Abstracts Archive - Page 2061 of 2607 - ACR Meeting Abstracts

Abstract Number: 2613 • 2014 ACR/ARHP Annual Meeting
Positive Spine MRI for Inflammation Predicts Radiographic Progression in Patients with Ankylosing Spondylitis
Walter P. Maksymowych¹, S Wichuk², Z Zhao³, P Chiowchanwisawakit⁴, RG Lambert⁵ and Sj Pedersen⁶, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³PLA General Hospital, Beijing, China, ⁴Mahidol University, Bangkok, Thailand, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark
Background/Purpose: Inflammation at vertebral corners on MRI has been shown to predict development of syndesmophytes in patients with AS. However, it is unclear at a…
Abstract Number: 2612 • 2014 ACR/ARHP Annual Meeting
Different Performance of the Major Disease Activity Measures ASDAS and Basdai in Patients with Axial Spondyloarthritis Treated with Non-Steroidal Anti-Inflammatory Agents – Results from a Prospective Study
Xenofon Baraliakos¹, Uta Kiltz¹, Frank Heldmann¹, Heiner Appel², Friedrich Dybowski³, Manfred Igelmann⁴, Ludwig Kalthoff⁵, Dietmar Krause⁶, Hans-Jürgen Menne⁷, Ertan Saracbasi⁸, Elmar Schmitz-Bortz⁹ and Jürgen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumatology and Nephrology Practice, Hamm, Germany, ³Rheumatology Practice, Herne, Germany, ⁴Rheumatology Practice, Bochum, Germany, ⁵Rheumatology practice, Herne, Germany, ⁶Rheumatology practice, Gladbeck, Germany, ⁷Rheumatology practice, Dortmund, Germany, ⁸Rheumatology practice, Oberhausen, Germany, ⁹Rheumatology practice, Hattingen, Germany
Background/Purpose: The ASAS/EULAR recommendations for the management of patients (pts) with axial spondyloarthritis (axSpA) have established non-steroidal anti-inflammatory agents (NSAIDs) as first choice of medical…
Abstract Number: 2611 • 2014 ACR/ARHP Annual Meeting
Short Term Efficacy of Tumor Necrosis Factor Inhibitors in Patients with non–radiographic Axial Spondylarthritis and ankylosing Spondylitis; Results from Turkbio Registry
Pinar Cetin¹, Umut Kalyoncu², Bunyamin Kisacik³, Ismail Sari¹, Dilek Solmaz⁴, Omer Karadag², Ahmet Mesut Onat³, Gezmis Kimyon⁵, Levent Kilic⁶, Fatos Onen¹, Sedat Kiraz², Merih Birlik¹, Ihsan Ertenli², Omer Nuri Pamuk⁷ and Nurullah Akkoc¹, ¹Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, ²Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Department of Internal Medicine, Division of Rheumatology, Namik Kemal University School of Medicine, Tekirdag, Turkey, ⁵Department of Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁶Rheumatology, HacettepeUniversity School of Medicine, Ankara, Turkey, ⁷Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey
Background/Purpose Axial spondylarthritis (AxSpA) has been proposed as an umbrella term for ankylosing spondylitis (AS) and non-radiographic (nr) AxSpA). This new concept makes diagnosis of…
Abstract Number: 2610 • 2014 ACR/ARHP Annual Meeting
The Role of IL-20 in the Pathogenesis of Ankylosing Spondylitis with Peripheral Joint Involvement
Göksal Keskin¹, Baris Mavi², Lale Ozisik³, Rahsan Ilikci⁴ and Mehmet Yildiz², ¹Immunology, Medical School of Ankara, Ankara, Turkey, ²Internal Medicine, Diskapi Training and Research Hospital, Ankara, Turkey, ³Internal Medicine, MD, Ankara, Turkey, ⁴Basic Immunology, BC, Ankara, Turkey
Background/Purpose The interleukin-20 (IL-20) is a pro-inflammatory cytokine of the IL-10 family and sequence amino acid is very similar. It has been reported to be…
Abstract Number: 2609 • 2014 ACR/ARHP Annual Meeting
Treating Axial-Spa to Target: Prevalence of Ankylosing Spondylitis Disease Activity Score (ASDAS) Inactive Disease in a Cohort of Patients Treated with Anti-TNFα Agents
Sara Monti¹, Silvia Breda², Francesca De Nard², Vittorio Grosso³, Monica Todoerti², Carlomaurizio Montecucco⁴ and Roberto Caporali⁵, ¹Division of Rheumatology, University of Pavia, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy, ²Division of Rheumatology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ³Division of Rheumatology, University of Pavia, Foundation IRCCS Policlinico S. Matteo, Pavia, Italy, ⁴Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, ⁵Division of Rheumatology, Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy
Background/Purpose . Treating disease to target is emerging as the recommended strategy also in the management of axial-SpA (axSpA) (1). Reaching remission, defined as inactive…
Abstract Number: 2608 • 2014 ACR/ARHP Annual Meeting
Do You Assess Gastro-Intestinal Auto-Antibodies and Symptoms in Patients with Spondyloarthritis?
Consuelo Romero Sanchez^1,2,3, Wilson Bautista-Molano⁴, Viviana Parra-Izquierdo⁵, Carlos Martínez⁶, Ferney Garcia⁶, Juliette De Avila⁷, Haroldo Juliao⁸, Juan Manuel Bello³, John Londoño⁹ and Rafael Valle-Oñate^9,10, ¹Rheumatology, Spondyloarthritis Group. Rheumatology Department. Hospital Militar Central/Universidad de La Sabana. Bogotá. Colombia, Bogotá, Colombia, ²UIBO Institute (Oral Basic Research Unit) School of Dentistry Universidad El Bosque, School of Dentistry, Colombia, Bogotá, Colombia, ³Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, ⁴Department of Rheumatology, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, ⁵Spondyloarthritis Group. Rheumatology Department. Hospital Militar Central/Universidad de La Sabana. Bogotá. Colombia, Bogota, Colombia, ⁶Coloproctology, Coloproctology Deparment, Hospital Militar Central, Bogotá, Colombia, ⁷School of Dentistry, UIBO Institute (Oral Basic Research Unit) School of Dentistry Universidad El Bosque, Bogotá, Colombia, ⁸Gastroenterology, Gastroenterology Deparment, Hospital Militar Central, Bogotá, Colombia, ⁹Spondyloarthritis Group. Rheumatology Department. Hospital Militar Central/Universidad de La Sabana. Bogotá. Colombia, Bogotá, Colombia, ¹⁰Rheumatology, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia
Background/Purpose Spondyloarthritis (SpA) are a group of chronic inflammatory rheumatic diseases. Extra-articular manifestations affect approximately 30% of patients with SpA, and gastrointestinal manifestations (GI) represents…
Abstract Number: 2607 • 2014 ACR/ARHP Annual Meeting
Fatigue in Ankylosing Spondylitis: A Multivariable Analysis Implicates Inflammation As the Key Determinant of Disability
Mohamed Bedaiwi¹, Arane Thavaneswaran², Nigil Haroon³, Ammepa Anton⁴ and Robert D. Inman⁵, ¹Division of Rheumatology, Toronto Western Hospital, clinical and research fellow, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada, ⁵Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Fatigue is one of the cardinal features of ankylosing spondylitis (AS). The clinical and laboratory correlates of fatigue in AS however are not well…
Abstract Number: 2606 • 2014 ACR/ARHP Annual Meeting
How to Classify Spondyloarthritis after a Two Year Follow up? Results from the French Recent onset spondyloarthritis Cohort
Pierre Gazeau¹, Divi Cornec², Marie Agnès Timsit¹, Valerie Devauchelle³, Sandrine Jousse-Joulin¹, Thierry Marhadour⁴, Emmanuel Nowak⁵, Maxime Dougados⁶ and Alain Saraux⁷, ¹Rheumatology, CHU Brest, Brest, France, ²Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, ³Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁴Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁵CIC, CHU Brest, Brest, France, ⁶INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ⁷Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France
Background/Purpose: In early arthritis, after a two years follow up, rheumatologist diagnosis of rheumatoid arthritis agrees well with 2010 ACR/EULAR criteria (Saraux A et al.…
Abstract Number: 2605 • 2014 ACR/ARHP Annual Meeting
Profiling Ankylosing Spondylitis Patients Likely to Respond to NSAID Treatment
Mohamed Bedaiwi¹, Arane Thavaneswaran², Nigil Haroon³, Ammepa Anton⁴ and Robert D. Inman⁵, ¹Division of Rheumatology, Toronto Western Hospital, clinical and research fellow, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada, ⁵Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease with unpredictable course of progression. Treatment of AS thus should be tailored according to disease…
Abstract Number: 2584 • 2014 ACR/ARHP Annual Meeting
Smoking Is Not Associated with Response to TNF Blockers in Patients with Axial Spondyloarthritis
Anna Dellyes¹, Pierre Lafforgue¹, Vincent Pradel² and Thao Pham¹, ¹Rheumatology, APHM, Aix Marseille University, Marseille, France, ²Epidemiology, APHM, Aix Marseille University, Marseille, France
Background/Purpose Smoking has been reported as associated with increase disease activity, more functional impairment, poorer quality of life and more radiographic damages in patients (pts)…
Abstract Number: 2583 • 2014 ACR/ARHP Annual Meeting
Unexpected High Prevalence of Cardiac Disease in Patients with Ankylosing Spondylitis
S.C. Heslinga^1,2, Thelma C. Konings³, Irene E. Van der Horst - Bruinsma⁴, M.L. John⁴ and Mike T. Nurmohamed², ¹Internal Medicine, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Cardiology, VU University Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose Ankylosing spondylitis (AS) is associated with an increased cardiovascular (CV) risk that is caused by accelerated atherosclerosis as well as specific cardiac manifestations: valvular…
Abstract Number: 2582 • 2014 ACR/ARHP Annual Meeting
Serum Levels of Bone Morphogenetic Protein-7 and Sclerostin Are Elevated in Ankylosing Spondylitis, but Not Linked with Structural Damage
Weiping Kong¹, Xiaotong WANG¹, Tongliang Zhou², Yue Jin³, Qingwen TAO¹, Yuan Xu¹, Yingze Zhang¹, Jianming WANG¹ and Xiaoping Yan¹, ¹Department of TCM Rheumatology, China-Japan Friendship Hospital, BEIJING, China, ²CLINICAL RESEARCH INSTITUTE OF IMMUNOLOGY, China-Japan Friendship Hospital, BEIJING, China, ³COMBINATION OF WESTERN AND CHINESE MEDICINE, Beijing University of Chinese Medicine, BEIJING, China
Background/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by new bone formation that progressively leads to ankylosis and functional disability. The mechanisms of…
Abstract Number: 2581 • 2014 ACR/ARHP Annual Meeting
Clinically Active Non-Radiographic Axial Spondyloarthritis Patients Who Initially Have a Negative MRI and Normal CRP May Develop a Positive MRI or Elevated CRP at a Later Timepoint
Xenofon Baraliakos¹, Joachim Sieper², Su Chen³, Aileen L. Pangan³ and Jaclyn K. Anderson³, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³AbbVie Inc., North Chicago, IL
Background/Purpose: Patients (pts) with non-radiographic axial spondyloarthritis (nr-axSpA) and active disease may have objective evidence of inflammation, either as bone marrow edema (BME) on magnetic…
Abstract Number: 2580 • 2014 ACR/ARHP Annual Meeting
A Comparison of Baseline Characteristics and Real-Life Effectiveness of Anti-TNF Therapy in Non-Radiographic Axial Spondyloarthritis Versus Ankylosing Spondylitis – a Single Center Cohort Study
Sarka Forejtova¹, Jakub Zavada², Michal Uher³, Karel Hejduk³ and Karel Pavelka⁴, ¹Rheumatology, Institute of Rheumatology, Prague, Czech Republic, ²Charles University, Prague, Czech Republic, ³Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Background/Purpose: The recent Assessment of SpondyloArthritis international Society (ASAS) classification criteria proposed the concept of axial spondylarthritis (axSpA) to enable earlier treatment not only for…
Abstract Number: 2579 • 2014 ACR/ARHP Annual Meeting
How Should We Calculate the ASDAS If the Conventional C-Reactive Protein Is below the Limit of Detection? – an Analysis in the DESIR Cohort
Pedro Machado^1,2, Victoria Navarro-Compán^1,3, Robert Landewé^4,5, Floris van Gaalen¹, Christian Roux⁶ and Desirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²University College London, London, United Kingdom, ³University Hospital La Paz, Madrid, Spain, ⁴Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Atrium Medical Center, Heerlen, Netherlands, ⁶Paris Descartes University, Cochin Hospital, Paris, France
Background/Purpose: The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a composite measure of disease activity in axial spondyloarthritis. It was suggested that when the conventional …

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