Abstracts Archive - Page 2064 of 2607 - ACR Meeting Abstracts

Abstract Number: 2563 • 2014 ACR/ARHP Annual Meeting
The Distribution of Inflammatory Lesions in the Anterior and Posterior Structures of the Spine in Patients with Active Ankylosing Spondylitis and the Effect of TNF-α-Blockade
Xenofon Baraliakos¹, Kay-Geert A. Hermann², Stephen Xu³, Benjamin Hsu³ and Jürgen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ³Janssen Research & Development, LLC., Spring House, PA
Background/Purpose Magnetic resonance imaging (MRI) is a key tool for the assessment of inflammatory lesions used for diagnosis and the monitoring of treatment effects in…
Abstract Number: 2564 • 2014 ACR/ARHP Annual Meeting
Ileocolonoscopic Findings in the Korean Patients with Ankylosing Spondylitis
Soo Min Ahn, Bin Yoo, Chang-Keun Lee, Yong-Gil Kim, Seokchan Hong, Seung-Hyeon Bae and Doo-Ho Lim, Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: The prevalence of concurrent Ankylosing spondylitis (AS) and inflammatory bowel disease, either Crohn's disease (CD) or Ulcerative colitis (UC), is estimated at 5-10%. Up…
Abstract Number: 2561 • 2014 ACR/ARHP Annual Meeting
Low Cardio-Respiratory Fitness Is Associated with Increased Arterial Stiffness in Patients with Ankylosing Spondylitis
Inger Jorid Berg¹, Anne Grete Semb², Silje H. Sveaas^3,4, Camilla Fongen³, Désirée van der Heijde^3,5, Tore K. Kvien³, Hanne Dagfinrud³ and Sella A. Provan³, ¹Dep of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Health Sience, University of Oslo, Oslo, Norway, ⁵Leiden University Medical Center, Leiden, Netherlands
Background/Purpose We have previously shown that patients with ankylosing spondylitis (AS) have lower cardio-respiratory fitness (CRF) than population controls. CRF is inversely associated to risk…
Abstract Number: 2560 • 2014 ACR/ARHP Annual Meeting
Sustained Improvements in Workplace and Household Productivity and Social Participation with Certolizumab Pegol over 96 Weeks in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis
Desiree van der Heijde¹, Juergen Braun², Martin Rudwaleit³, Oana Purcaru⁴ and Arthur Kavanaugh⁵, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Endokrinologikum, Berlin, Germany, ⁴Allee De La Recherche 60, UCB Pharma, Anderlecht, Belgium, ⁵University of California San Diego, La Jolla, CA
Background/Purpose Axial spondyloarthritis (axSpA) includes both ankylosing spondylitis (AS, meeting modified New York criteria) and axSpA with no sacroiliitis on X-ray (non-radiographic axSpA, nr-axSpA). Previous…
Abstract Number: 2539 • 2014 ACR/ARHP Annual Meeting
Antibodies to Human Interferon-Inducible Protein-16 Are Present in Primary Sjögren’s Syndrome and Systemic Lupus, but Are Rare in Dermatomyositis
Alan N. Baer¹, Michelle Petri², David Fiorentino³, Tao Wang⁴, Jungsan Sohn⁴, Antony Rosen¹ and Livia Casciola-Rosen⁵, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, ⁴Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Interferon inducible protein-16 (IFI16) is an intracellular DNA receptor involved in innate immunity. We evaluated the frequency and clinical significance of anti-IFI16 antibodies in…
Abstract Number: 2538 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Guided Core Needle Biopsy of the Major Salivary Glands Is a Safe and Useful Diagnostic Tool in the Evaluation of Suspected or Established Sjögren’s Syndrome
Anand Narayan¹, Thomas Grader-Beck², Julius Birnbaum³, Jean Kim⁴, Qing Kay Li⁵, Deborah Belchis⁵, Joel Fradin¹ and Alan N. Baer⁶, ¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Ultrasound-guided core needle biopsy (CNB) has greater inherent risks than fine-needle aspiration for the diagnosis of major salivary gland neoplasms, but provides tissue for…
Abstract Number: 2537 • 2014 ACR/ARHP Annual Meeting
Diagnostic Accuracies of Sialography and Salivary Ultrasonography in Sjogren’s Syndrome Patients: A Meta-Analysis
Young Ho Lee¹ and Gwan Gyu Song², ¹Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Div of Rheum, Dept of Int Medicine, Guro Hospital, Korea Univ College of Medicine, Seoul, South Korea
Background/Purpose Ultrasonography (US) may come to replace conventional invasive examinations in clinical practice. However, the diagnostic accuracy of salivary US has not been clearly compared…
Abstract Number: 2536 • 2014 ACR/ARHP Annual Meeting
The Sjögren’s Syndrome Responder Index, a Data-Driven Combined Endpoint, Could Detect Biologics Efficacy
Divi Cornec¹, Valerie Devauchelle-Pensec², Xavier Mariette³, Sandrine Jousse-Joulin⁴, Jean-Marie Berthelot⁵, Aleth Perdriger⁶, Xavier Puéchal⁷, Véronique le Guern⁸, Jean Sibilia⁹, Jacques Gottenberg¹⁰, Laurent Chiche¹¹, Eric Hachulla¹², Pierre-Yves Hatron¹³, Vincent Goëb¹⁴, Gilles Hayem¹⁵, Jacques Morel¹⁶, Charles Zarnitsky¹⁷, Jean Jacques Dubost¹⁸, Raphaèle Seror¹⁹, Jacques-Olivier Pers²⁰, Emmanuel Nowak²¹ and Alain Saraux²², ¹Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, ²Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France, ³rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France, ⁴Rheumatology, CHU Brest, Brest, France, ⁵Rheumatology, CHU Nantes (Nantes University Hospital), Nantes, France, ⁶Rhumatologie, Rennes, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁸Department of Internal Medicine, Hôpital Cochin, Paris, France, ⁹Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹⁰Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹¹147 Boulevard Baille, CHU Marseille, Marseille, France, ¹²Internal Medicine, National Scleroderma Centre, Lille CEDEX, France, ¹³CHU Lille, Lille, France, ¹⁴Rheumatology, Amiens University Hospital, Amiens, France, ¹⁵CHU Bichat, Paris, France, ¹⁶Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ¹⁷Rheumatology, Le Havre General Hospital, Le Havre, France, ¹⁸Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France, ¹⁹Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ²⁰CHU Brest, Brest, France, ²¹CIC, CHU Brest, Brest, France, ²²Rheumatology, CHU de la Cavale Blanche and Université Bretagne occidentale, Brest Cedex, France
Background/Purpose Efficacy of rituximab remains debated in primary Sjögren’s syndrome (pSS), but that could be partly due to the absence of validated endpoint. To determine…
Abstract Number: 2535 • 2014 ACR/ARHP Annual Meeting
Performance of the Ocular Staining Score (OSS) Vs. the Van Bijsterveld Score in the Assessment of Sjögren’s Syndrome-Related Keratoconjunctivitis Sicca
Astrid Rasmussen¹, Michael Brown¹, Donald U Stone², Keith Earley³, Kimberly S. Hefner⁴, Lida Radfar⁵, David M. Lewis⁶, Stephen Young⁶, Nelson L. Rhodus⁷, Barbara M. Segal⁸, Christopher J. Lessard⁹, Courtney G. Montgomery¹⁰, R. Hal Scofield¹¹ and Kathy L. Sivils¹², ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Dean McGee Eye Institute, Oklahoma City, OK, ³US Air Force, Oklahoma City, OK, ⁴Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁵College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷University of Minnesota, Minneapolis, MN, ⁸Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ⁹825 N.E. 13th St., Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disorder characterized by xerostomia and xerophthalmia due to exocrine gland dysfunction. There is no single diagnostic test…
Abstract Number: 2534 • 2014 ACR/ARHP Annual Meeting
Ocular Surface Temperature in Early Sjogren’s Syndrome and Established Disease
Andreea Coca¹, Ranjini Kottaiyan², Mircea Coca³, Debbie Campbell⁴, Holly Hindman² and James Aquavella², ¹Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ²Ophtalmology, University of Rochester, Rochester, NY, ³Ophtalmology, University of Texas Medical Branch, Galveston, TX, ⁴Allergy, Immunology and Rheumatology, Univerity of Rochester, Rochester, NY
Background/Purpose Due to a variety of factors it is challenging to make a definite diagnosis in the early stages of Sjögren’s syndrome (SS). The ocular…
Abstract Number: 2553 • 2014 ACR/ARHP Annual Meeting
Compromised Volumetric Bone Density, Bone Microarchitecture and Bone Strength in Patients with Ankylosing Spondylitis: High-Resolution Peripheral Quantitative Computerized Tomography (HRpQCT) Based Study
Nisha Nigil Haroon¹, Eva Szabo², Janet Raboud³, Ammepa Anton⁴, Robert Josse¹, Robert D. Inman¹ and Angela Cheung¹, ¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Osteoporosis Program, UHN, TOronto, ON, Canada, ³Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose Patients with ankylosing spondylitis (AS) have high fracture risk. BMD, bone microarchitecture and strength determine fracture risk. However, in AS, DXA-based BMD measurements of…
Abstract Number: 2552 • 2014 ACR/ARHP Annual Meeting
Effectiveness and Safety of Low-Dose Cyclosporine a in Patients with Primary Sjögren’s Syndrome (pSS) with Articular Involvement – Results of a Pilot Study
Claudia Kedor¹, Jan Zernicke¹, Anja Hagemann², Kathrin Mattat¹, Gerd Burmester¹ and Eugen Feist¹, ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Department of Rheumatology and Immunology, Charité University Medicine, Berlin, Germany
Background/Purpose Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, where musculoskeletal manifestations are usually treated by symptomatic measures and different conventional DMARDs by off-label…
Abstract Number: 2551 • 2014 ACR/ARHP Annual Meeting
Presence of Germinal Centers at Baseline Is Associated with Clinical Response of Glandular Essdai Domain after Abatacept Treatment in Primary Sjogren’s Syndrome
Erlin A. Haacke¹, Frans G.M. Kroese², Petra M. Meiners³, Bert van der Vegt¹, Arjan Vissink⁴, Fred K.L. Spijkervet³ and Hendrika Bootsma², ¹Pathology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: Abatacept inhibits the costimulatory interaction of T-lymphocytes and antigen-presenting cells. Treatment of early and active primary Sjögren's Syndrome (pSS) with abatacept decreases disease activity.…
Abstract Number: 2550 • 2014 ACR/ARHP Annual Meeting
Impaired Speckle Tracking As a Marker of Subclinical Left Ventricular Dysfunction in Patients Affected By Primary Sjögren’s Syndrome
Fabiola Atzeni¹, Stefano Galaverna², Chiara Colombo², Luigi Gianturco², Laura Boccassini¹, Piercarlo Sarzi-Puttini¹ and Maurizio Turiel², ¹Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ²Cardiology Unit, IRCCS-Galeazzi Orthopedic Institute,, Milan, Italy
Background/Purpose Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease that particularly affects the salivary and lachrymal glands, and leads to dry eyes and…
Abstract Number: 2549 • 2014 ACR/ARHP Annual Meeting
Renal Involvement in Primary Sjögren’s Syndrome: A Multicenter French Study of 95 Biopsy Proven Cases
Benjamin Terrier¹, Magali Jasiek², Hélène Francois³, Rafik Mesbah⁴, Laurent Chiche⁵, Anne-Laure Fauchais⁶, Guillaume Moulis⁷, Guillaume Le Guenno⁸, Estibaliz Lazaro⁹, Nathalie Costedoat-Chalumeau¹⁰, Raphaèle Seror¹¹, Luc Mouthon¹, Loïc Guillevin¹, Xavier Mariette¹², Eric Thervet¹³, Alexandre Karras¹⁴ and Véronique Le Guern¹⁵, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ²Nephrology, Bicêtre Hospital, University Paris Sud, France, Paris, France, ³1Nephrology, Bicêtre Hospital, University Paris Sud, France, PARIS, France, ⁴Nephrology, Hôpital Boulogne sur Mer, France, Boulogne Sur Mer, France, ⁵147 Boulevard Baille, CHU Marseille, Marseille, France, ⁶Department of Internal Medicine A, Dupuytren Hospital, Limoges University Hospital, Limoges, France, ⁷Internal Medicine department, Toulouse, Toulouse, France, ⁸Internal Medicine department, Clermont-Ferrand, France, ⁹Hôpital Haut-Lévêque, Pessac, France, ¹⁰Internal medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ¹¹Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ¹²rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France, ¹³Nephrology, Hopital Européen Georges Pompidou, APHP, PARIS, France, ¹⁴Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, ¹⁵Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France
Background/Purpose Renal involvement is reported in 5 to 25% of patients with primary Sjögren's syndrome (pSS). However, data on pSS-related nephropathy with renal biopsy (RB)…

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