Abstracts Archive - Page 2021 of 2616 - ACR Meeting Abstracts

Abstract Number: 2112 • 2015 ACR/ARHP Annual Meeting
Analysis of Gout Subjects Receiving Lesinurad and Allopurinol Combination Therapy By Baseline Renal Function
Kenneth G. Saag¹, Thomas Bardin², Alexander So^3,4, Puja Khanna⁵, Chris Storgard⁶, Scott Baumgartner⁷, Maple Fung⁷, Nihar Bhakta⁷, Scott Adler⁸, Jeff Kopicko⁷ and Michael A. Becker⁹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Lariboisière Hospital, Paris, France, ³Rheumatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, ⁴CHU Vaudois, University of Lausanne, Lausanne, Switzerland, ⁵Division of Rheumatology/Dept. of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, ⁶4939 Directors Place, Ardea Biosciences, Inc., San Diego, CA, ⁷Ardea Biosciences, Inc., San Diego, CA, ⁸AstraZeneca Pharmaceuticals, Wilmington, DE, ⁹University of Chicago, Chicago, IL
Background/Purpose: Two randomized, double-blind, placebo-controlled Phase III clinical trials showed that lesinurad (200 or 400 mg) when added to allopurinol (200-900 mg) significantly increased the…
Abstract Number: 2113 • 2015 ACR/ARHP Annual Meeting
Lesinurad, a Novel Selective Uric Acid Reabsorption Inhibitor, in Combination with Febuxostat, in Patients with Tophaceous Gout
Nicola Dalbeth¹, Graeme Jones², Robert Terkeltaub³, Dinesh Khanna⁴, Jeff Kopicko⁵, Nihar Bhakta⁵, Maple Fung⁵, Chris Storgard⁶, Scott Baumgartner⁵ and Fernando Perez-Ruiz⁷, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Medicine-Rheumatology, University of California, San Diego, La Jolla, CA, ⁴Div of Rheumatology, University of Michigan, Ann Arbor, MI, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶4939 Directors Place, Ardea Biosciences, Inc., San Diego, CA, ⁷Servicio de Reumatologia, Hospital Universitario Cruces, Baracaldo, Spain
Background/Purpose: Lesinurad (LESU; RDEA594) is a selective uric acid reabsorption inhibitor (SURI) being investigated for the treatment of gout in combination with a xanthine oxidase…
Abstract Number: 2114 • 2015 ACR/ARHP Annual Meeting
Higher Total Knee Arthroplasty Revision Rates in Black Americans: A Systematic Literature Review and Meta-Analysis
Anne R. Bass¹, Kelly McHugh¹, Kara Fields^2,3, Rie Smethurst⁴, Michael Parks⁵ and Susan M. Goodman¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Medicine/Rheumatology, Hospital for Special Surgery, New York, NY, ³Biostatistics, Hospital for Special Surgery, New York, NY, ⁴Education - Academic Training, Hospital for Special Surgery, New York, NY, ⁵Orthopedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Utilization of total knee arthroplasty (TKA) is lower among blacks than whites in the United States (U.S.), which may be due to blacks' perception…
Abstract Number: 2115 • 2015 ACR/ARHP Annual Meeting
Intra-Operative Synovitis Predicts Worse Pain and Function 2 Years after Total Knee Arthroplasty for Osteoarthritis
Lisa Mandl¹, Shivi Duggal², Kelly McHugh³, Xian Wu⁴, Geoffrey H. Westrich², Thomas Sculco², John A. Carrino⁵, Edward F. DiCarlo⁶, Steven R. Goldring¹ and Charles Cornell², ¹Hospital for Special Surgery, New York, NY, ²Orthopedics, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, ⁵Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Laboratory Medicine, Hospital for Special Surgery, New York, NY
Intra-Operative Synovitis Predicts Worse Pain and Function 2 Years After Total Knee Arthroplasty for Osteoarthritis Background/Purpose: Total knee arthroplasty (TKA) is one of the most common…
Abstract Number: 2116 • 2015 ACR/ARHP Annual Meeting
Advice to Remain Active While Awaiting Physiotherapy Is Associated with Superior Long-Term Outcome Among Patients with Distal Arm Pain – Results from a Randomised Controlled Trial
Gareth T Jones^1,2, Gary J. Macfarlane^1,2, Keith Palmer^3,4, David Coggon^3,4, Karen Walker-Bone^3,4, Kim Burton⁵, Peter Heine⁶, Candida McCabe^7,8, Paul McNamee⁹ and Alex McConnachie¹⁰, ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²University of Aberdeen, Arthritis Research UK / MRC Centre for Musculoskeletal Health and Work, Aberdeen, United Kingdom, ³MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁴University of Southampton, Arthritis Research UK / MRC Centre for Musculoskeletal Health and Work, Southampton, United Kingdom, ⁵Centre for Applied Psychological and Health Research, University of Huddersfield, Huddersfield, United Kingdom, ⁶Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom, ⁷Nursing and Midwifery, University of the West of England, Bristol, United Kingdom, ⁸Royal United Hospital NHS Foundation Trust, Bath, United Kingdom, ⁹Health Economics Research Unit, University of Aberdeen, Aberdeen, United Kingdom, ¹⁰Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Pain in the distal upper limb (elbow, forearm, wrist or hand) is common, yet the best approach to management is unclear. While the etiological…
Abstract Number: 2117 • 2015 ACR/ARHP Annual Meeting
Weight Predicts Back Pain in Young Adult Women, Independent of Physical Activity: Data from the Australian Longitudinal Study on Women’s Health
Sharmayne Brady¹, Sultana Monira Hussain², Wendy Brown³, Stephane Heritier¹, Baki Billah¹, Yuanyuan Wang⁴, Helena Teede^5,6, Donna Urquhart¹ and Flavia Cicutinni¹, ¹Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ²Department of Epidemiology and Preventive Medicine,, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ³Faculty of Health and Behavioural Sciences, School of Human Movement Studies, University of Queensland, Brisbane, Australia, ⁴Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁵School of Public Health and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia, ⁶Diabetes and Endocrine Unit, Monash Health, Melbourne, Australia
Background/Purpose: Low back pain (LBP) causes enormous financial and disability burden worldwide, and therapeutic options have limited efficacy. This burden could be potentially reduced by…
Abstract Number: 2118 • 2015 ACR/ARHP Annual Meeting
Prescription Medication Use in Community-Based US Adults with Chronic Low Back Pain: Nhanes 2009-2010
Anna Shmagel¹ and Robert Foley², ¹Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ²Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN
Background/Purpose: Chronic low back pain (cLBP) is a significant public health problem. Establishing treatment guidelines has been difficult due to heterogeneity of research data. Little…
Abstract Number: 2119 • 2015 ACR/ARHP Annual Meeting
Findings and Therapeutic Impact of Magnetic Resonance Imaging (MRI) Studies for Patients with Lower Back Pain with Neurologic Symptoms. Are We Choosing Wisely?
Patrick Nguyen¹, Nathalie Carrier² and Ariel Masetto³, ¹Internal Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ³Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada
Background/Purpose: According to different guidelines, the presence of neurological symptoms in patients with lower back pain (LBP) is a validated indication for more complex imaging…
Abstract Number: 2120 • 2015 ACR/ARHP Annual Meeting
Alterations in Complement C3 and iC3b in SLE Pregnancies
Marta M. Guerra¹, Martin Schmidt², Elianna Kaplowitz³, Vibeke Strand⁴ and Jane E. Salmon⁵, ¹Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, ²Kypha, Inc., St. Louis, MO, ³Hospital for Special Surgery, New York, NY, ⁴Division of Immunology/Rheumatology, Stanford University School of Medicine, Portola Valley, CA, ⁵Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Pregnancy in patients with SLE is associated with increased risk of maternal and fetal complications. Studies in experimental models and humans suggest that complement…
Abstract Number: 2121 • 2015 ACR/ARHP Annual Meeting
Placentas of Lupus Pregnancies Are Characterized By Marked Inflammatory Changes Despite Good Disease Control
Wendy Marder¹, Jason S. Knight², Mariana J. Kaplan³, Emily C. Somers⁴, Xu Zhang⁴, Alexander A. O'Dell⁵, Vasantha Padmanabhan⁴ and Richard W. Lieberman⁴, ¹Div of Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴University of Michigan, Ann Arbor, MI, ⁵Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with increased risk of adverse pregnancy outcomes (APO), including preeclampsia and intrauterine growth restriction. While significant placental…
Abstract Number: 2122 • 2015 ACR/ARHP Annual Meeting
A Novel Severity Score Based on Cardiac Neonatal Lupus Manifestations Serves As a Predictor and Outcome Measure of Morbidity in Anti-Ro Exposed Fetuses
Amit Saxena¹, Peter M. Izmirly¹, Sung Won Han², Paraskevi Briassouli¹, Tania Rivera³, Mark Halushka⁴, Hua Zhong⁵, Deborah Friedman⁶, Robert Clancy¹ and Jill P. Buyon¹, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Population Health, New York University School of Medicine, New York, NY, ³Rheumatology, Scripps Memorial Hospital La Jolla, La Jolla, CA, ⁴Division of Cardiovascular Pathology, John Hopkins Pathology, Baltmore, MD, ⁵Population Health, New York University School of Medicine, New York, NY, ⁶Pediatric Cardiology, New York Medical College, Valhalla, NY
Background/Purpose: Women with anti-Ro face a spectrum of fetal consequences when pregnant, from complete wellbeing to death from cardiac neonatal lupus (cardiac NL). Transplacental passage…
Abstract Number: 2123 • 2015 ACR/ARHP Annual Meeting
Incidence and Prognosis of Neonatal and Late-Onset Dilated Cardiomyopathy Associated with Cardiac Neonatal Lupus
Kateri Levesque^1,2, Nathalie Morel³, Alice Maltret⁴, Gabriel Baron⁵, Mohamed Hamidou⁶, Pauline Orquevaux⁷, Jean Charles Piette⁸, Francois Barriere⁹, Jérome Lebidois⁴, Laurent Fermont⁴, Olivier Fain¹⁰, Arnaud Theulin¹¹, Francois Sassolas¹², Philippe Pézard¹³, Gaëlle Guettrot-Imbert¹⁴, Delphine Le Mercier¹⁵, Sophie Georgin-Lavialle¹⁶, Christophe Deligny¹⁷, Eric Hachulla¹⁸, Luc Mouthon¹⁹, Philippe Ravaud²⁰, Elisabeth Villain⁴, Damien Bonnet²¹ and Nathalie Costedoat-Chalumeau³, ¹Internal Medicine, CHU Ste-Justine, Montréal, QC, Canada, ²Medicine Interne, Hopital Cochin, Paris, France, ³Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁴Cardiology, Groupe Hospitalier Necker - Enfants Malades, Paris, France, ⁵Hôpital Hôtel Dieu, Paris, France, ⁶Internal Medicine Department, Nantes University Hospital, Nantes, France, ⁷Hu Robert Debre, CHU Reims, Reims, France, ⁸Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ⁹Pediatry, CHU Nantes, Nantes, France, ¹⁰Internal Medicine, Hospital J. Verdier, Bondy, France, ¹¹Internal medicine, CHRU Strasbourg, Strasbourg, France, ¹²Cardiology, CHU Lyon, Lyon, France, ¹³Pediatric cardiologist, CHU Angers, Angers, France, ¹⁴Internal Medicine, Hopital Saint-Antoine, Paris, France, ¹⁵Obstetrics and gynecology, Hopital Necker, Paris, France, ¹⁶Internal medicine, Hopital Tenon, Paris, France, ¹⁷Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ¹⁸Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹⁹Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ²⁰Rheumatology, Paris, France, ²¹Pediatric cardiologist, Hopital Necker, Paris, France
Background/Purpose: Dilated cardiomyopathy (DCM) is a well-known complication of cardiac neonatal lupus syndrome and is associated with a high mortality rate. Its risk factors are…
Abstract Number: 2124 • 2015 ACR/ARHP Annual Meeting
Racial Disparities in Lupus Pregnancy
Megan E. B. Clowse¹ and Chad Grotegut², ¹Rheumatology & Immunology, Duke University, Durham, NC, ²Obstetrics & Gynecology, Duke University, Durham, NC
Background/Purpose: Both lupus and pregnancy have significant racial disparities, with black women experiencing higher rates of complication compared to other race and ethnic groups. …
Abstract Number: 2125 • 2015 ACR/ARHP Annual Meeting
Rheumatic and Non-Rheumatic Autoimmune Diseases in SLE Offspring
Julie Couture¹, Sasha Bernatsky², Susan Scott³, Christian A. Pineau² and Evelyne Vinet², ¹McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Autoimmune diseases (AID) have familial aggregation and frequently share a common genetic predisposition. Only few small uncontrolled studies have evaluated the risk of AID…
Abstract Number: 2126 • 2015 ACR/ARHP Annual Meeting
Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients with Rheumatoid Arthritis
George D. Kitas¹, Peter Nightingale², Jane Armitage³, Naveed Sattar⁴, Jill Belch⁵, Deborah P.M. Symmons⁶ and TRACE RA Consortium, ¹Dudley Group NHS Foundation Trust, Dudley, and Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ²Wolfson Computer Laboratory, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Clinical Trial Service Unit and Epidemiology Unit, University of Oxford, Oxford, United Kingdom, ⁴University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, United Kingdom, ⁵Division of Cardiovascular and Diabetes Medicine, University of Dundee, Dundee, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease (CVD) compared to the general population, both due to classical and novel…

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