Abstracts Archive - Page 2003 of 2616 - ACR Meeting Abstracts

Abstract Number: 1842 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus and Chikungunya Fever: Interactions during the 2014 Outbreak in Martinique
Bastien Bigeard¹, Katlyne Polomat², Emilie Javelle³, Serge ARFI², Lauren Brunier-Agot⁴, Florence MOINET², Fatiha Najioullah⁵, Elodie Curlier⁶, Andre Cabié⁷, Michel DeBandt¹, Georges Jean Baptiste² and Christophe Deligny², ¹internal medicine and rheumatology, Zobda Quitman Hospital, Fort de France, Martinique, ²Rheumatology and Internal Medicine, Zobda Quitman Hospital, Fort de France, Martinique, ³Tropical and Infectious Diseases, Laveran Military Teaching Hospital, Marseille, France, ⁴Internal medicine and rheumatology, Zobda Quitman Hospital, Fort de France, Martinique, ⁵virology, Zobda Quitman Hospital, Fort de France, Martinique, ⁶infectiology, dermatology and internal medicine, CHU de Guadeloupe, Pointe à Pitre, Guadeloupe, ⁷infectious disease, Zobda Quitman Hospital, Fort de France, Martinique
Background/Purpose: There is no data in the literature about chikungunya fever (chik) and SLE. Martinique (French West Indies) experienced for the first time an outbreak…
Abstract Number: 1843 • 2015 ACR/ARHP Annual Meeting
Bloodstream Infections in Systemic Lupus Erythematosus Patients Are Associated with Severe Lupus Flares
José Jiram Torres Ruiz¹, Ana Barrera-Vargas², Rigoberto Ortíz-Hernández², Jorge Alcocer-Varela² and Diana Gómez-Martín², ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Infections are an important cause of mortality and morbidity in systemic lupus erythematosus (SLE) patients. Bloodstream infections (BI), which are especially severe and relatively…
Abstract Number: 1844 • 2015 ACR/ARHP Annual Meeting
Risk Factors for Complicated Pneumonia in Systemic Lupus Erythematosus (SLE)
Gabriela García-Guevara¹, Ricardo Ríos-Corzo², Juan Ávila-Vázquez³, John Hernández-Flores⁴, Eduardo Carrillo-Maravilla⁵, Juan Jakez-Ocampo⁶, Hilda Fragoso-Loyo⁷, Luis Llorente⁸ and Yemil Atisha-Fregoso⁹, ¹Vasco de Quiroga #15, Tlalpan, Belisario Domínguez Sección XVI, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ²Escuela de Medicina, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico, ³Escuela Nacional de Medicina, Instituto Tecnológico y de Estudios Superiores de Monterrey, Mexico, Mexico, ⁴Escuela de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico, ⁵Medicina Interna, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, Mexico, ⁷Vasco de Quiroga 15 Col Seccio, INNCMSZ-Departamento de Inmunología y Reumato, Mexico, Mexico, ⁸Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁹Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico
Background/Purpose: Pneumonia, remains as a main cause of mortality in patients with SLE. In patients without autoimmune disease, scores as Pneumonia Severity Index (PSI) and…
Abstract Number: 1845 • 2015 ACR/ARHP Annual Meeting
HMGB1 Early Marker in Lupus Nephritis
Aisha Badawy¹, Randa Salam², Hanan Fouad³, Amira Bassam⁴ and Sahar Lashen⁵, ¹Internal medicine cairo university, professor of internal medicine and rheumatology, cairo, Egypt, ²Internal medicine cairo university, Assistant professor internal medicine, cairo, Egypt, ³medical biochemistry cairo university, Professor of medical biochemistry, cairo, Egypt, ⁴pathology Cairo university, Lecturer of Pathology Cairo university, cairo, Egypt, ⁵Internal medicine, assistant lecturer of internal medicine cairo university, cairo, Egypt
Background/Purpose: Systemic Lupus Erythematosis is a systemic autoimmune disease characterised by involvement of multiple organ systems Lupus nephritis (LN) is a severe and frequent manifestation…
Abstract Number: 1846 • 2015 ACR/ARHP Annual Meeting
IGFBP-2 As a Novel Biomarker for Disease Activity and Renal Pathology in Lupus Nephritis
Huihua Ding¹, Chandra Mohan¹ and Tianfu Wu², ¹Biomedical Engineering, University of Houston, Houston, TX, ²Department of Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus. Invasive renal biopsy remains the golden standard for the diagnosis…
Abstract Number: 1847 • 2015 ACR/ARHP Annual Meeting
Serum Ferritin and Insulin-like Growth Factor-Binding Protein 2 As Biomarkers of Clinical and Histopathological Treatment Response in Lupus Nephritis
Ioannis Parodis¹, Huihua Ding², Agneta Zickert¹, Chandra Mohan² and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of Systemic Lupus Erythematosus (SLE). Renal biopsy is gold standard for evaluation of renal activity and damage…
Abstract Number: 1848 • 2015 ACR/ARHP Annual Meeting
Increased Expression of Bruton Tyrosine Kinase in Patients with Lupus Nephritis and Its Clinic Significance
Wei Kong, Wei Deng, Xuebing Feng, Genhong Yao, Weiwei Chen, Xiaojun Tang, Yue Sun, Saisai Huang, Zhuoya Zhang, Bingyu Shi and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease manifested by multiorgan impairment including glomerulonephritis, cutaneous lesions and arthritis. B cells participate in the onset…
Abstract Number: 1849 • 2015 ACR/ARHP Annual Meeting
Serum Axl and Tumor Necrosis Factor Receptor II Portend Long-Term Renal Outcome in Lupus Nephritis
Ioannis Parodis¹, Huihua Ding², Agneta Zickert¹, Chandra Mohan² and Iva Gunnarsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of Systemic Lupus Erythematosus (SLE). Renal biopsy is gold standard for evaluation of renal activity and damage.…
Abstract Number: 1850 • 2015 ACR/ARHP Annual Meeting
Increased Levels of Immunoglobulin Binding Protein 1 Are Associated with Disease Activity Including Renal Damage in Patients with Systemic Lupus Erythematosus
Eun-Ju Lee^1,2, Seokchan Hong³, Doo-Ho Lim¹, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Asan Institute for Life Science, Asan Medical Center, Seoul, South Korea, ³Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: Systemic lupus erythematous (SLE) is a multisystem autoimmune inflammatory disease. Lupus nephritis (LN) is one of the most serious complications in patients with SLE.…
Abstract Number: 1851 • 2015 ACR/ARHP Annual Meeting
Antibody Against Ribonuclease-H Is a Novel Autoantibody Specifically Recognized in Systemic Lupus Erhythematosus
Kazuhisa Nozawa¹, Kentaro Doe², Kaori Hiruma³, Yusuke Yamada⁴ and Yoshinari Takasaki⁵, ¹2-1-1 Hongo Bunkyo-ku, Juntendo University, Tokyo, Japan, ²2-1-1 Hongo, Bunkyo-Ku, Juntendo University School of Medicine, Tokyo, Japan, ³Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Proliferating cell nuclear antigen (PCNA) is known to be an autoantigen specifically recognized in patients with SLE. PCNA constitutes PCNA-complex along with several PCNA-binding…
Abstract Number: 1852 • 2015 ACR/ARHP Annual Meeting
Association of Antibodies to the NR1 Subunit of N-Methyl-D-Aspartate Receptors with Neuropsychiatric Systemic Lupus Erythematosus
Eisuke Ogawa¹, Tatsuo Nagai², Yuko Sakuma³, Yoshiyuki Arinuma⁴ and Shunsei Hirohata⁴, ¹Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ²Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ⁴Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan
Background/Purpose: To explore the roles of autoantibodies to N-methyl-D-aspartate (NMDA) receptor NR1 subunit in the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE).Methods: Paired serum and…
Abstract Number: 1853 • 2015 ACR/ARHP Annual Meeting
Binding of a Novel IgG3 VH4-34 Monoclonal Antibody to ssRNA in SLE
Asiya Chida¹, Kevin Cashman¹, Scott Jenks², Louise Hartson¹, Youliang Wang¹, Quan-Zhen Li Li^3,4, Chandra Mohan⁵ and Ignacio Sanz^6,7, ¹Medicine, Emory University, Atlanta, GA, ²Rheumatology, Emory University School of Medicine, Atlanta, GA, ³Immunology, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Biomedical Engineering, University of Houston, Houston, TX, ⁶Rheumatology, Emory University, Atlanta, GA, ⁷Medicine/Rheumatology, Emory University, Atlanta, GA
Background/Purpose: IgG antibodies expressing the idiotope for the 9G4 idiotype, the framework-1 hydrophobic patch (HP) of VH4-34, are expanded in SLE and provide a unique…
Abstract Number: 1854 • 2015 ACR/ARHP Annual Meeting
Identification and Characterization of microRNAs Related to the Pathogenesis of Cardiovascular Disease in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus. Role of Specific Autoantibodies
Chary Lopez-Pedrera¹, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon¹, Nuria Barbarroja¹, Yolanda Jiménez Gómez¹, Eduardo Collantes-Estevez¹, Mª Jose Cuadrado², Rocio Gonzalez-Conejero³, Constantino Martinez³ and Carlos Perez-Sanchez¹, ¹IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, ²Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, ³Regional Centre for Blood Donation, University of Murcia, Murcia, Spain
Background/Purpose: 1) To identify and characterize miRNAs related to the pathogenesis of CVD in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) patients; 2) To…
Abstract Number: 1855 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Exosomes Contain Distinct RNA Transcripts That Differentiate Disease Activity and Modulate Cellular Function
Samantha Slight-Webb¹, Krista M. Bean¹, Nicolas Dominguez¹, Mikhail G. Dozmorov², Judith A. James³ and Joel M. Guthridge¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple organ systems and periods of waxing and waning disease activity. The lack of…
Abstract Number: 1856 • 2015 ACR/ARHP Annual Meeting
Exosomes from Patients with Active Systemic Lupus Erythematosus Induce a Strong Inflammatory Response
Joo Youn Lee¹, Jin Kyun Park^1,2, Eun Young Lee³, Eun Bong Lee³ and Yeong Wook Song^1,2, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: Exosomes are 60–150 nm membrane vesicles that are secreted by various cells into surrounding body fluids including blood and urine. As vehicles for intercellular…

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