Abstracts Archive - Page 2023 of 2425 - ACR Meeting Abstracts

Abstract Number: 419 • 2014 ACR/ARHP Annual Meeting
Comparative Dynamics of Rheumatoid Arthritis Disease Activity and Disease Severity Measures Using Rarbis, Ciras and DAS28 in a Population Based Cohort of Patients with RA
Arun K. Chandran¹, Cynthia S. Crowson², Birkan İlhan³, C. John Michet III¹, Eric L. Matteson¹ and Elena Myasoedova⁴, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey, ⁴Internal Medicine and Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: There is an extensive list of composite scores of rheumatoid arthritis (RA) activity status for the use in clinical practice including Disease Activity Score…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 437 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Heat Shock Protein 90 Antibodies Identified in Bronchoalveolar Lavage Fluid Are a Marker of Lung-Specific Immune Responses
Lisa Harlow¹, Bernadette Gochuico², Ivan Rosas³, Tracy Doyle⁴, Juan Osorio⁴, Timothy Travers⁵, Carlos Camacho⁶, Chester V. Oddis⁷ and Dana P. Ascherman⁸, ¹Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ²Medical Genetics Branch, National Institutes of Health, Bethesda, MD, ³Medicine/Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁴Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁵Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁶Compuational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Background/Purpose . Previous work has demonstrated an association between serum anti-citrullinated HSP90 antibodies and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). To further investigate this potential…
Abstract Number: 436 • 2014 ACR/ARHP Annual Meeting
Increasing Cartilage Turnover in Smokers Developing Rheumatoid Arthritis Is Associated with High Disease Activity in Early Disease
Carl Turesson¹, Christina Book², Ulf Bergström², Lennart Jacobsson^2,3 and Tore Saxne⁴, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, ⁴Dept of Rheumatology, Dept of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden
Background/Purpose Autoantibodies and other biomarkers of rheumatoid arthritis (RA) that may be detected years before disease onset in a subset of investigated individuals could be…
Abstract Number: 435 • 2014 ACR/ARHP Annual Meeting
Smoking Functions As a Negative Regulator of IGF-1 Levels and Adipokine Network in Patients with Rheumatoid Arthritis
Maria Bokarewa¹, Malin Erlandsson², Sofia Töyrä Silfverswärd³, Andreea Ioan-Fascinay⁴ and Roberto Doria Medina⁵, ¹Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden, ²Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵University of Göteborg, Göteborg, Sweden
Background/Purpose Smoking is an important player in the pathogenesis of rheumatoid arthritis (RA) being tightly connected to the genetic (carriage of HLA-DRB1 shared epitope) and…
Abstract Number: 434 • 2014 ACR/ARHP Annual Meeting
Characterization of Lung Inflammation in the Lungs of Early Rheumatoid Arthritis
Gudrun Reynisdottir¹, Vijay Joshua², Aase Haj Hensvold², Lars Klareskog³ and Anca I Catrina², ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet,, Stockholm, Sweden, ²Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska institutet, Stockholm, Sweden
Background/Purpose We have previously demonstrated that lung abnormalities are present already at disease onset in ACPA positive RA patients. We aimed to further investigate lung…
Abstract Number: 433 • 2014 ACR/ARHP Annual Meeting
Bronchiectasis: A Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis
Anne-Marie Quirke¹, Elizabeth Perry², Alison Cartwright¹, Clive Kelly³, Anthony De Sozya^4,5, Paul Eggleton⁶, David Hutchinson² and Patrick Venables⁷, ¹Kennedy Institute, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom, ³Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom, ⁴Institute for Cellular Medicine, Newcastle University, Newcastle, United Kingdom, ⁵Sir William Leech Centre, The Freeman Hospital, Newcastle, United Kingdom, ⁶Medical School, University of Exeter, Exeter, United Kingdom, ⁷Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
Background/Purpose Anti-citrullinated peptide antibodies (ACPA) are associated with smoking in patients with rheumatoid arthritis (RA). Bronchiectasis (BR), which tends to occur in non-smokers, has been…
Abstract Number: 432 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Associated Interstitial Lung Disease: Risk Factors for Disease Progression
Yashaar Chaichian¹, Imre Noth¹, Mary Strek¹, Tammy O. Utset² and Rekha Vij¹, ¹University of Chicago Medical Center, Chicago, IL, ²University of Chicago, Chicago, IL
Background/Purpose Rheumatoid arthritis (RA) is the most common systemic connective tissue disease in the U.S. Interstitial lung disease (ILD) is a frequent extra-articular manifestation of…
Abstract Number: 431 • 2014 ACR/ARHP Annual Meeting
Joint Dermal Temperature Specifically Identifies the Individual RA Patient Most Likely to Develop Radiographic Change on Sharp Score; An Exam in Less Than a Minute Can Predict Who Specifically Needs Biologic Therapy
Maria Greenwald¹, Joann Ball² and Harold Paulus³, ¹Desert Medical Advances, PALM DESERT, CA, ²rheumatology, Desert Medical Advaces, Palm Desert, CA, ³Rheumatology, UCLA, Los Angeles, CA
Background/Purpose: Joint dermal temperature (temp) measured in less than a minute can identify specifically the individual RA patient most likely to develop radiographic change on…
Abstract Number: 430 • 2014 ACR/ARHP Annual Meeting
Minimally Important Difference in the European Quality of Life-Five Dimensions in Patients with Rheumatoid Arthritis
Daisuke Hoshi, Eiichi Tanaka, Eisuke Inoue, Kumi Shidara, Yoko Shimizu, Akiko Kobayashi, Naoki Sugimoto, Eri Sato, Yohei Seto, Ayako Nakajima, Shigeki Momohara, Atsuo Taniguchi and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Patient-reported outcomes (PROs) have been recognized as important in evaluating disease status of rheumatoid arthritis (RA). The minimally important difference (MID) in PROs has…
Abstract Number: 429 • 2014 ACR/ARHP Annual Meeting
Investigation of MRI Bone Changes in Early-Stage RA Patients Achieved in Sustained Clinical Good Response: Sub-Analysis from Nagasaki University Early Arthritis Cohort
Mami Tamai¹, Kazuhiko Arima², Yoshikazu Nakashima¹, Masataka Umeda¹, Shoichi Fukui¹, Ayako Nishino¹, Takahisa Suzuki¹, Yoshiro Horai¹, Akitomo Okada³, Tomohiro Koga¹, Shin-ya Kawashiri², Naoki Iwamoto¹, Kunihiro Ichinose¹, Hideki Nakamura¹, Tomoki Origuchi⁴, Masataka Uetani⁵, Kiyoshi Aoyagi² and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan, ⁴Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose Given the improved detection of joint injury by MRI than by clinical examination, EULAR recommendations for the use of imaging of the joints in…
Abstract Number: 428 • 2014 ACR/ARHP Annual Meeting
Patient-Physician Discordance of Disease Activity Assessments Predicts Inadequate Treatment Response in Early Rheumatoid Arthritis
John M. Davis III¹, Cynthia S. Crowson², Tim Bongartz¹, Clement J. Michet¹, Eric L. Matteson¹ and Sherine E. Gabriel³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose Discordance between patients’ and physicians’ global assessments of disease activity occurs in up to a third of clinical evaluations for rheumatoid arthritis (RA). In…
Abstract Number: 427 • 2014 ACR/ARHP Annual Meeting
Multimedia Patient Education Tool for Patients with Rheumatoid Arthritis
Maria A. Lopez-Olivo¹, Aparna Ingleshwar², Robert Volk², Andrea Barbo³, Maria Jibaja-Weiss⁴, Heather Lin⁵ and Maria E. Suarez-Almazor⁶, ¹Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁴Office of Outreach and Health Disparities, Baylor College of Medicine, Houston, TX, ⁵Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁶The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Effective patient education provides individuals with essential information about their disease and treatment alternatives, and aids informed decision-making. The purpose of our study was…
Abstract Number: 403 • 2014 ACR/ARHP Annual Meeting
Metaflammation, PEDF and Chemerin: Potential Systemic Factors Which Link Obesity to Response to Therapy in Early Rheumatoid Arthritis
Elisa Gremese, Barbara Tolusso, Anna Laura Fedele, Maria Rita Gigante, Silvia Canestri, Clara Di Mario, Angela Carbonella and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose . Obesity per se is a systemic, low-grade inflammatory state and the adipose tissue is an endocrine organ that releases bioactive substances, including pro-inflammatory…
Abstract Number: 402 • 2014 ACR/ARHP Annual Meeting
Can GP88 (Progranulin) be Used As a Biomarker for the Diagnosis and Therapy Evaluation of Rheumatoid Arthritis?
Masao Sato^1,2, Masao Takemura^2,3, Kuniaki Saito⁴ and Yasuko Yamamoto⁴, ¹Rheumatology, Matsunami General Hospital, Gifu, Japan, ²Matsunami Reserch Park, Gifu, Japan, ³Informative Laboratory Merdicine, Gifu University, Gifu, Japan, ⁴Human Health Science, Kyoto University, Kyoto, Japan
Background/Purpose GP88 (progranulin; PGRN), a glycoprotein with a molecular weight of approximately 88000, is suggested to play an important role in the immune response and…

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