Abstracts Archive - Page 2038 of 2607 - ACR Meeting Abstracts

Abstract Number: 2942 • 2014 ACR/ARHP Annual Meeting
A Longitudinal Population-Based Study 1994-2010 of Age, Period, and Cohort Effects in the Prevalence of Arthritis: The Effect of Improving Socioeconomic Status and Increasing Obesity over Time
Elizabeth M. Badley^1,2, Mayilee Canizares^3,4, Anthony V. Perruccio^5,6, Sheilah. Hogg-Johnson^6,7 and Monique A.M. Gignac^6,7, ¹Division Health Care and Outcomes Research,, Toronto Western Research Institute, Toronto, ON, Canada, ²Dalla Lana School of Public Health,, University of Toronto, Toronto, ON, Canada, ³Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ⁵Arthritis Program, Toronto Western Hospital, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁷Institute for Work and Health, Toronto, ON, Canada
Background/Purpose: To examine birth cohort and period effects in the age-trajectories of reported arthritis from 1994 to 2010 in a representative sample of Canadians; and…
Abstract Number: 2943 • 2014 ACR/ARHP Annual Meeting
Severity of Foot Pain Is Linked to the Prevalence of Depressive Symptoms: The Framingham Foot Study
Arunima Awale¹, Alyssa B. Dufour², Patricia P. Katz³, Virginia A. Casey¹ and Marian T. Hannan⁴, ¹Institute for Aging Research, Hebrew SeniorLife, Boston, MA, ²Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, ³Medicine, University of California, San Francisco, CA, ⁴Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: While a number of risk factors for foot pain are established, the relation between depression and foot pain has not been well studied. The…
Abstract Number: 2944 • 2014 ACR/ARHP Annual Meeting
Sedentary Time Is an Independent Risk Factor for Disability Onset Among Adults at Elevated Risk: Prospective Cohort Study
Jungwha Lee¹, Jing Song², Barbara Ainsworth³, Rowland W. Chang⁴, Linda S. Ehrlich-Jones⁵, Christine Pellegrini⁶, Pamela Semanik⁷, Dorothy D. Dunlop² and Leena Sharma⁸, ¹Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Arizona State University, Pheonix, AZ, ⁴Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rehabilitation Institute of Chicago, Chicago, IL, ⁶Center for Behavioral Health, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Rush University, Chicago, IL, ⁸Northwestern University, Chicago, IL
Background/Purpose: Disability threatens personal independence and is a major driver of health care costs. Physical activity has been shown to prevent disability. Sedentary behavior, already…
Abstract Number: 2945 • 2014 ACR/ARHP Annual Meeting
Foot Structure and Function Show Associations with Lower Extremity Physical Function
Yvonne M. Golightly¹, Marian T. Hannan², Patricia P. Katz³, Howard J. Hillstrom⁴, Alyssa B. Dufour⁵ and Joanne M. Jordan⁶, ¹Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ²Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Rehabilitation, Hospital Special Surgery (HSS), New York, NY, ⁵Institute for Aging Research, Hebrew SeniorLife & Boston Univ, Boston, MA, ⁶University of North Carolina Dept of Epidemiology, Chapel Hill, NC
Background/Purpose . Foot pain is associated with poorer physical function in older adults, but few studies have examined how foot structure (high / low arches) and…
Abstract Number: 2946 • 2014 ACR/ARHP Annual Meeting
The Association Between Accelerometer Monitored Sedentary Behavior and Observed Physical Function Loss
Pamela Semanik¹, Rowland W. Chang², Jing Song³, Jungwha Lee⁴ and Dorothy D. Dunlop³, ¹Nursing, Rush University College of Nursing, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Preservation of function in older adults is critical to maintaining independence. Physical activity interventions often focus on increasing activity while giving limited attention to…
Abstract Number: 2947 • 2014 ACR/ARHP Annual Meeting
Adenosine a_2A Receptor As a Potential New Therapeutic Target for the Prevention/Treatment of Osteoarthritis
Carmen Corciulo¹, Aranzazu Mediero², Tuere Wilder³ and Bruce N. Cronstein⁴, ¹Division of Translational Medicine, Department of Medicine, NYU School of Medicine, New York, NY, ²Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ³Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Osteoarthritis results from trauma, mechanical factors or metabolic changes in bone and cartilage. Adenosine, acting via the A2AR, inhibits inflammation and plays a critical…
Abstract Number: 2948 • 2014 ACR/ARHP Annual Meeting
S100 Proteins Induce Canonical Wnt Signaling, Which Causes Increased Expression of MMPs in the Synovium
Martijn H. van den Bosch¹, Arjen B. Blom², R. Pelle Hoek², Rik F. Schelbergen³, Sylvia W. Suen², Anke E. van Erp², Wim B. van den Berg¹, Peter M. van der Kraan¹ and Peter L. van Lent⁴, ¹Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Radboud university medical center, Nijmegen, Netherlands, ⁴Experimental Rheumatology, Experimental Rheumatology, Radboud University, Nijmegen, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found that the alarmins S100A8 and A9,…
Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Ru Bryan¹, Xianling Zhao², Yun Wang³, Han Sol Lee², Hyunje Kim⁴, Alifah Akasdi² and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²VAMC, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ⁴Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
Abstract Number: 2950 • 2014 ACR/ARHP Annual Meeting
Synovial Macrophages Promote TGF-β Activation after Intra-Articular Injections of Oxidized LDL in Naïve Murine Knee Joints, Preventing Production of Pro-Inflammatory Factors S100A8/9, Chemokines and Aggrecanase-Induced Neo-Epitopes
Wouter de Munter, Peter M. van der Kraan, Wim B. van den Berg and Peter L. van Lent, Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In previous studies we found that synovial macrophages regulate joint pathology during experimental osteoarthritis (OA). Recently, we found that high systemic levels of LDL…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting
S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium
Peter L. van Lent¹, Rik Schelbergen², Arjen B. Blom¹, Tomas Leanderson³, Helena Eriksson⁴ and Wim B. van den Berg⁵, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Immunology Group, Lund University, Lund, Sweden, ⁴BioScience, Active Biotech AB, Lund, Sweden, ⁵Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…
Abstract Number: 2953 • 2014 ACR/ARHP Annual Meeting
International Immunochip Study in the Idiopathic Inflammatory Myopathies Identifies Novel Susceptibility Loci and Confirms HLA As Strongest Genetic Risk Factor
Simon Rothwell¹, Robert G. Cooper², Ingrid E. Lundberg³, Frederick W. Miller⁴, Peter K. Gregersen⁵, Jiri Vencovsky⁶, Katalin Danko⁷, Lucy R Wedderburn⁸, Vidya Limaye⁹, Albert Selva O'Callaghan¹⁰, Michael G. Hanna¹¹, Pedro Machado¹¹, Lauren M. Pachman¹², Ann M. Reed¹³, Lisa G. Rider⁴, Joanna Cobb¹, Hazel Platt¹⁴, Øyvind Molberg¹⁵, Olivier Benveniste¹⁶, Pernille Mathiesen¹⁷, Timothy Radstake¹⁸, Andrea Doria¹⁹, Jan De Bleecker²⁰, Boel De Paepe²¹, Britta Maurer²², William E. Ollier¹⁴, Leonid Padyukov³, Terrance P. O'Hanlon⁴, Annette Lee²³, Hector Chinoy¹ and Janine Lamb¹⁴, ¹Centre for Genetics and Genomics, Arthritis Research UK, University of Manchester, Manchester, United Kingdom, ²MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁵The Feinstein Institute for Medical Research, Manhasset, NY, ⁶Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁷University of Debrecen, University of Debrecen, Debrecan, Hungary, ⁸Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁹Royal Adelaide Hospital, Adelaide, Australia, ¹⁰Vall d'Hebron General Hospital, Barcelona, Spain, ¹¹MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom, ¹²Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ¹³Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, United Kingdom, ¹⁵Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ¹⁶Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ¹⁷Paediatric Department, Holbaek University Hospital, Holbaek, Denmark, ¹⁸University Medical Center Utrecht, Utrecht, Netherlands, ¹⁹Department of Medicine - DIMED, University of Padova, Padova, Italy, ²⁰University of Ghent, Ghent, Belgium, ²¹Neuromuscular Reference Center, University of Ghent, Ghent, Belgium, ²²Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²³Genomics & Human Genetics, Feinstein Institute Med Rsch, Manhasset, NY
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes…
Abstract Number: 2954 • 2014 ACR/ARHP Annual Meeting
The Amino Acid Positions 11, 13 and 26 of HLA-DR Beta Chain 1 Explain the Majority of the Association Between Systemic Lupus Erythematosus and the Major Histocompatibility Complex Locus
Kwangwoo Kim^1,2,3, So-Young Bang⁴, Hye-Soon Lee⁴, Yukinori Okada^2,3,5, Woei-Yuh Saw⁶, Paul IW. de Bakker^2,3,7, Yik-Ying Teo^6,8, Soumya Raychaudhuri^2,9,10 and Sang-Cheol Bae¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Broad Institute, Cambridge, MA, ⁴Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁵Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁶National University of Singapore, Singapore, Singapore, ⁷Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ⁸Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, ⁹Broad Institute of MIT and Harvard, Cambridge, MA, ¹⁰Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Background/Purpose: Genetic association of the major histocompatibility complex (MHC) locus is well-established in systemic lupus erythematosus (SLE), but the causal functional variants in this region…
Abstract Number: 2955 • 2014 ACR/ARHP Annual Meeting
The Impact of Northern European Ancestry and Susceptibility Loci on the Risk of Lupus Nephritis
Sarah French¹, Kimberly E. Taylor², Sharon A. Chung¹, Joanne Nitiham³, Michelle Petri⁴, Peter K. Gregersen⁵, Ward Ortmann⁶, Annette T. Lee⁷, Timothy W. Behrens⁶, Susan Manzi⁸, F. Yesim Demirci⁹, M. Ilyas Kamboh¹⁰, Robert R. Graham⁶, Michael F. Seldin¹¹ and Lindsey A. Criswell³, ¹School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁶ITGR Human Genetics, Genentech, Inc., South San Francisco, CA, ⁷Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁸Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁹University of Pittsburgh, Pittsburgh, PA, ¹⁰Human Genetics, University of Pittsburgh, Pittsburgh, PA, ¹¹Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA
Background/Purpose Lupus nephritis (LN) has a higher prevalence among African Americans, Hispanics, and Asians compared to Caucasians. Significant differences in SLE severity also exist within…
Abstract Number: 2915 • 2014 ACR/ARHP Annual Meeting
Effects of Methotrexate on Anti-TNF Treatment in Rheumatoid Arthritis: An in-Depth Analysis of a Prospective Observational Study with Adalimumab
Marc Schmalzing¹, Frank Behrens^2,3, Eva C. Scharbatke¹, Michaela Koehm^3,4, Bianca Wittig⁵, Gerd Greger⁶, Harald Burkhardt^2,7 and Hans-Peter Tony⁸, ¹Rheumatology/Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology, Goethe-University Frankfurt, Frankfurt, Germany, ³Clinical Research, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt/Main, Germany, ⁴Rheumatology, Goethe-University Frankfurt, Frankfurt/Main, Germany, ⁵Abbvie Deutschland GmbH & Co. KG, Wiesbaden, Germany, ⁶AbbVie GmbH & Co KG, Wiesbaden, Germany, ⁷Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt/Main, Germany, ⁸Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany
Background/Purpose Methotrexate (MTX) is currently the most frequently used drug in the treatment of rheumatoid arthritis (RA). MTX co-medication can improve the therapeutic benefit of…

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