Abstracts Archive - Page 1999 of 2616 - ACR Meeting Abstracts

Abstract Number: 1764 • 2015 ACR/ARHP Annual Meeting
Type 1 Interferon in the Skin Stimulated By Ultraviolet B Light Generates Immune Suppression Mediated By Idoleamine 2,3-Dioxygenase 1
Clayton Sontheimer¹ and Keith B. Elkon², ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Photosensitivity is a common symptom in patients with systemic lupus erythematosus (SLE) and lupus skin lesions show local Type 1 Interferon (IFN-I) profiles similar…
Abstract Number: 1765 • 2015 ACR/ARHP Annual Meeting
MiR155 Deficient Mice Show Reduced Disease Severity in Pristane-Induced Lupus
Harald Leiss¹, Wilhelm Salzberger², Barbara Schwarzecker³, Irina Gessl¹, Nicolas Kozakowski⁴, Stephan Blüml⁵, Antonia Puchner¹, Birgit Niederreiter⁶, Carl-Walter Steiner², Josef S. Smolen⁷ and Georg H. Stummvoll², ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁷Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNAs (miRs) are an important class of regulators of gene expression that are associated with a variety of biological functions. Deregulation of endogenous miR155…
Abstract Number: 1766 • 2015 ACR/ARHP Annual Meeting
HPV Vaccination of Nzbxw/F1 Mice
Maria Teresa Arango¹, Lucija Tomljenovic², Miri Blank¹ and Yehuda Shoenfeld³, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²University of British Columbia, Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, Vancouver, BC, Canada, ³Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Human-papilloma virus vaccine (HPVv) is currently used worldwide. Still this vaccine has been linked to a variety of neurological and autoimmune manifestations. For instance,…
Abstract Number: 1767 • 2015 ACR/ARHP Annual Meeting
Noninvasive Assessment of Macrophage Activation in Experimental Glomerulonephritis Using Optical Imaging with Near-Infrared Light Serves As a Surrogate of Disease Activity
Sebastian Braehler¹, Dongyue Huang², Matthew Cheung², Walter Akers³ and Alfred Kim², ¹Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ²Rheumatology, Washington University School of Medicine, Saint Louis, MO, ³Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: Glomerulonephritis (GN) represents a major cause of morbidity & mortality. The standard for diagnosing GN is through renal biopsy, but this is not performed…
Abstract Number: 1768 • 2015 ACR/ARHP Annual Meeting
Improved Tissue Clearing and 2-Photon Imaging of Mouse Kidneys Reveals Immune Cell Architecture in Nephrotoxic Nephritis
Matthew Cheung, Dongyue Huang and Alfred Kim, Rheumatology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: Tissue clearing approaches such as CLARITY renders tissue transparent, and in combination with two-photon microscopy, enables microscopic visualization deep internal structures within unaltered organs.…
Abstract Number: 1769 • 2015 ACR/ARHP Annual Meeting
Role of Topical Administration of Peptidylarginine Deiminase Inhibitors in Murine Lupus
Erica Moore¹, Huw Lewis², Carolyne K. Smith¹, Venkataraman Subramaniam³, Victoria Hoffmann⁴, Paul Thompson⁵ and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Immuno Inflammation, GSK, Stevenage, United Kingdom, ³University of Massachusetts, Boston, MA, ⁴ORS, National Institutes of Health, Bethesda, MD, ⁵University of Massachusetts, Worcester, MA
Background/Purpose: Peptidylarginine deiminases (PADs), specifically PAD4, have recently been implicated in the pathogenesis of systemic lupus erythematosus (SLE) through their role in citrullinating histones in…
Abstract Number: 1770 • 2015 ACR/ARHP Annual Meeting
A New Perspective in Extracorporeal Immunotherapy of Systemic Lupus Erythematosus: Dnase I-Based Blood Perfusion Experiment Using Rat Model
Ekaterina Simakova, Andrey Trofimenko, Ilya Gontar and Irina Zborovskaya, Research Institute of Clinical and Experimental Rheumatology, Volgograd, Russia
Background/Purpose: DNA, nucleosomes, and other deoxyribonucleoproteins (DNP) are currently believed to be the key autoantigens in SLE. However, these extracellular DNP itself appear to be…
Abstract Number: 1771 • 2015 ACR/ARHP Annual Meeting
Blockade of Immune Complex-Mediated Glomerulonephritis By Highly Selective Inhibition of Bruton’s Tyrosine Kinase
Samantha Chalmers¹, Jessica Doerner², Todd Bosanac³, Sara Khalil³, Dustin Smith³, Christian Harcken³, Janice Dimock³, Evan Der², Leal Herlitz⁴, Deborah Webb³, Elise Seccareccia³, Jay Fine³, Elliott Klein³, Meera Ramanujam³ and Chaim Putterman⁵, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Cleveland Clinic, Cleveland, OH, ⁵Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Renal disease with loss of organ function results in significant morbidity and mortality in SLE. In the kidneys of affected patients, autoantibody-containing immune complexes…
Abstract Number: 1772 • 2015 ACR/ARHP Annual Meeting
Anti-Pentraxin 3 Antibodies Ameliorate Disease Manifestations and Lupus-like Nephritis in New Zealand Black/New Zealand White F1 Mice
Mariele Gatto¹, Nicola Bassi¹, Anna Ghirardello¹, Roberto Luisetto¹, Silvano Bettio¹, Luca Iaccarino¹, Leonardo Punzi² and Andrea Doria², ¹Department of Medicine-DIMED, University of Padova, Padova, Italy, ²Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose: Pentraxin 3 (PTX3) is an acute-phase protein released by different cell types including renal epithelial cells and immune-competent cells. PTX3 is able to either…
Abstract Number: 1773 • 2015 ACR/ARHP Annual Meeting
Pan JAK Inhibitor Tofacitinib Ameliorate Autoimmunity and Nephritis in Lupus Prone Mice Via Inhibition of Interferon Signaling Pathway
Keigo Ikeda^1,2, Kunihiro Hayakawa², Maki Fujishiro³, Mikiko Kawasaki³, Takuya Hirai^2,4, Shinji Morimoto^2,4, Yoshinari Takasaki⁵ and Iwao Sekigawa^3,4, ¹Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, ²Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ³Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ⁴Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Chiba, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: We previously reported that Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway-mediated regulation of interferon (IFN) regulatory factor (IRF)-related genes may have an…
Abstract Number: 1774 • 2015 ACR/ARHP Annual Meeting
Bone Marrow Derived Dendritic Cells Modified By Lentiviral-Mediated RelB shRNA Possess Tolerogenic Phenotype and Functions on Lupus Splenic Lymphocytes
Haijing Wu, Yi Lo, Albert Chan and Mo Yin Mok, Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by high morbidity and mortality and remains challenging in treatment. Dendritic cells (DCs)…
Abstract Number: 1775 • 2015 ACR/ARHP Annual Meeting
Fn14 Deficiency Protects Lupus-Prone Mice from Cutaneous Lesions Induced By Ultraviolet B (UVB) Irradiation
Jessica Doerner¹, Adam Friedman², Linda Burkly³ and Chaim Putterman⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²Department of Dermatology, George Washington School of Medicine and Health Sciences, Washington, DC, ³Biogen Idec, Cambridge, MA, ⁴The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Sunlight, via ultraviolet B (UVB) irradiation, is a well-recognized trigger of cutaneous lupus erythematosus (CLE) skin lesions. TNF-like weak inducer of apoptosis (TWEAK), a…
Abstract Number: 1776 • 2015 ACR/ARHP Annual Meeting
Significantly Reduced Lymphadenopathy, Salivary Gland Infiltrates and Proteinuria in MRL-Lpr/Lpr Mice Treated with Ultrasoluble Curcumin/Turmeric: Increased Survival with Curcumin Treatment
Biji T Kurien^1,2,3, Valerie M Harris^1,4, Syed MS Quadri^1,4, Patricia Coutinho-de Souza¹, Joshua Cavett^5,6, Amanda Moyer⁴, Bilal Ittiq⁷, Angela Metcalf⁶, Husayn Ramji⁸, Dat Truong⁸, Kristi A. Koelsch^4,9,10, Mike Centola¹¹, Adam Payne¹², D. Danda¹³ and R. Hal Scofield^1,14, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Allergy and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷University of Oklahoma Health Sciences Center, Oklahoma, OK, ⁸University of Oklahoma, Oklahoma City, OK, ⁹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ¹⁰Department Veterans Affairs Medical Center, Oklahoma City, OK, ¹¹Haus Bioceuticals, Oklahoma City, OK, ¹²Arthritis and Immunology, Oklahoma Medical Research Foun, Oklahoma City, OK, ¹³Christian Medical College, Vellore, India, ¹⁴US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Commercial curcumin (CU), derived from food spice turmeric, has been widely studied as a potential therapeutic for a variety of oncological and inflammatory conditions.…
Abstract Number: 1777 • 2015 ACR/ARHP Annual Meeting
Lymphocyte Depletion, Recovery and Efficacy in NZBWF1 Lupus Mice Following Continuous or Intermittent Dosing Regimen of Venetoclax (ABT-199), a Potent and Selective BCL-2 Inhibitor
Li Chun Wang¹, Stuart Perper¹, Kimberly Black¹, Regina Mario¹, Candace Graff^2,3, Dawna Hartman³, Andrew Souers⁴, Steven Elmore⁴ and Lisa Olson^1,3, ¹Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²DMPK, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ³AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁴AbbVie Inc., North Chicago, IL
Background/Purpose: Proteins in the BCL-2 family are key regulators of apoptosis, or programmed cell death. We report here that continuous daily treatment with 30mpk venetoclax…
Abstract Number: 1778 • 2015 ACR/ARHP Annual Meeting
Disease Progression Is Altered By Moderate Exercise and Social Stress in a Murine Model of Lupus Nephritis
Jeffrey Hampton¹, Nicholas A. Young², Sudha Agarwal³, Saba Aqel³, Kendra Jones³, Lai-Chu Wu^2,4, Nicole Powell⁵, John Sheridan⁵, Michael Bruss³ and Wael N. Jarjour², ¹Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, ⁵Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Chronic inflammation is pathognomonic of autoimmune diseases and contributes to organ damage. Our group has previously shown that moderate daily exercise reduces systemic inflammation…

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