Abstracts Archive - Page 2018 of 2607 - ACR Meeting Abstracts

Abstract Number: 2209 • 2015 ACR/ARHP Annual Meeting
Stimulation of the Adenosine A2A Receptor (A2AR) Regulates the Expression of Netrin-1 (Ntn1) and Its Receptors (Unc5b, DCC) and Inhibits Wear Particle-Induced Inflammatory Osteolysis in a Model of Joint Prosthesis Loosening
Aranzazu Mediero¹, Bhama Ramkhelawon², Miguel Perez-Aso³, Kathryn Moore² and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³Provital S.A., Barberà del Vallès, Spain, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Ntn1 is a member of the family of axonal guidance proteins that plays a role in leukocyte function and inflammation and is critical for…
Abstract Number: 2210 • 2015 ACR/ARHP Annual Meeting
Immunological Dysregulation and Inadequate Hypoxia Adaptation – HIF-Stabilization As Possible Prevention of Fracture Healing Disorders in RA or Immune-Suppressed Patients
Annemarie Lang^1,2,3, Sarah Fuegener², Paula Hoff^1,2, Katharina Schmidt-Bleek⁴, Timo Gaber^1,2 and Frank Buttgereit², ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ³Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ⁴Julius Wolff Institut, Charité University Medicine, Berlin, Germany
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) are often affected by fracture-healing complications such as increased fracture healing time or non-unions. There is not much…
Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting
Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired
Marina C. Oliveira¹, Onno J. Arntz¹, Esmeralda Blaney Davidson¹, Wim van den Berg¹, Adaliene V.M. Ferreira² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…
Abstract Number: 2212 • 2015 ACR/ARHP Annual Meeting
Identification of a Novel Chemokine-Dependent Molecular Mechanism Underlying Rheumatoid Arthritis-Associated Autoantibody-Mediated Bone Destruction
Akilan Krishnamurthy¹, Vijay Joshua², Aase Haj Hensvold³, Tao Jin⁴, Meng Sun³, Marianne Engström³, Khaled Amara¹, Malin MAgnusson⁴, Camilla Svensson⁵, Vivianne Malmström³, L. Klareskog¹, Heidi Wähämaa³ and Anca I Catrina³, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, Gothenberg, Sweden, ⁵Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of…
Abstract Number: 2213 • 2015 ACR/ARHP Annual Meeting
RA-Associated Autoantibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua², Aase Haj Hensvold^1,3, Khaled Amara⁴, Vivianne Malmström¹, Heidi Wähämaa¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with a more aggressive disease phenotype and bone destruction. Synovial fibroblasts (SFs) are…
Abstract Number: 2214 • 2015 ACR/ARHP Annual Meeting
Activation Feature of RANKL/RANK Signaling Pathway in Ankylosing Spondylitis Patients Compared with Healthy People
Benyong Liu¹, Hongxiao Liu¹, Nan Jiang², Yingyan Zhou³, Xinghua Feng¹, Xiaoyan Feng⁴, Heqiu Zhang⁴, Quan Jiang¹, Xiaodan Wang⁴, Junyao Song¹ and Ziqi Xu¹, ¹Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ²Department of Rheumatology and Nephrology, The Second Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin, China, ³Department of Rheumatology, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, China, ⁴Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, China
Background/Purpose: Bone destruction is one of the main pathological features in ankylosing spondylitis (AS). This research aims to explore the role of nuclear factor kappa-B…
Abstract Number: 2215 • 2015 ACR/ARHP Annual Meeting
Ticagrelor Regulates Osteoblast and Osteoclast Function and Promotes Bone Formation in Vivo By Increasing Adenosine Levels
Aranzazu Mediero¹, Tuere Wilder², Carl Whatling³ and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³CVMD Innovative Medicine Unit, Translational Sciences, AstraZeneca R&D, Mölndal, Sweden, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: The antiplatelet drugs Ticagrelor and clopidogrel are P2Y12 antagonists but ticagrelor also inhibits cellular adenosine uptake via ENT1 and thereby increases extracellular adenosine levels.…
Abstract Number: 2216 • 2015 ACR/ARHP Annual Meeting
Quality Assessment of Websites Providing Educational Content about Rheumatoid Arthritis
Maria A. Lopez-Olivo¹, Ana Ojeda-Prias², Eric Heung³, Amye L. Leong⁴, Irmgard Willcockson⁵ and Maria E. Suarez-Almazor¹, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²The University of Houston, Houston, TX, ³Lake Erie College of Osteopathic Medicine, Erie, PA, ⁴Spokesperson; Strategic Relations, BONE AND JOINT DECADE, Santa Barbara, CA, ⁵School of Biomedical Informatics, The University of Texas, Houston Science Center, Houston, TX
Background/Purpose: The Internet can support remote and immediate access to health information. It is the second most consulted information source next to physicians. Google is…
Abstract Number: 2217 • 2015 ACR/ARHP Annual Meeting
#Rheumjc: Development, Implementation and Analysis of an International Twitter-Based Rheumatology Journal Club
Christopher Collins¹, Paul Sufka², Jonathan S. Hausmann³, Arundathi Jayatilleke⁴, Jose Campos⁵ and Suleman Bhana⁶, ¹Rheumatology, Washington Hospital Center, Washington, DC, ²Rheumatology, HealthPartners, Saint Paul, MN, ³Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ⁴Medicine, Division of Rheumatology, Drexel University College of Medicine, Philadelphia, PA, ⁵Rheumatology, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain, ⁶Crystal Run Healthcare, Middletown, NY
Background/Purpose: Twitter is an increasingly popular platform for discussion and engagement amongst healthcare professionals. Here we describe the development, implementation and analysis of a rheumatology…
Abstract Number: 2218 • 2015 ACR/ARHP Annual Meeting
A Randomized Controlled Trial to Evaluate a Multimedia Patient Education Tool in Patients with Knee Osteoarthritis. Six-Month Results
Maria A. Lopez-Olivo¹, Andrea Barbo², Tara Rizvi³, Robert Volk⁴, Heather Lin⁵ and Maria E. Suarez-Almazor¹, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Rheumatology, Baylor College of Medicine, Houston, TX, ⁴General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, ⁵Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Video modelling is often used in patient education to improve patient outcomes. We conducted a multi-centered, open-label, parallel, randomized controlled trial that evaluated the…
Abstract Number: 2219 • 2015 ACR/ARHP Annual Meeting
Improving Outcomes with a Multimedia Patient Education Tool in Patients with Osteoporosis after 6 Months. a Randomized Controlled Trial
Maria A. Lopez-Olivo¹, Andrea Barbo², Tara Rizvi³, Robert Volk⁴, Heather Lin⁵ and Maria E. Suarez-Almazor¹, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Rheumatology, Baylor College of Medicine, Houston, TX, ⁴General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, ⁵Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: We conducted a 6-month multi-centered, open-label, parallel, randomized control trial to compare a multimedia-patient education tool (MM-PtET) including storylines and narratives with a written…
Abstract Number: 2220 • 2015 ACR/ARHP Annual Meeting
Appropriate Investigations and Costs in Rheumatology: Residents’ Attitudes and Knowledge
Victoria YY Xu¹, Neel Shah², Christine Soong³ and Shirley Chow⁴, ¹School of Medicine, Queen's University, Kingston, ON, Canada, ²Harvard Medical School, Harvard University, Cambridge, MA, ³Division of General Internal Medicine; Centre for Quality Improvement and Patient Safety, University of Toronto, Toronto, ON, Canada, ⁴Division of Rheumatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Background/Purpose: With the launching of the Choosing Wisely campaign, there has been a growing emphasis in the medical community on addressing unnecessary tests and procedures…
Abstract Number: 2221 • 2015 ACR/ARHP Annual Meeting
Engaging Learners in Lupus Education with Pivot (Practice Improvement using Virtual Online Training), a Novel, Digital Case-Based Curriculum
Karen Law¹, Michelle Lin², Sheryl McCalla³ and Maria Dall'Era⁴, ¹Emory University School of Medicine, Atlanta, GA, ²Emergency Medicine, UCSF, San Francisco, CA, ³American College of Rheumatology, Atlanta, GA, ⁴University of California San Francisco School of Medicine, San Francisco, CA
Background/Purpose: Lupus is one of the prototypic rheumatic diseases, yet only a small amount of time in medical school curricula is devoted to lupus-specific education.…
Abstract Number: 2222 • 2015 ACR/ARHP Annual Meeting
Teaching Rheumatology in Undergraduate Medical Education: What Are the Students Saying?
Amy C. Cannella¹, Gerald F. Moore², Ted R. Mikuls³, James R. O'Dell³, Sarah B. McBrien⁴, Michelene Hearth-Holmes², Lynell W. Klassen², Marcus H. Snow², Michael G. Feely², Zachary D. Fowler⁵, Maxwell Burchell⁵ and Alan R. Erickson⁶, ¹Divison of Rheumatology, University of Nebraska College of Medicine and VA Nebraska Western Iowa Health Care System, Omaha, NE, ²Division of Rheumatology, University of Nebraska College of Medicine and VA Nebraska Western Iowa Health Care System, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Educational Support Office, University of Nebraska College of Medicine, Omaha, NE, ⁵College of Information Science and Technology, University of Nebraska at Omaha, Omaha, NE, ⁶University of Nebraska College of Medicine and VA Nebraska Western Iowa Health Care System, Omaha, NE
Background/Purpose: At the University of Nebraska College of Medicine (COM), rheumatology is taught in a block to second year medical students (M2s). The educational content…
Abstract Number: 2223 • 2015 ACR/ARHP Annual Meeting
Improving Clinical Decisions for Rheumatoid Arthritis Management Using Online Medical Simulations
Nimish Mehta¹, Keith Johnson², Douglas Blevins³ and Martin Warters³, ¹Medscape, LLC, New York, NY, ²Medscape Education, New York, NY, ³Medscape, LLC, Durham, NC
Background/Purpose: In many patients with rheumatoid arthritis (RA), the disease is not adequately controlled, and only a minority of patients attain the goal of consistent…

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