Abstracts Archive - Page 2053 of 2425 - ACR Meeting Abstracts

Abstract Number: L15 • 2014 ACR/ARHP Annual Meeting
Remission Induction By Etanercept in Enthesitis Related Arthritis JIA-Patients (juvenile undifferentiated Spondylarthropathy)
Ivan Foeldvari¹, Gerd Horneff², Kirsten Minden³, Ralf Trauzeddel⁴, J B. Kuemmerle-Deschner⁵, Klaus Tenbrock⁶, Gerd Ganser⁷ and Hans-Iko Huppertz⁸, ¹Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ²Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, ³Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ⁴Pediatrics, Helios Clinics, Berlin, Germany, ⁵Division of Pediatric Rheumatology, Department of Pediatrics, University Hospital Tuebingen, Tuebingen, Germany, ⁶University Aachen, Aachen, Germany, ⁷Pediatric Rheumatology, Sankt Josef Stift, Sendenhorst, Germany, ⁸Kinderklinik, Krinikum Bremen-Mitte, Bremen, Germany
Background/Purpose: Enthesitis related arthritis (ERA) is a Juvenile Idiopathic Arthritis category, clinically related to the syndrome of undifferentiated spondyloarthropathy in adults. This study is intended…
Abstract Number: L23 • 2014 ACR/ARHP Annual Meeting
Humoral Immune Response to Pneumococcal Polysaccharide Vaccine in SLE Patients on Immunosuppressive Therapy: Assessment of Serotypes without Protective Antibody Levels
Rodrigo Poubel V. Rezende¹, Francinne M. Ribeiro¹, Luis Eduardo C. Andrade², Carlos Roberto M. Gayer³, Elisa M. N. Albuquerque¹ and Evandro Mendes Klumb¹, ¹Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²Fleury Laboratories, Sao Paulo, Brazil, ³Department of Biochemistry, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
Background/Purpose: Previous works assessing antibody response to pneumococcal polysaccharide vaccine (PPV) in systemic lupus erythematosus (SLE) relied exclusively on the quantitative increase in antibody titers…
Abstract Number: 197 • 2013 ACR/ARHP Annual Meeting
Discordance Of Patient-Physician Assessments Of General Health In a US Hispanic Population With Rheumatoid Arthritis
Leyda Díaz-Correa¹, Mariely Nieves-Plaza², Yesenia C. Santiago-Casas³, Tania González-Rivera⁴, Grissel Ríos³ and Luis M. Vilá³, ¹Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ⁴Department of Medicine, Division of Rheumatology, University of Michigan School of Medicine, Ann Arbor, MI
Background/Purpose: Instruments to measure rheumatoid arthritis (RA) activity such as the 28-Joint Disease Activity Score (DAS28) are used to assess response to treatment. One component…
Abstract Number: 198 • 2013 ACR/ARHP Annual Meeting
Accuracy Of International Classification Of Diseases (Ninth Revision) Coding For Rheumatoid Arthritis In The Primary Care Setting
Sheena Ogando¹, Karolina M. Weiss¹ and Harry D. Fischer², ¹Department of Medicine, Albert Einstein College of Medicine at Beth Israel Medical Center, New York, NY, ²Division of Rheumatology, Albert Einstein College of Medicine at Beth Israel Medical Center, New York, NY
Background/Purpose: Current quality measures are diagnosis driven and focus on management. For rheumatoid arthritis (RA), the Physician Quality Reporting System requires that a disease modifying…
Abstract Number: 160 • 2013 ACR/ARHP Annual Meeting
Association Analysis Of The Organic Anion Transporter 4 and Urate Transporter 1 Locus With Gout In New Zealand Case-Control Sample Sets Reveals Multiple Ancestral-Specific Effects
Tony R. Merriman¹, Amanda Phipps-Green¹, Jade E. Hollis-Moffatt², Marilyn E. Merriman¹, Ruth Topless¹, Grant Montgomery³, Brett Chapman³, Lisa K. Stamp⁴, Nicola Dalbeth⁵ and Tanya Flynn², ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Queensland Institute of Medical Research, Brisbane, Australia, ⁴University of Otago, Christchurch, New Zealand, ⁵Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: There are genetic variants in urate transporters SLC22A11 (OAT4) and SLC22A12 (URAT1) that influence serum urate levels in European Caucasian. However, there is no…
Abstract Number: 161 • 2013 ACR/ARHP Annual Meeting
H3K9 Demethylation By LSD1 Contributes To IL-1-Induced mPGES-1 Expression In OA Chondrocytes
Fatima Ezzahra El Mansouri¹ and Hassan Fahmi², ¹Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ²Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: Microsomal prostaglandin E synthase-1 catalyzes the terminal step in the biosynthesis of PGE2, which plays a critical role in the pathophysiology of osteoarthritis. To…
Abstract Number: 162 • 2013 ACR/ARHP Annual Meeting
Genotypic and Haplotypic Effects Of 7 Single-Nucleotide Polymorphisms In the CRP Gene On Levels Of C-Reactive Protein and DAS28 In a Cohort Of 180 Untreated Newly Diagnosed Rheumatoid Arthritis Patients (OPERA Study)
Christian G. Ammitzbøll¹, Rudi Steffensen², Peter Junker³, Mikkel Østergaard⁴, Julia Johansen⁵, Jan Pødenphant⁶, Merete Lund Hetland^7,8, Hanne M. Lindegaard⁹, Torkell Ellingsen¹⁰ and Kristian Stengaard-Pedersen¹, ¹Arhus University Hospital, Aarhus, Denmark, ²Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ³University of Southern Denmark, Odense, Denmark, ⁴Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁵Copenhagen University and Glostrup Hospital, Copenhagen, Denmark, ⁶Copenhagen University at Gentofte, Hellerup, Denmark, ⁷Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ⁸Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup, Denmark, ⁹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark
Background/Purpose: Single nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the basal C-reactive protein (CRP) expression and its response to…
Abstract Number: 163 • 2013 ACR/ARHP Annual Meeting
The Frequency Of Single Nucleotide Polymorphisms In Urate Transporter Genes and Their Association With Uric Acid Concentration Based On Data From Genome-Wide Association Studies In The Korean Population
Chan-Nam Son¹, So-Young Bang², Sang-Cheol Bae³ and Jae-Bum Jun³, ¹Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea, ²Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ³Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Gouty arthritis is characterized by hyperuricemia, which results from overproduction of, or impaired renal excretion of, uric acid. Recently, interest has increased in renal…
Abstract Number: 164 • 2013 ACR/ARHP Annual Meeting
Haptoglobin Chains As Potential Biomarkers In Serum Of Osteoarthritis Disease
Carolina Fernandez-Costa¹, Valentina Calamia¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Beatriz Rocha², Lucia Lourido¹, Jose Luis Capelo³, Cristina Ruiz-Romero^1,4 and Francisco J. Blanco¹, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³BIOSCOPE Group, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa,, Caparica, Portugal, ⁴CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: The aim of this study is to search for osteoarthritis (OA) biomarkers in human serum using an easy and fast approach and the validation…
Abstract Number: 165 • 2013 ACR/ARHP Annual Meeting
New Insights Into The Metabolic Origin Of Osteoarthritis
Ignacio Rego-Pérez¹, María Eugenia Vázquez-Mosquera², Angel Soto-Hermida², Mercedes Fernández-Moreno², Juan Fernández-Tajes², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^3,4,5, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: Metabolic alterations take place in osteoarthritis (OA) and the mtDNA haplogorups influence the prevalence and severity of the disease. The aim of this work…
Abstract Number: 166 • 2013 ACR/ARHP Annual Meeting
The Potential Role Of Protein Tyrosine Phosphatase Receptor D (PTPRD) Gene Copy Number Variation In Susceptibility To Rheumatoid Arthritis
Su Jin Yoo¹, Mi Kyoung Lim², Donghyuk Sheen³, In Seol Yoo⁴, Jinhyun Kim⁵, Seong Wook Kang⁴ and Seung-Cheol Shim⁶, ¹Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea, ²Medicine, Eulji University Hospital, Daejeon, South Korea, ³Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁴Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ⁵Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ⁶Department of Internal Medicine, Chungnam National University Hospital, Daejeon, South Korea
Background/Purpose: Since it is important to explore genetic variations associated with rheumatoid arthritis (RA), genome-wide association studies (GWAS) have led to the identification of RA…
Abstract Number: 167 • 2013 ACR/ARHP Annual Meeting
Association Of Functional Polymorphisms In IRF2 With Systemic Lupus Erythematosus In a Japanese Population
Aya Kawasaki¹, Hiroshi Furukawa², Nao Nishida³, Eiji Warabi⁴, Yuya Kondo⁵, Satoshi Ito⁶, Isao Matsumoto⁷, Makio Kusaoi⁸, Akiko Suda⁹, Shouhei Nagaoka¹⁰, Keigo Setoguchi¹¹, Tatsuo Nagai¹², Shunsei Hirohata¹³, Katsushi Tokunaga¹⁴, Yoshinari Takasaki¹⁵, Hiroshi Hashimoto¹⁶, Takayuki Sumida⁵, Shigeto Tohma² and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ³Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan, ⁴Environmental Molecular Biology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁵Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁶Niigata Rheumatic Center, Shibata, Japan, ⁷Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan, ⁸Department of Internal Medicine and Rheumatology, Juntendo University, Tokyo, Japan, ⁹Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan, ¹⁰Department of Rheumatology, Yokohama Minami Kyousai Hospital, Yokohama, Japan, ¹¹Allergy and Immunological Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan, ¹²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ¹³Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ¹⁴Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ¹⁵Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ¹⁶Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Interferon regulatory factor (IRF) families are transcription factors involved in type I interferon (IFN) pathway. Recent genetic studies identified association of IRF family genes,…
Abstract Number: 168 • 2013 ACR/ARHP Annual Meeting
Predicting The Severity Of Joint Damage In Rheumatoid Arthritis; The Contribution Of Genetic Factors
Hanna W. van Steenbergen¹, Roula Tsonaka², Tom W.J. Huizinga¹, Saskia le Cessie^2,3 and Annette H.M. van der Helm-van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ³Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The severity of radiologic progression is variable between rheumatoid arthritis (RA) patients. Recently several genetic severity variants have been identified and replicated. This study…
Abstract Number: 169 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On The Gene Expression Profile In Interleukin-1β Stimulated Synovial Fibroblast Cells Cultures
Cécile Lambert¹, Jean-Emile Dubuc², Eulalia Montell³, Josep Verges³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, ³Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. In this…
Abstract Number: 170 • 2013 ACR/ARHP Annual Meeting
Association Of BMI, 8 SNPs Reported To Be Related To Gout Phenotype and Their Interaction In Gout Incidence In Framingham Heart Study
Jasvinder A. Singh^1,2, Ana Vazquez³, Richard Reynolds³, Vinodh Srinivasasainagendra⁴, S. Louis Bridges Jr.⁵ and David Allison³, ¹Rheumatology, Birmingham VA, Birmingham, AL, ²Department of Medicine, University of Alabama, Tuscaloosa, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴University of alabama at birmingham, birmingham, AL, ⁵Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: We aim to assess the association of 8 serum urate SNPs and BMI and their interactions with incident gout in a population-based cohort study. Methods:…

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