU Hôtel Dieu, Nantes, Nantes, France, ⁵Hu Robert Debre, CHU Reims, Reims, France, ⁶Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France, ⁷Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ⁸Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ⁹Rheumatology, Bichat University Hospital, Paris, France, ¹⁰Internal Medicine, Jean Verdier Hospital, Bondy, France, ¹¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹²Internal Medicine, University Hospital of Limoges, Limoges, France, ¹³Internal Medicine, University Hospital St Etienne, St Etienne, France, ¹⁴Department of Internal Medicine, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, Tours, France, Tours, France, ¹⁵University Hospital Toulouse, Paris, France, ¹⁶Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, ¹⁷Internal Medicine, University Hospital Lilles, Lille CEDEX, France, ¹⁸Strasbourg University, Hospital, CNRS UPR 3572, Strasbourg, France, ¹⁹Internal Medicine, Le Mans Hospital, Le Mans, France, ²⁰Department of Internal Medicine, Centre Hospitalier de Dijon, Dijon, France, ²¹Cardiac Institute, Paris, France, ²²Cardiology, Groupe Hospitalier Necker - Enfants Malades, Paris, France, ²³Internal Medicine, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Congenital heart block (CHB) occurs in 1 to 2 % of pregnancies exposed to anti-SSA antibodies. Few data are available regarding the risk of…
Abstract Number: 2835 • 2013 ACR/ARHP Annual Meeting
Safety Of Gardasil® Vaccine In Systemic Lupus Erythematosus
J. Patricia Dhar¹, Lynnette Essenmacher², Renee Dhar³, Ardella Magee⁴, Joel Ager⁵, Malini Venkatram¹, Harpreet Sagar¹ and Robert Sokol⁶, ¹Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, ²Wayne State University, Detroit, MI, ³Department of Clinical and Translational Research, Wayne State University, Detroit, MI, ⁴Clinical Research Center, Wayne State University, Detroit, MI, ⁵Family Medicine Department, Wayne State University, Detroit, MI, ⁶Obstetrics and Gynecology, Wayne State University, Detroit, MI
Background/Purpose: Cervical neoplasia is increased in women with SLE presumably due to cervical infection with oncogenic Human Papillomavirus (HPV) types which persist in an immunosuppressed…
Abstract Number: 2836 • 2013 ACR/ARHP Annual Meeting
Development of a Health Index in Patients With Ankylosing Spondylitis (ASAS HI) – Final Result of a Global Initiative Based On the International Classification of Functioning, Disability and Health (ICF) Guided By Assesment of Spondyloarthritis International Society (ASAS)
Uta Kiltz¹, Désiréé van der Heijde², Annelies Boonen³, Alarcos Cieza⁴, Gerold Stucki⁵, Muhammad Asim Khan⁶, Walter P. Maksymowych⁷, Helena Marzo-Ortega⁸, John D. Reveille⁹, Simon Stebbings¹⁰, Cristina Bostan¹¹ and Juergen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Department of Psychology, University Southampton, Southampton, United Kingdom, ⁵University of Lucerne, Lucerne, Switzerland, ⁶Medicine/ Rheumatology, Case Western Reserve University Hospital, Cleveland, OH, ⁷Medicine/Rheumatic Dis Unit, University of Alberta, Edmonton, AB, Canada, ⁸Leeds Musculoskeletal Biomedical Research Unit and University of Leeds, Leeds, United Kingdom, ⁹Division of Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ¹⁰Dunedin School of Medicine, University of Otago, Dunedin, New Zealand, ¹¹Paraplegic Research Unit, Nottwil, Switzerland
Background/Purpose: The impact of ankylosing spondylitis (AS) on a patient’s life can be considerable. Patients suffer from pain, stiffness and fatigue, are limited in their…
Abstract Number: 2796 • 2013 ACR/ARHP Annual Meeting
Effects Of BAFF Inhibition On B Cell Selection In Murine SLE
Alexis Boneparth^1,2, Ramalingam Bethunaickan³, Weiqing Huang⁴ and Anne Davidson⁴, ¹Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ²Feinstein Institute for medical Research, Manhasset, NY, ³Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: BAFF inhibition is a new B cell targeted therapy approved for the treatment of moderately active SLE. Although BAFF regulates selection of naïve autoreactive…
Abstract Number: 2797 • 2013 ACR/ARHP Annual Meeting
B-Lymphocyte Stimulator and A Proliferation Inducing Ligand In Lupus Nephritis: Low Serum Levels Of BLyS Predict Treatment Response
Ioannis Parodis¹, Agneta Zickert¹, Elisabet Svenungsson², Vivianne Malmström² and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: B-lymphocytes have a pivotal role in the pathogenesis of Systemic Lupus Erythematosus (SLE). B-Lymphocyte Stimulator (BLyS) has an important role in the activation, differentiation…
Abstract Number: 2798 • 2013 ACR/ARHP Annual Meeting
Bone Marrow In Systemic Lupus Erythematosus Patients Contain a Highly Elevated Proportion Of Somatically Mutated, Activated Naive Cells Comprised Of Substantial Clonal Expansions
Jennifer Hom¹, Christopher Tipton², Christopher Fucile³, Bridget Neary¹, Chungwen Wei⁴, F. Eun-Hyung Lee¹, Alex Rosenberg³ and Inaki Sanz², ¹Emory University, Atlanta, GA, ²Medicine/Rheumatology, Emory University, Atlanta, GA, ³University of Rochester, Rochester, NY, ⁴Rheumatology, Emory University, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is a disease where autoreactive antibodies are produced as a result of abnormal B cell activation and broken self-tolerance. This…
Abstract Number: 2799 • 2013 ACR/ARHP Annual Meeting
Identification Of IL-10 Producing Plasma Cells In Human and Its Deficiency In Systemic Lupus Erythematosus Patients
Xiaoqian Wang¹, James Roger² and Ignacio Sanz³, ¹Emory University, Allergy, Immunology and Rheumatology, Atlanta, GA, ²Rheumatology, University of Rochester, Rochester, NY, ³Allergy, Immunology and Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Regulatory B cells are active participants in down-regulating inflammation and autoimmunity, through the production of IL-10. Despite intensive studies in mice, there is only…
Abstract Number: 2800 • 2013 ACR/ARHP Annual Meeting
Dose-Response Effects Of Denosumab, a Novel Subcutaneous RANKL Inhibitor, On The Progression Of Bone Erosion In Japanese Patients With Rheumatoid Arthritis Treated With Methotrexate: Results Of Phase II DRIVE Study – A Twelve Month Placebo Controlled, Randomized, Double Blind Study
Tsutomu Takeuchi¹, Yoshiya Tanaka², Naoki Ishiguro³, Hisashi Yamanaka⁴, Toshiyuki Yoneda⁵, Harry K. Genant⁶ and Désirée van der Heijde⁷, ¹Keio University School of Medicine, Tokyo, Japan, ²University of Occupational and Environmental Health, Kitakyushu, Japan, ³Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁴Institute of Rheumatology Tokyo Women's Medical University, Tokyo, Japan, ⁵Indiana University School of Medicine, Indianapolis, IN, ⁶University of California, San Francisco, CCBR-Synarc, Newark, Tiburon, CA, ⁷Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Denosumab is a fully human monoclonal antibody (IgG2 subclass) that binds specifically to RANKL. It inhibits osteoclast-induced bone resorption by preventing the binding of…
Abstract Number: 2801 • 2013 ACR/ARHP Annual Meeting
Comparative Longitudinal Analysis Of Periarticular Bone Structure In Patients Treated With Methotrexate In Combination Of Either TNF Blockers Or Tocilizumab
Sebastian Kraus¹, Matthias Englbrecht¹, Juergen Rech², Roland Kocijan¹, Georg A. Schett¹ and Stephanie Finzel¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Inhibition of tumor necrosis factor alpha (TNFi) and interleukin-6 receptor (IL6Ri, tocilzumab) are among the most potent therapeutic strategies in patients with rheumatoid arthritis…
Abstract Number: 2802 • 2013 ACR/ARHP Annual Meeting
A Treat-To-Target Strategy With Methotrexate and Intra-Articular Triamcinolone With Or Without Added Adalimumab Reduces Synovitis, Osteitis and Tenosynovitis and Halts Structural Damage Progression In Early Rheumatoid Arthritis: The Opera Magnetic Resonance Imaging Sub-Study
Mette Bjørndal Axelsen^1,2, Iris Eshed³, Kim Hørslev-Petersen⁴, Kristian Steengaard-Petersen⁵, Merete L. Hetland⁶, Jakob M. Møller⁷, Peter Junker⁸, Jan Pødenphant⁹, Torkell Ellingsen¹⁰, Palle Ahlquist¹¹, Hanne M. Lindegaard¹², Asta Linauskas¹³, Annette Schlemmer¹⁴, Mette Yde Dam¹⁵, Ib Hansen¹⁶, Hans Chr Horn¹⁷, Christian G. Ammitzbøll¹⁸, Anette Jørgensen¹⁹, Sophine B. Krintel²⁰, Johnny Raun²¹, Julia S. Johansen²², Niels Steen Krogh²³ and Mikkel Østergaard⁶, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Faculty of Health Sciences, Clinical Department of Orthopedics and Internal Medicine, Copenhagen University, Copenhagen, Denmark, ³Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, ⁴King Christian 10th Hospital for Rheumatic Diseases, South Jutland Hospital, Graasteen, Denmark, ⁵Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁶Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁷Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, ⁸Odense University Hospital, Odense, Denmark, ⁹Copenhagen University at Gentofte, Hellerup, Denmark, ¹⁰Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark, ¹¹Department of Internal Medicine, Vejle Regional Hospital, Vejle, Denmark, ¹²Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹³Vendsyssel Hospital, Hjørring, Denmark, ¹⁴Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ¹⁵Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark, ¹⁶Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ¹⁷Internal Medicine/Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁸Arhus University Hospital, Aarhus, Denmark, ¹⁹Rheumatology, Arhus University Hospital, Aarhus, Denmark, ²⁰Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, ²¹University of Southern Denmark, Graasten, Denmark, ²²Department of Internal Medicine and Oncology, Herlev Hospital, Herlev, Denmark, ²³ZiteLab ApS, Copenhagen, Denmark
Background/Purpose: The aim was to investigate if a treat-to-target strategy with methotrexate and intra-articular glucocorticoid suppressed synovitis and osteitis, and halted structural damage progression in…
Abstract Number: 2803 • 2013 ACR/ARHP Annual Meeting
Can Ultrasonographic Findings Predict Response To Tumor Necrosis Factor-α Inhibitor Treatment In Rheumatoid Arthritis?
Nevsun Inanc^1,2, Gülsen Ozen² and Haner Direskeneli³, ¹Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ²Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ³Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: Tumor necrosis factor-α inhibitors (TNFi) are highly effective in patients with rheumatoid arthritis (RA), while not effective in all, with predictors of response being…
Abstract Number: 2804 • 2013 ACR/ARHP Annual Meeting
Radiological Outcome Of Joints With MRI Detected Subclinical Inflammation In Early Arthritis Patients
A. Krabben¹, W. Stomp², J. a. B. van Nies¹, T.W.J. Huizinga¹, D. van der Heijde³, J.L Bloem², M. Reijnierse² and A. H. M. van der Helm-van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Extremity-MRI is becoming important in Rheumatoid Arthritis (RA) research as it is a sensitive tool to assess inflammation. Inflammation is measured by three features:…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].